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Effect of Daily Consumption of <i>Lactobacillus reuteri </i>CRL 1098 on Cholesterol Reduction in Hypercholesterolemic Subjects

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Food and Nutrition Sciences 2015年第17期6卷 1583-1590页

作者： Agustina Malpeli Marí a Pí a Taranto Ricardo C. Cravero Marina Tavella Victoria Fasano Dimas Vicentin Guillermina Ferrari Graciano Magrini Elvira Hé bert graciela Font de Valdez Ana M. Varea Julio M. Tavella Horacio F. Gonzá lez IDIP—Instituto de Desarrollo e Investigaciones Pediá tricas “Prof. Dr. Fernando E. Viteri” (Hospital de Niñ os de La Plata Ministerio de Salud/Comisi&oacute n de Investigaciones Cientí ficas de la Pro-vincia de Buenos Aires) La Plata Argentina CERELA—Centro de Referencia para Lactobacilos (CONICET) Tucum&aacute n Argentina Sancor CUL Departamento de Investigaci&oacute n Innovaci&oacute n y Desarrollo Sunchales Argentina

The effect of daily consumption of a yogurt containing Lactobacillus reuteri CRL 1098 on the lipid profile of hypercholesterolemic subjects was evaluated by performing a prospective, randomized, double-blind, cross-over placebo controlled clinical study. Participants consumed daily a yogurt containing L. reuteri CRL 1098 or a placebo for four weeks, separated by a wash-out period. Total cholesterol, triacylglycerol, high-density (HDL) and low-density (LDL) lipoprotein levels were assessed at the beginning and at the end of each period. We found a statistically significant reduction of total (–7.86 g/dl) and LDL (–7.02 g/dl) cholesterol in absolute changes (before-after) as well as a decreasing trend in the group receiving the yogurt containing L. reuteri with respect to the placebo group, without detecting changes in HDL-cholesterol and triacylglycerol levels. Our results suggest that low amounts of yogurt (125 g/day) and low doses of the CRL 1098 strain (106 CFU) are sufficient to reduce total and LDL-cholesterol levels in hypercholesterolemic subjects.

关键词： Lactobacillus reuteri Hypercholesterolemia Cardiovascular Risk Probiotics Functional Foods

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Solid State Bioconversion for Producing Common Bean(Phaseolus vulgaris L.)Functional Flour with High Antioxidant Activity and Antihypertensive Potential

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Food and Nutrition Sciences 2013年第4期4卷 480-490页

作者： Maria Lilia Guzmán-Uriarte Luis Martín Sánchez-Magaña graciela Yaneth Angulo-Meza Edith Oliva Cuevas-Rodríguez Roberto Gutiérrez-Dorado Saraid Mora-Rochín Jorge Milán-Carrillo Angel Valdez-Ortiz Cuauhtémoc Reyes-Moreno Faculty of Chemical-Biological Sciences Autonomous University of SinaloaCuliacánMexico Northwest Regional Program for Doctorate in Biotechnology Autonomous University of SinaloaCuliacánMexico

The main objective of this investigation was to study the time effect during solid state bioconversion (SSB) on total phenolics content (TPC) and antioxidant activity (AoxA) of common beans to improve antihypertensive functionality. Cooked cotyledons of dehulled common beans were inoculated with a suspension of R. oligosporus NRRL 2710 (1 × 106 spores/mL), and incubated at 35℃ for times of 24, 36, 48, 60, 72, 84, 96 and 108 h (after 108 h the cotyledons showed off odor). Flours from bioprocessed dehulled common bean from each incubation time were blended with their corresponding milled seed coats. The best time for producing bioprocessed common bean (added with seed coats) functional flour with the highest AoxA (ORAC value = 17,468 μmol Trolox equivalents (TE)/100 gsample, dw;ABTS value = 13,505 μmol TE/100 gsample, dw) was 108 h. The SSB process substantially increased TPC and total hydrophilic AoxA and antihypertensive potential of common beans in 2.24, 2.45 - 2.73 and 6769 times, respectively. Proteins hydrolyzates from unprocessed whole and bioprocessed (108 h) common beans had IC50 [concentration needed to inhibit 50% the activity of angiotensin converting enzyme (ACE)] of 79.2 and 0.0117 μg/mL, respectively. The SSB is an efective strategy to improve the TPC of common beans for enhanced functionality with improved antioxidant activity and antihypertensive potential.

关键词： Solid State Bioconversion Common Bean Functional Flour Antioxidant Activity Antihypertensive Activity

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Evaluation of the Antimicrobial Activity of Stryphnodendron barbatiman against Citrobacter freundii

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Materials Sciences and Applications 2013年第12期4卷 780-785页

作者： Nara Cde Souza Marcio N.Gomes Rafael R.G.Maciel Romário Jda Silva Tarquin F.Trescher Filipe D.S.Gorza graciela C.Pedro Kennedy C.S.Correa Marcio C.R.Souza Josmary R.Silva Grupo de Materiais Nanoestruturados Universidade Federal de Mato GrossoBarra do GarçasBrazil Faculdades Padrao GoianiaBrazil

Medicinal plants have been presented as a valuable source of preservation of human health. In special, Stryphnodendron barbatiman has been employed due to its antimicrobial activity. This plant is rich in tannins and has been used in popular medicine for the treatment of gastrointestinal disorder, treatment of lesions, and also as anti-inflammatory microbicide. Citrobacter freundii is a member of the family Enterobacteriaceae and is one of the major causes of opportunistic infections. This microorganism is a bacterium (bacillus) aerobic gram-negative with a length in the range of 1 to 5 mm. C. freundii is commonly found in water, soil, food and occasionally in the gastrointestinal tract of animals and humans. In this paper, we have demonstrated the antibacterial activity of S. barbatiman by observing cellular death by using inhibition halo approach. Atomic force microscopy and FT-IR spectroscopy results suggested that interaction between the main active components of S. barbatiman with cellular wall of C. freundii gives rise to cellular wall damage, and then leads this microorganism to death.

关键词： Stryphnodendron barbatiman Citrobacter freundii Atomic Force Microscopy Antimicrobial Activity

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1,2,3-三氮唑类化合物的合成及抗病毒活性

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中国药物化学杂志 2016年第1期26卷 18-23页

作者：文逸宁袁伟媛吴勇巍陈雪相玉红张卓勇刘宁宁 ANDREI graciela SNOECK Robert SCHOLS Dominique 武钦佩北京理工大学化工与环境学院应用化学与制药工程系北京100081 首都师范大学化学系北京100048 Rega Institute for Medical Research KU Leuven

目的设计合成一系列新型1,2,3-三氮唑类化合物,评价其抗人类巨细胞病毒和带状疱疹病毒活性。方法氰基乙酸乙酯与叠氮化物进行环加成反应得到5-氨基-1,2,3-三氮唑类化合物,再与胺类化合物反应将酯基转化为酰胺基得到目标化合物;苯基炔与... 详细信息

目的设计合成一系列新型1,2,3-三氮唑类化合物,评价其抗人类巨细胞病毒和带状疱疹病毒活性。方法氰基乙酸乙酯与叠氮化物进行环加成反应得到5-氨基-1,2,3-三氮唑类化合物,再与胺类化合物反应将酯基转化为酰胺基得到目标化合物;苯基炔与叠氮化物进行环加成反应得到另外一类1,4-双芳基-1,2,3-三氮唑类目标化合物。测试了部分目标化合物对人类巨细胞病毒(HCMV,AD-169 strain、Davis strain)和水痘-带状疱疹病毒(VZV,TK^+ strain、TK^- strain)的抗病毒活性。结果与结论合成了16个1,2,3-三氮唑类目标化合物,其中,12个是未见文献报道的新化合物。抗病毒活性测试结果显示,化合物4f能够有效地抑制HCMV(EC_(50)=11.7μmol·L^(-1))和VZV(EC_(50)>4μmol·L^(-1))病毒。

关键词： 1,2,3-三氮唑疱疹病毒抗病毒人类巨细胞病毒(HCMV) 带状疱疹病毒(VZV)

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对明串珠菌及其他细菌的抑制效果

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广西轻工业 2006年第4期22卷 23-26页

作者： Georgina Michelena Aidin Martinez graciela Cerutti Monica Coronel Antonio Bell Emilia Carrera Agustin Lopez-Murguia Roberto Portuondo Lazaro Mergarejo Frost M Steele 李宜海古巴甘蔗副产物研究所(ICIDCA) 阿根廷Obispo Colombres农工实验站墨西哥Morelos生物技术研究所美国BrighamYoung大学

在从压榨间直到蔗汁澄清的蔗糖生产过程中,蔗汁中微生物活动是破坏蔗糖品质的一个重要因素。蔗糖损失和葡聚糖的形成通常与蔗汁中微生物引起的变质有关。多年来,这一直成为糖厂试图改善蔗糖品质时所面临的问题。本文以直接影响得糖率的... 详细信息

在从压榨间直到蔗汁澄清的蔗糖生产过程中,蔗汁中微生物活动是破坏蔗糖品质的一个重要因素。蔗糖损失和葡聚糖的形成通常与蔗汁中微生物引起的变质有关。多年来,这一直成为糖厂试图改善蔗糖品质时所面临的问题。本文以直接影响得糖率的微生物减少和相对纯度为指标,研究了不同杀菌方法在蔗汁中的效果。浓度为0.007%的S抑制剂显示了对某糖厂初压汁和混合汁中的微生物菌群的抗菌效应。在对照组中,12h后观察到4.8单位的纯度降低。加入S抑制剂后,只降低2个单位。且蔗汁的稳定性在3个样品中几乎完全一致。以S抑制剂处理的蔗汁保持深褐色和清新的气味,且pH与初始相比无显著变化,而未处理的蔗汁变浅褐色,产生很强的酒味,pH和纯度显著降低。这种稳定效应尚未被其他常用的糖用杀菌剂所报导。同样,本文证明了有可能通过使用S抑制剂来稳定混合汁。经S抑制剂处理后,游离的还原物质和多聚糖比不经处理的样品低6倍。这些结果表明,形成的葡聚糖以及随之形成的游离果糖减少。

关键词：抑制效果明串珠菌微生物活动细菌微生物菌群抑制剂糖用杀菌剂生产过程杀菌方法抗菌效应

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Combinations of Solar Concentrators with Agricultural Plants

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Journal of Environmental Science and Engineering(B) 2020年第5期9卷 168-181页

作者： Ernst Kussul Tetyana Baydyk Nestor García graciela Velasco Herrera Airam Verónica Curtidor López Department of Micro and Nanotechnologies ICAT(Institute of Applied Sciences and Technology)UNAM(National Autonomous University of Mexico)Circuito Exterior s/nCd.UniversitariaCiudad de México 04510México

A new trend involving the combination of solar concentrators and agricultural plants on the same piece of land offers the possibility of realizing both electricity generation and a good crop *** analyze this situation for different countries,including Mexico,and based on authors’experience regarding the development of new solar concentrator prototypes,authors’primary objective was to describe the development of compact,light,and inexpensive solar concentrator prototypes that can be collocated on horizontal ***’second objective was to investigate the combination of such solar concentrator prototypes with agricultural plants on the same ***,several studies related to the combination of renewable energy generation and agricultural crops were *** such systems involving the combination of PV(Photovoltaic)panels with different types of vegetables exist in the USA,France(lettuce production),Japan(tomato production),India(aloe and corn),northern Italy(maize),Spain and México.

关键词： Solar concentrator agricultural plant flat triangular mirror

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Induced pluripotent stem cells for modeling neurological disorders

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World Journal of Transplantation 2015年第4期5卷 209-221页

作者： Fabiele B Russo Fernanda R Cugola Isabella R Fernandes graciela C Pignatari Patricia C B Beltrão-Braga Stem Cell Lab Department of SurgerySchool of Veterinary MedicineUniversity of Sao Paulo Center for Cellular and Molecular Therapy (NETCEM) School of MedicineUniversity of Sao Paulo Department of Obstetrics School of ArtsSciences and HumanitiesUniversity of Sao Paulo

Several diseases have been successfully modeled since the development of induced pluripotent stem cell(i PSC) technology in 2006. Since then, methods for increased reprogramming efficiency and cell culture maintenance have been optimized and many protocols for differentiating stem cell lines have been successfully developed, allowing the generation of several cellular subtypes in vitro. Gene editing technologies have also greatly advanced lately, enhancing disease-specific phenotypes by creating isogenic cell lines, allowing mutations to be corrected in affected samples or inserted in control lines. Neurological disorders have benefited the most from i PSC-disease modeling for its capability for generating disease-relevant cell types in vitro from the central nervous system, such as neurons and glial cells, otherwise only available from post-mortem samples. Patient-specific i PSC-derived neural cells can recapitulate the phenotypes of these diseases and therefore, considerably enrich our understanding of pathogenesis, disease mechanism and facilitate the development of drug screening platforms for novel therapeutic targets. Here, we review the accomplishments and the current progress in human neurological disorders by using i PSC modeling for Alzheimer's disease, Parkinson's disease, Huntington's disease, spinal muscular atrophy, amyotrophic lateral sclerosis, duchenne muscular dystrophy, schizophrenia and autism spectrum disorders, which include Timothy syndrome, Fragile X syndrome, Angelman syndrome, Prader-Willi syndrome, PhelanMc Dermid, Rett syndrome as well as Nonsyndromic Autism.

关键词： Neurological disorders Induced pluripotent stem cells Disease modeling Human neurons Drug screening

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A Privacy Taxonomy for the Management of Ubiquitous Environments

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通讯和计算机（中英文版） 2013年第12期10卷 1529-1553页

作者： Valderi Reis Quietinho Leithardt Guilherme Antonio. Borges Anubis graciela de Morals Rossetto CarlosOberdan Rolim Claudio Fernando Resin Geyer Luiz Henrique Andrade Correia David Nunes Jorge SaSilva Institute of Technology National Service of lndustrial Training (SENAI) Porto Alegre 91140-000 Brazil Institute of Informatics Group of Parallel and Distributed Processing (GPPD) Federal University of Rio Grande do Sul (UFRGS) Porto Alegre 91509-900 Brazil Federal University of Lavras Lavras 37200-000 Brazil Coimbra University Coimbra 3030-290 Portugal

Pervasive and ubiquitous environments must handle the detection and management of users, devices and services, while guaranteeing the privacy of both the users and the environment itself. Current techniques for handling privacy found in the literature treating the subject in various ways, while concentrating on the device management, communication protocols, user profiles and environmental access. This paper examines a control model for privacy in pervasive environments from the perspective of the environment. A prototype was devised and tested to validate the generic model of privacy which was also used to compare taxonomic concepts in the literature. Moreover, the prototype was devised and tested to validate the generic model of privacy for control and manage various users, devices and environments and so on. The prototype was based on Percontrol (a system for pervasive user management), which was only intended to identify users using Wi-Fi, and now it is capable of managing temperature, luminosity and other preferences, measured by a WSN (wireless sensor network) embedded to Percontrol, and the data treatment is done by an ANN (artificial neural network). Results confirmed the viability of device detection with Wi-Fi, Bluetooth and RFID (radio frequency identification) for an increases slight of the latency in registering new devices on the system.

关键词：设备管理计算环境隐私控制分类用户配置文件无线传感器网络原型设计用户管理系统

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Evaluation of a Fermented Millet Product of Bacillus subtilis ATCC 55033 as Potential in Biocontrol of Bacteriosis(Xanthomonas axonopodis)in Gulupa(Passiflora edulis Sims)

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Journal of Agricultural Science and Technology(A) 2020年第4期10卷 200-215页

作者： Benitez Hernández Solange Viviana Aragón Rojas Stephania Novoa Sindy Madrigal Sandra Núñez Paula Gómez Paola Montenegro Monica Ordoñez Elizabeth Lancheros graciela Sánchez Ligia Universidad Colegio Mayor de Cundinamarca Facultad de Ciencias de la SaludPrograma de BacteriologíaCalle 28 No.5B-02BogotáColombia Universidad de la Sabana Facultad de IngenieríaPrograma de Doctorado en BiocienciasCampus del Puente del ComúnKm.7Autopista Norte de BogotáChíaCundinamarcaColombia

The“oil stain disease”has become a phytosanitary status that involves economic losses for farmers who produce gulupa(Passiflora edulis Sims).For this reason,this research aimed to evaluate the biocontrol activity of Bacillus subtilis ATCC 55033 in a culture medium based on fermented millet as a biocontrol product of the ***,metabolite production of seven strains of *** and a reference strain B.s(ATCC 55033)was evaluated;in addition,the in vitro antagonistic ability was evaluated against Xanthomonas *** experiments were performed under in vitro conditions:(1)study of the presence of halos of hemolysis due to metabolite production;(2)analysis of the antagonistic ability by using double *** was observed that concerning the average,a number five times bigger of halos of hemolysis and 10 times bigger halos of inhibition in vitro on the growth of *** in the strains B.s(ATCC 55033)and B.s TB2 over other ***,the evaluation was performed under greenhouse conditions,based on a randomized block design,in which two treatments were applied over the soil:(1)application of the fermented medium based on millet with B.s ATCC 55033,24 h before X.a inoculation;(2)application of 5 d *** was observed that the treatment,previous infective process,obtained an average percentage of severity equal to 42.044%.In addition,after the evaluation month,a foliage restoration was *** conclusion,it is suggested that these products could act as inducers in the plant systemic resistance to trigger defense responses to infection of X.a.

关键词： Xanthomonas Bacillus biocontrol bacterioses.

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用中微子透视宇宙

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环球科学 2010年第6期 76-83页

作者：格拉谢拉·B·赫尔米尼（graciela B．Gelmini）亚历山大·库先科（Alexander Kusenko）托马斯·J·韦勒（Thomas J.Weller）虞骏（翻译）曹臻（审校）

中微子不再只是物理学里稀奇古怪的小玩意儿，而是探查太阳、超新星和其他天体特性的一件实用工具。

关键词：中微子宇宙物理学超新星

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