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第十七届国际生物物理大会;第十二届中国生物物理大会

作者： Noah Buncher greg gibson Robert Keller Bennett Van Houten Simon C.Watkins Patricia L.Opresko Neil Kad Department of Environmental and Occupational Health University of Pittsburgh Graduate School of Public HealthPittsburghPA 15219 Center for Biologic Imaging University of PittsburghPittsburgh15261 Department of Biology University of EssexColchesterEssex C04 3SQ UK Department of Pharmacology and Chemical Biology University of Pittsburgh School of Medicine The University of Pittsburgh Cancer Institute Hillman Cancer CenterPittsburghPennsylvania 15213 Department of Biology University of EssexColchesterEssex CO4 3SQ UK

Telomeres are nucleoprotein structures that cap the ends of linear *** telomeres are important contributing factors in aging and *** a typical human somatic cell,the telomeric repeat sequence TTAGGG is approximately 2-15 kb in length with a 3' single stranded overhang of 100-200 nt.A specialized protein complex called shelterin binds and protects the human telomeric *** humans,this

关键词： Telomere single-molecule fluorescence atomic force microscopy protein-DNA interactions TRF2

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Mochi: Composing Data Services for High-Performance Computing Environments

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Journal of Computer Science & Technology 2020年第1期35卷 121-144页

作者： Robert BRoss George Amvrosiadis Philip Carns Charles DCranor Matthieu Dorier Kevin Harms greg Ganger Garth gibson Samuel KGutierrez Robert Latham Bob Robey Dana Robinson Bradley Settlemyer Galen Shipman Shane Snyder Jerome Soumagne Qing Zheng Argonne National Laboratory LemontIL 60439U.S.A Parallel Data Laboratory Carnegie Mellon UniversityPittsburghPA 15213U.S.A Vector Institute for Artificial Intelligence TorontoOntarioCanada Los Alamos National Laboratory Los Alamos NMU.S.A The HDF Group Champaign ILU.S.A

Technology enhancements and the growing breadth of application workflows running on high-performance computing(HPC)platforms drive the development of new data services that provide high performance on these new platforms,provide capable and productive interfaces and abstractions for a variety of applications,and are readily adapted when new technologies are *** Mochi framework enables composition of specialized distributed data services from a collection of connectable modules and *** than forcing all applications to use a one-size-fits-all data staging and I/O software configuration,Mochi allows each application to use a data service specialized to its needs and access *** paper introduces the Mochi framework and *** Mochi core components and microservices are *** of the application of the Mochi methodology to the development of four specialized services are ***,a performance evaluation of a Mochi core component,a Mochi microservice,and a composed service providing an object model is *** paper concludes by positioning Mochi relative to related work in the HPC space and indicating directions for future work.

关键词： storage and I/O data-intensive computing distributed services high-performance computing

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