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No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk

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World Journal of Gastroenterology 2009年第18期15卷 2240-2244页

作者： Cheryl L Thompson Sarah J Plummer Alona Merkulova Iona Cheng Thomas C Tucker graham casey Li Li Departments of Family Medicine and Epidemiology and Biostatistics Case Centerfor Transdisciplinary Research on Energetics and CancerCase Comprehensive Cancer Center Case Western Reserve University. Cleveland OH 44106-7136 United States Department of Preventive Medicine University of Southern California Los Angeles CA90033-1006 United States Department of Cancer Biology Cleveland Clinic Foundation Cleveland OH 44195-0001 United States Department of Epidemiology and Biostatisticsand Institute for Human Genetics University of California SanFrancisco San Francisco CA 94143-0644 United States Markey Cancer Center University of Kentucky Lexington KY 40504-3381 United States

AIM：To investigate the association of variations in the cyclooxygenase-2 （COX2） and uridine diphosphate glucuronosyltransferase 1A6 （UGTIA6） genes and non-steroidal anti-inflammatory drugs （NSAIDs） use with risk of colon ***： NSAIDs, which are known to reduce the risk of colon cancer, act directly on COX2 and reduce its activity. Epidemiological studies have associated variations in the COX2 gene with colon cancer risk, but others were unable to replicate this finding. Similarly,enzymes in the UGT1A6 gene have been demonstrated to modify the therapeutic effect of NSAIDs on colon adenomas. Polymorphisms in the UGTIA6 gene have been statistically shown to interact with NSAID intake to influence risk of developing colon adenomas, but not colon cancer. Here we examined the association of tagging single nucleotide polymorphisms （SNPs） in the COX2 and UGTIA6 genes, and their interaction with NSAID consumption, on risk of colon cancer in a population of 422 colon cancer cases and 481 population ***： No SNP in either gene was individually statistically significantly associated with colon cancer, nor did they statistically significantly change the protective effect of NSAID consumption in our sample. Like others, we were unable to replicate the association of variants in the COX2 gene with colon cancer risk （P 〉 0.05）,and we did not observe that these variants modify the protective effect of NSAIDs （P 〉 0.05）. We were able to confirm the lack of association of variants in UGT1A6 with colon cancer risk, although further studies will have to be conducted to confirm the association of these variants with colon ***： Our study does not support a role of COX2 and UGTIA6 genetic variations in the development of colon cancer.

关键词： Uridine diphosphate glucuronosyltransferase 1A6 Cyclooxygenase-2 Non-steroidal anti-inflammatorydrugs Colon cancer Genetic association studies Singlenucleotide polymorphisms

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Epidemiology and transmission of hepatitis B and C viruses in Kazakhstan

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World Journal of Gastroenterology 2007年第8期13卷 1204-1207页

作者： Zhannat Z Nurgalieva F Blaine Hollinger David Y graham S Zhangabylova Abai Zhangabylov Department of Faculty Therapy Kazakh National Medical University named after SD Asfendiarov Almaty Kazakhstan Department of Medicine VA Medical Center and Baylor College of Medicine Baylor College of Medicine Houston TX United States Department of MolecularVirology and Microbiology Baylor College of Medicine Houston TX United States Department of Medicine VA Medical Center and Baylor College of Medicine Baylor College of Medicine Houston TX United States Department of Faculty Therapy Kazakh National Medical University named after SD Asfendiarov Almaty Kazakhstan

AIM: To investigate the epidemiology of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in the two major ethnic groups in Kazakhstan. METHODS: A cross-sectional prospective study of HBV and HCV seroprevalence was performed among individuals born in Kazakhstan with no history of chronic hepatitis or liver disease. RESULTS: There were 290 volunteers (140 Russians and 150 Kazakhs) aged 10 to 64 years, males accounted for 46%. Active HBV infection (HBsAg positive) was present in 3.8%, anti-HBc in 30%. The prevalence was similar in females and males (33% vs 25%) (P = 0.18). The prevalence of anti-HBc increased from 19% in 10-29 years old volunteers to 53% in 50-years and older volunteers. The prevalence of HBV infection was higher in married than in single adults (38% vs 26%, respectively) (P = 0.2) and more common in Kazakhs (35%) than in Russians (24%) (P = 0.07). HCV infection was present in 9 subjects (3.2%), 5 of them also were positive for anti-HBc in the absence of HBsAg. CONCLUSION: The frequency of active HBV infection (3.8%) coupled with a high prevalence of HBV exposure in those > 50 years of age increases with age, which suggests that horizontal transmission likely relates tothe use of contaminated needles. The low prevalence of HCV infection suggests that HBV and HCV are acquired differently in this group of subjects.

关键词： Viral hepatitis B Viral hepatitis C Hepatitis B virus Transmission Epidemiology Sero-epidemiology Kazakhstan

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No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer

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World Journal of Gastroenterology 2009年第30期15卷 3771-3775页

作者： Lynette S Phillips Cheryl L Thompson Alona Merkulova Sarah J Plummer Thomas C Tucker graham Case Li Li Department of Epidemiology and Biostatistics and Case Comprehensive Cancer Center Case Western Reserve University Cleveland OH 44106-7136 United States Departments of Family Medicine and Epidemiology and Biostatistics Case Center for Transdisciplinary Research on Energetics and Cancer Case Comprehensive Cancer Center Case Western Reserve University Cleveland OH 44106-7136m United States Department of Cancer Biology Cleveland Clinic Foundation Cleveland OH 44195-0001 United States graham casey Department of Preventive Medicine University of Southern California Los Angeles CA 90033-1006 United States assisted with patient referrals recruitment and reviewed the manuscript coordinated the lab work and reviewed the manuscript Li L led the study design data collection and assisted with the manuscript preparation

AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based casecontrol study of incident colon cancer individuals (n= 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene.

关键词： Colon cancer Phosphatase and tensinhomolog Candidate gene Genetic polymorphisms Single nucleotide polymorphism association

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台北艺术中心

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城市环境设计 2014年第6期 54-59页

作者： Yannis Chan Hin-Yeung Cheung Inge Goudsmit Vincent Kersten Chiaju Lin Kevin Mak Jim Dodson Alasdair graham Vivien Liu Kai Sun Luk Slobodan Radoman Roberto Requejo Saul Smeding Elaine Tsui Viviano Villarreal casey Wang Leonie Wenz

为什么过去百年间最令人兴奋的剧场盛事总是发生在正规场所之外?建筑如何才能超越自身卑微的命运,摆脱那种限制各种可能的宿命?近年来,世界各地的演艺中心数目渐增,但不知何故,这些演艺中心似乎达成一种共识,呈现出雷同的空间组合:一座... 详细信息

为什么过去百年间最令人兴奋的剧场盛事总是发生在正规场所之外?建筑如何才能超越自身卑微的命运,摆脱那种限制各种可能的宿命?近年来,世界各地的演艺中心数目渐增,但不知何故,这些演艺中心似乎达成一种共识,呈现出雷同的空间组合:一座约2 000席的大型演艺厅和一个1 500席的中型剧院,再加上一个黑盒子剧场。标志性的外形掩饰以典型19世纪做法为基础的

关键词：艺术中心观众剧场文化机构剧院台北台湾

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结直肠癌患者MLH1和MSH2基因突变的转变分析

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美国医学会杂志（中文版） 2006年第2期25卷 83-83页

作者： graham casey Noralane M. Lindor Nickolas Papadopoulos 许峰（译）祝学光（校）

背景：准确发现、解释结直肠癌患者错配修复基因的种系突变对临床治疗至关重要。近来的资料表明，错配修复突变具有高度的异质性，仅凭常规DNA测序无法检测到许多突变。

关键词：直肠癌患者基因突变 MSH2 MLH1 错配修复基因 DNA测序临床治疗种系突变异质性

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台北艺术中心

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建筑技艺 2012年第4期18卷 100-105页

作者： Yannis Chan Hin-Yeung Cheung Jim Dodson Inge Goudsmit Alasdair graham Vincent Kersten Chiaju Lin Vivien Liu Kai Sun Luk Kevin Mak Slobodan Radoman Roberto Requejo Saul Smeding Elaine Tsui Viviano Villarreal casey Wang Leonie Wenz Frans Parthesius Iwan Baan

正近年来,世界各地的演艺中心数目渐增,但不知何故,这些演艺中心似乎达成一种共识,呈现出雷同的空间组合:一座约2000席的大型演艺厅和一个1500席的中型剧院,再加上一个黑盒子剧场。标志性的外形,饰以典型19世纪做法的保守内部剧场布局,... 详细信息

正近年来,世界各地的演艺中心数目渐增,但不知何故,这些演艺中心似乎达成一种共识,呈现出雷同的空间组合:一座约2000席的大型演艺厅和一个1500席的中型剧院,再加上一个黑盒子剧场。标志性的外形,饰以典型19世纪做法的保守内部剧场布局,以及见证社会阶级观念的包厢。纵然剧院最基本的构造元素如舞台、镜框式剧场和观众席等已有三千多年的历史,但我们仍不应以此为借口,让现代剧场建筑的创新发展停滞不前。

关键词：艺术中心演艺中心创新发展标志性台北空间组合观众席构造元素剧场建筑阶级观念

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