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Effect of liner and porcelain application on zirconia surface structure and composition

International Journal of Oral Science 2016年第3期8卷 164-171页

作者： Tariq F Alghazzawi gregg m janowski Department of Prosthetic Dental Sciences College of DentistryTaibah University Department of materials Science and Engineering School of EngineeringThe University of Alabama at Birmingham

The purpose of this study was to determine if there is an effect of liner and porcelain application （layering and pressing techniques） on the surface of yttria-stabilized tetragonal zirconia polycrystals （Y-TZP）, which were exposed to permutations of liner, layered porcelain, and pressed porcelain. Scanning electron microscope （SEm）/energy dispersive spectroscope （EDS） was used to identify changes in composition and microstructure after removing liner and porcelain with hydrofluoric acid. Simulated aging was also conducted to determine the effect of liner and porcelain on low-temperature degradation. The control group had a typical equiaxed grain structure, referred to as unaffected. When covered with liner or porcelain, some areas changed in structure and composition and were termed affected. The frequency of affected sbructure decreased when liner was covered with either layered porcelain or pressed porcelain. There were statistical differences （P〈0.05） in the composition between affected and unaffected for zirconium （layered porcelain with liner： affected = 60% （0.8%）（m/m）, unaffected = 69% （4%）, layered porcelain without liner： affected = 59% （3%）, unaffected = 65% （3%）） and oxygen （layered porcelain with liner： affected = 35% （2%）, unaffected = 26% （4%）, layered porcelain without liner： affected = 35% （3%）, unaffected = 30% （2%））. However, there were statistical differences （P〈0.05） in the composition for zirconium and oxygen of the aged layered porcelain without liner only. The liner should not be used before porcelain application, especially when using the layering technique for zirconia restorations. Furthermore, pressing should be considered the technique of choice over layering.

关键词： aging coefficient of thermal expansion energy dispersive spectroscopy layering of porcelain pressing of porcelain scanning electron microscope zirconia

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Evaluation of zirconia–porcelain interface using X-ray diffraction

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International Journal of Oral Science 2015年第3期7卷 187-195页

作者： Tariq F Alghazzawi gregg m janowski Department of materials Science and Engineering School of Engineering The University of Alabama at Birmingham Department of Prosthetic Dental Sciences College of Dentistry Taibah University

The aim of this study was to determine if accelerated aging of porcelain veneering had an effect on the surface properties specific to a tetragonal-to-monoclinic transformation（TmT） of zirconia restorations. Thirty-six zirconia samples were milled and sintered to simulate core fabrication followed by exposure to various combinations of surface treatments including as-received（control）,hydrofluoric acid（HF）, application of liner plus firings, application of porcelain by manual layering and pressing with firing, plus accelerated aging. The quantity of transformed tetragonal to monoclinic phases was analyzed utilized an X-ray diffractometer and one-way analysis of variance was used to analyze data. The control samples as provided from the dental laboratory after milling and sintering process had no TmT（X m5 0）. There was an effect on zirconia samples of HF application with TmT（X m5 0.8%） and liner plus HF application with TmT（X m5 8.7%）. There was an effect of aging on zirconia samples（no veneering） with significant TmT（X m5 70.25%）. Both manual and pressing techniques of porcelain applications reduced the TmT（manual, X m5 4.41%, pressing,X m5 11.57%）, although there was no statistical difference between them. It can be concluded that simulated applications of porcelain demonstrated the ability to protect zirconia from TmT after aging with no effect of a liner between different porcelain *** HF treatment also caused TmT.

关键词： aging hydrofluoric acid monoclinic pressing tetragonal X-ray diffraction

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大型公共运输中的热塑性组合框架结构的设计、制造和分析

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钢结构 2008年第2期23卷 76-77页

作者： Haibin Ning Uday Vaidya gregg m. janowski George Husman

薄壁复合材料具有优越的性能,包括高强度、轻质、抗弯、抗剪性强等,因而经常用于大型交通领域。从目前的研究来看,已经设计、分析并制造出一种用于大型运输卡车的薄壁复合热塑组合结构来代替传统的金属结构。考虑了三种横截面构造,分别... 详细信息

薄壁复合材料具有优越的性能,包括高强度、轻质、抗弯、抗剪性强等,因而经常用于大型交通领域。从目前的研究来看,已经设计、分析并制造出一种用于大型运输卡车的薄壁复合热塑组合结构来代替传统的金属结构。考虑了三种横截面构造,分别是矩形、V字形、C形,对比了编织方向在(0/90)6,[±45/(0/90)2]s及[±45/(0/90)]3等不同的复合材料层合结构。该结构选用碳纤/聚亚苯硫化物(carbon/PPS)作为原材料,采用单模复合成型。通过面内冲压试验,验证了碳/PPS组合结构有限元分析结果,论证了薄壁碳/PPS热组合结构制造策略的设计理念。

关键词：热塑性复合材料碳纤维聚亚苯硫化物 (PPS) 大型交通薄壁结构

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用于大型公共交通的热塑性复合夹芯板结构设计与制造

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钢结构 2008年第2期23卷 74-74页

作者： Haibin Ning gregg m. janowski Uday K. Vaidya George Husman

轻质运输工具可以提高燃料的燃烧效率、降低运行费用,在大型公共交通系统中更为明显。轻质复合材料,如玻璃纤维增强聚合物,被用来替代传统的钢材和铝合金。介绍了采用热塑性复合材料的大型公共汽车侧板的设计、分析研究和制造。设计了... 详细信息

轻质运输工具可以提高燃料的燃烧效率、降低运行费用,在大型公共交通系统中更为明显。轻质复合材料,如玻璃纤维增强聚合物,被用来替代传统的钢材和铝合金。介绍了采用热塑性复合材料的大型公共汽车侧板的设计、分析研究和制造。设计了一种由E-玻璃纤维/聚丙烯表面覆盖和聚丙烯蜂窝核心构成的复合夹芯板,具有轻质,高强和良好的吸能性能。夹芯板的设计和分析采用Pro/E、Hy-permesh、ANSYS等软件进行。单一的膜结构用于制造玻璃纤维/聚丙烯表面覆盖,表面覆盖的微结构分析证明此过程可以保证很好的固结。表面覆盖与核心材料被牢固地结合起来并经过了模型测试。荷载达到11.7kN时由于粘结失效导致夹芯板破坏。夹芯板的静载能力已满足美国公共运输协会(AP-TA)的要求。与传统的铝面钢结构卡车相比,热塑性复合材料制造的夹芯板减轻了55%的重量。

关键词：热塑性复合材料夹芯板结构玻璃纤维/聚乙烯大型交通系统膜结构

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nflammasomes in cancer： a double-edgecl sword

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Protein & Cell 2014年第1期5卷 12-20页

作者： Ryan Kolb Guang-Hui Liu Ann m. janowski Fayyaz S. Sutterwala Weizhou Zhang Department of Pathology Carver College of Medicine University of Iowa Iowa City IA 52242 USA National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Gene Expression Laboratory Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Graduate Program in Immunology Carver College Of Medicine University of Iowa iowa City IA 52242 USA Department of Internal medicine Carver College of Medicine University of Iowa Iowa City IA 52242 USA Veterans Affairs medical Center Iowa City IA 52241 USA

Chronic inflammatory responses have long been observed to be associated with various types of cancer and play decisive roles at different stages of cancer development. Inflammasomes, which are potent induc- ers of interleukin （IL）-I~ and IL-18 during infammation, are large protein complexes typically consisting of a Nod-like receptor （NLR）, the adapter protein ASC, and Caspase-1. During malignant transformation or cancer therapy, the inflammasomes are postulated to become activated in response to danger signals arising from the tumors or from therapy-induced damage to the tumor or healthy tissue. The activation of inflammasomes plays diverse and sometimes contrasting roles in cancer promotion and therapy depending on the specific con- text. Here we summarize the role of different inflamma- some complexes in cancer progression and therapy. Inflammasome components and pathways may provide novel targets to treat certain types of cancer; however, using such agents should be cautiously evaluated due to the complex roles that inflammasomes and pro- inflammatory cytokines play in immunity.

关键词： inflammasome cancer inflammation

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Tolerance analysis of non-depolarizing double-pass polarimetry

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PhotoniX 2020年第1期1卷 75-94页

作者： Yimin Yu Nabila Baba-Ali gregg m.Gallatin Shanghai micro Electronics Equipment(Group)Co. Ltd.1525 Zhangdong Road201203 ShanghaiChina.2StamfordConnecticutUSA.

Double-pass polarimetry measures the polarization properties of a sample over a rangeof polar angles and all azimuths. Here, we present a tolerance analysis of all the opticalelements in both the calibration and measurement procedures to predict thesensitivities of the double-pass polarimeter. The calibration procedure is described by amueller matrix based on the eigenvalue calibration method (ECm) [1]. Our numericalresults from the calibration and measurement in the mueller matrix description withtolerances limited by systematic and stochastic noise from specifications ofcommercially available hardware components are in good agreement with previousexperimental observations. Furthermore, by using the orientation Zernike polynomials(OZP) which are an extension of the Jones matrix formalism, similar to the Zernikepolynomials wavefront expansion, the pupil distribution of the polarization propertiesof non-depolarizing samples under test are expanded. Using polar angles ranging upto 25°, we predict a sensitivity of 0.5% for diattenuation and 0.3° for retardance usingthe root mean square (RmS) of the corresponding OZP coefficients as a measure of theerror. This numerical tool provides an approach for further improving the sensitivities ofpolarimeters via error budgeting and replacing sensitive components with thosehaving better precision.

关键词： Tolerance analysis Polarimetry Jones matrix mueller matrix

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Formation of fine crystalline dolomites in lacustrine carbonates of the Eocene Sikou Depression, Bohai Bay Basin, East China

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Petroleum Science 2016年第4期13卷 642-656页

作者： Yong-Qiang Yang Long-Wei Qiu Jay gregg Zheng Shi Kuan-Hong Yu School of Geosciences China University of Petroleum Department of Geology Oklahoma State University

The genesis of the fine crystalline dolomites that exhibit good to excellent reservoir properties in the upper fourth member of the Eocene Shahejie Formation（Es4s）around the Sikou Sag, Bohai Bay Basin, is uncertain. This paper investigates the formation mechanisms of this fine crystalline dolomite using XRD, SEm, thin section analysis and geochemical data. The stratigraphy of the Sikou lacustrine carbonate is dominated by the repetition of metre-scale, high-frequency deposition cycles, and the amount of dolomite within a cycle increases upward from the cycle bottom. These dolomite crystals are 2–30 μm in length, subhedral to anhedral in shape and typically replace both grains and matrix. They also occur as rim cement and have thin lamellae within ooid cortices. Textural relations indicate that the dolomite predates equant sparry calcite cement and coarse calcite cement. The Sr concentrations of dolomites range from 900 to 1200 ppm. Dolomite δ18O values（-11.3 to-8.2 ‰ PDB） are depleted relative to calcite mudstone（-8.3 to-5.4 ‰ PDB） that precipitated from lake water, while δ13C values（0.06–1.74 ‰ PDB） are within the normal range of calcite mudstone values（-2.13 to 1.99 ‰ PDB）. High87Sr/86Sr values（0.710210–0.710844） indicate that amounts of Ca2＋ and mg2＋have been derived from the chemical weathering of Palaeozoic carbonate bedrocks. The high strontium concentration indicates that hypersaline conditions were maintainedduring the formation of the dolomites and that the dolomites were formed by the replacement of precursor calcite or by direct precipitation.

关键词： Dolomite Lacustrine carbonate Eocene Sikou Sag Bohai Bay Basin

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Application of anti-CD103 immunotoxin for saving islet allograft in context of transplantation

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Chinese medical Journal 2010年第24期123卷 3644-3651页

作者： ZHANG Lei gregg A. Hadley Department of General Surgery the Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150086 China Division of Transplantation Department of Surgery the Ohio State University Medical Center Columbus OH 43210 USA

Background Previous studies using knockout mice document a key role for the integrin CD103 in promoting organ allograft rejection and graft-versus-host disease. However, a determination of whether blockade of the CD103 pathway represents a viable therapeutic strategy for intervention in these processes has proven problematic due to the lack of reagents that efficiently deplete CD103＋ cells from wild type hosts. To circumvent this problem, in the present study, we invented an anti-CD103 immunotoxin （m290-SAP）. We investigated whether m290-SAP has capacity to eliminate CD103-expressing cells in vivo and protect transplanted islets from destroying by host immune *** Flow cytometry was used to analyze the efficacy of m290-SAP in depleting CD103-expressing cells in *** using allogenic islet transplantation models as well as NOD mice with recent onset type 1 diabetes, the therapeutic efficacy of CD103-expressing cell depletion was *** m290-SAP dramatically reduces the frequency and absolute numbers of CD103-expressing leukocytes in peripheral lymphatic tissues of treated mice. Balb/c islets transplanted into streptozotocin-induced diabetic C57BL/6 mice under single m290-SAP treatment showed an indefinite survival time compared with untreated mice, m290-treated mice and IgG-SAP treated mice （mean survival time, ＞100 days vs. ＜20 days）. C57BL/6 islets transplanted into hyperglycemic NOD mice under single m290-SAP treatment showed a pronounced delay in allograft rejection compared with untreated mice （mean survival time 12-13 days vs. ＜7 days）. Immunological analysis of mice with long-term islet allograft survival revealed an obvious atrophy thymus and severe downregulation of alloimmunity of CD8 subpopulation response to allogenic *** Regardless of the underlying mechanisms, these data document that depletion of CD103-expressing cells represents a viable strategy for therapeutic intervention in islet allograft rejection.

关键词： immunotoxin saporin CD8 T lymphocytes pancreatic islets transplantation thymus

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Protective effect of hydroxychloroquine on rheumatoid arthritis-associated atherosclerosis

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Animal models and Experimental medicine 2019年第2期2卷 98-106页

作者： Na Shi Shuangyue Zhang gregg Silverman mengtao Li Jun Cai Haitao Niu NHC Key Laboratory of Human Disease Comparative medicine (The Institute of Laboratory Animal Sciences CAMS&PUMC) Key Laboratory of Human Diseases Animal Model State Administration of Traditional Chinese Medicine Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Beijing China Department of Rheumatology Langone Medical Center New York University New York City New York Peking Union medical College Hospital Beijing China Fuwai Hospital Chinese Academy of Medical Sciences Beijing China

Background: Patients with rheumatoid arthritis (RA) have an increased risk for cardiovascular disease. We examined the effect of gut microbiota in a mouse model of RA that develops atherosclerosis. methods: We created three groups of K/BxN female mice that were positive for the anti‐glucose‐6‐phosphate isomerase (GPI) antibody: control diet (CD), high fat diet (HFD), and HFD with hydroxychloroquine (HFD + HCQ). Serological tests were used to detect the serum levels of total cholesterol (TCHO), low‐density lipoprotein cholesterol (LDL‐C), triglyceride (TG), high‐density lipoprotein cholesterol (HDL‐C), anti‐ GPI antibody titers, and serum cytokines. Atherosclerotic plaque was determined by histological analysis, and gut microbiota were determined by 16sV4 sequencing. Results: Relative to mice given the CD, those receiving the HFD had increased serum levels of LDL‐C, TCHO, and TG, decreased serum levels of HDL‐C, increased atherosclerotic lesions in the aortic root, and altered gut microbiota. Addition of HCQ to HFD decreased the serum levels of LDL‐C, TCHO, and TG, increased serum levels of HDL‐C, and decreased the atherosclerotic lesions in the aortic root. mice receiving HFD + HCQ also had the greatest bacterial diversity among the three experimental groups. moreover, HCQ treatment significantly increased the abundance of Akkermansia and Parabacteroides, and decreased the abundance of Clostridium sensu stricto cluster 1, and therefore may be responsible for the reduced RA‐associated atherosclerosis and dyslipidemia. Conclusion: Our mouse model of RA indicated that HFD increased ankle width and aggravated a therosclerosis a nd d yslipidemia, a nd t hat H CQ a lleviated t he d yslipidemia and atherosclerosis, but had no effect on ankle width.

关键词： atherosclerosis autoimmunity hydroxychloroquine intestinal microbiota rheumatoid arthritis

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多元统计方法在白云岩分类和类型识别中的应用

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江汉石油学院学报 1991年第1期13卷 11-16页

作者：田时芸 Jay m.gregg 江汉石油学院美国密苏里-罗拉大学

利用地球化学数据,用R-Q型联立因子分析对美国密苏里州东南Bonneterre组(塞武纪)滨外相的白云岩进行了分析,按成因意义有效地将该地区白云岩作了分类,并指出了各类白云岩的地化特征,分类结果与用岩石学方法作出的分类是一致的,二者可以... 详细信息

利用地球化学数据,用R-Q型联立因子分析对美国密苏里州东南Bonneterre组(塞武纪)滨外相的白云岩进行了分析,按成因意义有效地将该地区白云岩作了分类,并指出了各类白云岩的地化特征,分类结果与用岩石学方法作出的分类是一致的,二者可以相互补充。根据已分类的白云岩建立的Bayes判别函数仅涉及两项地球化学指标,其判对率己高达95%。以上方法简便易行,尤其在只使用岩石学方法难于分类的情况下,也许是很有用的。

关键词：白云岩岩石分析多元统计法

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