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Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation

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Bone Research 2022年第4期10卷 826-837页

作者： Yugo Morita Motoo Saito Javier Rangel-Moreno Anthony M.Franchini John R.Owen John C.Martinez John L.Daiss Karen L.de Mesy Bentley Stephen L.Kates Edward M.Schwarz gowrishankar muthukrishnan Center for Musculoskeletal Research University of Rochester Medical CenterRochesterNYUSA Division of Allergy Immunology and RheumatologyDepartment of MedicineUniversity of Rochester Medical CenterRochesterNYUSA Department of Environmental Medicine University of Rochester School of Medicine and DentistryRochesterNYUSA Department of Orthopedic Surgery Virginia Commonwealth UniversityRichmondVAUSA Department of Orthopedics University of Rochester Medical CenterRochesterNYUSA Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochesterNYUSA

Interleukin-27 is a pleiotropic cytokine whose functions during bacterial infections remain controversial,and its role in patients with *** osteomyelitis is *** address this knowledge gap,we completed a clinical study and observed elevated serum IL-27 levels(20-fold higher,P<0.05)in patients compared with healthy ***,IL-27 serum levels were 60-fold higher in patients immediately following septic death than in uninfected patients(P<0.05),suggesting a pathogenic role of *** test this hypothesis,we evaluated *** osteomyelitis in WT and IL-27Rα^(−/−)mice with and without exogenous IL27 induction by intramuscular injection of rAAV-IL-27p28 or rAAV-GFP,*** found that IL-27 was induced at the surgical site within 1 day of *** infection of bone and was expressed by M0,M1 and M2 macrophages and osteoblasts but not by ***,exogenous IL-27p28(~2 ng·mL^(−1) in serum)delivery ameliorated soft tissue abscesses and periimplant bone loss during infection,accompanied by enhanced local IL-27 expression,significant accumulation of RORγt^(+)neutrophils at the infection site,a decrease in RANK^(+) cells,and compromised osteoclast *** effects were not observed in IL-27Rα^(−/−)mice compared with WT mice,suggesting that IL-27 is dispensable for immunity but mediates redundant immune and bone cell functions during *** vitro studies and bulk RNA-seq of infected tibiae showed that IL-27 increased nos1,nos2,il17α,il17f,and rorc expression but did not directly stimulate ***,these results identify a novel phenomenon of IL-27 expression by osteoblasts immediately following *** infection of bone and suggest a protective role of systemic IL-27 in osteomyelitis.

关键词： abscess protective immunity

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Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”

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Bone Research 2019年第3期7卷 225-242页

作者： Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz gowrishankar muthukrishnan Center for Musculoskeletal Research University of Rochester Medical Center Rochester NY USA Department of Biomedical Engineering University of Rochester Medical Center Rochester NY USA Department of Pathology and Laboratory Medicine University of Rochester Medical Center Rochester NY USA Department of Orthopaedics University of Rochester Medical Center Rochester NY USA Department of Microbiology & Immunology University of Rochester Medical Center Rochester NY USA Department of Orthopaedic Surgery Kyoto University Kyoto Japan Department of Orthopaedic Surgery Virginia Commonwealth University Medical Center Richmond VA USA

Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, *** intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure.

关键词： disease caused by soft tissue necrotic tissuel

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Analysis of Efficient 32 Bit Adder Using Tree Grafting Technique

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Intelligent Automation & Soft Computing 2023年第1期35卷 1197-1209页

作者： R.gowrishankar N.Sathish Kumar KIT-Kalaignarkarunanidhi Institute of Technology Coimbatore641402TamilnaduIndia Sri Ramakrishna Engineering College Coimbatore641022TamilnaduIndia

Adder with high efficiency and accuracy is the major requirement for electronic circuit *** the optical logic gate based adder circuit is designed for better performance analysis of optical input signals varied with the *** of the adder can be improved by increasing the speed of operation,reducing the complexity and power *** maintain the high efficiency with accuracy,a new combination of adder has been proposed and tested in this work.A new adder by combining the logics of Brent Kung,Sklansky and Kogge Stone adders by Tree Grafting Technique(BSKTGT)has been tested along with individual Brent Kung,Sklansky,Kogge Stone,Knowles,Han Carlson and Ladner Fischer *** the existing and proposed adders have been designed and tested for efficiency with the help of Cadence platform with 45 nm *** in terms of Size reduction,Power reduction,Power Delay Product(PDP)and accuracy in adding 8 bit,16 bit and 32 bit values had been tested for all the adders and found that the 32 bit BSKTGT adder performed well in all aspects and have produced better efficiency with the power consumption of 52.512426μW with 3.16%of power saving over Brent Kung adder,utilised an area of 631.191 with 8.55%reduction over Kogge Stone Adder,has the cell count of 132 which is 10.61%reduction over Brent Kung Adder and PDP value of 122.6695 J,which is 0.46%less than that of the Han Carlson Adder.

关键词： Design automation computer integrated manufacturing autonomous control communication engineering

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Optimization, Kinetics, and Equilibrium Studies on the Removal of Lead（Ⅱ） from an Aqueous Solution Using Banana Pseudostem as an Adsorbent

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Engineering 2017年第3期3卷 409-415页

作者： Shridhar S. Bagali Bychapur S. gowrishankar Aashis S. Roy Department of Chemical Engineering Siddaganga Institute of Technology Tumkur Karnataka 572 103 India Department of Biotechnology Siddaganga Institute of Technology Tumkur Karnataka 572 103 India Department of lndustrial Chemistry Addis Ababa Science and Technology University Addis Ababa 16417 Ethiopia

香蕉假茎粉末等天然吸附剂对于去除废水中的重金属元素具有非常重要的作用。现有的去除重金属元素的常规方法难以满足水资源循环和化学工业的需求。本文论证了利用天然物质处理废水的可能性。利用环境扫描电子显微镜(ESEM)和傅里叶变换... 详细信息

香蕉假茎粉末等天然吸附剂对于去除废水中的重金属元素具有非常重要的作用。现有的去除重金属元素的常规方法难以满足水资源循环和化学工业的需求。本文论证了利用天然物质处理废水的可能性。利用环境扫描电子显微镜(ESEM)和傅里叶变换红外(FTIR)光谱学分析方法,研究了香蕉假茎粉末吸附铅离子前后的变化。实验采用批处理方法研究了水溶液中铅离子去除的效果。通过改变初始p H值、吸附剂用量、初始铅离子浓度、吸附时间等参数,研究了吸附动力学的影响。结果表明,在水溶液p H值为5.5时,香蕉假茎粉末达到零电荷点。采用吸附等温线和动力学模型分析实验数据,采用朗缪尔吸附等温式拟合铅离子在香蕉假茎粉末表面的吸附作用。实验表明,香蕉假茎粉末对铅离子的吸附量为34.21 mg·g^(–1),与拟二级动力学模型相匹配。此外,采用响应面分析法确定了铅离子吸附的最佳条件,铅离子的去除率高达89%。

关键词：香蕉假茎铅等温线吸附响应面分析法

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Optimization of ECM Process Parameters Using NSGA-II

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Journal of Minerals and Materials Characterization and Engineering 2012年第10期11卷 931-937页

作者： Chinnamuthu Senthilkumar gowrishankar Ganesan Ramanujam Karthikeyan Department of Manufacturing Engineering Annamalai University Annamalai Nagar Tamilnadu India Department of Mechanical Engineering Birla Institute of Technology and Science Pilani Dubai

Electrochemical machining (ECM) could be used as one of the best non-traditional machining technique for machining electrically conducting, tough and difficult to machine material with appropriate machining parameters combination. This paper attempts to establish a comprehensive mathematical model for correlating the interactive and higher-order influences of various machining parameters on the predominant machining criteria, i.e. metal removal rate and surface roughness through response surface methodology (RSM). The adequacy of the developed mathematical models has also been tested by the analysis of variance (ANOVA) test. The process parameters are optimized through Nondominated Sorting Genetic Algorithm-II (NSGA-II) approach to maximize metal removal rate and minimize surface roughness. A non-dominated solution set has been obtained and reported.

关键词： Electro Chemical Machining Metal Removal Rate Response Surface Methodology Surface Roughness NSGA-II

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Unified Performance and Availability Model for Call Admission Control in Heterogeneous Wireless Networks

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International Journal of Communications, Network and System Sciences 2010年第4期3卷 406-412页

作者： Ramesh Babu H. Siddamallaiah gowrishankar Subramanian Piriyapatna S. Satyanarayana 不详

The system capacity of wireless networks varies temporally. This may be due to the dynamic allocation of the channels and also the mobility of the users. The change in capacity will create greater impact on the system performance parameters. This variation of capacity particularly poses a greater challenge to the research community to ensure the Quality of Service (QoS) as it affects the call blocking probability which is one of the important QoS parameters. This paper proposes a performance model for call admission control and the availability model for a heterogeneous wireless network environment. The proposed model is able to handle three types of traffic considered for the study includes conversation traffic, interactive traffic and background traffic. The unified performance-availability model is developed using the Stochastic Area Networks (SAN). The performance of both analytical models and the SAN based performance-capacity models are verified by taking the call blocking probabilities for all the three types of traffics.

关键词： Call Admission Control Call Blocking Probability Heterogeneous Wireless Networks Stochastic Activity Networks Quality of Service

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A Perspective on Traffic Measurement Tools in Wireless Networks

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Wireless Engineering and Technology 2010年第1期1卷 14-19页

作者： Ramesh Babu H. Siddamallaiah gowrishankar Subramanian Piriyapatna S. Satyanarayana 不详

To understand the characteristics of the wireless networks, the network usage data from wireless measurement tools are essential. The data collection is a process of collecting the network time-varying information in standardized format and from standard interfaces. The characteristics include signal propagation, received signal quality, network traffic, active applications and mobility of the mobile terminal (MT). The purpose of the measurement is to collect vital data of the wireless network. There are several tools available for this purpose. The most widely used network measurement tools are client side measurement tool, Syslog, Simple Network Management protocol (SNMP), network sniffing, wireless sniffing. This paper discusses the different wireless measurement tools and their benefits and limitation these tools.

关键词： SNMP Wireless Sniffing Syslog Network Sniffing Wireless Networks

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Effect of kinesiotaping over medications on primary dysmenorrhea among nulligravida women-a randomized clinical control trail

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TMR Non-Drug Therapy 2022年第2期5卷 12-17页

作者： Vaibhav Kanti Suraj Kumar gowrishankar Potturi Vandana Annapurna Department of Obstetrics and Gynecology Uttar Pradesh University of Medical Sciences(UPUMS)SaifaiEtawah 206130India Faculty of Paramedical Sciences Uttar Pradesh University of Medical Sciences(UPUMS)SaifaiEtawah 206130India Department of Physiotherapy Faculty of Paramedical SciencesUttar Pradesh University of Medical Sciences(UPUMS)SaifaiEtawah 206130India Department of Physiotherapy Uttar Pradesh University of Medical Sciences(UPUMS)SaifaiEtawah 206130India.

Background:Dysmenorrhea is cramping pain in the lower abdomen or pelvis during *** is the most common gynecologic problem for all ages and racial *** objective of the study is to find the efficacy of kinesio taping among nulligravida women with dysmenorrhea on pain and functional ***:A total of 115 patients attending the Obstetrics and Gynecology outpatient department were screened and 66 subjects after satisfying inclusion criteria were recruited and randomly divided into two groups,Group A(control)(n=32)and Group B(Experimental)(n=34)by computerized randomization after attaining written *** A received single day dose of pain-relieving medications containing Dicyclominee(10 mg)and Mefenamic acid(250 mg)administered three times a day on the recommendation of a *** B was applied kinesio taping for three days starting from the day of *** pain scale(GPS)was used to assess the pain and functional independence,pre-intervention,12 hours,24 hours and,48 hours after the ***:There was improvement in both the groups in pain and functional *** experimental group demonstrated higher GPS scores when compared to Control group,however,the results are not statistically significant at P<***:From the results attained,this study concludes that kinesiotaping alleviates pain due to primary dysmenorrhea and improves functional independence.

关键词： dysmenorrhea dicyclomine global pain scale kinesiotaping mefenamic acid pain

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全基因组外显子测序首次发现CMD的常染色体隐性致病基因GJA1突变

全基因组外显子测序首次发现CMD的常染色体隐性致病基因GJA1突变

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中国遗传学会第九次全国会员代表大会暨学术研讨会

作者：胡颖 Ernst Reichenberger Salome de Almeida Valdenize Tiziani Kalpana gowrishankar 首都医科大学附属北京口腔医院 University of Connecticut Health Center

颅骨干垢端发育不良(Craniometaphyseal dysplasia,CMD)是一种罕见骨骼硬化性疾病,主要表现为颅面骨进行性硬化。常染色体显性遗传的CMD已经被证实是由于焦磷酸盐转运体ANKH基因突变所导致。尽管CMD常染色体隐性模式(AR CMD)的致病基因... 详细信息

颅骨干垢端发育不良(Craniometaphyseal dysplasia,CMD)是一种罕见骨骼硬化性疾病,主要表现为颅面骨进行性硬化。常染色体显性遗传的CMD已经被证实是由于焦磷酸盐转运体ANKH基因突变所导致。尽管CMD常染色体隐性模式(AR CMD)的致病基因早已通过连锁分析定位到6q21.22染色体区域,但是基因突变一直未见报道。我们对一个葡萄牙AR CMD患者进行全基因组外显子测序,发现GJA,(gap junction protein alpha-1)基因C-末端的一个纯合错义突变(c.716G>A,***239Gln)在家系中共分离,并且该突变随后分别在巴西和印度家系中得到验证。

关键词：颅骨干垢端发育不良常染色体隐性致病基因GJA1 突变分析全基因组外显子测序

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