Dynamic glial response and crosstalk in demyelination-remyelination and neurodegeneration processes

作     者：Tianci Chu Lisa B.E.Shields Wenxin Zeng Yi Ping Zhang Yuanyi Wang Gregory N.Barnes Christopher B.Shields Jun Cai Tianci Chu;Lisa B.E.Shields;Wenxin Zeng;Yi Ping Zhang;Yuanyi Wang;Gregory N.Barnes;Christopher B.Shields;Jun Cai

作者机构：Pediatric Research InstituteDepartment of PediatricsUniversity of Louisville School of MedicineLouisvilleKYUSA Norton Neuroscience InstituteNorton HealthcareLouisvilleKYUSA Department of Spine SurgeryThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of NeurologyUniversity of Louisville School of MedicineLouisvilleKYUSA Department of Pharmacology and ToxicologyUniversity of LouisvilleLouisvilleKYUSA Department of Neurological SurgeryUniversity of Louisville School of MedicineLouisvilleKYUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第7期

页      面：1359-1368页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：partially supported by grants from the National Institute of Neurological Disorders and Stroke of the National Institutes of Health(R21 NS098170, to JC and CBS) Kentucky Spinal Cord and Head Injury Research Trust(16-3 A, to JC and CBS) the National Natural Science Foundation of China(81601957, to YW)。 

主　　题：astrocyte crosstalk demyelination glial response microglia/macrophage multiple sclerosis neurodegeneration neuroinflammation oligodendrocyte lineage cells remyelination 

摘      要：Multiple sclerosis is an autoimmune disease in which the immune system attacks the myelin sheath in the central nervous system.It is characterized by blood-brain barrier dysfunction throughout the course of multiple sclerosis, followed by the entry of immune cells and activation of local microglia and astrocytes.Glial cells(microglia, astrocytes, and oligodendrocyte lineage cells) are known as the important mediators of neuroinflammation, all of which play major roles in the pathogenesis of multiple sclerosis.Network communications between glial cells affect the activities of oligodendrocyte lineage cells and influence the demyelination-remyelination process.A finely balanced glial response may create a favorable lesion environment for efficient remyelination and neuroregeneration.This review focuses on glial response and neurodegeneration based on the findings from multiple sclerosis and major rodent demyelination models.In particular, glial interaction and molecular crosstalk are discussed to provide insights into the potential cell-and molecule-specific therapeutic targets to improve remyelination and neuroregeneration.