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瑞舒伐他汀对存在亚临床动脉粥样硬化的低危人群颈动脉内膜中层厚度进展的影响——METEOR试验

美国医学会杂志（中文版） 2007年第4期26卷 208-216页

作者： Joh. R. Crouse Ⅲ Joel S. Raich.en Ward A. Riley gregory W. Evans Mike K. Palmer Daniel h. O＇ Leary Diederick E. Grobbee Mich.el L. Bots 李军（译） Wake Forest University Sch.ol of Medicine Medical Cel. ter Blvd Winston-SaJem NC 27157 Departments of Neurology Wake Forest University Winston- Salem NC Departments of Public h.alth.Sciences Wake Forest University Winston- Salem NC AstraZeneca Wilmington Del AstraZeneca Macclesfield England Caritas Carney h.spital Boston Mass Department of Epidemiology Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht the Netherlands 不详

背景：动脉粥样硬化往往在机体出现症状之前就已有所进展。目前，我们尚不清楚Framingh.m风险评分（Framingh.ln risk score，FRS）较低的轻中度亚临床动脉粥样硬化中年人群是否能从治疗中获益。目的：评价为期2年的他汀类药物治疗能否... 详细信息

背景：动脉粥样硬化往往在机体出现症状之前就已有所进展。目前，我们尚不清楚Framingh.m风险评分（Framingh.ln risk score，FRS）较低的轻中度亚临床动脉粥样硬化中年人群是否能从治疗中获益。目的：评价为期2年的他汀类药物治疗能否减缓颈动脉内膜中层厚度（carotid intimamedia th.ckness，CIMT）继续增厚或使粥样斑块消退。设计、地点及参试者：“瑞舒伐他汀对内膜中层厚度影响的测评研究（Measuring Effects on Intima-Media Th.ckness：an Evaluation of Rosuvastatin，METEOR）”是2002年8月至2006年5月在美国及欧洲61个基层医疗中心开展的一项随机、双盲、安慰剂对照研究，共纳入984名参试者，有的参试者仅以年龄（平均年龄，57岁）为冠心病的危险因素，有的参试者10年内FRS低于10％、CIMT重庞增厚（1．2～3．5mm）、LDL胆固醇水平有所升高（平均值，154mg／dL）。干预：参试者服用40mg瑞舒伐他汀或安慰剂。主要观测指标：12个颈动脉位点最大CIMT的变化率（经B超检测）；颈总动脉位点、颈动脉窦位点及颈内动脉位点最大CIMT的变化，颈总动脉位点平均CIMT的变化。仅在瑞舒伐他汀组中评估CIMT的消退情况。结果：瑞舒伐他汀组参试者LDL胆固醇平均（SD）水平由基线时的155（24．1）mg／dL降至78（27．5）mg／dL，平均降低49％（与安慰剂组相比P〈0.001）。瑞舒伐他汀组12个颈动脉位点最大CIMT的变化值为-0．0014（95％CI，-0．0041～0.0014）mm／y，安慰剂组12个颈动脉位点最大CIMT的变化值为Q0131（95％CI，Q0087～Q0174）mm／y（P〈0.001）。瑞舒伐他汀组颈总动脉位点最大CIMT的变化值为-0.0038（95％CI，-0.0064～-0.0013）mm／y（P〈0.001），颈动脉窦位点最大CIMT的变化值为-0.0040（95％CI，-0.0090～0.0010）mm／y（P〈0.001），颈内动脉位点最大CIMT的变化值为0.0039（95％CI，-0.0009～0.0088）mm／y（P=0.02）。瑞舒伐他汀组颈总动脉位点平均CIMT的变化值为0.0004（95％CI，-0.0011～0.0019）mm／y（P〈0.001）。P值均为与安慰剂组相比。总的来说，瑞舒伐他汀具有良好的耐受性，很少引发严重的心血管不良事件（在2年内有6名参试者[0.86％]出现8起不良事件[1．1％]）。结论：对于FRS低于10％的亚临床动脉粥样硬化中年人群而言，瑞舒伐他汀能够在2年内显著降低最大CIMT的进展速率，与安慰剂相比差异具有统计学显著性。但是，瑞舒伐他汀无法诱导病变消退。今后，我们仍需开展大型远期试验来明确上述研究结果的临床意义．

关键词：亚临床动脉粥样硬化颈动脉内膜中层厚度瑞舒伐他汀低危人群 Rosuvastatin 试验心血管不良事件安慰剂对照

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Closed-loop superconducting materials discovery

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npj Computational Materials 2023年第1期9卷 471-478页

作者： Elizabeth.A.Pogue Alexander New Kyle McElroy Nam Q.Le Mich.el J.Pekala Ian McCue Eddie Gienger Janna Domenico Elizabeth.h.drick Tyrel M.McQueen Brandon Wilfong Ch.istine D.Piatko Ch.istoph.r R.Ratto Andrew Lennon Ch.istine Ch.ng Timoth. Montalbano gregory Bassen Ch.istoph.r D.Stiles Research.and Exploratory Development Department Johns Hopkins University Applied Physics Laboratory11100 Johns Hopkins RoadLaurel 20723 MDUSA Department of Materials Science and Engineering Northwestern University2220 Campus DriveEvanston 60208 ILUSA Department of Materials Science and Engineering Johns Hopkins University3400 N.Charles StreetBaltimore 21218 MDUSA Department of Ch.mistry Johns Hopkins University3400 N.Charles StreetBaltimore 21218 MDUSA Institute for Quantum Matter William H.Miller III Department of Physics and AstronomyJohns Hopkins University3400 N.Charles StreetBaltimore 21218 MDUSA

Discovery of novel materials is slow but necessary for societal ***,we demonstrate a closed-loop mach.ne learning(ML)approach.to rapidly explore a large materials search.space,accelerating th. intentional discovery of superconducting *** experimentally validating th. results of th. ML-generated superconductivity predictions and feeding th.se data back into th. ML model to refine,we demonstrate th.t success rates for superconductor discovery can be more th.n *** four closed-loop cycles,we report discovery of a superconductor in th. Zr-In-Ni system,re-discovery of five superconductors unknown in th. training datasets,and identification of two additional ph.se diagrams of interest for new superconducting *** work demonstrates th. critical role experimental feedback provides in ML-driven discovery,and provides a blueprint for h.w to accelerate materials progress.

关键词： discovery materials loop

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Postpartum Intrauterine Device: Use and Follow-Up of Users in th. Maternity Ward of th. Ratoma Communal Medical Center in Conakry, Guinea

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Open Journal of Obstetrics and Gynecology（妇产科期刊） 2023年第10期

作者： Daniel W. A. leno T. M. Millimouno I.Conté A. Diallo A. F. M. Soumah.I. Sylla h. M. Keita D. Lamah.A. Delamou T. Sy

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Factors predicting survival in patients with.proximal gastric carcinoma involving th. esoph.gus

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World Journal of Gastroenterology 2012年第27期18卷 3602-3609页

作者： Yi-Fen Zh.ng Jiong Sh. h.i-Ping Yu An-Ning Feng Xiang-Sh.n Fan gregory Y Lauwers h.rosh. Mash.mo Jason S Gold Gang Ch.n Qin h.ang Department of Path.logy Nan-jing Drum Tower Hospital the Affiliated Hospital of NanjingUniversity Medical School Nanjing 210008 Jiangsu ProvinceChina Department of Path.logy MassachusettsGeneral Hospital Harvard Medical School Boston MA 02114United States Department of Gastroenterology VeteransAffairs Boston Healthcare System Harvard Medical SchoolWest Roxbury MA 02132 United States

AIM： To investigate th. clinicopath.logic features wh.ch.predict surgical overall survival in patients with.proxima gastric carcinoma involving th. esoph.gus （PGCE）. METh.DS： Electronic path.logy database establish.d in th. Department of Path.logy of th. Nanjing Drum Tower h.spital was search.d for consecutive resection cases of proximal gastric carcinoma over th. period from May 2004 th.ough.July 2009. Each.retrieved pa- th.logy report was reviewed and th. cases with.tumors crossing th. gastroesoph.geal junction line were se- lected as PGCE. Each.tumor was re-staged, following th. guidelines on esoph.geal adenocarcinoma, accord- ing to th. 7th.edition of th. American Joint Commission on Cancer Staging Manual. All h.stology slides were studied along with.th. path.logy report for a retrospec- tive analysis of 13 clinicopath.logic features, i.e., age, gender, h.licobacter pylori （h. pylon} infection, surgical modality, Siewert type, tumor Bormann＇s type, size, dif- ferentiation, h.stology type, surgical margin, lymph.- vascular and perineural invasion, and path.logic stage in relation to survival after surgical resection. Prognos- tic factors for overall survival were assessed with.uni- and multi-variate analyses. RESULTS： Patients＇ mean age was 65 years （range： 47-90 years）. Th. male： female ratio was 3.3. Th. 1-, 3- and 5-year overall survival rates were 87%, 61% and 32%, respectively. By univariate analysis, age, male gender, h. pylori, tumor Bormann＇s type, size, h.stology type, surgical modality, positive surgical margin, lym- ph.vascular invasion, and pT stage were not predictive for overall survival; in contrast, perineural invasion （P = 0.003）, poor differentiation （P = 0.0003）, 〉 15 to- tal lymph.nodes retrieved （P = 0.008）, positive lymph.nodes （P = 0.001）, and distant metastasis （P = 0.005） predicted poor post-operative overall survival. Celiac axis nodal metastasis was associated with.significantly worse overall survival （P = 0.007）. By multivariate analys

关键词： Cancer Esoph.gus Gastroesoph.geal junc-tion Staging Stomach

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Scintigraph. in laryngoph.ryngeal and gastroesoph.geal reflux disease:A definitive diagnostic test?

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World Journal of Gastroenterology 2015年第12期21卷 3619-3627页

作者： gregory L Falk Joh. Beattie Alvin Ing SE Falk Mich.el Magee Leticia Burton h.ns Van der Wall Sydney h.artburn Clinic Gastroenterology Concord Hospital University of Sydney Macquarie University Sydney Ryde Medical Centre Sydney Department of Respiratory Medicine Concord Hospital th. University of Sydney Sydney h.artburn Clinic Gastroenterology Sydney Concord Nuclear Imaging Clinic

AIM: To investigate th. utility of scintigraph.c studies in predicting response to laparoscopic fundoplication(LF) for ch.onic laryngoph.ryngeal reflux ***: Patients with.upper aero-digestive symptoms th.t remained undiagnosed after a period of 2 mo were studied with.conventional p h.and manometric studies. Patients mainly complained of cough. sore th.oat, dysph.nia and globus. Th.se patients were imaged after ingestion of 99m-tech.etium dieth.lene triamine pentaacetic acid. Studies were quantified with.time activity curves over th. ph.rynx, upper and lower oesoph.gus and background. Late studies of th. lungs were obtained for aspiration. Patients underwent LF with.post-operative review at 3 mo after ***: Th.rty four patients(20 F, 14 M) with.an average age of 57 years and average duration of symptoms of 4.8 years were studied. Twenty four h.ur p h.and manometry studies were abnormal in all patients. On scintigraph., 27/34 patients demonstrated ph.ryngeal contamination and a rising or flat ph.ryngeal curve. Lung aspiration was evident in 50% of patients. Th.re was evidence of pulmonary aspiration in 17 of 34 patients in th. delayed study(50%). Ph.ryngeal contamination was found in 27 patients. All patients with.aspiration sh.wed ph.ryngeal contamination. In th. 17 patients with.aspiration, graph.cal time activity curve sh.wed rising activity in th. ph.rynx in 9 patients and a flat curve in 8 patients. In th.se 17 patients with.ut pulmonary aspiration, 29%(5 patients) h.d eith.r a rising or flat ph.ryngeal graph. A rising or flat curve predicted aspiration with.a positive predictive value of 77% and a negative predictive valueof 100%. Over 90% of patients reported a satisfactory symptomatic response to LF with.an acceptable sideeffect profile. CONCLUSION: Scintigraph.c reflux studies offer a good screening tool for ph.ryngeal contamination and aspiration in patients with.gastroesoph.geal reflux disease.

关键词： Laryngoph.ryngeal reflux p h studies Oesoph.geal m

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质量开发提升竞争力

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中国质量 2020年第12期 32-39页

作者：格利高里·沃森范青

在上海举行的首届中国国际进口博览会(CIIE)上,政府宣布将从以质量管理为基础转为专注质量开发。质量管理旨在通过对日常管理系统中的工作进行标准化和改进来保证产品和服务交付的质量,而质量开发是运用商业创造力设计出新能力的一种创...

在上海举行的首届中国国际进口博览会(CIIE)上,政府宣布将从以质量管理为基础转为专注质量开发。质量管理旨在通过对日常管理系统中的工作进行标准化和改进来保证产品和服务交付的质量,而质量开发是运用商业创造力设计出新能力的一种创新、跨学科的方法。这就要求在应用质量管理方法上要有坚实的基础,以确保可以良好地维持基本运营绩效;

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Granulocyte-colony stimulating factor suppresses early inflammatory response of striatum in a cardiopulmonary bypass-circulatory arrest model of isch.mic brain injury in newborn piglets

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World Journal of Cardiovascular Diseases 2013年第2期3卷 197-205页

作者： Peter Pastuszko gregory J. Sch.ars Joanna Kubin William J. Greeley Vinay Nadkarni David F. Wilson Anna Pastuszko Department of Anesth.siology & Critical Care Children’s Hospital of Philadelphia Philadelphia USA Department of Anesth.siology & Critical Care Mayo Clinic Rochester USA Department of Bioch.mistry & Bioph.sics Perelman School of Medicine University of Pennsylvania Philadelphia USA Department of Surgery University of California San Diego USA

We investigated th. effect of Granulocyte-Colony Stimulating Factor (G-CSF) on expression of pro- and anti-inflammatory proteins in th. striatum of new- born piglet brain following cardiopulmonary bypass (CPB) and deep h.poth.rmic circulatory arrest (Dh.A). Piglets were placed on CPB, cooled to 18?C, subjected to 30 min of Dh.A and 1 h.of low-flow (20 ml/kg/min), rewarmed to 37?C, separated from CPB circuit and monitored for 2 h. Striatum was th.n isolated for protein analysis. Th. levels of proteins are presented relative to th. mean in th. control group (mean ± SEM, n = 6). Dh.A increased th. levels of pro-inflammatory proteins: IL-1alph. (158% ± 23%, P = 0.05), IL-6 (152% ± 16%, P = 0.03), TNF-alph. (144% ± 2%, P = 0.003), MIP-3 alph. (148% ± 12.6%, P = 0.03), NAP-3 (216% ± 16%, P = 0.05), GRO (165% ± 19%, P = 0.03) and BLC (140.4 ± 15%, P = 0.05). Compared to Dh.A, th. G-CSF-treated group h.d significantly decreased levels of IL-6 (110.8% ± 11% vs. 152% ± 16%, P = 0.05), TNF-alph. (120.6% ± 5.4% vs. 144% ± 2%, P = 0.001), MIP-3 alph. (148% ± 12.6% vs. 104.8% ± 13%, P = 0.02) and NAP-2 (216% ± 16% vs. 122% ± 23%, P = 0.002). Th. levels of anti-inflammatory proteins did not ch.nge in Dh.A group compared to control, except for VEGF wh.ch.decreased to 37.5% ± 9%, P = 0.003. Th. levels of all protective proteins in th. G-CSF group increased versus th. Dh.A group, but th. increases did not attain a P value of 0.05. Conclusions: In an immature brain subjected to circulatory arrest, th. early inflammatory response in th. striatum is diminish.d by pretreatment with.G-CSF.

关键词： Brain Cardiopulmonary Bypass Inflammatory Response Animal Model

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纳米晶异质结构的空穴自旋弛豫动力学研究(英文)

纳米晶异质结构的空穴自旋弛豫动力学研究(英文)

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第七届中国功能材料及其应用学术会议

作者： gregory D.Sch.les Department of Ch.mistry Institute for Optical Sciencesand Centre for Quantum Information and Quantum ControlUniversity of Toronto80 St.George StreetToronto ON M5S 3H6Canada

To realize quantum information devices th. development of qubits th.t are not greatly susceptible to decoh.rence is required.A lot of research.h.s focused on th. properties of ch.rge carriers in semiconductor nanostructures,such.as quantum dots,because it is envisioned th.t th. spin of quantum confined electrons is a good candidate for *** studies h.ve establish.d th.t rath.r th.n electrons in conduction orbitals h.les in valence orbitals are most resilient to th. effects of *** colloidal nanocrystalline quantum dots are exposed to th. environment and carriers th.rein experience rapid decoh.rence,th.y are excellent model systems because research.rs are able to control size,sh.pe,and structure of nanocrystals with.exquisite precision and th.reby tune th. properties of excitons and ch.rge carriers in diverse *** we report h.le spin relaxation dynamics in CdTe/CdSe core-sh.ll nanocrystals measured by an ultrafast polarization transient grating *** ch.rge separation in type-Ⅱstructures suppresses th. electron-h.le exch.nge interaction and th. h.le spin relaxation time constant is found to increase from～0.3ps to～10ps at 293K as th. CdSe sh.ll th.ckness increases from～0.2 nm to～2.4 *** of th.se data suggests th.t h.le spin relaxation in semiconductor nanostructures is tunable between type-Ⅰand type-Ⅱlocalization according to an electron-h.le overlap *** use of type-Ⅱnanocrystal h.terostructures th.refore promises an effective way to isolate h.les as qubits after optical orientation.

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Pilot study of atomoxetine in patients with.Parkinson’s disease and dopa-unresponsive Freezing of Gait

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Translational Neurodegeneration 2015年第1期4卷 205-208页

作者： Gonzalo J.Revuelta Aaron Embry Jordan J.Elm Ch.is gregory Amy Delambo Steve Kautz Vanessa K.h.nson Movement Disorders Division Department of NeurologyCollege of MedicineMedical University of South Carolina208B Rutledge AvenueMSC 108CharlestonSC 29425USA Department of h.alth.Sciences and Research Center for Rehabilitation Research in Neurological ConditionsCollege of Health ProfessionsMedical University of South CarolinaCharlestonSCUSA Department of Public h.alth.Sciences College of MedicineMedical University of South CarolinaCharlestonSC 29425USA Ralph.h.Joh.son VA Medical Center CharlestonSCUSA

Background:Freezing of gait(FoG)is a common and debilitating condition in Parkinson’s disease(PD)associated with.executive dysfunction.A subtype of FoG does not respond to dopaminergic th.rapy and may be related to noradrenergic *** pilot study explores th. effects of atomoxetine on gait in PD patients with.dopaunresponsive FoG using a novel paradigm for objective gait ***:Ten patients with.PD and dopa-unresponsive FoG were enrolled in th.s eigh.-week open label pilot *** included an exploratory gait analysis protocol th.t quantified spatiotemporal parameters during straigh.-away walking and turning,wh.le performing a dual ***,and subjective assessments of gait,quality of life,and safety were also *** primary outcome was a validated subjective assessment for FoG(FOG-Q).Atomoxetine was well tolerated,h.wever,no significant ch.nge was observed in th. primary *** gait analysis protocol correlated well with.clinical scales,but not with.subjective *** patients were more likely to increase gait velocity(p=0.033),and improved in oth.r clinical ***:Objective gait analysis protocols assessing gait wh.le dual tasking are feasible and useful for th.s patient population,and may be superior correlates of FoG severity th.n subjective *** findings can inform future trials in th.s population.

关键词： Parkinson’s disease Freezing of gait Noradrenaline Atomoxetine Dopa-response

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采取全面质量方法的必要性

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中国质量 2020年第9期 33-37页

作者：格利高里·沃森范青美国质量学会(ASQ)

过去几年,我经常去非洲中部和东部给质量专家做培训辅导。让我惊讶的是,我发现大家普遍缺乏对员工质量责任的理解。这些学员普遍认为"质量就是符合检查清单和各项要求",如果做到了这两点,那么质量自然有提升。在梳理要求或培养创建魅力...

过去几年,我经常去非洲中部和东部给质量专家做培训辅导。让我惊讶的是,我发现大家普遍缺乏对员工质量责任的理解。这些学员普遍认为"质量就是符合检查清单和各项要求",如果做到了这两点,那么质量自然有提升。在梳理要求或培养创建魅力质量的敏感性,从而为产品开发新市场或扩展市场方面,这些专家没有真正把顾客考虑在内,

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