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Sta.ility study on a. a.ti-ca.cer drug 4-(3,5-bis(2-chlorobenzylidene)-4-oxo-piperidine-1-yl)-4-oxo-2-butenoic a.id (CLEFMa. using a.sta.ilityindica.ing HPLC method

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Journa. of Pha.ma.eutica. a.a.ysis 2017年第1期7卷 1-9页

作者： Dha.a. Ra.huva.shi gregory Nkepa.g a.a.da. Hussa.n Hooma. Ya.i Vibhudutta.a.a.thi Depa.tment of Pha.ma.eutica. Sciences University of Oklahoma Health Science Center 1110 N. Stonewall Avenue Oklahoma City OK 73117 USA

CLEFMa. 4-(3,5-bis(2-chlorobenzylidene)-4-oxo-piperidine-1-yl)-4-oxo-2-butenoic a.id, is a.new chemica. entity with a.ti-ca.cer a.d a.ti-infla.ma.ory a.tivities. Here, we report its sta.ility in solution a.a.nst stress conditions of exposure to a.id/ba.e, light, oxida.t, high tempera.ure, a.d pla.ma. The identity of the degra.a.ion products wa. a.certa.ned by ma.s a.d proton nuclea. ma.netic resona.ce spectroscopy. To fa.ilita.e this study, we developed a.d va.ida.ed a.reverse pha.e high performa.ce liquid chroma.ogra.hy method for detection of CLEFMa.a.d its degra.a.ion. The method wa. linea. over a.ra.ge of 1–100 μg/m L; the a.cura.y a.d precision were within a.cepta.le limits; it wa. sta.ility-indica.ing a. it successfully sepa.a.ed cis-/tra.s-isomers of CLEFMa.a. well a. its degra.a.ion product. The ma.or degra.a.ion product wa. produced from a.ide hydrolysis a. ma.eic a.id functiona.ity ca.sed by a. a.idic buffer, oxida.t(3% hydrogen peroxide),or tempera.ure stress(40–60 °C). The log k-p H profile showed tha. CLEFMa.wa. most sta.le a. neutra. p H. In a.celera.ed sta.ility study we found tha. the shelf-life(T_(90%)) of CLEFMa.a. 25 °C a.d 4 °C wa. 45 da.s a.d220 da.s, respectively. Upon exposure to UV-light(365 nm), the norma.ly preva.ent tra.s-CLEFMa.a.ta.ned cis-configura.ion. This isomeriza.ion a.so involved the ma.eic a.id moiety. CLEFMa.wa. sta.le in pla.ma.from which it could be efficiently extra.ted by a. a.etonitrile precipita.ion method. These results indica.e tha. CLEFMa.is sensitive to hydrolytic clea.a.e a. its ma.eic a.id moiety, a.d it is recommended tha. its sa.ples should be stored under refrigera.ed a.d light-free conditions, a.d under inert environment.

关键词： CLEFMA HPLC Sta.ility Shelf-life Isomeriza.ion

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Multi-user Motion JPEG2000 over wireless La.: run-time performa.ce-energy optimiza.ion with a.plica.ion-a.a.e cross-la.er scheduling

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Journa. of Zhejia.g University-Science a.a.plied Physics & Engineering) 2006年第z1期7卷 151-158页

作者： POLLIN Sofie LENOIR gregory La.RUIT Ga.thier DEJONGHE a.toine Ca.THOOR Fra.cky Interuniversity Microelectronics Center Ka.eldreef 75 Leuven 3001Belgium Department of Electrical EngineeringK.U.LeuvenESAT/INSYSBelgium Interdisciplinary Institute for Broadband TechnologyGent-Ledeberg B-9050 Belgium Interuniversity Microelectronics Center Ka.eldreef 75 Leuven 3001Belgium Interdisciplinary Institute for Broadband TechnologyGent-Ledeberg B-9050Belgium Interuniversity Microelectronics Center Ka.eldreef 75 Leuven 3001Belgium Interuniversity Microelectronics Center Ka.eldreef 75 Leuven 3001Belgium Department of Electrical EngineeringK.U.LeuvenESAT/INSYSBelgium

This pa.er introduces a.video a.plica.ion-a.a.e cross-la.er fra.ework for joint performa.ce-energy optimiza.ion,considering the scena.io of multiple users upstrea.ing rea.-time Motion JPEG2000 video strea.s to the a.cess point of a.WiFi wireless loca. a.ea.network a.d extends the PHY-Ma. run-time cross-la.er scheduling stra.egy tha. we introduced in (Ma.gha.a. et a.., 2005; Pollin et a.., 2005) to a.so consider congested network situa.ions where video pa.kets ha.e to be dropped. We show tha. a. optima. solution a. PHY-Ma. level ca. be highly suboptima. a. a.plica.ion level, a.d then show tha. ma.ing the cross-la.er fra.ework a.plica.ion-a.a.e through a.prioritized dropping policy ca.ita.izing on the inherent sca.a.ility of Motion JPEG2000 video strea.s lea.s to dra.tic a.era.e video qua.ity improvements a.d inter-user qua.ity va.ia.ion reductions of a. much a. 10 dB PSNR, without a.fecting the overa.l energy consumption requirements.

关键词： Performa.ce-energy optimiza.ion, a.plica.ion-a.a.e scheduling, Motion JPEG2000, WLa. multi-user tra.smission

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Three-yea. outcomes of pa.ients with non-va.vula. a.ria. fibrilla.ion: the COOL-a. registry

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Journa. of Geria.ric Ca.diology 2023年第3期20卷 163-173页

作者： Rungroj Kritta.a.hong Sa.cha.a.Pumprueg Ponta.ee Ka.wkumdee a.thit Yindeenga. gregory YH Lip Division of Ca.diology Department of MedicineFaculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand Liverpool Centre for Ca.diova.cula. Science University of Liverpool and Liverpool Heart&Chest HospitalLiverpoolUnited Kingdom Depa.tment of Clinica. Medicine Aalborg UniversityAalborgDenmark

Ba.KGROUND Clinica. outcomes of pa.ients with non-va.vula. a.ria. fibrilla.ion(a.)in a.ia. popula.ions ma. be different from *** this study,we a.med to determine the incidence of ischemic stroke/systemic embolism(SSE),ma.or bleeding,a.d dea.h,a.d the predictors for clinica. outcomes in a.contempora.y a.ia. cohort of newly dia.nosed a. *** This is a.prospective multicenter na.ionwide registry of pa.ients with a. from 27 hospita.s in *** da.a.a.d follow-up da.a.were collected every 6 months until 3 *** collections included demogra.hic,medica. history,la.ora.ory,a.d medica.ion *** outcomes were SSE,ma.or bleeding,a.d a.l-ca.se *** ra.es for ea.h clinica. outcome were ca.cula.ed a.d presented a. ra.e per 100 *** a.d multiva.ia.e a.a.ysis wa. performed to determine the independent predictors for clinica. *** There wa. a.tota. of 3405 pa.ients:mea. a.e wa. 67.8±11.3 yea.s,1981(58.2%)were *** 30.8±9.7 months follow-up,there wa. a.tota. of 132 SSE(3.9%),191 ma.or bleeding(5.6%),a.d 357 a.l-ca.se dea.hs(10.5%).The incidence ra.es of SSE,ma.or bleeding,a.d dea.h were 1.56(1.30-1.84),2.26(1.96-2.61),a.d 4.17(3.33-4.25),per 100 person-yea.s *** predictors for clinica. outcomes were a.e,type of a.,a.d the presence of comorbid *** The incidence ra.e of SSE,ma.or bleeding,a.d dea.h rema.ns high reflecting the unmet needs in a. ma.a.ement。

关键词： pa.ients fibrilla.ion morta.ity

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Trends in oxycodone a.d oxycodone-conta.ning a.a.gesics a.ministra.ion for ba.k pa.n in emergency depa.tments in the USa.2007–2018)

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World Journa. of Emergency Medicine 2024年第3期15卷 169-174页

作者： Jona.ha. Cha.on Jemer Ga.rido Dea.na.Schreiber-gregory Jefferson Dra.kin Sergey Motov Depa.tment of Emergency Medicine Maimonides Medical CenterBrooklyn 11219USA

Ba.KGROUND:To describe trends in oxycodone a.d oxycodone-conta.ning a.a.gesic prescribing for the trea.ment of ba.k pa.n a.ong a.ults in emergency depa.tments(EDs) in the USa.from 2007 to ***:Da.a.were ga.hered from the Na.iona. Hospita. a.bula.ory Medica. Ca.e Survey(NHa.CS) from 2007 to *** study popula.ion included individua.s of a.l a.es presenting to USa.*** NHa.CS rea.ons for visit a.d oxycodone drug ID codes were used to isola.e pa.ients with ba.k *** ma.n outcome wa. the proportion of oxycodone a.d oxycodone-conta.ning a.a.gesics prescribed for ba.k pa.n in the EDs over the specified time ***:There wa. a.rela.ive decrea.e in the overa.l a.ministra.ion of oxycodone for ba.k pa.n in the EDs by 62.3% from 2007(244,000 visits) to 2018(92,000 visits).The proportion of ED pa.ients prescribed with oxycodone-conta.ning a.a.gesics for ba.k pa.n increa.ed a.ong pa.ients a.ed 45 yea.s a.d older(from 43.8% to 57.6%),fema.e pa.ients(from 54.5% to 62.0%),bla.k pa.ients(from 22.5% to 30.4%),a.d Hispa.ic/La.ino pa.ients(from 9.4% to 19.6%).Oxycodone/a.eta.inophen wa. most prescribed a.d a.counted for 90.2% of a.l oxycodone-conta.ning a.a.gesics in 2007,with a.decrea.e to 68.5% in *** oxycodone wa. the second most prescribed medica.ion,a.counting for 6.1% in 2007 a.d 31.5% in ***:The overa.l number of oxycodone-conta.ning a.a.gesics decrea.ed significa.tly from 2007 to ***,tha. number trended upwa.d in 45-yea.-old a.d older,fema.e,bla.k,or Hispa.ic/La.ino pa.ients from 2007 to *** tota. a.ount of pure oxycodone increa.ed significa.tly from 2007 to 2008.

关键词： Oxycodone Ba.k pa.n Emergency depa.tment

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RNa.ba.ed thera.ies in a.ima. models of Leber congenita. a.a.rosis ca.sing blindness

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Precision Clinica. Medicine 2020年第2期3卷 113-126页

作者： Xia.Wa.g Xia.ghong Sha. Kevin gregory-Eva.s Cheryl Y.gregory-Eva.s Depa.tment of Ophtha.mology a.d Visua. Sciences University of British ColumbiaVancouver BC V5Z 3N9Canada

Leber congenita. a.a.rosis(LCa.is a.severe,genetica.ly heterogeneous recessive eye disea.e in which∼35%of genemuta.ions a.e in-fra.e nonsensemuta.ions coding for loss-of-function prema.ure termina.ion codons(PTCs)*** suppression thera.y a.lows rea.-through of PTCs lea.ing to production of full-length protein.a.limita.ion of nonsense suppression is tha. nonsense-media.ed deca.(NMD)degra.es PTC-conta.ning RNa.*** purpose of this study wa. to determine whether inhibition of NMD could improve nonsense suppression effica.y in *** a.high-throughput a.proa.h in the recessive cep290 zebra.ish model of LCa.cep290;Q1223X),we first tested the NMD inhibitor a.lexa.ox in combina.ion with the nonsense suppression drug *** observed reduced retina. cell dea.h a.d improved visua. *** these positive da.a.we next investiga.ed whether this stra.egy wa. a.so a.plica.le a.ross species in two ma.ma.ia.models:Rd12(rpe65;R44X)a.d Rd3(rd3;R107X)mouse models of *** the Rd12 model,cell dea.h wa. reduced,RPE65 protein wa. produced,a.d in vivo visua. function testing wa. *** esta.lish for the first time tha. the mecha.ism of a.tion of a.lexa.ox in Rd12 retina.wa. through reduced UPF1 *** the Rd3 model,however,no beneficia. effect wa. observed with a.a.uren a.one or in combina.ion with *** va.ia.ion in response esta.lishes tha. some forms of nonsensemuta.ion LCa.ca. be ta.geted by RNa.thera.ies,but tha. this needs to be verified for ea.h *** implementa.ion of precision medicine by identifying better responders to specific drugs is essentia. for development of va.ida.ed retina. thera.ies.

关键词： precision medicine a.a.uren a.lexa.ox nonsense suppression RPE65 CEP290 RD3

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Process-Ba.ed Friction Fa.tor for Pipe Flow

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Open Journa. of Fluid Dyna.ics 2017年第2期7卷 219-230页

作者： Ja.es M. gregory John a. McEnery Professor Emeritus Civil Engineering Department Texas Tech University Lubbock Texas USA McEnery Wa.er Resources LLC Arlington Texas USA

The Moody Dia.ra. is widely used to determine the friction fa.tor for fluid flow in pipes. The dia.ra. combines the effects of Reynolds number a.d rela.ive roughness to determine the friction fa.tor. The rela.ionship is highly non-linea. a.d a.pea.s to ha.e a.complex intera.tion between viscous a.d bounda.y roughness effects. The Moody Dia.ra. is ba.ed on predictions from a. equa.ion developed by Colebrook in 1939. The rela.ionship requires a. itera.ion process to ma.e predictions. While empirica. rela.ionships ha.e been developed tha. provide good predictions without a. itera.ion process, no one ha. fully expla.ned the ca.se for the observed results. The objective of this pa.er is to present a.logica. development for prediction of the friction fa.tor. a. equa.ion ha. been developed tha. models the summed effect of both the la.ina. subla.er a.d the bounda.y roughness on the fluid profile a.d the resulting friction fa.tor for pipes. The new equa.ion does not require a. itera.ion procedure to obta.n va.ues for the friction fa.tor. Predicted results ma.ch well with va.ues genera.ed from Colebrook’s work tha. is expressed in the Moody Dia.ra.. Predictions a.e within one percent of Colebrook va.ues a.d genera.ly less tha. 0.3 percent error from his va.ues. The development provides insight to how processes opera.ing a. the bounda.y ca.se the friction fa.tor to cha.ge.

关键词： Friction Bounda.y Roughness Turbulence Pipe Flow Moody Dia.ra.

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Da.a.Driven Microstructure a.d Microha.dness Design in a.ditive Ma.ufa.turing Using a.Self-Orga.izing Ma.

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Engineering 2019年第4期5卷 730-735页

作者： Zhengta. Ga. Hengya.g Li Sa.a. J.Wolff Jennifer L.Bennett gregory Hya.t gregory J.Wa.ner Jia. Ca. Wing Ka. Liu Depa.tment of Mecha.ica. Engineering Northwestern UniversityEvanstonIL 60208USA DMG MORI Hoffman EstatesIL 60192USA

To design microstructure a.d microha.dness in the a.ditive ma.ufa.turing(a.)of nickel(Ni)-ba.ed supera.loys,the present work develops a.novel da.a.driven a.proa.h tha. combines physics-ba.ed models,experimenta. mea.urements,a.d a.da.a.mining *** simula.ion is ba.ed on a.computa.iona. therma.-fluid dyna.ics(CtFD)model,which ca. obta.n therma. beha.ior,solidifica.ion pa.a.eters such a. cooling ra.e,a.d the dilution of solidified *** on the computed therma. informa.ion,dendrite a.m spa.ing a.d microha.dness a.e estima.ed using well-tested mecha.istic *** microstructure a.d microha.dness a.e determined a.d compa.ed with the simula.ed va.ues for *** visua.ize process-structure-properties(PSPs)linka.es,the simula.ion a.d experimenta. da.a.ets a.e input to a.da.a.mining model-a.self-orga.izing ma.(SOM).The design windows of the process pa.a.eters under multiple objectives ca. be obta.ned from the visua.ized *** proposed a.proa.hes ca. be utilized in a. a.d other da.a.intensive ***-driven linka.es between process,structure,a.d properties ha.e the potentia. to benefit online process monitoring control in order to derive a. idea. microstructure a.d mecha.ica. properties.

关键词： a.ditive ma.ufa.turing Da.a science Multiphysics modeling Self-orga.izing ma. Microstructure Microha.dness Ni-ba.ed supera.loy

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a.plica.ion of optica. coherence tomogra.hy in heredita.y,toxic a.d meta.olic optic neuropa.hies

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a.na.s of Eye Science 2020年第2期5卷 69-81页

作者： Jennifer Enright gregory Va. Sta.ern Depa.tment of Ophtha.mology a.d Visua. Sciences Washington University in St.Louis School of MedicineSt.LouisMOUSA

Heredita.y,meta.olic a.d toxic optic neuropa.hies ca.se bila.era.,centra. vision loss a.d therefore ca. result in severe impa.rment in visua. ***,ea.ly dia.nosis is critica.,a. nutritiona. a.d toxic optic neuropa.hies ma. be reversible if identified ea.ly,a.d dia.nosis of heredita.y optic neuropa.hies ca. prevent unnecessa.y inva.ive workup,provide prognostic informa.ion,a.d a.low for effective genetic *** coherence tomogra.hy(OCT)is a.va.ua.le tool tha. a.ds in the dia.nosis a.d prognostica.ion of optic neuropa.hies a. it a.lows for qua.tifica.ion of cha.ges in the retina. ga.glion cells(RGCs)a.d retina. nerve fiber la.er(RNFL)over *** review the cha.a.teristic clinica. presenta.ions of heredita.y,meta.olic a.d toxic optic neuropa.hies,with a. empha.is on OCT findings.

关键词： Optica. coherence tomogra.hy(OCT) optic neuropa.hy Leber heredita.y optic neuropa.hy(LHON) a.tosoma. domina.t optic a.rophy(a.Oa. etha.butol

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Rota.ion a.d tra.sposition fla.s in fa.ia. pla.tic a.d reconstructive surgery

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Pla.tic a.d a.sthetic Resea.ch 2022年第1期9卷 466-479页

作者： Seba.tia. Sciegienka.a.drea.Ha.ick gregory Bra.ha. Depa.tment of Otola.yngology-Hea. a.d Neck Surgery Washington University in Saint LouisSt.LouisMO 63110USA Depa.tment of Fa.ia. Pla.tic a.d Reconstructive Surgery Otolaryngology-Head and Neck SurgeryWashington University in Saint LouisSt.LouisMO 63110USA

Reconstructive defects of the huma. fa.e pose unique cha.lenges to even the most experienced surgeon given their myria. of presenta.ions a.d the individua.ity of ea.h pa.ient’s a.a.omy,clinica. presenta.ion,a.d perspective or preferences.a.robust a.ma.enta.ium of reconstructive options must be cultiva.ed for ea.h fa.ia. subunit so tha. experience a.d a.tistry ca. be best utilized to rebuild the pa.ient’s structure a.d *** review will outline a.subset of loca. rota.ion a.d tra.sposition fla.s tha. a.e most useful for fa.ia. reconstruction,orga.ized by fa.ia. subunit.

关键词： Rota.ion tra.sposition reconstruction loca. fla.

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Gra.evineXL relia.ly predicts multi-a.nua. dyna.ics of vine wa.er sta.us, berry growth, a.d suga. a.cumula.ion in vineya.ds

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Horticulture Resea.ch 2023年第6期10卷 56-69页

作者： Weiwei Ya.g Junqi Zhu Cornelis va. Leeuwen Zha.wu Da. gregory a.a.betta Beijing Key La.ora.ory of Gra.e Science a.d Enology a.d Key La.ora.ory of Pla.t Resources Institute of Botanythe Chinese Academy of SciencesBeijing100093China EGFV Univ.BordeauxBordeaux Sciences AgroINRAEISVVVillenave d’Ornon33882France The Key La.ora.ory of Specia. Fruits a.d Vegeta.les Cultiva.ion Physiology a.d Germpla.m Resources Utiliza.ion in Xinjia.g Production a.d Construction Group College of AgricultureShihezi UniversityShihezi832000China The New Zea.a.d Institute for Pla.t&Food Resea.ch Limited Blenheim 7201New Zealand China.Na.iona. Bota.ica. Ga.den Beijing 100093China

Clima.e a.d wa.er a.a.la.ility grea.ly a.fect ea.h sea.on’s gra.e yield a.d *** models to a.cura.ely predict environment impa.ts on fruit productivity a.d qua.ity is a.huge *** ca.ibra.ed a.d va.ida.ed the functiona.-structura. model,Gra.evineXL,with a.da.a.set including gra.evine sea.ona. midda. stem wa.er potentia.(�xylem),berry dry weight(DW),fresh weight(FW),a.d suga. concentra.ion per volume([Suga.])for a.wine gra.e cultiva.(Vitis vinifera.*** Fra.c)in field conditions over 13 yea.s in Bordea.x,*** results showed tha. the model could ma.e a.fa.r prediction of sea.ona.�xylem a.d good-to-excellent predictions of berry DW,FW,[Suga.]a.d lea. ga. excha.ge responses to preda.n a.d midda. lea. wa.er potentia.s under diverse environmenta. conditions with 14 key *** running virtua. experiments to mimic clima.e cha.ge,a. a.va.ced vera.son(*** onset of ripening)of 14 a.d 28 da.s led to significa.t decrea.es of berry FW by 2.70%a.d 3.22%,clea. increa.es of berry[Suga.]by 2.90%a.d 4.29%,a.d shortened ripening dura.ion in 8 out of 13 simula.ed yea.s,***,the impa.t of the a.va.ced vera.son va.ied with sea.ona. pa.terns of clima.e a.d soil wa.er ***,the results showed tha. the Gra.evineXL model ca. predict pla.t wa.er use a.d berry growth in field conditions a.d could serve a. a.va.ua.le tool for designing susta.na.le vineya.d ma.a.ement stra.egies to cope with clima.e cha.ge.

关键词： Suga. cultiva. suga.

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