Three-year outcomes of patients with non-valvular atrial fibrillation: the COOL-AF registry

作     者：Rungroj Krittayaphong Satchana Pumprueg Pontawee Kaewkumdee Ahthit Yindeengam Gregory YH Lip Rungroj Krittayaphong;Satchana Pumprueg;Pontawee Kaewkumdee;Ahthit Yindeengam;Gregory YH Lip

作者机构：Division of CardiologyDepartment of MedicineFaculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand Liverpool Centre for Cardiovascular ScienceUniversity of Liverpool and Liverpool Heart&Chest HospitalLiverpoolUnited Kingdom Department of Clinical MedicineAalborg UniversityAalborgDenmark 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2023年第20卷第3期

页      面：163-173页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：funded by a grant from the Health System Research Institute(Grant number 59-053) the Heart Association of Thailand under the Royal Patronage of H.M.the King 

主　　题：patients fibrillation mortality 

摘      要：BACKGROUND Clinical outcomes of patients with non-valvular atrial fibrillation(AF)in Asian populations may be different from *** this study,we aimed to determine the incidence of ischemic stroke/systemic embolism(SSE),major bleeding,and death,and the predictors for clinical outcomes in a contemporary Asian cohort of newly diagnosed AF *** This is a prospective multicenter nationwide registry of patients with AF from 27 hospitals in *** data and follow-up data were collected every 6 months until 3 *** collections included demographic,medical history,laboratory,and medication *** outcomes were SSE,major bleeding,and all-cause *** rates for each clinical outcome were calculated and presented as rate per 100 *** and multivariate analysis was performed to determine the independent predictors for clinical *** There was a total of 3405 patients:mean age was 67.8±11.3 years,1981(58.2%)were *** 30.8±9.7 months follow-up,there was a total of 132 SSE(3.9%),191 major bleeding(5.6%),and 357 all-cause deaths(10.5%).The incidence rates of SSE,major bleeding,and death were 1.56(1.30-1.84),2.26(1.96-2.61),and 4.17(3.33-4.25),per 100 person-years *** predictors for clinical outcomes were age,type of AF,and the presence of comorbid *** The incidence rate of SSE,major bleeding,and death remains high reflecting the unmet needs in AF management。