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Thyroid Function in Pregnant Women from a West-African Population

Open Journal of Molecular and Integrative Physiology 2018年第1期8卷 1-11页

作者： Bonaventure Awede Mariane SHounnou Christiane Tshabu-Aguemon grace adehan Francois Djrolo Marcellin Amoussou-Guenou Anatole Laleye Unite de Physiologie Faculte des Sciences de la SanteUniversite d’Abomey-CalaviCotonouBenin Unite de Gynecologie et d’Obstetrique Faculte des Sciences de la SanteUniversite d’Abomey-CalaviCotonouBenin Unite de Biophysique et de Medecine Nucleaire Facultédes Sciences de la SanteUniversite d’Abomey-CalaviCotonouBenin Unite d’Endocrinologie et de Nutrition Faculte des Sciences de la SanteUniversite d’Abomey-CalaviCotonouBenin Unite de Biologie Humaine Faculte des Sciences de la SanteUniversite d’Abomey-CalaviCotonouBenin

Thyroid dysfunction is frequent in pregnant women and is often associated with an increased risk of adverse maternal and fetal outcome. In the present work, thyroid function of pregnant women from Benin republic was studied. Two hundred forty (240) pregnant women, without thyroid disease history, have been included in the study. A blood sample was drawn for measurement of TSH, free T3 and free T4 serum levels. From the first to the third trimester, plasma levels of free T3 and free T4 decreased when plasma levels of TSH increased. Using recommendations of the 2011 American Thyroid Association (ATA) guidelines, thyroid dysfunction was observed in 24.17% of subjects. Hypothyroidism was present in 22.50% of subjects with 19.17% of subclinical hypothyroidism, 0.83% of overt hypothyroidism and 2.50% of hypothyroxinemia and hyperthyroidism was observed in 1.67% of subjects. An increase from 15.52% to 28.07% was observed in the frequency of hypothyroidism from the first to the third trimester of pregnancy. When an upper cut-off value of 4 mU/L was used for TSH, as recommended in the 2017 ATA guidelines, prevalence of thyroid disorders was 14.58% with 12.91% of hypothyroidism but no hypothyroidism was observed in women in the first trimester of pregnancy. A rise in hypothyroidism frequency was observed when pregnant women age increased. Hypothyroidism was very common in pregnant women in Benin. To allow accurate assessment of thyroid status in pregnant women in Benin, pregnancy specific range for plasma level of TSH and thyroid hormones should be established.

关键词： Pregnancy Thyroid Function Hypothyroidism

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Synthesis,Characterizations and Applications of Cadmium Chalcogenide Nanowires:A Review

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Journal of Materials Science & Technology 2015年第6期31卷 556-572页

作者： Liubing Huang Jia grace Lu Department of Physics and Department of Electrical Engineering University of Southern California

Cadmium chalcogenide nanowires have demonstrated superior electrical and optical properties,and have emerged as prominent building blocks for nanoscale electronic and optoelectronic *** addition to the effort devoted to advance techniques of fabricating high quality nanowires,much has been endeavored to elucidate their unique physical properties for better design and development of functional devices with low power consumption and high ***,this article provides a comprehensive review of the forefront research on cadmium chalcogenide nanowires,ranging from material synthesis,property characterizations,and device applications.

关键词： Cadmium chalcogenide Nanowire synthesis Electrical

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Sphincter of Oddi dysfunction and bile duct microlithiasis in acute idiopathic pancreatitis

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World Journal of Gastroenterology 2008年第7期14卷 1023-1026页

作者： grace H Elta Division of Gastroenterology University of MichiganAnn ArborMichigan 48109-0362United States

Although there are numerous causes of acute panc-reatitis, an etiology cannot always be found. Two potential etiologies, microlithiasis and sphincter of Oddi dysfunction, are discussed in this review. Gallbladder microlithiasis, missed on transcutaneous ultrasound, is reported as the cause of idiopathic acute pancreatitis in a wide frequency range of 6%-80%. The best diagnostic technique for gallbladder microlithiasis is endoscopic ultrasound although biliary crystal analysis and empiric cholecystectomy remain as reasonable options. In contrast, in patients who are post-cholecystectomy, bile duct microlithiasis does not appear to have a role in the pathogenesis of acute pancreatitis. Sphincter of Oddi dysfunction is present in 30%-65% of patients with idiopathic acute recurrent pancreatitis in whom other diagnoses have been excluded. It is unclear if this sphincter dysfunction was the original etiology of the first episode of pancreatitis although it appears to have a causative role in recurring episodes since sphincter ablation decreases the frequency of recurrent attacks. Unfortunately, this conclusion is primarily based on small retrospective case series; larger prospective studies of the outcome of pancreatic sphincterotomy for SOD-associated acute pancreatitis are sorely needed. Another problem with this diagnosis and its treatment is the concern over potential procedure related complications from endoscopic retrograde cholangiopancreatography (ERCP), manometry and pancreatic sphincterotomy. For these reasons, patients should have recurrent acute pancreatitis, not a single episode, and have a careful informed consent before assessment of the sphincter of Oddi is undertaken.

关键词： Sphincter of Oddi dysfunction Microlithiasis Idiopathic pancreatitis

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Machine Learning‑Based Detection of Graphene Defects with Atomic Precision

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Nano-Micro Letters 2020年第12期12卷 331-343页

作者： Bowen Zheng grace X.Gu Department of Mechanical Engineering University of CaliforniaBerkeleyCA 94720USA

Defects in graphene can profoundly impact its extraordinary properties,ultimately influencing the performances of graphene-based *** to detect defects with atomic resolution in graphene can be technically demanding and involve complex sample *** alternative approach is to observe the thermal vibration properties of the graphene sheet,which reflects defect information but in an implicit *** learning,an emerging data-driven approach that offers solutions to learning hidden patterns from complex data,has been extensively applied in material design and discovery *** this paper,we propose a machine learning-based approach to detect graphene defects by discovering the hidden correlation between defect locations and thermal vibration *** prediction strategies are developed:an atom-based method which constructs data by atom indices,and a domain-based method which constructs data by domain *** show that while the atom-based method is capable of detecting a single-atom vacancy,the domain-based method can detect an unknown number of multiple vacancies up to atomic *** methods can achieve approximately a 90%prediction accuracy on the reserved data for testing,indicating a promising extrapolation into unseen future graphene *** proposed strategy offers promising solutions for the non-destructive evaluation of nanomaterials and accelerates new material discoveries.

关键词： Machine learning Graphene Defects Molecular dynamics Nanomaterials

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Joy of gardening: a hospital-based cooking and gardening program

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World Journal of Pediatrics 2020年第5期16卷 533-536页

作者： grace Kim Kirsten Thompson Department of Pediatrics University of WashingtonSeattleWA 98105USA Department of Nutrition Seattle Children's HospitalOC 7.820PO Box 5371SeattleWA 98105USA

Background Nutrition interventions aid in implementing healthy ***-enhanced nutrition intervention programs have been conducted in *** sought to assess feasibility of a hospital-based cooking and gardening *** The cohort study implemented a 3-week integrated cooking and gardening program in the United States(Seattle,WA).We recruited participants with ages 8-15 years from ambulatory *** conducted three 3-week series hospitalbased cooking and gardening *** and parents were given pre-and post-program(1 year)*** surveys assessed child participation in food preparation and gardening,strengths and weaknesses of the program,and identified parents'opinions towards sustaining healthy *** Eighteen children participated in the hospital-based cooking and gardening *** l-year follow-up,78%of participants were gardening at home and 100%of participants were cooking at *** Novel approaches to combat obesity are needed.A hospital-based cooking and gardening program is a novel intervention to consider for nutrition education.

关键词： Child nutrition Community health education Health education Healthy lifestyle Healthy nutrition

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TLCR is endorsed by the Spanish Lung Cancer Group(SLCG): new horizons for strong academic collaboration in lung cancer

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Chinese Journal of Cancer Research 2013年第6期25卷 782-783页

作者： grace Li Editorial Office Translational Lung Cancer Research

From November 1,2013, Translational Lung Cancer Research （TLCR） is officially endorsed by the Spanish Lung Cancer Group （Figure 1）. This is a meaningful milestone for TLCR as an acknowledgment of its expansion and... 详细信息

关键词： lung new horizons for strong academic collaboration in lung cancer TLCR is endorsed by the Spanish Lung Cancer Group SLCG

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Connecting particle sphericity and circularity

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Particuology 2021年第1期19卷 1-4页

作者： John R.grace Arian Ebneyamini Department of Chemical&Biological Engineering University of British ColumbiaVancouver V6T 1Z3Canada

Sphericity,a measure of how much a particle’s shape deviates from spherical,is useful as a shape factorwhen characterizing particulate ***,particle surface areas,required when determiningthe sphericity,are very difficult to *** a result,the circularity,derivable from microscopic views,is often measured instead and assumed to be equal to the *** paper shows that the twoquantities are generally not equal for simple non-spherical shapes and provides advice on improving theestimation of sphericity from circularity.

关键词： Non-spherical particles Sphericity Circularity Shape factorsa

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Effects of the plenum chamber volume and distributor geometry on fluidized bed hydrodynamics

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Particuology 2010年第1期8卷 2-12页

作者： Kiarash Vakhshouri John R. grace Department of Chemical and Biological Engineering University of British Columbia

Most hydrodynamic fluidized bed models, including CFD codes, neglect any effects of the plenum chamber volume. Experiments were performed in a 0.13 m ID fluidization column to determine plenum chamber volume effects on fluidized bed hydrodynamics for FCC and glass particles. Two low-pressure-drop distributors were used, one with a single orifice, and the other with 33 orifices and the same total open area as the single orifice. The results show two peaks in the frequency spectra for the single-orifice distributor, one representing bubble eruption at the bed surface and the other of higher frequency corresponding to the bubbling frequency at the distributor. The latter decreased slightly with increasing plenum volume and with increasing bed depth. For the multi-orifice distributor, broad frequency spectra from pressure measurements became narrower and moved towards higher frequency with decreasing plenum volume.

关键词： Fluidization Bubble Distributor Plenum chamber Hydrodynamics Pressure drop

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Employing electrochemically derived pH gradients for Lab-on-PCB protein preconcentration devices

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Microsystems & Nanoengineering 2024年第1期10卷 79-87页

作者： grace Maxted Pedro Estrela Despina Moschou Department of Electronic and Electrical Engineering University of BathBath BA27AYUK Centre for Bioengineering and Biomedical Technologies(CBio) University of BathBath BA27AYUK

Protein preconcentration is an essential sample preparation step for analysis in which the targeted proteins exist in low concentrations,such as bodily fluids,water,or ***,very few practical implementations of miniaturized protein preconcentration devices have been demonstrated in practice,and even fewer have been integrated with other microanalytical *** approaches rely heavily on additional chemicals and reagents and introduce complexity to the overall *** this paper,we propose a novel miniaturized isoelectric focusing-based protein preconcentration screening device based on electrochemically derived pH gradients rather than existing chemical reagent *** this way,we reduce the need for additional chemical reagents to zero while enabling device incorporation in a seamlessly integrated full protein analysis microsystem via Lab-on-PCB *** apply our previously presented Lab-on-PCB approach to quantitatively control the pH of a solution in the vicinity of planar electrodes using electrochemical acid generation through redox-active self-assembled *** presented device comprises a printed circuit board with an array of gold electrodes that were functionalized with 4-aminothiophenol;this formed a self-assembled monolayer that was electropolymerized to improve its electrochemical *** preconcentration was performed in two *** first was open and needed the use of a holder to suspend a well of fluid above the electrodes;the second used microfluidic channels to enclose small volumes of *** here are the resulting data for protein preconcentration in both these forms,with a quantitative concentration factor shown for the open form and qualitative proof shown for the microfluidic.

关键词： electrochemical proof qualitative

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Feature selection of ultrahigh-dimensional covariates with survival outcomes:a selective review

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Applied Mathematics(A Journal of Chinese Universities) 2017年第4期32卷 379-396页

作者： HONG Hyokyoung grace LI Yi Department of Statistics and Probability Michigan State University Department of Biostatistics University of Michigan

Many modern biomedical studies have yielded survival data with high-throughput *** goals of scientific research often lie in identifying predictive biomarkers,understanding biological mechanisms and making accurate and precise *** screening is a crucial first step in achieving these *** work conducts a selective review of feature screening procedures for survival data with ultrahigh dimensional *** present the main methodologies,along with the key conditions that ensure sure screening *** practical utility of these methods is examined via extensive *** conclude the review with some future opportunities in this field.

关键词： survival analysis ultrahigh dimensional predictors variable screening sure screening property

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