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Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

Hypoxia Conditioning for High-Altitude Pre-acclimatization Martin

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Journal of Science in Sport and Exercise 2022年第4期4卷 331-345页

作者： Burtscher grégoire P.Millet Johannes Burtscher University of Innsbruck 6020 InnsbruckAustria Austrian Society for Alpine and High-Altitude Medicine 6020 InnsbruckAustria Institute of Sport Sciences University of Lausanne1015 LausanneSwitzerland Department of Biomedical Sciences University of Lausanne1015 LausanneSwitzerland

Purpose Main purposes of pre-acclimatization by hypoxia conditioning(HC)are the prevention of high-altitude illnesses and maintenance of aerobic exercise ***,robust evidence for those effects or evidence-based guidelines for exposure strategies,including recommendations to ensure safety,are largely ***,we summarize the current knowledge on the physiology of acclimatization to hypoxia and HC with the aim to derive implications for pre-acclimatization strategies before going on high-altitude treks and *** Based on the literature search and personal experience,core studies and important observations have been selected in order to present a balanced view on the current knowledge of high-altitude illnesses and the acclimatization process,specifically focusing on pre-acclimatization strategies by *** and Conclusions It may be concluded that in certain cases even short periods(e.g.,7 h)of pre-acclimatization by HC are effective,but longer periods(e.g.,>60 h)are needed to elicit more robust *** 300 h of HC(intermittently applied)may be the optimal preparation for extreme altitude sojourns,although every additional hour spent in hypoxia may confer further *** inclusion of hypobaric exposures(i.e.,real altitude)in pre-acclimatization protocols could further increase their *** level of simulated altitude is progressively increased or individually adjusted *** should not be terminated earlier than 1-2 weeks before altitude *** monitoring of the pre-acclimatization program is strongly recommended.

关键词： Hypoxia Normobaric Hypobaric Conditioning Acclimatization Altitude

Is Hypoxic/Altitude Training an Important Topic in the Field of Hypoxia?

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Journal of Science in Sport and Exercise 2022年第4期4卷 293-305页

作者： grégoire P.Millet Martin Burtscher Johannes Burtscher Institute of Sport Sciences University of LausanneCampus Dorigny1015 LausanneSwitzerland Department of Biomedical Sciences University of Lausanne1015 LausanneSwitzerland Department of Sport Science University of InnsbruckInnsbruckAustria

Hypoxia is an essential topic in medical or biological *** main aims of the present study were to examine the most important medical articles(i.e.,the top 100 most cited)on *** examine how the Nobel-prize awarded hypoxia inducible factor(HIF)-pathway discovery in the early 1990s has changed the thematic composition of this body of literature,with a special emphasis on the studies linking hypoxia and *** searched Pubmed for articles with the terms#Hypox,#Altitude,or#Mountain in the title that have been published in biomedical journals and ranked the articles on their number of citations in Web of Science.A second search was performed in all journals for articles related to hypoxia and ***,only 12 of the top-100 most-cited articles on hypoxia and only 3 articles of the top-100 articles related to cancer were published before ***,only 5 articles from prior 1995 reached 1000 citations,while 27 articles published in 1995 or later were cited more than 1000 times,most of them on the HIF-1 *** percent of the top-100 articles were related to the HIF pathway,while there were no articles on the application of hypoxia either for therapeutic use(i.e.,hypoxic conditioning in patients)or for performance enhancement(i.e.,altitude training in athletes).In conclusion,the early-1990s discovery of the HIF pathway and of its molecular regulation has shifted the focus of hypoxia research towards molecular mechanisms and consequences of tissue hypoxia,most notably in *** importance of studies focusing on clinical and performance applications of systemic hypoxia is relatively lower.

关键词： Altitude training Cancer Hypoxia HIF pathway Mountain

Rationale for the potential use of mesenchymal stromal cells in liver transplantation

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World Journal of Gastroenterology 2014年第44期20卷 16418-16432页

作者： Morgan Vandermeulen Céline grégoire Alexandra Briquet Chantal Lechanteur Yves Beguin Olivier Detry Department of Abdominal Surgery and Transplantation CHU Liege University of Liege Department of Hematology CHU Liege University of Liege Laboratory of Cell and Gene Therapy CHU Liege University of Liege

Mesenchymal stromal cells (MSCs) are multipotent and self-renewing cells that reside essentially in the bone marrow as a non-hematopoietic cell population, but may also be isolated from the connective tissues of most organs. MSCs represent a heterogeneous population of adult, fibroblast-like cells characterized by their ability to differentiate into tissues of mesodermal lineages including adipocytes, chondrocytes and osteocytes. For several years now, MSCs have been evaluated for their in vivo and in vitro immunomodulatory and ‘tissue reconstruction’ properties, which could make them interesting in various clinical settings, and particularly in organ transplantation. This paper aims to review current knowledge on the properties of MSCs and their use in pre-clinical and clinical studies in solid organ transplantation, and particularly in the field of liver transplantation. The first available clinical data seem to show that MSCs are safe to use, at least in the medium-term, but more time is needed to evaluate the potential adverse effects of long-term use. Many issues must be resolved on the correct use of MSCs. Intensive in vitro and pre-clinical research are the keys to a better understanding of the way that MSCs act, and to eventually lead to clinical success.

关键词： Mesenchymal stem cells Organ transplantation Complication Immunosuppression Tolerance

Split-Tetraquaternion Algebra and Applications

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Journal of Applied Mathematics and Physics 2024年第7期12卷 2682-2690页

作者： grégoire Lutanda Panga Department of Mathematics and Informatic University of Lubumbashi Lubumbashi The Democratic Republic of the Congo

In this paper, from the spacetime algebra associated with the Minkowski space ℝ3,1by means of a change of signature, we describe a quaternionic representation of the split-tetraquaternion algebra which incorporates the Pauli algebra, the split-biquaternion algebra and the split-quaternion algebra, we relate these algebras to Clifford algebras and we show the emergence of the stabilized Poincaré-Heisenberg algebra from the split-tetraquaternion algebra. We list without going into details some of their applications in Physics and in Born geometry.

关键词： Tetraquaternion Algebra Split-Tetraquaternion Algebra Split Quaternion Algebra Clifford Algebra

2D Curves in Conformal Hyperquaternion Algebras H^⊗2m

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Journal of Applied Mathematics and Physics 2023年第10期11卷 2904-2912页

作者： grégoire Lutanda Panga Department of Mathematics and Informatic University of Lubumbashi Lubumbashi the Democratic Republic of the Congo

The aim of this paper is to outline the conditions of a conformal hyperquaternion algebra H⊗2m in which a higher order plane curve can be described by generalizing the well-known cases of conics and cubic curves in 2D. In other words, the determination of the order of a plane curve through n points and its conformal hyperquaternion algebra H⊗2m is the object of this work.

关键词： Clifford Algebra Hyperquaternion Algebra Conformal Hyperquaternion Al-gebra

Hyperquaternionic Representations of Conic Sections

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Journal of Applied Mathematics and Physics 2022年第10期10卷 2989-3002页

作者： grégoire Lutanda Panga Department of Mathematics and Informatic University of Lubumbashi Lubumbashi The Democratic Republic of the Congo

In this paper, by means of an isomorphism, we express the Clifford algebra Cl5,3 as hyperquaternion algebra H ⊗H ⊗H ⊗H (a four-fold tensor product of quaternion algebras) and we provide the hyperquaternionic approach ... 详细信息

关键词： Clifford Algebra Multivectors Quaternions Hyperquaternions

Geodynamic evolution of the Tethyan lithosphere as recorded in the Spontang Ophiolite,South Ladakh ophiolites(NW Himalaya,India)

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Geoscience Frontiers 2022年第1期13卷 326-349页

作者： Mallika K.Jonnalagadda Mathieu Benoit Shivani Harshe Romain Tilhac Raymond A.Duraiswami Michel grégoire Nitin R.Karmalkar Interdisciplinary School of Science Savitribai Phule Pune UniversityPune 411007India Department of Geology Savitribai Phule Pune UniversityPune 411007India Géosciences Environnement Toulouse CNRS-CNES-IRD-UniversitéPaul SabatierObservatoire Midi Pyrénées31400 ToulouseFrance Instituto Andaluz de Ciencias de la Tierra(IACT) CSIC–Universidad de Granada18100 ArmillaGranadaSpain Vice-Chancellor’s Office Savitribai Phule Pune UniversityPune 411007India

The Spontang Ophiolite complex represents the most complete ophiolite sequence amongst the South Ladakh ophiolites and comprises mantle rocks(depleted harzburgites,dunites and minor lherzolites)as well as crustal rocks(basalt,isotropic gabbros,layered gabbros etc.).In the present study,detailed geochemistry(whole rock as well as mineral chemistry)and Sr-Nd isotopic analyses of thirty-six ultramaficmafic samples have been attempted to constraint the evolution and petrogenetic history of the Tethyan oceanic ***,trace-element and REE patterns of the peridotites and their minerals indicate that the lherzolites experienced lower degrees of partial melting resembling abyssal peridotites(at higher temperatures,TREE=$1216℃)than the harzburgites(6%–8%versus 15%–17%).Elevated eNd(t)and variable^(87) Sr/^(86) Sr(t)ratios along with REE patterns suggest that the Spontang mafic rocks display N-MORB affinity with negligible participation of oceanic sediments in their genesis are originated from a depleted upper mantle with little contribution from subduction-related ***-type Neotethyan oceanic crust is associated with the earliest phase of subduction(of older Jurassic age)through which a younger intra-oceanic island arc(Spong arc)subsequently *** REE display typical U-shaped patterns,suggesting that these rocks have been metasomatized by LREE-enriched *** the other side,mafic rocks are characterized by heterogeneous(Nb/La)PMand(Hf/Sm)PMand relatively homogeneous eNd(t),indicating interaction of subduction-related melts with the upper mantle during the initiation of subduction,in Early Cretaceous times.

关键词： Peridotites Mafic rocks Partial melting Metasomatism Ladakh

L’hypnose en oncologie pédiatrique Hypnosis in Pediatric Oncology

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Psycho-Oncologie 2023年第4期17卷 225-233页

作者： Jennifer Marini Audrey Vanhaudenhuyse Marie Lacasse Maud Jaspard Marie-Elisabeth Faymonville Hadrien Tasset Christophe F.Chantrain Charlotte grégoire Service d’hémato-oncologie pédiatrique CHC MontLégiaLiège4000Belgique Sensation&Perception Research group(GIGA Consciousness Universitéde Liège)Liège4000Belgique Centre Interdisciplinaire d’Algologie CHU de LiègeLiège4000Belgique Institut de Cancérologie Arsène Burny CHU de LiègeLiège4000Belgique

Hypnosis is a modified state of consciousness which showed its benefits to decrease different symptoms,mainly *** the last decade,this technique has also been proposed to adults with cancer to improve other symptoms,such as emotional distress,fatigue,or sleep *** pediatric oncology,hypnosis is also used to decrease disease-,treatment-,and procedure-related pain and *** learning of self-hypnosis and self-care techniques also improves the well-being of adults or children with cancer,their parents,and their *** several clinical cases,we will illustrate how hypnosis and self-care techniques have been implemented in the pediatric haemato-oncology department of the CHC MontLégia(Liège,Belgium)and will describe their benefits.

关键词： Pediatric oncology hypnosis analgesia self-monitoring quality of life