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肝静脉压力梯度对预测终末期肝病的肝硬化患者存活率的影响

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世界核心医学期刊文摘（胃肠病学分册） 2006年第3期2卷 48-49页

作者： Ripoll C. Baares R. Rincón D. 李翔 Seccon de Hepatologa Servicio de Aparato Digestivo Hospital General Universitario Gregorio Maraón Dr Esquerdo 46 Madrid 28007 Spain

Measurements of portal pressure, usually obtained via the hepatic venous pressure gradient (HVPG) may be a prognostic marker in cirrhosis. The aim of this study was to evaluate the impact of HVPG on survival in patients with cirrhosis in addition to the Model for End-Stage Liver Disease (MELD) score. We also examined whether inclusion of HVPG in a model with MELD variables improves its prognostic ability. Retrospective analyses of all patients who had HVPG measurements between January 1998 and December 2002 were considered. Proportional hazards Cox models were developed. Prognostic calibrative and discriminative ability of the model was evaluated. In this period, 693 patients had a hepatic hemodynamic study, and 393 patients were included. Survival was significantly worse in those patients with greater HVPG value (univariate HR, 1.05; 95%CI, 1.02-1.08; P = .001). HVPG remained as an independent variable in a model adjusted by MELD, ascites, encephalopathy, and age (multivariate HR, 1.03; 95%CI, 1.00-1.06; P = .05) so that each 1 mmHg increase in HVPG had a 3%increase in death risk. In addition, HVPG as well as MELD score variables and age, significantly contributes to the calibrative predictive capacity of the prognostic model; however, discriminative ability improved only slightly (overall C statistic [95%CI]; MELD score variables: 0.71 [0.62-0.80], MELD score variables, age, and HVPG 0.76: [0.69-0.83]). In conclusion, HVPG has an independent effect on survival in addition to the MELD score. Although inclusion of HVPG and age in a survival predicting model would improve the calibrative ability of MELD, its discriminative ability is not significantly improved.

关键词：肝静脉压力梯度患者存活率终末期肝病模型血流动力学力值预测能力肝性脑病分辨能力预测模型

1例2岁儿童的双侧掌部皮下结节为深部环状肉芽肿

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世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 24-24页

作者： Mur E.C. Fernández C.M. Hermosa J.M.H. 李晓莉冯义国 Servicio de Dermatologa HGU Gregorio Maranón.C/Dr. Esquerdo no 47 28007 Madrid Spain

Granuloma annulare is a benign, relatively common dermatosis in childhood. The subcutaneous form is rare, and lesions typically occur on the legs, buttocks and scalp. We report a case of a deep granuloma annulare conf... 详细信息

关键词：环状肉芽肿掌部皮下结节下型

表现为生殖器脓皮病的HIV患者实为转移性Crohn病1例

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世界核心医学期刊文摘（皮肤病学分册） 2005年第6期1卷 41-41页

作者： Avilá rez-Ferná zaro-Ochaita es-Izquierdo J.A. Suández R. LP. Longo-Imedio M.I. J.A.avilés-lzquierdo 崔荣 Department of Dermatology Gregorio Maranon University Hospital Madrid Spain

The differential diagnosis of ulcerative genital lesions in patients with high risk sexual habits can be a challenge even for dermatologists. We present the case of a 27- year-old HIV-positive male with a history of recalcitrant genital ulcers. Microbiology studies were negative. A skin biopsy and a sample from a perineal fistula showed granulomatous infiltrates. The patient was treated with prednisone, metronidazole and aminosalicylates, showing complete resolution of the lesions in a few weeks. The clinical picture and histological findings are consistent with the diagnosis of cutaneous metastatic Crohn’ s disease. Although infrequent, metastatic Crohn’s disease should be suspected in cases of recalcitrant ulcerative conditions, even in the absence of intestinal disease.

关键词： Crohn病1 HIV患者脓皮病高危性行为对氨基水杨酸皮肤活检微生物检查顽固性溃疡皮肤科医生鉴别诊断

HIV screening and retention in care in people who use drugs in Madrid, Spain: a prospective study

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Infectious Diseases of Poverty 2021年第4期10卷 77-85页

作者： Pablo Ryan Jorge Valencia Guillermo Cuevas Jesus Troya Juan Torres-Macho Maria Jose Munoz-Gomez nuria Munoz-Rivas Isabel Canorea Sonia Vazquez-Moron Salvador Resino Hospital Universitario Infanta Leonor MadridSpain Universidad Complute nse de Madrid(UCM) MadridSpain Instituto de Investigacion Sanitaria gregorio Maranon(liSGM) MadridSpain Unidad de Reduccion de Darios"SMASD"Madrid Spain Unidad de Infeccion Viral e Inmunidad Centro Nacional de MicrobiologiaInstituto de Salud Carlos IIICarretera Majada-honda-PozueloKm 2.228220 MajadahondaMadridSpain

Background::The burden of human immunodeficiency virus(HIV)infection in people who use drugs(PWUD)is *** aimed to screen HIV infection among PWUD and describe their retention in HIV ***,we also screen for hepatitis C virus(HCV)infection among HIV-seropositive PWUD and describe their linkage to ***::We conducted a prospective study in 529 PWUD who visited the"Ca?ada Real Galiana"(Madrid,Spain).The study period was from June 1,2017,to May 31,*** diagnosis was performed with a rapid antibody screening test at the point-of-care(POC)and HCV diagnosis with immunoassay and PCR tests on dried blood spot(DBS)in a central *** PWUD were referred to the *** used the Chi-square or Fisher’s exact tests,as appropriate,to compare rates between ***::Thirty-five(6.6%)participants were positive HIV antibodies,but 34 reported previous HIV diagnoses,and 27(76%)had prior antiretroviral *** patients with a positive HIV antibody test,we also found a higher prevalence of homeless(Pnd injection drug use(PWID)(Pnd more decades of drug use(P=0.002).All participants received HIV test results at the *** the 35 HIV positives,28(80%)were retained in HIV medical care at the end of the HIV screening study(2018),and only 22(62.9%)at the end of ***,12/35(34.3%)were positive for the HCV RnA *** the latter,10/12(83.3%)were contacted to deliver the HCV results test(delivery time of 19 days),5/12(41.7%)had an appointment and were attended at the hospital and started HCV therapy,and only 4/12(33.3%)cleared ***::We found almost no new HIV-infected PWUD,but their cascade of HIV care was low and remains a challenge in this population at *** high frequency of active hepatitis C in HIV-infected PWUD reflects the need for HCV screening and reinforcing the link to care.

关键词： HIV Point-of-care Screening People who use drugs Retention in care Hepatitis C Dried blood spot Antiviral treatment