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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui Mao Xiang cao Yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

Effect of martensitic transformation on nano/ultrafine-grained structure in 304 austenitic stainless steel

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Journal of Iron and Steel Research International 2017年第12期24卷 1231-1237页

作者： Na gong hui-bin Wu Gang Niu Jia-ming cao Da Zhang Tana Instituted Engineering Technology University of Science and Technology BeijingBeiking 100083China Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China Sinohydro Renewable Energy Co. Ltd.Beijing 100083China

304 austenitic stainless steel was cold rolled in the range of 20%-80%reductions and then annealed at 700-900°C for 60 sto obtain nano/ultrafine-grained（NG/UFG）*** electron microscopy,electron backscatter diffraction and X-ray diffraction were used to characterize the resulting *** results showed that with the increase of cold reduction,the content of martensite was *** steel performed work hardening during cold-working owing to the occurrence of strain induced martensite which nucleated in single shear *** rolling broke up the lath-type martensite into dislocation-cell type martensite because of the formation of slip *** annealed at 800-960°C for 60 swere of NG/UFG structure with different percentage of nanocrystalline（60-100 nm）and ultrafine（100-500 nm）grains,submicron size（500-1000 nm）grains and micron size（〉1000 nm）*** value of the Gibbs free energy exhibited that the reversion mechanism of the reversion process was shear controlled by the annealing *** a certain annealing time during the reversion process,austenite nucleated first on dislocation-cell type martensite and the grains grew up subsequently and eventually to be micrometer/submicrometer grains,while the nucleation of austenite on lath-type martensite occurred later resulting in nanocrystalline/ultrafine *** existence of the NG/UFG structure led to a higher strength and toughness during tensile test.

关键词： 304 austenitic stainless steel Nano/ultrafine-grained structure Reversion mechanism Lath-type martensite Dislocation-cell type martensite Martensitic transformation

Curcumin in gastric cancer treatment:A commentary on mechanistic insights and future directions

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 265-267页

作者： Xin-Yue Wei Wen-Bo cao Sai-Jun Mo Zhi-Yan Sun Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medical Science Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Special Service No.988 Hospital of the Joint Service Support Force of PLAZhengzhou 450042Henan ProvinceChina

The study by Yang et al presents a comprehensive investigation into the thera-peutic potential of curcumin for gastric cancer(GC).Using network pharma-cology,the researchers identified 48 curcumin-related genes,31 of which overlap with GC *** genes,including ESR1,EGFR,CYP3A4,MAPK14,CYP1A2,and CYP2B6,are linked to poor survival in GC *** docking con-firmed strong binding affinity of curcumin to these *** vitro experiments demonstrated that curcumin effectively inhibits the growth and proliferation of BGC-823,suggesting its therapeutic potential in GC through multiple targets and pathways.

关键词： Curcumin Gastric cancer Network pharmacology Mechanism of action In vitro experiments

Cathodic behavior of molten CaCl_2-cao and CaCl_2-NaCl-cao

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International Journal of Minerals,Metallurgy and Materials 2010年第6期17卷 791-794页

作者： Shu-lan Wang Wei Wang Shi-chao Li Shan-hui cao Department of Chemistry Northeastem University Shenyang 110004 China

The cathodic behavior of molten CaCl2, CaCl2-cao and equimolar CaCl2-NaCl-cao was studied by cyclic voltammograms and constant potential polarization at temperatures of 1123 to 1173 K on molybdenum and titanium electrodes. The diffusion coefficient of Ca2＋（cao） in molten CaCl2-cao was calculated from the linear relationship between the square root of scan rate and the peak current density. The deposition potentials and the potential temperature coefficient of cao in molten CaCl2-0.5mol%cao and CaCl2-NaCl-0.5mol%cao were also obtained from their cyclic voltammograms. The result shows that cao is more easily reduced than CaCl2. The addition of NaCl in molten CaCl2-cao induces the underpotential electrodeposition of cao.

关键词： molten salts calcium oxide cyclic voltammetry polarization

A novel chemosensor-bipyridyl end capped hyperbranched conjugated polymer

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Chinese Chemical Letters 2011年第6期22卷 725-728页

作者： Xin Meng Qing Guo He hui Min cao Jian gong Cheng State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China

A novel hyperbranched conjugated chemosensor with bipyridyl groups as periphery groups（BPY-HPV） was ***-HPV was highly sensitive to metal ions（Cu^（2＋）,Ni^（2＋）） for the strong coordination interaction（K_（sv） at the order of 10~7 mol^（-1） L） monitored by fluorescence ***,by hydrogen bonds and charge transfer interaction,BPY-HPV shows strong interaction with 1,1,2,2-tetrachloroethane whatever in CH_2Cl_2（K_（sv）～10~6 mol^（-1） L） or film.

关键词： Hyperbranched conjugated polymer Hydrogen bonding Fluorescence Tetrachloroethane

Microstructure and creep properties of Ni-based single-crystal superalloys with Mo/Al addition at 760℃/850 MPa

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Rare Metals 2023年第11期42卷 3806-3813页

作者： Pei-Shan cao hui Wang Yi Ru Yun-Fei Liang Sheng-Kai gong Key Laboratory of Aerospace Materials and Performance(Ministry of Education) School of Materials Science and EngineeringBeihang UniversityBeijing100191China

The effect of Mo and Al addition on the microstructure as well as creep rupture properties at760.C/850 MPa was investigated by transmission electron microscopy(TEM)in a Ni-based single-crystal(SC)alloy with the composition of Ni-6.5Al-8.0Mo-2.4Cr-6.2Ta-4.9Co-1.5Re-(0.01-0.05)Y(wt%).The microstructure analysis shows that 0.5 wt%Al addition induces rapid decrease in creep rupture life,and this can be attributed to the formation of dense stacking faults cutting intoγ'precipitates,which can be explained by the increase in Orowan stress caused by the narrowerγchannel width and the decrease in stacking faults ***,1.5 wt%Mo addition increases the anti-phase boundary energy and decreases the stacking faults energy,resulting in fewer stacking faults and thus a slight decrease in the creep rupture life.

关键词： Ni-based single-crystal superalloy Transmission electron microscopy Stacking faults Mo and Al addition Creep rupture properties

Chemical U-Th-Pb Monazite Dating of Deformations versus Pluton Emplacement and the Proterozoic History of the Arkansas River Region,Colorado,USA

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Acta Geologica Sinica(English Edition) 2009年第5期83卷 917-926页

作者： cao hui State Key Laboratory of Geological Processes and Mineral Resources and Beijing Key Laboratory of Resources Information Research China University of Geosciences Beijing 100083 China School of Earth and Environmental Sciences James Cook University Townsville Queensland 4811 Australia

Five lengthy periods involving multiple phases of cordierite and andalusite growth were revealed by detailed studies of foliation inflection/intersection axes （FIA） preserved in porphyroblasts in schists from the Arkansas River region in Colorado, USA. The regionally consistent character of the succession of five different FIA trends enabled the relative timing of each FIA with respect to the next to be determined. The FIA succession from first to last is： FIA 1 trending W-E, FIA 2 trending SSW- NNE, FIA 3 trending NNW-SSE, FIA 4 trending NW-SE and FIA 5 trending SW-NE. For four of the FIA sets, samples were found containing monazite grains preserved as inclusions. These were dated on an electron microprobe. The ages obtained concur exactly with the FIA succession, with FIA 1 at 1506±15 Ma, FIA 2 at 1467±23 Ma, FIA 3 at 1425±18 Ma, FIA 4 not dated and FIA 5 at 1366±20 Ma. These ages are directly reflected in a succession of plutons in the surrounding region dated by other isotopic approaches, suggesting that deformation, metamorphism and pluton emplacement occurred together episodically, but effectively continuously, for some 140 Ma.

关键词： monazite dating Arkansas River region foliation inflection/intersection axes

Unlocking the power of ions toward enhanced electrocatalysis

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Science China Chemistry 2024年第12期67卷 4098-4109页

作者： Ran Wang Xueting cao Ming gong Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan UniversityShanghai 200438China

Electrocatalysis plays a vital role in advancing energy conversion and storage *** addition to the prominent strategies of advanced electrocatalysts,the exploration of the ion effects on electrocatalytic processes constitutes an emerging *** significant progress,challenges persist in understanding the controversial mechanisms and addressing the universality of these ion *** this feature article,we summarize our recent advances in exploring the ion effects on electrocatalytic oxidation reactions,mainly involving three systems:(1)hierarchical borate and fluoride anions synergize neutral water oxidation;(2)cation-intermediate interactions steer the glycerol oxidation selectivity;(3)cation coordination delays catechol polymerization and promotes selective ring C–C *** findings not only enrich our understanding of the ion effects through specific non-covalent interactions but also shed light on the potential of finely-tuned electrode–electrolyte interfaces toward the improved electrocatalytic performance for various electrocatalytic *** the summary,we outline the current challenges and opportunities within the ionic effect studies and offer insights into prospective research directions.

关键词： ion effect electrocatalysis electrode/electrolyte interface microenvironment

Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang Shijie Su Weicheng Feng Yaona Lai Kongli Huang Dandan cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease