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Immunoregulatory and Anti-cancer Activities of Combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast Cancer Bearing Mice

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Chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu Kan Ben Chung-Lap Chan grace gar-lee yue LI Pei-ting Sharon Sze-Man Hon HUANG Dan-qi Miranda Sin-Man Tsang Clara Bik-San Lau Ping-Chung Leung Chun-Kwok Wong Institute of Chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of Chemical Pathology The Chinese University of Hong KongHong Kong SARChina China-Australia International Research Centre for Chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TNBC).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(P<0.05),altered the hypoxia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as C-C motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(P<0.05).4HF-doxorubicin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines Chinese medicine tumor microenvironment

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Effect of Scutellariae Radix extract on experimental dextran-sulfate sodium-induced colitis in rats

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World Journal of Gastroenterology 2007年第42期13卷 5605-5611页

作者： Ho-Lam Chung grace gar-lee yue Ka-Fai To Ya-Lun Su Yu Huang Wing-Hung Ko Department of Physiology Faculty of MedicineThe Chinese University of Hong Kong Shatin Hong Kong China Institute of Chinese Medicine The ChineseUniversity of Hong Kong Shatin Hong Kong China Department of Anatomical and Cellular Pathology Faculty of Medicine The Chinese University of Hong KongShatin Hong Kong China Institute of Materia Medica Chinese Academy ofMedical Sciences and Peking Union Medical College Beijing100050 China Department of Physiology and LiKa Shing Institute of Health Sciences Faculty of Medicine TheChinese University of Hong Kong Shatin Hong Kong China

AIM： To investigate the effect of Scutellariae Radix extract （SRE） on ulcerative colitis （UC） in rats induced by dextran-sulfate sodium （DSS）. METHODS： Colitis was induced in male Sprague-Dawley （SD） rats （170-180 g） by 4% dextran sulfate sodium （DSS, wt/v, MW 54000） in drinking water for 8 d. The treated rats received 4% DSS and SRE orally （100 mg/kg per day）. Control rats received either tap water or SRE only. Macroscopic assessment which included body weight changes, fecal occult blood and stool consistency were determined daily. At the appointed time, the rats were sacrificed and the entire colons were removed. The colon length and the myeloperoxidase （MPO） activity were measured. The severity of colitis was graded by morphological and histological assessments. The ion transport activity of the colonic mucosa was assessed by electrophysiological technique. RESULTS： Rats treated with oral administration of 4% DSS regularly developed clinical and macroscopic signs of colitis. Treatment with SRE relieved the symptoms, including the reduction in body weight, shortening 2nd ulceration of the colon. Administration of SRE also significantly reduced the histological damage induced by DSS. Moreover, the Isc responses of the colonic mucosa to forskolin, were suppressed after the induction of colitis. The stimulated ion transport activity of DSS-rats treated with SRE displayed significant improvement in the secretory responsiveness. CONCLUSION： SRE was effective in treating acute DSS- induced ulcerative colitis, as gauged by reduced clinical disease, improved macroscopic and histological damage scores, and enhanced recovery of normal colonic secretory function.

关键词： Ulcerative colitis Scutellariae Radix Inflammatory bowel disease Colonic ion transport Traditional Chinese medicine

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A Potential Anti-metastatic Chinese Herb Andrographis paniculata—Its In Vitro Activities in Esophageal Cancer Cells and Endothelial Cells

A Potential Anti-metastatic Chinese Herb Andrographis panicu...

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第十四届全国中药和天然药物学术研讨会

作者： grace gar-lee yue Julia Kin-Ming lee Kar-Man Chan Kwok-Pui Fung Philip Wai-Yan Chiu Clara Bik-San Lau The Chinese University of Hong Kong

＜正＞Esophageal cancer is associated with high postoperative recurrence and systemic *** adjuvant chemotherapy and concurrent radiation have shown favourable efficacies,searching for alternative treatments for metast...

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In vitro investigations on the effects of a natural cyclopeptide,RA-V on cell adhesion in human breast cancer cells

In vitro investigations on the effects of a natural cyclopep...

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第十四届全国中药和天然药物学术研讨会

作者： Hoi-Wing Leung grace gar-lee yue Kwok-Pui Fung Ping-Chung Leung Ning-Hua Tan Clara Bik-San Lau Institute of Chinese Medicine State Key Laboratory of Phytochemistry and Plant Resources in West China(CUHK) School of Biomedical Sciences The Chinese University of Hong Kong State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of Sciences

＜正＞Cancer cell adhesion occurs in *** cells need to acquire adhesive ability to extracellular matrix（ECM）to provide a path for them to migrate to adjacent tissues and ultimately *** receptors（integrins）,vascular cell adhesion molecules（VCAMs）and intercellular adhesion molecules（ICAMs）,responsible for cell adhesion,are

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Individual consistency in spatiotemporal characteristics of migratory Whimbrels in the East Asian-Australasian Flyway

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Avian Research 2024年第3期15卷 308-315页

作者： Siwei An Fenliang Kuang Wei Wu Chris J.Hassell Jonathan T.Coleman Zijing Gao Xuena Sun yue Yuan grace Maglio Kar-Sin K.Leung Xuesong Feng Zhijun Ma Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering Coastal Ecosystems Research Station of the Yangtze River EstuaryInstitute of Biodiversity ScienceSchool of Life SciencesFudan UniversityShanghai200433China School of Chemistry and Environment Yunnan Minzu UniversityKunming650504China Shanghai Chongming Dongtan Nature Reserve Administration Center ChongmingShanghai202183China Global Flyway Network PO Box 3089BroomeWA 6725Australia Australasian Wader Studies Group BroomeWA6725Australia Queensland Wader Study Group Shailer ParkQLD4128Australia Hong Kong Waterbirds Ringing Group Hong Kong999077China

Many migratory birds exhibit interannual consistency in migration schedules,routes and stopover *** the interannual consistency in spatiotemporal characteristics helps understand the maintenance of migration and enables the implementation of targeted conservation *** tracked the migration of Whimbrel(Numenius phaeopus)in the East Asian-Australasian Flyway and collected spatiotemporal data from individuals that were tracked for at least two *** non-parametric tests were used to compare the interannual variations in the dates of departure from and arrival at breeding/nonbreeding sites,and the inter-annual variation in the longitudes when the same individual across the same *** exhibited a high degree of consistency in the use of breeding,nonbreeding,and stopover sites between *** variation of arrival dates at nonbreeding sites was significantly larger than that of the departure dates from nonbreeding and breeding *** used stopover sites by the same individuals in multiple years were concentrated in the Yellow Sea coast during northward migration,but were more widespread during southward *** stopover duration at repeatedly used sites was significantly longer than that at sites used only *** flying across the Yellow Sea,Whimbrels breeding in Sakha(Yakutia)exhibited the highest consistency in migration routes in both autumn and ***,the consistency in migration routes of Yakutia breeding birds was generally higher than that of birds breeding in *** results suggest that the northward migration schedule of the Whimbrels is mainly controlled by endogenous factors,while the southward migration schedule is less affected by endogenous *** repeated use of stopover sites in the Yellow Sea coast suggests this region is important for the migration of Whimbrel,and thus has high conservation value.

关键词： Consistency Migration route Migration timing Shorebird

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AN IN VITRO PLATFORM FOR SCREENING CHINESE HERBAL MEDICINES THAT INHIBIT CANCER STEM-LIKE CELLS IN BREAST CANCER

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World Journal of Traditional Chinese Medicine 2016年第2期 81-81页

作者： Hoi-Wing Leung Chun-Hay Ko grace gar-lee yue Clara Bik-San Lau Institute of Chinese Medicine State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong

Introduction:With the high recurrence rate of breast cancer,cancer stem-like cells(CSCs)are believed to be one of the possible cause of cancer *** are subpopulation among cancer cells that possess stem cell characteri... 详细信息

关键词： AN IN VITRO PLATFORM FOR SCREENING CHINESE HERBAL MEDICINES THAT INHIBIT CANCER STEM-LIKE CELLS IN BREAST CANCER

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Individual consistency in spatiotemporal characteristics of migratory Whimbrels in the East Asian–Australasian Flyway

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Avian Research 2024年第3期 308-315页

作者： Siwei An Fenliang Kuang Wei Wu Chris J.Hassell Jonathan T.Coleman Zijing Gao Xuena Sun yue Yuan grace Maglio Kar-Sin K.Leung Xuesong Feng Zhijun Ma Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering Coastal Ecosystems Research Station of the Yangtze River Estuary Institute of Biodiversity Science School of Life Sciences Fudan University School of Chemistry and Environment Yunnan Minzu University Shanghai Chongming Dongtan Nature Reserve Administration Center Global Flyway Network Australasian Wader Studies Group Queensland Wader Study Group Hong Kong Waterbirds Ringing Group

Many migratory birds exhibit interannual consistency in migration schedules, routes and stopover sites. Detecting the interannual consistency in spatiotemporal characteristics helps understand the maintenance of migration and enables the implementation of targeted conservation measures. We tracked the migration of Whimbrel(Numenius phaeopus) in the East Asian–Australasian Flyway and collected spatiotemporal data from individuals that were tracked for at least two years. Wilcoxon non-parametric tests were used to compare the interannual variations in the dates of departure from and arrival at breeding/nonbreeding sites, and the interannual variation in the longitudes when the same individual across the same latitudes. Whimbrels exhibited a high degree of consistency in the use of breeding, nonbreeding, and stopover sites between years. The variation of arrival dates at nonbreeding sites was significantly larger than that of the departure dates from nonbreeding and breeding sites. Repeatedly used stopover sites by the same individuals in multiple years were concentrated in the Yellow Sea coast during northward migration, but were more widespread during southward migration. The stopover duration at repeatedly used sites was significantly longer than that at sites used only once. When flying across the Yellow Sea, Whimbrels breeding in Sakha(Yakutia) exhibited the highest consistency in migration routes in both autumn and spring. Moreover, the consistency in migration routes of Yakutia breeding birds was generally higher than that of birds breeding in Chukotka. Our results suggest that the northward migration schedule of the Whimbrels is mainly controlled by endogenous factors, while the southward migration schedule is less affected by endogenous factors. The repeated use of stopover sites in the Yellow Sea coast suggests this region is important for the migration of Whimbrel, and thus has high conservation value.

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ANTI-ANGIOGENIC AND IMMUNOMODULATORY ACTIVITIES OF A LABDANE DITERPENE FROM LEONURUS HETEROPHYLLUS

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World Journal of Traditional Chinese Medicine 2016年第2期 81-81页

作者： grace gar-lee yue Julia Kin-Ming lee Hin-Fai Kwok Da-Rong Wu Shao-Hua Liu Wei-Lie Xiao Clara Bik-San Lau Institute of Chinese Medicine State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong Chengdu No.1 Pharmaceutical Group Co. Ltd. State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of Sciences

Introduction:Heteronone B(HB)is a labdane diterpene isolated from Leonurus heterophyllus Sweet which is known as Yimucao in Chinese medicines and is traditionally used for the treatment of gynaecological *** was first... 详细信息

关键词： HB ANTI-ANGIOGENIC AND IMMUNOMODULATORY ACTIVITIES OF A LABDANE DITERPENE FROM LEONURUS HETEROPHYLLUS RNA

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Genes for sexual body size dimorphism in hybrid tilapia(Oreochromis sp.x Oreochromis mossambicus)

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Aquaculture and Fisheries 2019年第6期4卷 231-238页

作者： Zi Yi Wan grace Lin Genhua yue Molecular Population Genetics and Breeding Group Temasek Life Sciences Laboratory1 Research LinkNational University of Singapore117604Singapore School of Biological Sciences Nanyang Technological University60 Nanyang Drive637551Singapore Department of Biological Sciences National University of Singapore14 Science Drive 4117543Singapore

Tilapias are important aquaculture ***-biased sexual size dimorphism is very common and males are preferred for aquaculture in ***,the mechanisms underlying sexual dimorphism remain to be *** hundred and thirty-six sex-biased genes,of which 23 were male-biased and 113 were femalebiased,were identified via reanalysis of a muscle transcriptome data using the latest reference genome *** genes were mapped to KEGG pathways that are related to somatic cell metabolism,growth and differentiations,such as MAPK,FoxO4 and metabolism pathways as well as developmental processes responsible for skeletal muscle *** related to cell growth and proliferations such as MAPK signaling pathways are upregulated in males while pathways regulating cell division such as FoxO4 are upregulated in ***-biased genes in tilapia skeletal muscle have higher evolution rates(dN/dS)compared to unbiased ***-biased and male-biased genes showed 17.4%and 13.5%higher dN/dS,respectively,compared to unbiased *** results suggest that some of the male and female sex-biased genes were under selection *** SNPs located in the promoter region of one sex-biased gene RASGRF1 on LG1 were associated with bodyweight differences in the hybrid *** sex-biased genes identified in this study may serve as candidate genes for future functional analysis on sexual size dimorphism and for developing DNA markers for selecting fast-growing saline tilapia in aquaculture.

关键词： Sexual dimorphism Body size RNA-Seq Tilapia Aquaculture Evolution

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Databases as Virtual XML Documents:an Interoperable Approach

Databases as Virtual XML Documents:an Interoperable Approach

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第十八届全国数据库学术会议

作者： grace wai-yue Leung Management Services Department CLP Power LimitedHong Kong

XML documents have constructs that describe the structure and layout of its ***, XML enables data to be modeled according to a schema,adding semantics to the information *** these features,XML is more powerful than HTML in providing data level abstraction,and is more suitable for business to business transactions on the *** objective of our research is to explore how information in databases can be represented and exchanged using XML,thereby allowing corporate data to be sharable among heterogenous legacy systems and *** this paper we present our approach of building such an interoperable system using XML,JDBC,and Java *** specifically,we adopte and extende SAX to operate on JDBC data sources;the latter are then treated as virtual XML documents by means of proper extensions to the SAX *** an illustration,a prototype of application has been developed to demonstrate how XML can be integrated with database systems for information exchange on the Web.

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