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Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c and C57BL/6J mice

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Protein & Cell 2020年第10期11卷 776-782页

作者： Jinliang Wang Lei Shuai Chong Wang Renqiang Liu Xijun He Xianfeng Zhang Ziruo Sun Dan Shan Jinying Ge Xijun Wang Ronghong Hua Gongxun Zhong Zhiyuan Wen Zhigao Bu State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150069 China National High Containment Laboratory for Animal Diseases Control and Prevention Harbin 150069 China

Dear Editor,As of June,2020,more than ten million cases of COVID-19 have been reported worldwide.The causative pathogen of the disease is a novel coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)(World Health Organization,2020).Animal infection models are important to characterize the infection,pathogenesis,and immunology of SARS・CoV・2,as well as for the development of medications and vaccines against COVID-19.Mice are particularly attractive animal models for their identical genetic background,reliable reproducibility,well characterized biology,and the huge availability of research reagents and knockout animals.Models in inbreed mice such as BALB/c and C57BL/6J(C57),which are widely used in research,are highly desired.

关键词： C57BL/6J BALB/c respiratory

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Replication, pathogenicity, and transmission of SARS-CoV-2 in minks

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National Science Review 2021年第3期8卷 21-28页

作者： Lei Shuai Gongxun Zhong Quan Yuan Zhiyuan Wen Chong Wang Xijun He Renqiang Liu Jinliang Wang Qinjian Zhao Yuxiu Liu Ningning Huo Junhua Deng Jingjing Bai Hongchao Wu Yuntao Guan Jianzhong Shi Kegong Tian Ningshao Xia Hualan Chen Zhigao Bu State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences National High Containment Laboratory for Animal Diseases Control and Prevention State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious DiseasesSchool of Public Health Xiamen University National Research Center for Veterinary Medicine

Minks are raised in many countries and have transmitted severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) to humans.However,the biologic properties of SARS-CoV-2 in minks are largely unknown.Here,we investigated and found that SARS-CoV-2 replicates efficiently in both the upper and lower respiratory tracts,and transmits efficiently in minks via respiratory droplets;pulmonary lesions caused by SARS-CoV-2 in minks are similar to those seen in humans with COVID-19.We further found that a spike protein-based subunit vaccine largely prevented SARS-CoV-2 replication and lung damage caused by SARS-CoV-2 infection in minks.Our study indicates that minks are a useful animal model for evaluating the efficacy of drugs or vaccines against COVID-19 and that vaccination is a potential strategy to prevent minks from transmitting SARS-CoV-2.

关键词： SARS-CoV-2 mink replication pathogenicity transmission animal model

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