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Determination of the Normal Contact Stiffness and Integration Time Step for the Finite Element Modeling of Bristle-Surface Interaction

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Computers, Materials & Continua 2018年第7期56卷 169-184页

作者： Libardo V.Vanegas-Useche Magd M.Abdel-Wahab graham a.parker Facultad de Ingeniería Mecánica Universidad Tecnológica de Pereira.Pereira 660003Colombia Division of Computational Mechanics Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Civil Engineering Ton Duc Thang UniversityHo Chi Minh CityVietnam Soete Laboratory Faculty of Engineering and ArchitectureGhent UniversityTechnologiepark Zwijnaarde 903Zwijnaarde B-9052Belgium Faculty of Engineering and Physical Sciences University of Surrey.GuildfordUK

In finite element modeling of impact,it is necessary to define appropriate values of the normal contact stiffness,Kn,and the Integration Time Step(ITS).Because impacts are usually of very short duration,very small ITSs are ***,the selection of a suitable value of Kn is a critical issue,as the impact behavior depends dramatically on this *** this work,a number of experimental tests and finite element analyses have been performed in order to obtain an appropriate value of Kn for the interaction between a bristle of a gutter brush for road sweeping and a concrete ***,a suitable ITS is *** experiments consist of releasing a steel bristle that is placed vertically at a certain distance from a concrete surface and tracking the ***,in the finite element analyses,a beam is modeled in free fall and impacting a surface;contact and target elements are attached to the beam and the surface,*** results of the experiments and the modeling are integrated through the principle of conservation of energy,the principle of linear impulse and momentum,and Newton’s second *** results demonstrate that,for the case studied,Kn and the impact time tend to be independent of the velocity just before impact and that Kn has a very large variation,as concrete is a composite material with a rough ***,the ratio between the largest height of the bristle after impact and the initial height tends to be constant.

关键词： Brush street sweeping finite element modeling contact mechanics

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Numerical Analysis of Tilted Cutting and F128 Brushes

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Computer Modeling in Engineering & Sciences 2019年第10期121卷 23-47页

作者： Libardo V.Vanegas-Useche Magd M.Abdel-Wahab graham a.parker Facultad de Ingeniería Mecánica Universidad Tecnológica de PereiraLa JulitaPereira 660003Colombia Division of Computational Mechanics Ton Duc Thang UniversityHo Chi Minh CityViet Nam Faculty of Civil Engineering Ton Duc Thang UniversityHo Chi Minh CityViet Nam Soete Laboratory Faculty of Engineering and ArchitectureGhent UniversityTechnologiepark Zwijnaarde 46B-9052 ZwijnaardeBelgium Faculty of Engineering and Physical Sciences University of Surrey.Guildford GU27XHUK.

Road sweeping is an essential service that has to be conducted for public health,as well as aesthetic *** many countries,sweeping vehicles are used for this *** usually comprise a gutter brush that sweeps the debris that is located in the road *** work studies the performance of two kinds of gutter brushes:a cutting brush and a flicking(F128)*** is carried out by means of a 3-D dynamic,nonlinear Finite Element(FE)brush model developed by the *** this model,inertia forces are applied to the bristle,and its clamped end is ***,the surface(road)is rotated,translated,and ***-road interaction is modelled as flexible-to-rigid *** particular,the aim of this article is to compare the performance of a conventional brush and a brush rotating at variable *** brushes normally work tilted,FE analyses are carried out for tilted cutting and F128 brushes,rotating at speeds that fluctuate at different *** is concluded that brush oscillations have a significant effect on bristle tip velocities and bristle-road ***,at certain frequencies,oscillations seem to improve sweeping performance of the F128 ***,they do not appear to improve significantly the performance of the cutting brush.

关键词： Gutter brushes cutting brush flicking brush FEM variable speed brushing

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Effects of environmental stressors on stem cells

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World Journal of Stem Cells 2019年第9期11卷 565-577页

作者： Jessica R Worley graham C parker Department of Pediatrics Wayne State University School of Medicine

Environmental toxicants are ubiquitous,and many are known to cause harmful health ***,much of what we know or think we know concerning the targets and long-term effects of exposure to environmental stressors is sadly *** exposure may have health effects that are currently mischaracterized or at least mechanistically incompletely *** much of the recent excitement about stem cells(SCs)focuses on their potential as therapeutic agents,they also offer a valuable resource to give us insight into the mechanisms and risks of toxicant *** only as a response to the increasing ethical pressure to reduce animal testing,SC studies allow us valuable insight into the true effects of human exposure to environmental stressors under controlled *** present a review of the history of publications on the effects of environmental stressors on SCs,followed by a consolidation of the literature over the past five years on a subset of key environmental stressors of importance to human health and their effects on both embryonic and tissue *** review will make constructive suggestions as to areas of toxicant research where further studies are needed,as well as making indications of the potential utility for advancing knowledge and directing research on environmental toxicology.

关键词： Environmental substances Toxic Stem cells Endocrine disruptors Alcohols Tobacco smoking Metals Heavy Particulate matter Volatile organic compounds Ozone

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PIK3CA基因相关过度生长综合征群的诊治规范:国际专家共识

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临床儿科杂志 2023年第11期41卷 875-880页

作者：周清李辛刘晖常国营徐敏王剑顾松王秀敏(译) Sofia Douzgou Myfanwy Rawson Eulalia Baselga Moise Danielpour Laurence Faivre Alon Kashanian Kim M Keppler-Noreuil Paul Kuentz Grazia M S Mancini Marie-Cecile Maniere Victor Martinez-Glez Victoria E parker Robert K Semple Siddharth Srivastava Pierre Vabres Marie-Claire Y De Wit John M graham Jr Jill Clayton-Smith Ghayda M Mirzaa Leslie G Biesecker 福建省儿童医院(上海儿童医学中心福建医院) 福建医科大学妇儿临床医学院内分泌遗传代谢科福建福州350000 上海交通大学医学院附属上海儿童医学中心内分泌代谢科医学遗传科上海200127 上海交通大学医学院附属上海儿童医学中心普外科上海200127 上海交通大学医学院附属上海儿童医学中心遗传分子诊断科上海200127 不详

PIK3CA基因激活突变所导致的一系列发育障碍表型谱被统称为PIK3CA基因相关过度生长综合征群(PIK3CA-related overgrowth spectrum,PROS)。临床表现分型众多,各型分类见表1A。由于基因变异发生在受精卵形成后,临床表型为嵌合体,因此PIK3C... 详细信息

PIK3CA基因激活突变所导致的一系列发育障碍表型谱被统称为PIK3CA基因相关过度生长综合征群(PIK3CA-related overgrowth spectrum,PROS)。临床表现分型众多,各型分类见表1A。由于基因变异发生在受精卵形成后,临床表型为嵌合体,因此PIK3CA基因变异在外周血中的阳性检出率很低,通常需要非血液标本或通过组织活检来发现超低频嵌合体。PIK3CA基因激活变异的作用为促生长,变异导致的表型取决于基因变异发生的时间、组织细胞类型、变异细胞的分布以及变异的激活强度。

关键词：组织活检过度生长基因变异诊治规范临床表型发育障碍细胞类型嵌合体

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Identification of new genetic risk factors for prostate cancer

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Asian Journal of Andrology 2009年第1期11卷 49-55页

作者： Michelle Guy Zsofia Kote-Jarai graham G. Giles Ali Amin Al Olama Sarah K. Jugurnauth Shani Mulholland Daniel A. Leongamomlert Stephen M. Edwards Jonathan Morrison Helen I. Field Melissa C. Southey Gianluca Severi Jenny L. Donovan Freddie C. Hamdy David R Dearnaley Kenneth R. Muir Charmaine Smith Melisa Bagnato Audrey T. Ardern-Jones Amanda L. Hall Lynne T. O＇Brien Beatrice N. Gehr-Swain Rosemary A. Wilkinson Angela Cox Sarah Lewis Paul M. Brown Sameer G. Jhavar Malgorzata Tymrakiewicz Artitaya Lophatananon Sarah L. Bryant The UK Genetic Prostate Cancer Study Collaborators British Association of Urological Surgeons＇ Section of Oncology and The UK ProtecT Study Collaborators Alan Horwich Robert A. Huddart Vincent S. Khoo Christopher C. parker Christopher J. Woodhouse Alan Thompson Tim Christmas Chris Ogden Cyril Fisher Charles Jameson Colin S. Cooper Dallas R. English John L. Hopper David E. Neal Douglas E Easton Rosalind A. Eeles Section of Cancer Genetics The Institute of Cancer Research Sutton Surrey SM2 5NG UK Cancer Epidemiology Centre The Cancer Council Victoria Carlton VIC 3053 Australia Centre for Molecular Environmental Genetic and Analytic Epidemiology The University of Melbourne Carlton VIC 3053 Australia Cancer Research UK Genetic Epidemiology Unit University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Department of Oncology University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Genetic Epidemiology Laboratory Department of Pathology The University of Melbourne Parkville VIC 3052 Australia Department of Social Medicine University of Bristol Bristol BS8 2PR UK Academic Urology Unit University of Sheffield Sheffield SIO 2JF UK The Royal Marsden NHS Foundation Trust Sutton Surrey SM2 5PT and London SW3 6JJ UK University of Nottingham Medical School Queens Medical Centre Nottingham NG7 2UH UK Institute for Cancer Studies University of Sheffield Sheffield SIO 2RX UK Surgical Oncology （Uro-Oncology S4） Departments of Oncology and Surgery University of Cambridge Addenbrooke＇s Hospital Cambridge CB2 2QQ UK A full list of authors is provided in the Supplementary Note online Ka Shing Centre Cambridge CB2 ORE UK Cancer Research UK Cambridge Research Institute Li Ka Shing Centre Cambridge CB2 ORE UK.

There is evidence that a substantial part of genetic predisposition to prostate cancer （PCa） may be due to lower penetrance genes which are found by genome-wide association studies. We have recently conducted such a study and seven new regions of the genome linked to PCa risk have been identified. Three of these loci contain candidate susceptibility genes： MSMB, LMTK2 and KLK2/3. The MSMB and KLK2/3 genes may be useful for PCa screening, and the LMTK2 gene might provide a potential therapeutic target. Together with results from other groups, there are now 23 germline genetic variants which have been reported. These results have the potential to be developed into a genetic test. However, we consider that marketing of tests to the public is premature, as PCa risk can not be evaluated fully at this stage and the appropriate screening protocols need to be developed. Follow-up validation studies, as well as studies to explore the psychological implications of genetic profile testing, will be vital prior to roll out into healthcare.

关键词： prostate cancer genetics susceptibility loci SNPs relative risks

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

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