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No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors

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Translational Neurodegeneration 2019年第1期8卷 127-133页

作者： Franziska Hopfner Stefanie HMüller Dagmar Steppat Joanna Miller Nele Schmidt Klaus-Peter Wandinger Frank Leypoldt Daniela Berg Andre Franke Wolfgang Lieb Lukas Tittmann Monika Balzer-Geldsetzer Simon Baudrexel Richard Dodel Ruediger Hilker-Roggendorf Elke Kalbe Jan Kassubek Thomas Klockgether Inga Liepelt-Scarfone Brit Mollenhauer Petra Neuser Kathrin Reetz Oliver Riedel Claudia Schulte Jörg BSchulz Annika Spottke Alexander Storch Claudia Trenkwalder Hans-Ulrich Wittchen Karsten Witt Ullrich Wüllner Günther Deuschl gregor kuhlenbäumer Department of Neurology University Hospital Schleswig HolsteinArnold-Heller Str.324105 KielGermany Center of Blood Transfusion University Hospital Schleswig HolsteinKiel&LübeckGermany Department of Clinical Chemistry University Hospital Schleswig-HolsteinKielGermany Institute of Clinical Molecular Biology University Hospital Schleswig-HolsteinKielGermany Institute of Epidemiology University Hospital Schleswig-HolsteinKielGermany Chair of Geriatric Medicine University Hospital EssenEssenGermany Department of Neurology Philipps-University MarburgMarburgGermany Department of Neurology Goethe UniversityFrankfurt/MainGermany Brain Imaging Center Goethe UniversityFrankfurt/MainGermany Department of Medical Psychology|Neuropsychology and Gender Studies&Center for Neuropsychological Diagnostics and Intervention(CeNDI) University Hospital CologneCologneGermany Psychological Gerontology Institute of GerontologyUniversity of VechtaVechtaGermany Department of Neurology University of UlmUlmGermany Department of Neurology University of Bonnand German Center for Neurodegenerative Diseases(DZNE)BonnGermany Center for Neurology Hertie Institute for Clinical Brain ResearchDepartment of Neurodegenerative DiseasesUniversity of TübingenTübingenGermany DZNE German Center for Neurodegenerative DiseasesTübingenGermany Paracelsus-Elena-Klinik KasselGermany Institute of Neuropathology and Department of Neurosurgery University Medical Center GöttingenGöttingenGermany Coordinating Centre for Clinical Trials Philipps-UniversityMarburgGermany Department of Neurology RWTH Aachen UniversityAachenGermany JARA-BRAIN Institute of Molecular Neuroscience and Neuroimaging Forschungszentrum Jülich GmbH and RWTH Aachen UniversityAachenGermany Leibniz Institute for Prevention Research and Epidemiology-BIPS Achterstrasse 3028359 BremenGermany Department of Neurology Technische Universität Dresden01307 DresdenGermany German Center for Neurodegenerative Diseases(DZNE) Research Site Rostock18147 RostockGerma

Background:IgG-class autoantibodies to N-Methyl-D-Aspartate(NMDA)-type glutamate receptors define a novel entity of autoimmune *** examining the prevalence of NMDA IgA/IgM antibodies in patients with Parkinson disease with/without dementia produced conflicting *** measured NMDA antibodies in a large,well phenotyped sample of Parkinson patients without and with cognitive impairment(n=296)and controls(n=295)free of neuropsychiatric *** phenotyping and large numbers allowed statistically meaningful correlation of antibody status with diagnostic subgroups as well as quantitative indicators of disease severity and cognitive ***:NMDA antibodies were analysed in the serum of patients and controls using well established validated *** used anti-NMDA antibody positivity as the main independent variable and correlated it with disease status and phenotypic ***:The frequency of NMDA IgA/IgM antibodies was lower in Parkinson patients(13%)than in controls(22%)and higher than in previous studies in both *** IgA/IgM antibodies were neither significantly associated with diagnostic subclasses of Parkinson disease according to cognitive impairment,nor with quantitative indicators of disease severity and cognitive impairment.A positive NMDA antibody status was positively correlated with age in controls but not in Parkinson ***:It is unlikely albeit not impossible that NMDA antibodies play a significant role in the pathogenesis or progression of Parkinson disease *** Parkinson disease with dementia,while NMDA IgG antibodies define a separate disease of its own.

关键词： NMDA antibody NMDA IgA/IgM antibodies Parkinson disease Cognitive impairment

原始的面具——奥古斯特·马克与弗朗兹·马尔克的原始主义和文化批判

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内蒙古艺术学院学报 2024年第1期21卷 47-56页

作者： [德国]gregor Wedekind() 何佳(译) 王荟(校) 美茵茨约翰内斯·古腾堡大学德国莱茵兰内蒙古艺术学院内蒙古呼和浩特010070 集美大学福建厦门361021

本文以德国表现主义艺术家奥古斯特·马克(August Macke)与弗朗兹·马尔克(Franz Marc)为例,分析论述两位艺术家在其社会文化背景下创作的艺术风格。

关键词：德国表现主义原始主义文化批判

维普期刊数据库博看期刊

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生产准备时间缩短一半

现代制造 2024年第8期 30-30,32页

作者： Lars Rödel Jonas Krebs gregor Müller Timo Denner 不详

在生产准备工作实现自动化之后,才能实现节约生产成本的目标。而利用弗劳恩霍夫IPA生产技术和自动化研究所开发的“设计链(Designchain)”系统可实现生产准备的自动化。当前,虽然经济形势不容乐观,但Ceratizit公司的订单合同依然比较充... 详细信息

在生产准备工作实现自动化之后,才能实现节约生产成本的目标。而利用弗劳恩霍夫IPA生产技术和自动化研究所开发的“设计链(Designchain)”系统可实现生产准备的自动化。当前,虽然经济形势不容乐观,但Ceratizit公司的订单合同依然比较充足。究其原因,是由于此前受全球疫情影响,Ceratizit公司忘记了如何快速高效地处理客户合同订单,还是因为供应链受到干扰而出现订单积压?

关键词：自动化研究所供应链设计链生产准备时间合同订单生产准备工作节约生产订单合同

A Stochastic Modeling Approach for Interplanetary Supply Chain Planning

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Space(Science & Technology) 2023年第1期3卷 98-111页

作者： gregor Blossey Department of Information Systems Productionand Logistics ManagementUniversity of InnsbruckInnsbruckAustria Department of Business Informatics European University ViadrinaFrankfurt(Oder)Germany

The unique and complex challenges of sustainable interplanetary travel necessitate a novel space logistics paradigm,which is hereafter referred to as the interplanetary supply *** lay the groundwork for this anticipated paradigm shift,this work aims to introduce principles and methodologies of supply chain(SC)planning to the field of space *** this end,a stochastic multistage mixed integer linear programming model is proposed that explores the vision of a permanent human presence on Mars from a logistics *** model optimizes material flows,propellant production,and in-space infrastructure allocations to identify the optimal SC network ***,demand uncertainty at the Mars base is considered,which makes it the first model to investigate the effects of stochasticity in space logistics *** case studies are investigated,which incorporate data on Earth-Mars transfer windows and flight trajectories obtained through the National Aeronautics and Space Administration’s trajectory *** results reveal numerous interdependencies and,thus,highlight the need for holistic SC modeling approaches that go beyond the isolated mission planning of the extant *** instance,the findings show frequent interactions among spacecraft as they regularly engage in division of labor regarding cargo and propellant ***,complex propellant supply networks that involve strategic in-space infrastructure allocation and propellant production on celestial bodies are ***,the developed model provides valuable insights into the planning of a sustainable interplanetary travel,offers a new SC perspective,and lays the foundation for future research in this area.

关键词： travel hereafter sustainable

Study of tree shrew biology and models: A booming and prosperous field for biomedical research

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Zoological Research 2024年第4期45卷 877-909页

作者： Yong-Gang Yao Li Lu Rong-Jun Ni Rui Bi Ceshi Chen Jia-Qi Chen Eberhard Fuchs Marina Gorbatyuk Hao Lei Hongli Li Chunyu Liu Long-Bao Lv Kyoko Tsukiyama-Kohara Michinori Kohara Claudia Perez-Cruz gregor Rainer Bao-Ci Shan Fang Shen An-Zhou Tang Jing Wang Wei Xia Xueshan Xia Ling Xu Dandan Yu Feng Zhang Ping Zheng Yong-Tang Zheng Jumin Zhou Jiang-Ning Zhou Key Laboratory of Genetic Evolution and Animal Models Yunnan Key Laboratory of Animal Models and Human Disease MechanismsKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility) and National Resource Center for Non-Human PrimatesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Mental Health Center and Psychiatric Laboratory West China HospitalSichuan UniversityChengduSichuan 610041China Sichuan Clinical Medical Research Center for Mental Disorders ChengduSichuan 610044China German Primate Center Leibniz Institute of Primate ResearchGöttingen 37077Germany Department of Optometry and Vision Science School of OptometryUniversity of Alabama at BirminghamBirminghamAL 35294USA State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanHubei 430071China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubei 430074China Soong Ching Ling Institute of Maternity and Child Health International Peace Maternity and Child Health HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Transboundary Animal Diseases Center Joint Faculty of Veterinary MedicineKagoshima UniversityKagoshima-cityKagoshima 890-8580Japan Department of Microbiology and Cell Biology Tokyo Metropolitan Institute of Medical ScienceTokyo 156-8506Japan Pharmacology Department CinvestavMexico City 07360Mexico Department of Medicine University of FribourgFribourg CH-1700Switzerland Beijing Engineering Research Center of Radiog

The tree shrew(Tupaia belangeri)has long been proposed as a suitable alternative to non-human primates(NHPs)in biomedical and laboratory research due to its close evolutionary relationship with *** recent years,significant advances have facilitated tree shrew studies,including the determination of the tree shrew genome,genetic manipulation using spermatogonial stem cells,viral vector-mediated gene delivery,and mapping of the tree shrew brain ***,the limited availability of tree shrews globally remains a substantial challenge in the ***,determining the key questions best answered using tree shrews constitutes another *** shrew models have historically been used to study hepatitis B virus(HBV)and hepatitis C virus(HCV)infection,myopia,and psychosocial stress-induced depression,with more recent studies focusing on developing animal models for infectious and neurodegenerative *** these efforts,the impact of tree shrew models has not yet matched that of rodent or NHP models in biomedical *** review summarizes the prominent advancements in tree shrew research and reflects on the key biological questions addressed using this *** emphasize that intensive dedication and robust international collaboration are essential for achieving breakthroughs in tree shrew *** use of tree shrews as a unique resource is expected to gain considerable attention with the application of advanced techniques and the development of viable animal models,meeting the increasing demands of life science and biomedical research.

关键词： Tree shrew Animal model Neurodegenerative diseases Infectious diseases Neuroscience Phenome

Development of a low-cost measurement system for cutting edge profile detection

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Chinese Optics Letters 2011年第7期9卷 33-36页

作者： gregor Gerstorfer Bernhard G.Zagar Institute for Measurement Technology Johannes Kepler University

The use of a compact disk （CD） pickup head as a displacement measurement system is described. The components contained in a pickup head are explained and how they are combined to obtain the functionality of a pickup head. The application of measuring a knife edge profile is introduced. The results reveal some insuffiencies with the current system. The cutting edge＇s radius of curvature can be estimated.

关键词： Development of a low-cost measurement system for cutting edge profile detection VCM

QoS Guided Min—Min Heuristic for Grid Task Scheduling

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Journal of Computer Science & Technology 2003年第4期18卷 442-451页

作者：何晓珊孙贤和 gregor von Laszewski Department of Computer Science Illinois Institute of Technology IL USA Mathematics and Computer Science Division Argonne National Laboratory IL USA

Task scheduling is an integrated component of computing. With the emergence of Grid and ubiquitous computing, new challenges appear in task scheduling based on properties such as security, quality of service, and lack of central control within distributed administrative domains. A Grid task scheduling framework must be able to deal with these issues. One of the goals of Grid task scheduling is to achieve high system throughput while matching applications with the available computing resources. This matching of resources in a non-deterministically shared heterogeneous environment leads to concerns over Quality of Service (QoS). In this paper a novel QoS guided task scheduling algorithm for Grid computing is introduced. The proposed novel algorithm is based on a general adaptive scheduling heuristics that includes QoS *** algorithm is evaluated within a simulated Grid environment. The experimental results show that the new QoS guided Min-Min heuristic can lead to significant performance gain for a variety of applications. The approach is compared with others based on the quality of the prediction formulated by inaccurate information.

关键词： QoS 任务调度网格计算服务质量非贡献计算

Probabilistic Assessment of Impact of Flexible Loads Under Network Tariffs in Low-voltage Distribution Networks

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Journal of Modern Power Systems and Clean Energy 2021年第4期9卷 951-962页

作者： Donald Azuatalam Archie C.Chapman gregor Verbic School of Electrical and Information Engineering The University of SydneySydneyNew South WalesAustralia

Given the historically static nature of low-voltage networks, distribution network companies do not possess the tools for dealing with an increasingly variable demand due to the high penetration of distributed energy resources (DERs). Within this context, this paper proposes a probabilistic framework for tariff design that minimises the impact of DER on network performance, stabilises the revenue of network company, and improves the equity of network cost allocation. To deal with the lack of customers’ response, we also show how DER-specific tariffs can be complemented with an automated home energy management system (HEMS) that reduces peak demand while retaining the desired comfort level. The proposed framework comprises a nonparametric Bayesian model which statistically generates synthetic load and PV traces, a hot-water-use statistical model, a novel HEMS to schedule customers’ controllable devices, and a probabilistic power flow model. Test cases using both energy- and demand-based network tariffs show that flat tariffs with a peak demand component reduce the customers’ cost, and alleviate network constraints. This demonstrates, firstly, the efficacy of the proposed tool for the development of tariffs that are beneficial for the networks with a high penetration of DERs, and secondly, how customers’ HEM systems can be part of the solution.

关键词： Battery energy storage system demand-based tariff distributed energy resource(DER) home energy management system(HEMS) low-voltage network solar photovoltaic(PV) thermostatically controlled load

A Sub-element Adaptive Shock Capturing Approach for Discontinuous Galerkin Methods

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Communications on Applied Mathematics and Computation 2023年第2期5卷 679-721页

作者： Johannes Markert gregor Gassner Stefanie Walch Department for Mathematics and Computer Science University of CologneWeyertal 86-9050931 CologneGermany Department for Mathematics and Computer Science Center for Data and Simulation ScienceUniversity of CologneWeyertal 86-9050931 CologneGermany I.Physikalisches Institut Center for Data and Simulation ScienceUniversity of CologneZülpicher Str.7750937 CologneGermany

In this paper,a new strategy for a sub-element-based shock capturing for discontinuous Galerkin(DG)approximations is *** idea is to interpret a DG element as a col-lection of data and construct a hierarchy of low-to-high-order discretizations on this set of data,including a first-order finite volume scheme up to the full-order DG *** dif-ferent DG discretizations are then blended according to sub-element troubled cell indicators,resulting in a final discretization that adaptively blends from low to high order within a single DG *** goal is to retain as much high-order accuracy as possible,even in simula-tions with very strong shocks,as,e.g.,presented in the Sedov *** framework retains the locality of the standard DG scheme and is hence well suited for a combination with adaptive mesh refinement and parallel *** numerical tests demonstrate the sub-element adaptive behavior of the new shock capturing approach and its high accuracy.

关键词： High-order methods Discontinuous Galerkin spectral element method Finite volume method Shock capturing Astrophysics Stellar physics