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Characterization and mode of action analysis of black soldier fly(Hermetia illucens)larva-derived hemocytes

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Insect Science 2022年第4期29卷 1071-1095页

作者： Yvette m.von Bredow Ariane müller Philipp F.Popp Denis Iliasov Christoph-Rüdiger von Bredow Justus-Liebig-Universität Gießen Institut für Allgemeine Zoologie und EntwicklungsbiologieZelluläre Erkennungs-und AbwehrprozesseGießenGermany Technische Universität Dresden Fakultät BiologieInstitut für ZoologieDresdenGermany Technische Universität Dresden Fakultät BiologieInstitut für MikrobiologieDresdenGermany Present address:Philipp F.Popp Institute for Biology-Bacterial PhysiologyHumboldt-Universität zu BerlinBerlinGermany

With the growing importance of the black soldier fly(Hermetia illucens)for both sustainable food production and waste management as well as for science,a great demand of understanding its immune system ***,we present the first description of the circulating larval hemocytes with special emphasis on uptake of microorganisms and distinguishing hemocyte *** histological,zymographic,and cytometric methods and with a set of hemocyte binding lectins and antibodies,the hemocytes of *** are identified as plasmatocytes,crystal cells,and putative *** hemocyte counts(THC)are determined,and methods for THC determination are *** 1100 hemocytes per microliter hemolymph are present in naive animals,while hemocyte density decreases dramatically shortly after wounding,indicating a role of hemocytes in response to wounding(and immune response in general).The determination of the relative abundance of each hemocyte type(differential hemocyte count,DHC)revealed that plasmatocytes are highly abundant,whereas prohemocytes and crystal cells make up only a small percentage of the circulating *** are not only the most abundant but also the professional phagocytes in *** rapidly engulf and take up bacteria both in vivo and in vitro,indicating a very potent cellular defense against invading *** bioparticles such as yeasts are also removed from circulation by phagocytosis,but slower than *** is the first analysis of the potent cellular immune response in the black soldier fly,and a first toolbox that helps to identify hemocyte(types)is presented.

关键词： black soldier fly(Hermetia ilucens) cellular immunity crystal cell hemocyte types immunity of economically imporant insects microbe phagoeytosis plasmatocyte

Liver disease in pregnancy

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World Journal of Gastroenterology 2009年第8期15卷 897-906页

作者： Noel m Lee Carla W Brady Department of medicine Duke University Medical Center Durham NC 27710 United States Division of Gastroenterology Duke University Medical Center Durham NC 27710 United States

Liver diseases in pregnancy may be categorized into liver disorders that occur only in the setting of pregnancy and liver diseases that occur coincidentally with pregnancy. Hyperemesis gravidarum, preeclampsia/eclampsia, syndrome of hemolysis, elevated liver tests and low platelets (HELLP), acute fatty liver of pregnancy, and intrahepatic cholestasis of pregnancy are pregnancy-specific disorders that may cause elevations in liver tests and hepatic dysfunction. Chronic liver diseases, including cholestatic liver disease, autoimmune hepatitis, Wilson disease, and viral hepatitis may also be seen in pregnancy. management of liver disease in pregnancy requires collaboration between obstetricians and gastroenterologists/hepatologists. Treatment of pregnancy-specific liver disorders usually involves delivery of the fetus and supportive care, whereas management of chronic liver disease in pregnancy is directed toward optimizing control of the liver disorder. Cirrhosis in the setting of pregnancy is less commonly observed but offers unique challenges for patients and practitioners. This article reviews the epidemiology, pathophysiology, diagnosis, and management of liver diseases seen in pregnancy.

关键词： Liver disease Pregnancy maternal outcome Fetal outcome Cesarean section Cholestasis Viral hepatitis.

Quantum Inspired Differential Evolution with Explainable Artificial Intelligence-Based COVID-19 Detection

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Computer Systems Science & Engineering 2023年第7期46卷 209-224页

作者： Abdullah m.Basahel mohammad Yamin Department of management Information Systems Faculty of Economics and AdministrationKing Abdulaziz UniversityJeddah21589Saudi Arabia

Recent advancements in the Internet of Things(Io),5G networks,and cloud computing(CC)have led to the development of Human-centric IoT(HIoT)applications that transform human physical monitoring based on machine *** HIoT systems find use in several applications such as smart cities,healthcare,transportation,***,the HIoT system and explainable artificial intelligence(XAI)tools can be deployed in the healthcare sector for effective *** COVID-19 pandemic has become a global health issue that necessitates automated and effective diagnostic tools to detect the disease at the initial *** article presents a new quantum-inspired differential evolution with explainable artificial intelligence based COVID-19 Detection and Classification(QIDEXAI-CDC)model for HIoT *** QIDEXAI-CDC model aims to identify the occurrence of COVID-19 using the XAI tools on HIoT *** QIDEXAI-CDC model primarily uses bilateral filtering(BF)as a preprocessing tool to eradicate the *** addition,RetinaNet is applied for the generation of useful feature vectors from radiological *** COVID-19 detection and classification,quantum-inspired differential evolution(QIDE)with kernel extreme learning machine(KELm)model is *** utilization of the QIDE algorithm helps to appropriately choose the weight and bias values of the KELm *** order to report the enhanced COVID-19 detection outcomes of the QIDEXAI-CDC model,a wide range of simulations was carried *** comparative studies reported the supremacy of the QIDEXAI-CDC model over the recent approaches.

关键词： Human-centric IoT quantum computing explainable artificial intelligence healthcare COVID-19 diagnosis

Effect of RF power on the structural and optical properties of ZnS thin films prepared by RF-sputtering

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Journal of Semiconductors 2018年第12期39卷 26-31页

作者： C.m.Samba Vall m.Chaik H.Ait Dads H.El Aakib m.Elyaagoubi m.Aggour A.Outzourhit Laboratory of Nanomaterials for Energies and Environments Faculty of Sciences Semlalia Cadi Ayyad University Laboratory of Renewable Energy and Environment Faculty of Science Kenitra Ibn Tofail University

Zinc sulphide(ZnS) thin films have grown on glass and Si substrates by reactive cathodic radio frequency(RF) sputtering. The RF power was varied in the range of 100 to 250 W, while the deposition time is set at75 min. The optical, structural, and morphological properties of these thin films have been studied. The optical properties(mainly thickness, refractive index,absorption coefficient, and optical band gap) were investigated by optical transmittance measurements in the wavelength range of ultraviolet-visible-near infrared spectroscopy and spectroscopy infrared with Fourier transform. Fourier(FT-IR) and XRD analysis indicated that all sputtering ZnS films had a single-phase with a preferred orientation along the(111) plane of the zinc sphalerite phase(ZB). The crystallite size ranged from 11.5 to 48.5 nm with RF power getting a maximum of 200 W. UV-visible measurements exhibited that the ZnS film had more than 80% transmission in the visible wavelength region. In addition, it has been observed that the band gap energy of ZnS films is decreased slightly from 3.52 to 3.29 eV, and as the RF power is increased, the film thickness increases with the speed of deposit growth. Scanning electron microscopy observations revealed the types of smooth-surfaced films. The measurements(FT-IR) revealed at wave number1118 and 465.02 cmabsorption bands corresponding to the symmetrical and asymmetric vibration of the Zn-S stretching mode. X-ray reflectometry measurements of ZnS films have shown that the density of the films is(3.9 g/cm~3) close to that of solid ZnS.

关键词： ZnS thin films by sputtered RF-sputtering ZnS ZnS buffer layer for solar cell

N-Substituted benzoxazolyl ureas and thioureas in Biginelli reaction promoted by trifluoromethane sulfonic acid:An efficient and convenient synthesis of substituted benzoxazolyl 3,4-dihydropyrimidine(1H)-(thio)-ones

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Chinese Chemical Letters 2009年第8期20卷 909-912页

作者： m.Saranga Pani m.Arjun D.Sridhar K.Srinivas T.Raviprasad Department of Pharmacy Kakatiya University Department of Chemistry Kakatitya University

An efficient synthesis of 3,4-dihydropyrimidine 2 （1H）-ones and thiones （3,4-DHPms） core was prepared by one-pot threecomponent Biginelli condensation and which was catalyzed by trifluoromethane sulfonic acid. The classical BigneUi reaction has been extended by the use of N-substituted benzoxazolyl semicarbazides and thiosemicarbazides and this method has the advantage of excellent yields and short reaction times. ？2009 m. Saranga Pard. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Trifluoromcthane sulfonic acid N-substituted scmicarbazidcs and thioscmicarbazidcs β-Ketocster Substituted benzoxazolyl 3,4-dihydropyrimidinc (IH)-(thio)-ones

HIGH-ORDER EXPLICIT TImE-INTEGRATORS FOR DISCONTINUOUS GALERKIN DISCRETIZATIONS OF THE mAXWELL EQUATIONS

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International Journal of modeling, Simulation, and Scientific Computing 2013年第1期4卷 132-153页

作者： H.FAHS m.SAFA LAmA Laboratory University Paris-Est Marne-la-Vallee UMR CNRS 80505 boulevard Descartes 77454 Marne-la-Vall´ee Cedex 2France INRIA Paris-Rocquencourt Domaine de Voluceau BP.10578153 Le Chesnay CedexFrance

We investigate the practical implementation of a high-order explicit time-stepping method based on polynomial approximations,for possible application to large-scale problems in *** the spatial discretization by a high-order discontinuous Galerkin method,we obtain a linear system of differential equations of the form,∂tY(t)=HY(t)+S(t),where H is a matrix containing the spatial derivatives and t is the time *** formal solution can be written in terms of the matrix exponential,exp(tH),acting on some *** introduce a general family of time-integrators based on the approximation of exp(tH)by Jacobi polynomial *** discuss the efficient implementation of this technique,and based on some test problems,we compare the virtues and shortcomings of the *** also demonstrate how these schemes provide an efficient alternative to standard explicit integrators for computing solutions over long time intervals.

关键词： maxwell’s equations discontinuous Galerkin method time-stepping schemes

Numerical simulation of wave scouring beneath marine pipeline using smoothed particle hydrodynamics

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International Journal of Sediment Research 2011年第3期26卷 331-342页

作者： A.mIRmOHAmmADI m.J.KETABDARI Faculty of marine Technology Amirkabir University of Technology424 Hafez AvenueTehran-IranP.O.

In this paper a smoothed particle hydrodynamics(SPH)approach is presented to simulate scouring due to wave around a marine pipeline on a sloping sea *** proposed method is similar to socalled SPH projection method and consists of three *** first two steps play the role of prediction,while in the third step a Poisson Equation is used for both fluid and sea bed to impose incompressibility *** is assumed that the sandy sediments around pipeline section which represent the variable boundary and scour profile,behave as a non-Newtonian *** scouring below a pipe under waves in a test flume with a piston wave maker and sandy sloping bed is estimated using Newtonian-non Newtonian fluid flow interaction *** Bingham model is cautiously utilized for simulation of the sea bed *** results with or without viscosity were compared with analytical,empirical and experimental results and a reasonable agreement was *** show that the developed model is a powerful tool to simulate complex free surface and Newtonian-non Newtonian fluid interaction problems.

关键词： Wave scouring Numerical simulation Free surface marine pipeline SPH method

Role of vascular endothelial growth factor as a critical neurotrophic factor for the survival and physiology of motoneurons

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Neural Regeneration Research 2023年第8期18卷 1691-1696页

作者： Paula m.Calvo Rosendo G.Hernández Rosa R.de la Cruz Angel m.Pastor Departamento de Fisiología Facultad de BiologíaUniversidad de SevillaSevillaSpain

Vascular endothelial growth factor(VEGF)was discovered by its angiogenic ***,during evolution,it appeared earlier as a neurotrophic factor required for the development of the nervous system in invertebrates lacking a circulatory *** aimed at reviewing recent evidence indicating that VEGF has neuroprotective effects in neurons exposed to a variety of *** particular interest is the link established between VEGF and motoneurons,especially after the design of the VEGFδ/δmutant *** mice are characterized by low levels of VEGF and develop muscle weakness and motoneuron degeneration resembling amyotrophic lateral *** administration of VEGF through several routes to animal models of amyotrophic lateral sclerosis delays motor impairment and motoneuron degeneration and increases life *** are new recent advances in the role of VEGF in the physiology of *** experimental aims use the extraocular(abducens)motoneurons lesioned by axotomy as a model for studying VEGF *** abducens motoneurons exhibit severe alterations in their discharge activity and a loss of synaptic *** exogenous administration of VEGF to axotomized abducens motoneurons,either from the transected nerve or intraventricularly,fully restores the synaptic and discharge properties of abducens motoneurons,despite being *** addition,when an anti-VEGF neutralizing antibody is delivered from the muscle to intact,uninjured abducens motoneurons,these cells display alterations in their discharge pattern and a loss of synaptic boutons that resemble the state of *** these data indicate that VEGF is an essential neurotrophic factor for motoneurons.

关键词： abducens nucleus amyotrophic lateral sclerosis cell death extracellular single-unit recordings eye movements neurodegeneration oculomotor trophic factors

Fragment antigen binding domains (F_(ab)s) as tools to study assembly-line polyketide synthases

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Synthetic and Systems Biotechnology 2022年第1期7卷 506-512页

作者： Katarina m.Guzman Chaitan Khosla Department of Chemical Engineering Stanford UniversityStanfordCA94305USA Department of Chemistry Stanford ChEM-HStanford UniversityStanfordCA94305USA

The crystallization of proteins remains a bottleneck in our fundamental understanding of their ***,discovering tools that aid crystallization is *** this review,the versatility of fragment-antigen binding domains(F_(ab)s)as protein crystallization chaperones is discussed.F_(ab)s have aided the crystallization of membrane-bound and soluble proteins as well as *** ability to bind three F_(ab)s onto a single protein target has demonstrated their potential for crystallization of challenging *** describe a high-throughput workflow for identifying F_(ab)s to aid the crystallization of a protein of interest(POI)by leveraging phage display technologies and differential scanning fluorimetry(DSF).This workflow has proven to be especially effective in our structural studies of assembly-line polyketide synthases(PKSs),which harbor flexible domains and assume transient *** are of interest to us due to their ability to synthesize an unusually broad range of medicinally relevant *** years of research studying these megasynthases,their overall topology has remained *** F ab in particular,1B2,has successfully enabled X-ray crystallographic and single particle cryo-electron microscopic(cryoEm)analyses of multiple modules from distinct assembly-line *** use has not only facilitated multidomain protein crystallization but has also enhanced particle quality via cryoEm,thereby enabling the visualization of intact PKS modules at near-atomic(3–5Å)*** identification of PKS-binding F_(ab)s can be expected to continue playing a key role in furthering our knowledge of polyketide biosynthesis on assembly-line PKSs.

关键词： Crystallography Cryo-Em Polyketide synthases Fragment antigen binding domains