High-resolution two-photon polymerization:the most versatile technique for the fabrication of microneedle arrays

作     者：Zahra Faraji Rad Philip D.Prewett Graham J.Davies 

作者机构：School of Mechanical and Elearical EngineeringUniversity of Southern QueenslandSpringfield CentralQLD 4300Australia Department of Mechanical EngineeringUniversity of BirminghamBirmingham B152TTUK Oxacus LtdDorchester-on-Thames 0X107HNUK Faculty of EngineeringUNSW AustraliaKensingtonNSW 2052Australia College of Engineering and Physical SciencesSchool of EngineeringUniversity of BirminghamBirmingham B152TTUK 

出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)

年 卷 期：2021年第7卷第5期

页      面：1-17页

核心收录：

学科分类：0808[工学-电气工程] 0809[工学-电子科学与技术（可授工学、理学学位）] 07[理学] 0817[工学-化学工程与技术] 0807[工学-动力工程及工程热物理] 0805[工学-材料科学与工程（可授工学、理学学位）] 0802[工学-机械工程] 070202[理学-粒子物理与原子核物理] 0811[工学-控制科学与工程] 0702[理学-物理学] 

基　　金：the Queensland node of the Australian National Fabrication Facility  a company established under the National Collaborative Research Infrastructure Strategy to provide nano- and microfabrication facilities for Australia's researchers 

主　　题：resolution needle additive 

摘      要：Microneedle patches have received much interest in the last two decades as drug/vaccine delivery or fluid sampling systems for diagnostic and monitoring *** are manufactured using a variety of additive and subtractive micromanufacturing *** the last decade,much attention has been paid to using additive manufacturing techniques in both research and industry,such as 3D printing,fused deposition modeling,inkjet printing,and two-photon polymerization(2PP),with 2PP being the most flexible method for the fabrication of microneedle arrays.2PP is one of the most versatile and precise additive manufacturing processes,which enables the fabrication of arbitrary three-dimensional(3D)prototypes directly from computer-aided-design(CAD)models with a resolution down to 100 *** to its unprecedented flexibility and high spatial resolution,the use of this technology has been widespread for the fabrication of bio-microdevices and bio-nanodevices such as microneedles and microfluidic *** is a pioneering transformative technology that facilitates the fabrication of complex miniaturized structures that cannot be fabricated with established multistep manufacturing methods such as injection molding,photolithography,and ***,microstructures are designed according to structural and fluid dynamics considerations rather than the manufacturing constraints imposed by methods such as machining or etching *** article presents the fundamentals of 2PP and the recent development of microneedle array fabrication through 2PP as a precise and unique method for the manufacture of microstructures,which may overcome the shortcomings of conventional manufacturing processes.