Replication, pathogenicity, and transmission of SARS-CoV-2 in minks
Replication, pathogenicity, and transmission of SARS-CoV-2 in minks作者机构：State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences National High Containment Laboratory for Animal Diseases Control and Prevention State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious DiseasesSchool of Public Health Xiamen University National Research Center for Veterinary Medicine
出 版 物：《National Science Review》 (国家科学评论(英文版))
年 卷 期：2021年第8卷第3期
页 面：21-28页
核心收录：
基 金：supported by the National Key R&D Program of China (2018YFC1200601, 2020YFC0846500 and2020YFC0841100) the Applied Technology Research and Development Project of Heilongjiang Province,China(GA20C006)
主 题：SARS-CoV-2 mink replication pathogenicity transmission animal model
摘 要：Minks are raised in many countries and have transmitted severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) to humans.However,the biologic properties of SARS-CoV-2 in minks are largely unknown.Here,we investigated and found that SARS-CoV-2 replicates efficiently in both the upper and lower respiratory tracts,and transmits efficiently in minks via respiratory droplets;pulmonary lesions caused by SARS-CoV-2 in minks are similar to those seen in humans with COVID-19.We further found that a spike protein-based subunit vaccine largely prevented SARS-CoV-2 replication and lung damage caused by SARS-CoV-2 infection in minks.Our study indicates that minks are a useful animal model for evaluating the efficacy of drugs or vaccines against COVID-19 and that vaccination is a potential strategy to prevent minks from transmitting SARS-CoV-2.
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