检索结果-南通市图书馆

Intrahepatic flow diversion prior to segmental Yttrium-90 radioembolization for challenging tumor vasculature

journal of Interventional Medicine 2022年第2期5卷 79-83页

作者： Lindsay B.Young Marcin Kolber Michael j.king Mona Ranade Vivian L.Bishay Rahul S.Patel Francis S.Nowakowski Aaron M.Fischman Robert A.Lookstein Edward Kim Icahn School of Medicine at Mount Sinai Deparmnent of Dignostc Molecular and lterventionl RadiologyOne Gustave L.Levry Place Box 1234NY100296574New YorkUSA University of Teras Southwestem Medical Center Division of Vascular and Inerentional Radiology5323 Hary Hines BhvdTx753909316DallasUSA David Geffen School of Medicine at the Univerity of Calfornia-LoS Angeles Deparment of Itrentionol Radiology27235 Toumey RoadSuite 1500Califormia91355ValenciaUSA

Background: Hepatic tumors with complex vascular supply or poor relative perfusion are prone to decreased rates of objective response. This is compounded in the setting of Yttrium-90(Y90) transarterial radioembolization(TARE), which is minimally embolic and flow-dependent, relying on high threshold dose for complete ***: We describe our experience with intrahepatic flow diversion(FD) prior to TARE of hepatocellular carcinoma(HCC) with challenging vascular *** and methods: Between April 2014 and january 2020, 886 cases of coinciding MAA or TARE and bland embolization or temporary occlusion were *** embolizations performed for more routine purposes were excluded. FD was performed by bland embolization or temporary occlusion of vessels supplying non-malignant parenchyma in cases where flow was not preferential to target tumor. Lesion characteristics, vascular supply, treatment approach, angiography, and adverse events(AEs) were reviewed. Radiographic response was assessed using mRECIST ***: 22 cases of FD of focal HCC were identified. Embolics included calibrated microspheres(n = 11), microcoils(n = 4), gelfoam(n = 3), temporary balloon occlusion(n = 2) and temporary deployment of a microvascular plug(n = 1). Post-treatment SPECT-CT dosimetry coverage was concordant with target lesions in all cases. Mean follow-up was 16.7 months(1.4–45 mos). Tumor-specific response per m RECIST was 41% complete response, 50% objective response, and 59% disease control rate. No major adverse events or grade 3/4 hepatotoxicity were ***: Our findings suggest that FD prior to TARE is safe and potentially effective in treating HCC with complex vascular supply or poor tumor perfusion.

关键词： embolization routine balloon

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Putting PLX5622 into perspective:microglia in central nervous system viral infection

引用

Neural Regeneration Research 2023年第6期18卷 1269-1270页

作者： Alanna G.Spiteri Nicholas j.C.king Viral Immunopathology Laboratory InfectionImmunity and Inflammation Research ThemeSchool of Medical SciencesFaculty of Medicine and HealthThe University of SydneySydneyNSWAustralia Sydney Cytometry The University of Sydney and Centenary InstituteSydneyNSWAustralia Ramaciotti Facility for Human Systems Biology The University of Sydney and Centenary InstituteSydneyNSWAustralia Charles Perkins Centre The University of SydneyAustralia The University of Sydney Institute for Infectious Diseases The University of SydneySydneyNSWAustralia The University of Sydney Nano Institute the University of SydneySydneyNSWAustralia

Elucidating the exact contribution of microglia to central nervous system(CNS)pathology has historically been extremely *** resident parenchymal myeloid cells are considered to have critical roles as frontline responders during pathogen invasion and CNS ***,understanding the precise temporal kinetics of microglial function is central to the evolution of novel therapeutics for disease intervention and/or resolution(Spiteri et al.,2022a).The development of PLX5622,a colony-stimulating factor 1 receptor(CSF-1R)inhibitor typically formulated into a rodent chow for simple oral administration has facilitated exploration of microglial functions in disease(Spangenberg et al.,2019).

关键词： invasion system precise

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High-resolution two-photon polymerization:the most versatile technique for the fabrication of microneedle arrays

引用

Microsystems & Nanoengineering 2021年第5期7卷 1-17页

作者： Zahra Faraji Rad Philip D.Prewett graham j.Davies School of Mechanical and Elearical Engineering University of Southern QueenslandSpringfield CentralQLD 4300Australia Department of Mechanical Engineering University of BirminghamBirmingham B152TTUK Oxacus Ltd Dorchester-on-Thames 0X107HNUK Faculty of Engineering UNSW AustraliaKensingtonNSW 2052Australia College of Engineering and Physical Sciences School of EngineeringUniversity of BirminghamBirmingham B152TTUK

Microneedle patches have received much interest in the last two decades as drug/vaccine delivery or fluid sampling systems for diagnostic and monitoring *** are manufactured using a variety of additive and subtractive micromanufacturing *** the last decade,much attention has been paid to using additive manufacturing techniques in both research and industry,such as 3D printing,fused deposition modeling,inkjet printing,and two-photon polymerization(2PP),with 2PP being the most flexible method for the fabrication of microneedle arrays.2PP is one of the most versatile and precise additive manufacturing processes,which enables the fabrication of arbitrary three-dimensional(3D)prototypes directly from computer-aided-design(CAD)models with a resolution down to 100 *** to its unprecedented flexibility and high spatial resolution,the use of this technology has been widespread for the fabrication of bio-microdevices and bio-nanodevices such as microneedles and microfluidic *** is a pioneering transformative technology that facilitates the fabrication of complex miniaturized structures that cannot be fabricated with established multistep manufacturing methods such as injection molding,photolithography,and ***,microstructures are designed according to structural and fluid dynamics considerations rather than the manufacturing constraints imposed by methods such as machining or etching *** article presents the fundamentals of 2PP and the recent development of microneedle array fabrication through 2PP as a precise and unique method for the manufacture of microstructures,which may overcome the shortcomings of conventional manufacturing processes.

关键词： resolution needle additive

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Threshold-Based Software-Defined Networking(SDN)Solution for Healthcare Systems against Intrusion Attacks

引用

Computer Modeling in Engineering & Sciences 2024年第2期138卷 1469-1483页

作者： Laila M.Halman Mohammed j.F.Alenazi Department of Computer Engineering College of Computer ScienceKing Saud UniversityRiyadh11451Saudi Arabia

The healthcare sector holds valuable and sensitive *** amount of this data and the need to handle,exchange,and protect it,has been increasing at a fast *** to their nature,software-defined networks(SDNs)are widely used in healthcare systems,as they ensure effective resource utilization,safety,great network management,and *** this sector,due to the value of thedata,SDNs faceamajor challengeposed byawide range of attacks,such as distributed denial of service(DDoS)and probe *** attacks reduce network performance,causing the degradation of different key performance indicators(KPIs)or,in the worst cases,a network failure which can threaten human *** can be significant,especially with the current expansion of portable healthcare that supports mobile and wireless devices for what is called mobile health,or *** this study,we examine the effectiveness of using SDNs for defense against DDoS,as well as their effects on different network KPIs under various *** propose a threshold-based DDoS classifier(TBDC)technique to classify DDoS attacks in healthcare SDNs,aiming to block traffic considered a hazard in the form of a DDoS *** then evaluate the accuracy and performance of the proposed TBDC *** technique shows outstanding performance,increasing the mean throughput by 190.3%,reducing the mean delay by 95%,and reducing packet loss by 99.7%relative to normal,with DDoS attack traffic.

关键词： Network resilience network management attack prediction software defined networking(SDN) distributed denial of service(DDoS) healthcare

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A method to evaluate REE-HFSE mineralised provinces by value creation potential, and an example of application: Gardar REE-HFSE province, Greenland

引用

Geoscience Frontiers 2020年第6期11卷 2141-2156页

作者： graham j.Banks Símun D.Olsen Antonio Gusak Geological Survey of Denmark and Greenland Øster Voldgade 10DK-1350CopenhagenDenmark Permanent Address:Route to Reserves Ulriksdalvej 13Valby2500CopenhagenDenmark University of Copenhagen Øster Voldgade 10DK-1350CopenhagenDenmark

The rare earth elements and high-field-strength elements(REE-HFSE)exploration sector conducts most evaluations at deposit and smaller *** is not evident how the sector performs a preceding exploration stage—rating and prioritising REE-HFSE mineralised provinces—to determine which provinces are prospective enough to warrant *** we present an objective,repeatable,low-cost method to screen any REE-HFSE province,as a foundation for district-scale investigations or asset *** is original for REE-HFSE screening,and adapted from regional scale copper,cobalt and petroleum exploration,and CO2 storage,screening *** is centred upon a mineralised province’s favourability for potential value creation,and to identify:(a)its main information gaps;(b)its weakest links;(c)its exploration maturity and remaining potential category;(d)how it compares against other REE-HFSE provinces;and(e)if further investigation is *** method incorporates geoscience,strategy,economic and socio-environmental factors in a way that is understandable and directly usable across stakeholder *** workflow is systematic,yet flexible enough to accommodate organisationspecific criteria,and usable for other *** provides the platform to build a global REE-HFSE province map and database consistently across national boundaries and *** for the extent of province exploration maturity and remaining mineral potential are *** illustrate the applicability of these methods using the Gardar REE-HFSE Province(GRHP)of south *** conclude that it is a moderate size,frontier province that is currently of questionable favourability for value *** move GRHP into a positive favourability class,its current weak links need strengthening by research,government policy and industry stakeholders:evaluate the mineral system;integrate all information geospatially and place it in the public domain;help the region improve some communi

关键词： REE HFSE Province Screening Favourability Value

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

番茄渣可作肉鸡饲料中维生素E的来源

引用

饲料与畜牧（新饲料） 2008年第9期 31-33页

作者： Annie j.king Gideon Zeidler 黄彪(译) 不详南京农业大学动物科技学院

干的番茄渣，作为番茄加工过程中的副产品，含有丰富的维生素E，常在肉鸡饲料中作抗氧化剂。在饲喂试验中，添加番茄渣的小鸡体增重、料肉比和对照组相比并没有显著的差异。番茄渣可以作为维生素的来源饲喂肉鸡，以减少在加热和长期冷... 详细信息

干的番茄渣，作为番茄加工过程中的副产品，含有丰富的维生素E，常在肉鸡饲料中作抗氧化剂。在饲喂试验中，添加番茄渣的小鸡体增重、料肉比和对照组相比并没有显著的差异。番茄渣可以作为维生素的来源饲喂肉鸡，以减少在加热和长期冷冻时肉中的脂肪氧化（脂肪衰败），延长保质期。番茄的副产品中不胞和脂肪酸含量较高，番茄渣是脱脂的且没有损失维生素E，从而将氧化的可能性降到最低。

关键词：维生素E 肉鸡饲料番茄抗氧化剂饲喂试验脂肪氧化延长保质期脂肪酸含量

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

ABNORMAL PROTEIN TYROSINE KINASES ASSOCIATED WITH HUMAN HAEMATOLOGICAL MALIGNANCIES

引用

Chinese journal of Cancer Research 2002年第2期14卷 79-83页

作者：孙雪梅 graham j Lieschke The Affiliated Drum Tower Hospital Nanjing University Nanjing 210008 ChinaLudwig Institute for Cancer Research The Royal Melbourne Hospital Victoria 3050 Australia Ludwig Institute for Cancer Research The Royal Melbourne Hospital Victoria 3050 Australia

Objective: To survey the role of protein tyrosine kinases (PTKs) in the pathogenesis of several hematopoietic malignancies. Methods: By reviewing the published laboratory and clinical studies on PTK-related oncoproteins and their causative role in some leukemias and lymphomas. Results: Protein tyrosine kinases are key participants in signal transduction pathways that regulate cellular growth, activation and differentiations. Aberrant PTK activity resulting from gene mutation (often accompanying chromosome translocation) plays an etiologic role in several clonal hematopoietic malignancies. For example, the PTK product of the BCR-ABL fusion gene resulting from the t (9; 22) translocation exhibits several fold higher tyrosine kinase activity than the product of the ABL gene. Evidence suggests that the BCR-ABL oncoprotein alone is sufficient to case chronic myelogenous leukemia (CML) and other Ph positive acute leukemia. PTK over-activity resulting from chromosomal translocations creating TEL-ABL, TEL-jAK2 and TEL-PDGFRβ fusion proteins plays an important role in the pathogenesis of other types of leukemia. Another example occurs in anaplastic large cell lymphoma (ALCL). Experimental and clinical evidences indicate that translocations involving ALK gene on chromosome 2p23, most commonly resulting in an NPM-ALK fusion oncogene, result in constitutive activation of ALK and cause ALCL. This group of lymphomas is now named ALK positive lymphoma or ALKoma. Conclusion: Genetic lesions creating aberrant fusion proteins that result in excessive PTK activity are increasingly being recognized as central to the pathogenesis of hemotopoietic malignancies. These chimeric PTK molecules represent attractive disease-specific targets against which new classes therapeutic agents are being developed.

关键词： Protein tyrosine kinase (PTK) Hematopoietic malignancy BCR-ABL Chronic myelogenous leukemia (CML) Anaplastic large cell lymphoma (ALCL) STI 571 Protein tyrosine kinase inhibitor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comments on ‘Enhanced piezoresistivity in Ni-silicone rubber composites’

引用

Chinese Physics B 2010年第1期19卷 431-432页

作者： D.Bloor A.graham P.j. Laughlin D.Lussey Department of Physics Durham University Peratech Ltd Old Repeater StationBrompton-on-SwaleDL10 7JHUK

This paper describes the accepted meaning of the term ＇negative resistance＇ and its use in the literature, and discusses the features in the previously published data on QTC^TM （market name of a metal-polymer composite） that show that the non-linear, hysteretic current voltage characteristics are not caused by joule heating. The benefit of the high metal filler loading in QTC^TM and other unique features of this composite are reviewed.

关键词： I V characteristics quantum tunnelling oiezoresitivity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

用于增压直接喷射汽油机的喷束引导燃烧过程

引用

汽车与新动力 2014年第2期46卷 46-49页

作者： j.king P.Feulner 范明强

未来,燃烧在汽油机降低燃油耗方面将起到关键作用。英国Ricardo公司应用新型喷束引导燃烧过程的汽油直接喷射方法能使涡轮增压汽油机以非常有利的燃油耗值,在部分运行范围内以典型的柴油机燃油耗值运行。应用这种技术,汽油机能几乎完全... 详细信息

未来,燃烧在汽油机降低燃油耗方面将起到关键作用。英国Ricardo公司应用新型喷束引导燃烧过程的汽油直接喷射方法能使涡轮增压汽油机以非常有利的燃油耗值,在部分运行范围内以典型的柴油机燃油耗值运行。应用这种技术,汽油机能几乎完全无节流地运行,并能在绝大部分的特性曲线场内利用稀薄燃烧的优势。这种燃烧方法燃用汽油运行,也能燃用诸如E85或M40等燃油正常工作。

关键词：增压直接喷射汽油机分层充量燃烧过程氮氧化物排放

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

大豆细胞核的分离及其超显微结构的研究

引用

journal of Genetics and Genomics 1988年第1期 21-24+83页

作者：刘育乐米景九 j.king 萨斯克彻温大学生物系加拿大北京农业大学生物学院分子遗传教研室

本文通过对影响大豆细胞核分离诸因素的研究,介绍一种快速、简便的核分离方法。采用这种方法分离出的细胞核产量高,光镜,电镜观察证明核制品形态好,纯度较高,核膜较完整。

关键词：大豆原生质体细胞核

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：