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Journal of Applied Mathematics and Physics 2014年第12期2卷 1085-1090页

作者： Benabderrahmane Hakim Kerrou Jaouher Tacher Laurent Deman gregory Perrochet Pierre Research & Development Department ANDRA 1-7 rue Jean Monnet Chatenay-Malabry Cedex France Centre of Hydrogeology and Geothermics (CHYN) University of Neuchatel Rue Emile Argand 11 Neuchatel Switzerland Laboratoire de Mécanique des Sols (EPfL-LMS) Ecole Polytechnique Fédérale de Lausanne Lausanne Switzerland

The french National Agency for Nuclear Waste Management (Andra) conducted a site investiga- tions program within the project of a deep geological disposal of radioactive waste in the Meuse/ Haute-Marne region. The construction of the tunnel of 5 Km length and the shafts of about 500 m depth to access the repository located in the clay host formation of Callovo-Oxfordian age, will lead to the perturbations of the groundwater flow fields. The prediction of the behaviour of these perturbations is needed to support: 1) the engineering and monitoring operations, and 2) the assessment of the consequences on groundwater resources. A variably-saturated flow model of a local multi-layered aquifer system is developed. It integrates the Oxfordian aquifer (limestone), the Kimmeridgianaquitard (marl) and the Barrois limestone aquifer including the karst conduits network. The variably-saturated flow Richard’s equation is solved with a finite element simulator. Prior to the simulation of the predictive repository impacts, a transient flow model is calibrated with respect to Underground Research Laboratory (URL) construction data. The results are analysed and evaluated by the use of performance measures.

关键词： Numerical Modelling Variably-Saturated flow Karst Repository Hydraulic Impacts

Origin of major ions in monthly rainfall events at the Bamenda Highlands, North West Cameroon

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Journal of Environmental Sciences 2014年第4期26卷 801-809页

作者： Mengnjo J. Wirmvem Takeshi Ohba Wilson Y. fantong Samuel N. Ayonghe Jonathan N. Hogarh Justice Y. Suila Asobo Nkengmatia E. Asaah Seigo Ooki gregory Tanyileke Joseph V. Hell Department of Chemistry School of Science Tokai University Hiratsuka 259-1211 Japan Institute of Geological and Mining Research Yaounde Cameroon Department of Environmental Science Faculty of Science University of Buea Buea Cameroon Department of Environmental Science Kwame Nkrumah University of Science & Technology Kumasi Ghana G.B.H.S. Atiela Nkwen Bamenda Cameroon Department of Earth and Planetary Sciences Tokyo Institute of Technology Tokyo 152-8551 Japan

Rainwater characteristics can reveal emissions from various anthropogenic and natural sources into the atmosphere. The physico-chemical characteristics of 44 monthly rainfall events （collected between January and December 2012） from 4 weather stations （Bamenda, Ndop plain, Ndawara and Kumbo） in the Bamenda Highlands （BH） were investigated. The purpose was to determine the sources of chemical species, their seasonal inputs and suitability of the rainwater for drinking. The mean pH of 5 indicated the slightly acidic nature of the rainwater. Average total dissolved solids （TDS） were low （6.7 mg/L）, characteristic of unpolluted atmospheric moisture/air. Major ion concentrations （mg/L） were low and in the order K＋〉 Ca2＋〉 Mg2~ 〉 Na＋ for cations and NO3 〉〉 HCO3 〉 SO] 〉 CI- 〉 PO3- 〉 f- for anions. The average rainwater in the area was mixed Ca-Mg-SO4-CI water type. The CI-/Na＋ ratio （1.04） was comparable to that of seawater （1.16）, an indication that N a＋ and CI originated mainly from marine （Atlantic Ocean） aerosols. High enrichments of Ca2＋, Mg2＋ and SO2- to Na＋ ratios relative to seawater ratios （constituting 44% of the total ions） demonstrated their terrigenous origin, mainly from Saharan and Sahelian arid dusts. The K＋/Na＋ ratio （2.24）, which was similar to tropical vegetation ash （2.38）, and NO3 was essentially from biomass burning. Light （〈 100 mm） pre-monsoon and post-monsoon convective rains were enriched in major ions than the heavy （〉 100 mm） monsoon rains, indicating a high contribution of major ions during the low convective showers. Despite the acidic nature, the TDS and major ion concentrations classified the rainwater as potable based on the WHO guidelines.

关键词： rainwater chemistry tropical atmosphere drinking-water Bamenda Highlands Cameroon

Pre-implantation exogenous progesterone and pregnancy in *** on fetalplacental development and nutrient transporters in late pregnancy

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Journal of Animal Science and Biotechnology 2021年第3期12卷 952-971页

作者： Katherine M.Halloran Emily C.Hoskins Claire Stenhouse Robyn M.Moses Kathrin A.Dunlap M.Carey Satterfield Heewon Seo gregory A.Johnson Guoyao Wu fuller W.Bazer Department of Animal Science Texas A&M UniversityCollege StationTX 77843-2471USA Department of Veterinary Integrative Biosciences Texas A&M UniversityCollege StationTX 77843USA

Background:Administration of progesterone(P4)to ewes during the first 9 to 12 days of pregnancy accelerates blastocyst development by day 12 of pregnancy,likely due to P4-induced up-regulation of key genes in uterine epithelia responsible for secretion and transport of components of histotroph into the uterine *** study determined if acceleration of blastocyst development induced by exogenous P4 during the pre-implantation period affects fetal-placental development on day 125 of *** ewes(n=35)were mated to fertile rams and assigned randomly to receive daily intramuscular injections of either corn oil vehicle(CO,n=18)or 25 mg progesterone in CO(P4,n=17)for the first 8 days of *** ewes were hysterectomized on day 125 of pregnancy and:1)fetal and placental weights and measurements were recorded;2)endometrial and placental tissues were analyzed for the expression of candidate mRNAs involved in nutrient transport and arginine metabolism;and 3)maternal plasma,fetal plasma,allantoic fluid,and amniotic fluid were analyzed for amino acids,agmatine,polyamines,glucose,and ***:Treatment of ewes with exogenous P4 did not alter fetal or placental growth,but increased amounts of aspartate and arginine in allantoic fluid and amniotic fluid,*** that received exogenous P4 had greater expression of mRNAs for SLC7A1,SLC7A2,SLC2A1,AGMAT,and ODC1 in endometria,as well as SLC1A4,SLC2A5,SLC2A8 and ODC1 in *** addition,AZIN2 protein was immunolocalized to uterine luminal and glandular epithelia in P4-treated ewes,whereas AZIN2 localized only to uterine luminal epithelia in CO-treated ***:This study revealed that exogenous P4 administered in early pregnancy influenced expression of selected genes for nutrient transporters and the expression of a protein involved in polyamine synthesis on day 125 of pregnancy,suggesting a‘programming’effect of P4 on gene expression that affected the composition of nutrients in f

关键词： Amino acids Endometrium fructose Gene expression Glucose Placenta Polyamines Progesterone

A cluster-randomized trial comparing two SWITCH implementation support strategies for school wellness intervention effectiveness

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Journal of Sport and Health Science 2023年第1期12卷 87-96页

作者： Richard R.Rosenkranz Philip M.Dixon David A.Dzewaltowski Gabriella M.McLoughlin Joey A.Lee Senlin Chen Spyridoula Vazou Lorraine M.Lanningham-foster Doug A.Gentile gregory J.Welk Department of food NutritionDietetics&HealthKansas State UniversityManhattanKS 66506USA Department of Statistics Snedecor HallIowa State UniversityAmesIA 50011-1210USA Department of Health Promotion University of NebraskaOmahaNE 68198-4365USA Implementation Science Center for Cancer Control and Prevention Research Center Brown SchoolWashington University in St.LouisSt.LouisMO 63130USA Division of Public Health Sciences(Department of Surgery) Washington University School of MedicineWashington University in St.LouisSt.LouisMO 63130USA Department of Health Sciences University of Colorado Colorado SpringsColorado SpringsCO 80918USA Department of Kinesiology Iowa State UniversityAmesIA 50011-4008USA Department of food Science&Human Nutrition Iowa State UniversityAmesIA 50011USA Department of Psychology Iowa State UniversityAmesIA 50011-1041USA

Background:The School Wellness Integration Targeting Child Health(SWITCH)intervention has demonstrated feasibility as an implementation approach to help schools facilitate changes in students’physical activity(PA),sedentary screen time(SST),and dietary intake(DI).This study evaluated the comparative effectiveness of enhanced(individualized)implementation and standard(group-based)***:Twenty-two Iowa elementary schools participated,with each receiving standardized training(wellness conference and webinars).Schools were matched within region and randomized to receive either individualized or group implementation *** PA,SST,and DI outcomes of 1097 students were assessed at pre-and post-intervention periods using the Youth Activity *** mixed models evaluated differential change in outcomes by condition,for comparative effectiveness,and by ***:Both implementation conditions led to significant improvements in PA and SST over time(pfferential changes between the group and individualized conditions for PA(p=0.51),SST(p=0.19),or DI(p=0.73).There were no differential effects by gender(i.e.,non-significant condition-by-gender interactions)for PA(p_(for interaction)=0.86),SST(p_(for interaction)=0.46),or DI(p_(for interaction)=0.15).Effect sizes for both conditions equated to approximately 6 min more PA per day and approximately 3 min less sedentary ***:The observed lack of difference in outcomes suggests that group implementation of SWITCH is equally effective as individualized implementation for building capacity in school wellness ***,the lack of interaction by gender suggests that SWITCH can be beneficial for both boys and *** research is needed to understand the school-level factors that influence implementation(and outcomes)of SWITCH.

关键词： Children Implementation science Obesity prevention Physical activity School health

新生小猪脑含氧量和O-酪氨酸在双侧颈动脉结扎和失血中的变化(英文)

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昆明医学院学报 2002年第3期23卷 8-13页

作者：沈进 Jennifer Greed Tatiana Zaitseva gregory Schears David f Wilson Anna Pastuszko 昆明医学院第一附属医院影像中心昆明650032 美国宾夕法尼亚大学医学院生物化学生物与物理系美国宾州费城19104

采用小猪双侧颈动脉结扎伴失血模型检测双侧颈动脉的结扎伴失血对脑氧分压和O -酪氨酸变化的影响 ,结果发现 :小猪脑氧分压为 (5 1± 4)托颈动脉结扎和失血后 6 0min降为 (10± 1 5 )托 (P <0 0 0 1) ,当颈动脉恢复通畅和失血再灌注... 详细信息

采用小猪双侧颈动脉结扎伴失血模型检测双侧颈动脉的结扎伴失血对脑氧分压和O -酪氨酸变化的影响 ,结果发现 :小猪脑氧分压为 (5 1± 4)托颈动脉结扎和失血后 6 0min降为 (10± 1 5 )托 (P <0 0 0 1) ,当颈动脉恢复通畅和失血再灌注后 ,脑氧分压增至 (4 0± 6 )托 ,此值与预试验时的脑氧分压无明显差异对照组中脑纹状体中的O -酪氨酸的含量为 (0 5 7± 0 19)nmoles/ g组织缺血试验后 1h其含量明显升为 (2 9± 0 5 )nmoles/ g组织 (P <0 0 0 5 ) ,显示缺血后再灌注导致脑纹状体O -酪氨酸显著上升提示组织中羟基产生增加。

关键词： O-酪氨酸双侧颈动脉结扎失血脑缺氧小猪脑缺血再灌注损伤

Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 713C and SARS-CoV-2 main protease

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Acta Pharmaceutica Sinica B 2022年第10期12卷 3924-3933页

作者： Bo Qin gregory B.Craven Pengjiao Hou Julian Chesti Xinran Lu Emma S.Child Rhodri M.L.Morgan Wenchao Niu Lina Zhao Alan Armstrong David J.Mann Sheng Cui NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100076China Department of Life Sciences Imperial College LondonSouth Kensington CampusLondon SW72AZUK Department of Chemistry Imperial College LondonMolecular Sciences Research HubWhite City CampusWood LaneLondon W120BZUK CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy PhysicsUniversity of Chinese Academy of SciencesBeijing 100049China

RNA viruses are critically dependent upon virally encoded proteases to cleave the viral polyproteins into functional *** of these proteases exhibit a similar fold and contain an essential catalytic cysteine,offering the opportunity to inhibit these enzymes with electrophilic small *** we describe the successful application of quantitative irreversible tethering(qIT)to identify acrylamide fragments that target the active site cysteine of the 3C protease(3Cpro)of Enterovirus 71,the causative agent of hand,foot and mouth disease in humans,altering the substrate binding ***,we re-purpose these hits towards the main protease(Mpro)of SARS-CoV-2 which shares the 3C-like fold and a similar active *** hit fragments covalently link to the catalytic cysteine of Mpro to inhibit its *** demonstrate that targeting the active site cysteine of Mpro can have profound allosteric effects,distorting secondary structures to disrupt the active dimeric unit.

关键词： SARS-CoV-2 Protease inhibitors Covalent fragments Allosteric inhibition EV71

Anti-ulcer activity of ficus religiosa leaf ethanolic extract

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Asian Pacific Journal of Tropical Biomedicine 2013年第7期3卷 554-556页

作者： Marslin gregory B. Divya Revina Ann Mary M. M. Hipolith Viji V. K. Kalaichelvan V. Palanivel Department of pharmacology Annamalai UniversityChidambaram India Centre for the Research and Technology of Agro-Environment and Biological Sciences (CITAB) Department of Biology University of MinhoPortugal Padmavathi College of Pharmacy and Research Institute Periyanahalli DharmapuriTamilnadu India Department of Nursing Science A.J College of Nursing ChennaiTamilnadu India Department of Phytochemistry Natural Remedies Research lab BangaloreKarnataka India

Objective:To evaluate the anti-ulcer activity and acute toxicity officus religiosa(f. religiosa)leaf ethanolic extract in animal ***:Anti-ulcer activity off. religiosaethanolicextract(250 and 500 mg/kg body weight) was studied on stress induced ulcer animal *** was used as standard. The anti-ulcer activity off. religiosawas evaluated with thehelp of ulcer area and histopatholgical examination. Preliminary phyto-chemical screeningand acute toxicity studies off. religiosaalso carried ***:Results showed that theextract treatments prevented ulcer area and gastric secretion in a dose-dependent *** of 2000 mg/kg extract did not show any acute toxicity in albino mice. Preliminaryphytochemical analysis identified the presence of flavonoids in the ethanolic extract off. ***:The extract is non-toxic even at relatively high concentrations. The anti-ulceractivity is probably due to the presence of flavanoids.

关键词： ficus religiosa flavonoids Ethanolic extract Ulcer area Ranitidne

甘肃张掖早白垩世彩丘中古土壤的判别、类型和序列特征

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第四纪研究 2019年第2期39卷 429-437页

作者：毛学刚刘秀铭 gregory Retallack 师永辉陈金牛福建师范大学地理研究所福建福州350007 福建省湿润亚热带山地生态重点实验室--省部共建国家重点实验室培育基地福建福州350007 Department of Earth Science University of Oregon Eugene Oregon USA 97403-1272 Department of Environment and Geography Macquarie University Sydney NSW 2109 Australia 福建师范大学地理科学学院福建福州350007

古土壤记录了丰富的古气候和古环境信息,然而古土壤受后期地质作用影响常不易被正确地识别。甘肃张掖彩丘是白垩纪早期发育的彩色地层,目前详细的地层序列尚未建立。张掖彩丘表现为红色、黄色、灰色、紫色等多种颜色交替变化,通常被认... 详细信息

古土壤记录了丰富的古气候和古环境信息,然而古土壤受后期地质作用影响常不易被正确地识别。甘肃张掖彩丘是白垩纪早期发育的彩色地层,目前详细的地层序列尚未建立。张掖彩丘表现为红色、黄色、灰色、紫色等多种颜色交替变化,通常被认为是河湖相沉积或洪积相沉积,然而野外考察发现大量的古土壤特征。野外观察识别古土壤主要从根迹、土壤结构和土壤发生层等方面,主要表现为红色根迹或青灰色晕状根迹,半干旱环境下形成的钙质淀积层,土壤在干湿交替环境下形成的粘土滑擦面,土壤发生层之间的过渡边界。本文通过对张掖彩丘地层的系统考察,建立了较为详细的厚760 m的地层序列,根据古土壤的发育特征,识别出14种不同类型的古土壤,整个彩丘地层共计156个古土壤剖面,是独特的古土壤序列。14种古土壤类型与现代土壤类型对照,并与国际土壤分类对比,类比的现代土壤类型主要出现在南亚的亚热带或热带气候条件,说明白垩纪早期比现在更为温暖。根据古土壤发育程度序列,结合古土壤特征和地层特点,将古气候变化分成4个阶段,依次是湿润(0~268 m)、半干旱(268~550 m)、湿润(550~740 m)、干旱(740~760 m)阶段。张掖彩丘古土壤的系统识别和发育程度序列的建立为进一步古气候研究奠定基础。

关键词：张掖彩丘古土壤根迹早白垩世

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恺撒入侵不列颠：月亮与潮汐

中国国家天文 2008年第8期2卷 118-123页

作者： Donald Olson Russell Doescher Kellie N．Beicker Amanda f．gregory 李碧葛（译）

一个借助于天文学手段的研究小组发现，几乎所有的历史学家都弄错了罗马军队在不列颠两栖登陆的历史日期。

关键词：不列颠潮汐月亮入侵历史学家天文学

Nanostructured 3-D Collagen/Nanotube Biocomposites for future Bone Regeneration Scaffolds

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Nano Research 2009年第6期2卷 462-473页

作者： Edelma E.da Silva Heloisa H.M.Della Colleta Andre S.ferlauto Roberto L.Moreira Rodrigo R.Resende Sergio Oliveira gregory T.Kitten Rodrigo G.Lacerda Luiz O.Ladeira Universidade federal de Minas Gerais Departamento de FísicaLaboratório de NanomateriaisAv.Antônio Carlos662730123-970Belo HorizonteMGBrazil Universidade federal de Minas Gerais Departamento de MorfologiaAv.Antônio Carlos662730123-970Belo HorizonteMGBrazil

The fi eld of bionanotechnology has been rapidly growing during the last few years and we can now envision a controllable integration between biological and artificial matter,where new biomimetic structures with a wide range of chemical and physical properties will promote the development of a novel generation of medical *** this work we describe a collagen/carbon nanotube composite which has the potential to be used as a scaffold for tissue *** this biocomposite incorporates the advantageous properties of both collagen and carbon nanotubes,it has most of the characteristics that an ideal biomaterial requires in order to be used as an osteoinductive *** biocomposite is bioresorbable and biodegradable and has the desired mechanical rigidity while maintaining a three-dimensional(3-D)nanostructured *** stability and swelling were achieved under fluid environments by varying the amount of carbon nanotubes(CNTs)incorporated into the *** variations can dictate the degree of interaction between fibroblastic cells and the ***-of-concept was shown by performing an in vitro induced mineralization of hydroxylapatite crystals under physiological ***,the ability to attach biofunctional groups to the CNT walls can open a new road for tissue regeneration since the combination of CNTs with specific growth factors or cellular ligands can create an environment capable of signaling and infl uencing specifi c cell *** observations suggest that collagen/carbon nanotube biocomposites will have important uses in a wide range of biotechnological areas.

关键词： Biomaterials carbon nanotubes collagen tissue engineering biocompatibility