检索结果-南通市图书馆

Dynamic glial response and crosstalk in demyelination-remyelination and neurodegeneration processes

neural Regeneration Research 2021年第7期16卷 1359-1368页

作者： Tianci Chu Lisa B.E.Shields Wenxin Zeng Yi Ping Zhang Yuanyi Wang Gregory N.Barnes Christopher B.Shields Jun Cai Pediatric Research Institute Department of PediatricsUniversity of Louisville School of MedicineLouisvilleKYUSA norton neuroscience Institute Norton HealthcareLouisvilleKYUSA Department of Spine Surgery The First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of neurology University of Louisville School of MedicineLouisvilleKYUSA Department of Pharmacology and Toxicology University of LouisvilleLouisvilleKYUSA Department of neurological Surgery University of Louisville School of MedicineLouisvilleKYUSA

Multiple sclerosis is an autoimmune disease in which the immune system attacks the myelin sheath in the central nervous system.It is characterized by blood-brain barrier dysfunction throughout the course of multiple sclerosis, followed by the entry of immune cells and activation of local microglia and astrocytes.Glial cells(microglia, astrocytes, and oligodendrocyte lineage cells) are known as the important mediators of neuroinflammation, all of which play major roles in the pathogenesis of multiple sclerosis.network communications between glial cells affect the activities of oligodendrocyte lineage cells and influence the demyelination-remyelination process.A finely balanced glial response may create a favorable lesion environment for efficient remyelination and neuroregeneration.This review focuses on glial response and neurodegeneration based on the findings from multiple sclerosis and major rodent demyelination models.In particular, glial interaction and molecular crosstalk are discussed to provide insights into the potential cell-and molecule-specific therapeutic targets to improve remyelination and neuroregeneration.

关键词： astrocyte crosstalk demyelination glial response microglia/macrophage multiple sclerosis neurodegeneration neuroinflammation oligodendrocyte lineage cells remyelination

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Altered physiology of gastrointestinal vagal afferents following neurotrauma

引用

neural Regeneration Research 2021年第2期16卷 254-263页

作者： Emily n.Blanke gregory M.Holmes Emily M.Besecker Department of Health Sciences Gettysburg CollegeGettysburgPAUSA Department of neural and Behavioral Sciences Penn State University College of MedicineHersheyPAUSA

The adaptability of the central nervous system has been revealed in several model systems.Of particular interest to central nervous system-injured individuals is the ability for neural components to be modified for regain of function.In both types of neurotrauma,traumatic brain injury and spinal cord injury,the primary parasympathetic control to the gastrointestinal tract,the vagus nerve,remains anatomically intact.However,individuals with traumatic brain injury or spinal cord injury are highly susceptible to gastrointestinal dysfunctions.Such gastrointestinal dysfunctions attribute to higher morbidity and mortality following traumatic brain injury and spinal cord injury.While the vagal efferent output remains capable of eliciting motor responses following injury,evidence suggests impairment of the vagal afferents.Since sensory input drives motor output,this review will discuss the normal and altered anatomy and physiology of the gastrointestinal vagal afferents to better understand the contributions of vagal afferent plasticity following neurotrauma.

关键词： gastrointestinal functions microbiome neurotrauma nodose ganglia sensory neuropathy spinal cord injury traumatic brain injury vagal afferents visceral reflexes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mimicking Protein Activity in Simple Synthetic Polymers

Mimicking Protein Activity in Simple Synthetic Polymers

引用

ASTF2023（第五届）抗菌科学与技术论坛

作者： gregory n.Tew Polymer Science and Engineering Department University of Massachusetts

Our primary research aim is to create new materials using a combination of principles,many of which are inspired by biology.In addition,the design of simple molecules that mimic the complex structures and functions of...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

The Conceptualization of Qing-Era （1644-1911） Chinese Literature in nineteenth Century Choson （1392-1910） Korea

引用

Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2013年第3期7卷 396-421页

作者： gregory n. Evon School of Humanities and Languages The University of New South Wales Sydney NSW2052 Australia

In a poem composed in 1832, the Chosrn-Korean polymath Chrng Yagyong （1762-1836） declared his fidelity towards Confucian literary principles. Chrng＇s poem was a product of an elite education, and in both form and content, it embodied the ideals of the Chosrn elite： written in classical Chinese rather than Korean, it was an expression of cultural self-confidence. From the point of view of nationalism and its emphasis on vernaculars, it seems strange to define oneself through a cosmopolitan written language. But Chrng was no nationalist. He was a Confucian conservative, and the sense of distinction and difference that animated Chrng＇s poem was Confucian and literary. His articulation of such ideals manifested unease over the erosion of Confucian literary values in China and the prospect of the same occurring in Chos6n under Chinese influence. The source of that influence was books imported from China. What Chrng was reacting against was, at root, the commodification of literature and all that had entailed in Ming （1368-1644） and Qing （1644-1911） China. Although such concerns had grown increasingly urgent a half-century before, they had a long pedigree in Choson, stretching back to debates that had arisen in relation to Ming China and the principal emblem of the commodification of literature： commercial bookstores. This paper examines some of the principal differences between Chinese and Korean literary cultures that were embodied in Chang. It therefore begins with a brief overview of Chang and his poem, before turning to a discussion of some key sociopolitical and intellectual features that distinguished Chosrn＇s literary culture from that of China. Sixteenth-century attitudes towards bookstores are discussed to contextualize subsequent worries over Chinese books, with special attention given to the historical and historiographical dimensions of the question, before concluding with an assessment of the final moments of direct Chinese literary influence in Korea.

关键词： Chong Yagyong Chinese literature in Choson Korea literarycommercialization Ming-Qing China Choson Korea

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An Elevated Perspective: Dyke-Related Fracture networks Analysed with Uav Photogrammetry

引用

Acta Geologica Sinica(English Edition) 2016年第S1期90卷 54-55页

作者： gregory DERInG Steven MICKLETHWAITE Stephen J.barnes Marco FIOREnTInI Alexander CRUDEn Eric TOHVER School of Earth Sciences ARC Centre of Excellence for Core to Crust Fluid Systems University of Western Australia Mineral Resources Flagship CSIRO School of Earth Atmosphere and Environment Monash University

An abundance of data from seismic and geodetic monitoring has provided new insight into dyke propagation and emplacement mechanisms.These studies show that faulting and fracturing is part of the magma

关键词： rock An Elevated Perspective Dyke-Related Fracture networks Analysed with Uav Photogrammetry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A survey of high resolution image processing techniques for cereal crop growth monitoring

引用

Information Processing in Agriculture 2022年第2期9卷 300-315页

作者： Sanaz Rasti Chris J.Bleakley n.M.Holden Rebecca Whetton David Langton gregory O’Hare School of Computer Science University College DublinDublinIreland School of Agriculture and Food Science University College DublinDublinIreland School of Biosystems and Food Engineering University College DublinDublinIreland Origin Enterprises plc DublinIreland

This paper presents a survey of image processing techniques proposed in the literature forextracting key cereal crop growth metrics from high spatial resolution, typically proximalimages. The descriptive crop growth metrics considered are: crop canopy cover, aboveground biomass, leaf area index (including green area index), chlorophyll content, andgrowth stage. The paper includes an overview of relevant fundamental image processingtechniques including camera types, colour spaces, colour indexes, and image segmentation. The descriptive crop growth metrics are defined. Reference methods for groundtruth measurement are described. Image processing methods for metric estimation aredescribed in detail. The performance of the methods is reviewed and compared. The surveyreveals limitations in image processing techniques for cereal crop monitoring such as lackof robustness to lighting conditions, camera position, and self-obstruction. Directions forfuture research to improve performance are identified.

关键词： Crop canopy cover Above ground biomass Leaf area index Chlorophyll content Growth stage Cereal image processing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Beyond the SDG 15.3.1 Good Practice Guidance 1.0 using the Google Earth Engine platform: developing a self-adjusting algorithm to detect significant changes in water use efficiency and net primary production

引用

Big Earth Data 2023年第1期7卷 59-80页

作者： Andrea Markos neil Sims gregory Giuliani Foundation for the Conservation of the Chiquitano Forest Santa CruzBolivia Bolivian national Academy of Sciences La PazBolivia Centre for Earth Observation Space&AstronomyCSIROClaytonAustralia GEO LDn Initiative Institute for Environmental Sciences EnviroSPACE LabUniversity of GenevaGenevaSwitzerland Institute for Environmental Sciences GRID-GenevaUniversity of GenevaGenevaSwitzerland

Monitoring changes in Annual net Primary Productivity(AnPP)is required for reporting on Un Sustainable Development Goal(SDG)Indicator 15.3.1:the proportion of land that is degraded over the total land area.Calibrating time-series observations of AnPP to derive Water Use Efficiency(WUE;a measure of AnPP per unit of evapotranspiration)can minimize the influence of climate factors on AnPP observations and highlight the influence of non-climatic drivers of degradation such as land use changes.Comparing the AnPP and WUE time series may be useful for identifying the primary drivers of land degradation,which could be used to support the Land Degradation neutrality objectives of the Un Convention to Combat Desertification(UnCCD).This paper presents an algorithm for the Google Earth Engine(freely and openly available upon request-http://***/10.5281/zenodo.4429773)to calculate and compare AnPP and WUE time series for Santa Cruz,Bolivia,which has recently experienced an intensification in its land use.This code builds on the Good Practice Guidance document(ver-sion 1)for monitoring SDG Indicator 15.3.1.We use the MODIS 16-day average,250 m resolution to demonstrate that the Enhanced Vegetation Index(EVI)responds faster to changes in water avail-ability than the normalized Difference Vegetation Index(nDVI).We also consider the relationships between AnPP and WUE.Significant and concordant trends may highlight good agricultural practices or increased resilience in ecosystem structure and productivity when they are positive or reducing resilience and functional integrity if negative.The sign and significance of the correlation between AnPP and WUE may also diverge over time.With further analysis,it may be possible to interpret this relationship in terms of the drivers of change in plant productivity and ecosystem resilience.

关键词： Land degradation land productivity water use efficiency Google Earth Engine MODIS Good Practice Guidance SDG 15.3.1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A method to deliver patterned electrical impulses to Schwann cells cultured on an artificial axon

引用

neural Regeneration Research 2019年第6期14卷 1052-1059页

作者： Antonio Merolli Yong Mao gregory Voronin Joseph A.M.Steele n.Sanjeeva Murthy Joachim Kohn new Jersey Center for Biomaterials Rutgers-The State University of New Jersey In Vivo Research Services Rutgers-The State University of New Jersey

Information from the brain travels back and forth along peripheral nerves in the form of electrical impulses generated by neurons and these impulses have repetitive patterns. Schwann cells in peripheral nerves receive molecular signals from axons to coordinate the process of myelination. There is evidence, however,that non-molecular signals play an important role in myelination in the form of patterned electrical impulses generated by neuronal activity. The role of patterned electrical impulses has been investigated in the literature using co-cultures of neurons and myelinating cells. The co-culturing method, however, prevents the uncoupling of the direct effect of patterned electrical impulses on myelinating cells from the indirect effect mediated by neurons. To uncouple these effects and focus on the direct response of Schwann cells,we developed an in vitro model where an electroconductive carbon fiber acts as an artificial axon. The fiber provides only the biophysical characteristics of an axon but does not contribute any molecular signaling.In our "suspended wire model", the carbon fiber is suspended in a liquid media supported by a 3D printed scaffold. Patterned electrical impulses are generated by an Arduino 101 microcontroller. In this study, we describe the technology needed to set-up and eventually replicate this model. We also report on our initial in vitro tests where we were able to document the adherence and ensheath of human Schwann cells to the carbon fiber in the presence of patterned electrical impulses(hSCs were purchased from ScienCell Research Laboratories, Carlsbad, CA, USA; ScienCell fulfills the ethic requirements, including donor's consent). This technology will likely make feasible to investigate the response of Schwann cells to patterned electrical impulses in the future.

关键词： Schwann cell carbon fiber myelination electrical impulse artificial axon in vitro system Arduino microcontroller myelin basic protein

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The diagnostic and prognostic utility of the dual-task tandem gait test for pediatric concussion

引用

Journal of Sport and Health Science 2021年第2期10卷 131-137页

作者： Katie A.Van Deventer Corrine n.Seehusen gregory A.Walker Julie C.Wilson David R.Howell University of Colorado School of Medicine AuroraCO 80045USA Sports Medicine Center Children’s Hospital ColoradoAuroraCO 80045USA Department of Orthopedics University of Colorado School of MedicineAuroraCO 80045USA Department of Pediatrics University of Colorado School of MedicineAuroraCO 80045USA

Background:The tandem gait test has gained interest recently for assessment of concussion recovery.The purpose of our study was to determine the prognostic and diagnostic use of the single-and dual-task tandem gait test,alongside other clinical measures,within 10 days of pediatric concussion.Methods:We assessed 126 patients post-concussion(6.3§2.3 days post-injury,mean§SD)at a pediatric sports medicine clinic and compared them to 58 healthy controls(age:15.6§1.3 years;43%female).We also compared the 31 patients with concussion who developed persistent post-concussion symptoms(PPCS)(age=14.9§2.0 years;48%female)to the 81 patients with concussion who did not develop PPCS following the initial assessment(age:14.1§3.0 years;41%female).All subjects completed a test battery,and concussion patients were monitored until they experienced concussion-symptom resolution.The test battery included tandem gait(single-task,dual-task(performing tandem gait while concurrently completing a cognitive test)conditions),modified Balance Error Scoring System(mBESS),and concussion symptom assessment(Health and Behavior Inventory).We defined PPCS as symptom resolution time>28 days post-concussion for the concussion group.Measurement outcomes included tandem gait time(single-and dual-task),dual-task cognitive accuracy,mBESS errors(single/double/tandem stances),and symptom severity.Results:The concussion group completed the single-task(mean difference=9.1 s,95%confidential interval(95%CI):6.1-12.1)and dual-task(mean difference=12.7 s,95%CI:8.716.8)tandem gait test more slowly than the control group.Compared to those who recovered within 28 days of concussion,the PPCS group had slower dual-task tandem gait test times(mean difference=7.9 s,95%CI:2.0-13.9),made more tandem-stance mBESS errors(mean difference=1.3 errors,95%CI:0.2-2.3),and reported more severe symptoms(mean difference=26.6 Health and Behavior Inventory rating,95%CI:21.1-32.6).Conclusion:Worse dual-task tandem gait test time and mBESS tandem stance performance predicted PPCS in

关键词： Adolescent Balance Mild traumatic brain injury Postural stability Prognosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Smaller and bolder prey snails have higher survival in staged encounters with the sea star Pisaster giganteus

引用

Current Zoology 2017年第6期63卷 633-638页

作者： William C. FOSTER Connor M. ARMSTROnG gregory T. CHISM Jonathan n. PRUITT Department of Ecology Evolution and Marine Biology University of California Santa Barbara Santa Barbara CA93180 USA

Temporally consistent individual differences in behavior, also known as animal personality, can have large impacts on individual fitness. Here, we explore the degree to which individual differences in anti-predator response (or boldness) influence survival rates in groups of snails when they encounter a predatory sea star . The snail shows consistent individual variation in predator response where some fearful snails actively flee bodies of water occupied by predators whereas bolder snails consistently do not. We show here that bold snails are significantly more likely to survive encounters with a predatory sea star and, somewhat counterintuitively, fearful snails actually suffer higher mortality rates. We also found that smaller snails and those occurring at higher experimental densities experienced higher per capita survival rates. Positive effects of prey boldness on survival are not uncommonly reported in the animal personality literature; however, such results are inconsistent with classic animal personality theory borrowed from the optimal foraging literature. The findings herein add to the growing body of evidence that consistent individual differences in behavior can impact predator-prey interactions and that boldness is potentially under positive predator-driven selection in some systems.

关键词： behavioral syndrome behavioral type personality predation risk survival selection temperament

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：