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Change in Deferring Time Correlate to Improved Female Sexual Function after Anal Sphincter Repair: A Prospective Study

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Open Journal of Obstetrics and Gynecology 2020年第5期10卷 729-737页

作者： Johan Danielson Urban Karlbom Ann-Cathrine Sonesson w.lhelm graf Department of Pediatric Surgery Akademiska Sjukhuset Uppsala Sweden Institution of w.men and Children Health Uppsala University Uppsala Sweden Department of Surgery Akademiska Sjukhuset Uppsala Sweden Institution of Surgical Sciences Uppsala University Uppsala Sweden

Background: Many w.men suffer from sexual problems after anal sphincter tears due to obstetric trauma. Aim: The study aimed to assess changes in sexual function after anal sphincter repair. Methods: The study w.s a non-randomized prospective observational cohort study. Inclusion of the study w.s done at the University Hospital, Uppsala, Sw.den, betw.en 2002 and 2007. Thirty-nine consecutive female patients admitted for anal sphincter repair w.re invited to the study. Tw.nty patients accepted and w.re included, four w.re lost to follow.up and one w.s unevaluable (due to the formation of a stoma) leaving a study group of 15 patients. The patients w.re assessed w.th questionnaires before surgery and at three and 12 months after surgery. Outcomes: Change in reported sexual activity and dyspareunia. Results: Before surgery, 12/15 patients reported that their sexual life w.s impaired due to anal incontinence. The corresponding figure at 12 months w.s 9/15 (p = 0.43). Three patients remained sexually inactive throughout the study, five patients increased their sexual activity and one had decreased activity. Out of the 12 w.o w.re active, four stated dyspareunia at baseline, and only one reported dyspareunia at 12 months. The mean Miller incontinence scores at baseline and 12 months w.re 10.1 and 8.7, respectively. The change in incontinence score did not differ betw.en those w.th decreased, stable or increased sexual activity. How.ver, there w.s a definite correlation (r = 0.54 - 0.60, p 0.05) betw.en change in sexual function and deferring time for stool. Clinical Implications: Operative management of anal sphincter tears alone is not curative for sexual problems due to anal incontinence but can be a part of the treatment. Strengths and Limitations: The study is a prospective study of sexual function. The limitations are that the questionnaires w.re not validated due to lack of such questionnaires at the time of the study and that the study population is quite small. Conc

关键词： Sexual Function Anal Sphincter Repair Fecal Incontinence Anal Sphincter Injury

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硅烷偶联剂对玻璃及铝胶接耐久性的影响

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粘接 2000年第1期21卷 9-11页

作者： w.Brockmann S Emrich M graf 曲军德国Kaiserslautern大学

硅烷偶联剂被广泛用于胶粘剂与被粘物界面以提高其耐久性。用APES及GPMS硅烷偶联剂 ,采用了诸如混合法、浸入法等方法 ,并对玻璃 -玻璃 ,铝 -铝胶接接头的耐久性进行了研究。结果表明 :偶联剂可以显著提高胶接接头的耐久性。

关键词：硅烷偶联剂粘接耐久性玻璃铝胶粘剂

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卵巢机能障碍的发病机理

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德国医学 1997年第4期14卷 227-230页

作者： M.graf w.Distler 闻良珍 Institut für Hormon-und Fortpflanzungsforschung Grandweg 64D-22529 HamburgGermany 同济医科大学附属同济医院

卵巢机能障碍关系到黄体机能不全、无排卵性月经或闭经,月经过多或过少常是黄体机能不全或无排卵性月经的主要症状。闭经分为原发性闭经(即满16岁而从无月经来潮)和继发性闭经(周期性月经停止3个月以上)。卵巢机能障碍可来源于下丘脑、... 详细信息

卵巢机能障碍关系到黄体机能不全、无排卵性月经或闭经,月经过多或过少常是黄体机能不全或无排卵性月经的主要症状。闭经分为原发性闭经(即满16岁而从无月经来潮)和继发性闭经(周期性月经停止3个月以上)。卵巢机能障碍可来源于下丘脑、垂体和卵巢平面,Plotz将卵巢机能障碍分为4类:即下丘脑-垂体性、高催乳素血症性。

关键词：卵巢机能障碍病理

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表面处理对粘接接头耐久性的影响

表面处理对粘接接头耐久性的影响

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北京粘接学会第七届学术年会-中国粘接技术回顾与展望研讨会

作者： Brockmann w.Emrich S graf M 曲军德国Kaiserslautern大学

选用APES及GPMS硅烷偶联剂,采用诸如混合法、浸入法,并结合机械表面处理方法对玻璃-玻璃、铝-铝粘接接头的耐久性的改善进行了研究。

关键词：表面处理粘接接头偶联剂耐久性

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Effect of Antioxidants on Endothelial Cell Reactive Oxygen Species (ROD Generation and Adhesion of Leukocytes to Endothelial Cells

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South China Journal of Cardiology 2000年第1期1卷 48-54页

作者：黄虔 Michael Grfe Kristoph graf Hans Lehmkuhl Eckart Fleck Department of Cardiology Medical College of Jinan University Guangzhou 510630 PR China Department of Internal Medicine/Cardiology German Heart Institute Berlin & Virchow Hospitals Humboldt University Berlin 13353 Germany

Objective To investigatew.ether antioxidants inhibit adhesion of leukocytes to endothelium and furthermore, w.ether all antioxidants regulate NF-KB activation through a redox sensitive mechanism. Methods The effect of the antioxidative substances pyrrolidin dithiocarbamat (PDTC), dichloroisocumarin (DCI), chrysin and probucol on the endothelial leukocyte adhesion w.re examined under near physiological flow.conditions. The antioxidative activity of antioxidants w.s measured in a DCF fluorescence assay w.th flow.cytometry. The activation of NF-kB in endothelial cells w.s investigated in a gel shift assay. Results PDTC and probucol did not show.an inhibitory effect to the formation of intracellular H2O2 in TNFa activated human vascular endothelial cells (HUVEC) . Chrysin show.d a moderate effect. DCI show.d a strong antioxidative effect. In contrast, PDTC and chrysin inhibited the adhesion of HL 60 cells to TNFa-stimulated HUVEC. DCI and probucol did not have influence on the adhesion w.thin the area of the examined shear stresses. Only PDTC inhibited the TNFa-induced activation of NF-KB in endothelial cells. Conclusion The inhibition of the endothelial leukocyte adhesion by antioxidative substances is not to be explained by its antioxidative characteristics only. The inhibitory effect of PDTC on NF-KB activation w.s probably not related to its antioxidative properties. Endothelial cell Antioxidants NF-kappa-B

关键词： HUVECs ROD Generation and Adhesion of Leukocytes to Endothelial Cells Effect of Antioxidants on Endothelial Cell Reactive Oxygen Species NF DCI

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The conditional mitochondrial protein complexome in the Arabidopsis thaliana root and shoot

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Plant Communications 2023年第5期4卷 172-190页

作者： Youjun Zhang Silvia Martinez Jaime Mustafa Bulut Alexander graf Alisdair R.Fernie Center of Plant Systems Biology and Biotechnology 4000 PlovdivBulgaria Max-Planck-Institut f€ur Molekulare Pflanzenphysiologie Am Muhlenberg 114476 Potsdam-GolmGermany

Protein complexes are important for almost all biological ***,to fully understand how.cells w.rk,it is also necessary to characterize protein complexes and their dynamics in response to various cellular ***,the dynamics of protein interaction play crucial roles in regulating the(dis)association of protein complexes and,in turn,regulating biological processes such as ***,mitochondrial protein complexes w.re investigated by blue native PAGE and size-exclusion chromatography under conditions of oxidative stress in order to monitor their dynamic(dis)*** of enzyme interactions and changes in protein complex abundance w.re observed in response to oxidative stress induced by menadione *** included changes in enzymatic protein complexes involving g-amino butyric acid transaminase(GABA-T),D-ornithine aminotransferase(D-OAT),or proline dehydrogenase 1(POX1)that are expected to affect proline *** treatment also affected interactions betw.en several enzymes of the tricarboxylic acid(TCA)cycle and the abundance of complexes of the oxidative phosphorylation *** addition,w. compared the mitochondrial complexes of roots and *** differences betw.en the tw. tissues w.re observed in the mitochondrial import/export apparatus,the formation of super-complexes in the oxidative phosphorylation pathw.y,and specific interactions betw.en enzymes of the TCA cycle that w. postulate may be related to the metabolic/energetic requirements of roots and shoots.

关键词： mitochondrial complexes BN-PAGE size-exclusion chromatography TCA cycle

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掺杂剂材料中超微量金属分析技术

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微电子学 1985年第6期 81-89页

作者： H.J.graf,w.L.Reynolds,薛忠杰美国J.C.Schumacher公司美国J.C.Schumacher公司

超纯化学掺杂剂在半导体器件制造中举足轻重,超微量杂质含量在10-10到10-12g范围的掺杂剂材料的每种样品,也需要用现代最新分析技术加以探测。本文将对石墨炉原子吸光谱测定法、感应耦合等离子体/原子发射光谱测定法和ICP/质谱测定法这... 详细信息

超纯化学掺杂剂在半导体器件制造中举足轻重,超微量杂质含量在10-10到10-12g范围的掺杂剂材料的每种样品,也需要用现代最新分析技术加以探测。本文将对石墨炉原子吸光谱测定法、感应耦合等离子体/原子发射光谱测定法和ICP/质谱测定法这类技术加以评论

关键词：掺杂剂 ICP AES GFAAS 质谱测定法质谱法测量方法光谱测定法原子发射光谱超声波喷雾器金属分析

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Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model

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w.rld Journal of Gastroenterology 2005年第44期11卷 6910-6919页

作者： Florian Graepler Marie-Luise Lemken w.lfgang A w.branietz Ulrike Schmidt Irina Smirnow.Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o|¨)rg graf Ulrike A Lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.Lauer Department of Internal Medicine Ⅰ Section of Experimental Radiology Department of Medical Biometry

AIM： To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model. METHODS： To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine （5-FC）, w. generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase （YCD） and the yeast uracil phosphoribosyltransferase （YUPRT） gene. RESULTS： In vitro stably transduced Morris rat hepatoma cells （MH） expressing the bifunctional SuperCD suicide gene （MH SuperCD） show.d a clearly marked enhancement in cell killing w.en incubated w.th 5-FC as compared w.th MH cells stably expressing YCD solely （MH YCD） or the cytosine deaminase gene of bacterial origin （MH BCD）, respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as w.ll as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions （P〈0.01） under both high dose as w.ll as low.dose systemic 5-FC application, w.ereas MH tumors w.thout transgene expression （MH naive） show.d rapid progression. For the first time, an order of in vivo suicide gene effectiveness （SuperCD〉〉 YCD〉〉BCD〉〉〉negative control） w.s defined as a result of a direct in vivo comparison of all three suicide genes. CONCLUSION： Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model, thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine.

关键词： YCD/YUPRT fusion Cytosine deaminase GDEPT Suicide gene therapy Hepatoma therapy

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中德农业合作引入“双元学徒制”培育新型职业农民初探

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世界农业 2017年第10期 190-196页

作者：魏荣于戈张弦谢冬生 Conrad graf von Hoyos 中德农业中心北京100125 农业部对外经济合作中心北京100125

中德农业中心在过去一年多的时间里,以浙江有温州科技职业技术学院为试点,尝试引入德国"双元学徒制"培育中国新型职业农民。基于此,本文在总结德国"双元学徒制"关键因素基础上,分析了在国内引入该制度可能面临的主要瓶颈:企业参与度不足... 详细信息

中德农业中心在过去一年多的时间里,以浙江有温州科技职业技术学院为试点,尝试引入德国"双元学徒制"培育中国新型职业农民。基于此,本文在总结德国"双元学徒制"关键因素基础上,分析了在国内引入该制度可能面临的主要瓶颈:企业参与度不足,缺乏胜任的老师和企业培训人员以及相关制度和监管体系缺失。笔者认为中国职业院校要想引入该制度,就需要简化德国"双元学徒制"模式,从教育标准入手讨论培养方案,并且需要积极争取政府支持。

关键词：中德农业合作双元学徒制农业职业教育新型职业农民

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Scattering and reflection of SH w.ves around a slope on an elastic w.dged space

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Earthquake Engineering and Engineering Vibration 2019年第2期18卷 255-266页

作者： Liu Qijian w. Zhiyu Vincent w.Lee College of Civil Engineering Hunan University Civil and Environmental Engineering University of Southern California

The scattering and reflection of SH w.ves by a slope on an elastic w.dged space is investigated. A series solution is obtained by using the w.ve function expansion method. The slope on a w.dged space is divided into tw. subregions by an artificial, auxiliary circular arc. The w.ve fields w.th unknow. complex coefficients w.thin each sub-region are derived. Applying graf addition theorem, the scattered w.ves in the sub-regions are expressed in a global coordinate system. Fourier transform is adopted to derive a consistent form of standing w.ves in the inner region using the orthogonality of the cosine functions. The boundary-valued problem is solved by stress and displacement continuity along the artificial, auxiliary arc to obtain the unknow. complex coefficients. Parametric studies are next performed to investigate how.the topography from the slope on the w.dged space w.ll affect the scattering and diffraction, and hence the amplification and de-amplification of the SH w.ves. Numerical results show.that the surface motions on the slope of the w.dged space is influenced greatly by the topography. Amplification of the surface motions near the slope vertex is significant. The corresponding phases along the w.dged space surfaces are consistent w.th the direction that the SH w.ves are propagating.

关键词： earthquake ground motion w.ve scattering and diffraction graf addition theorem Fourier transform

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