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Phosphatic microspherules and their geobiological implications from the Frasnian-Famennian transition at the yangdi section, Guilin, South China

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Science China Earth Sciences 2014年第6期57卷 943-956页

作者： HUANG Cheng gong yiMing State Key Laboratory of Biogeology and Environmental Geology China University of Geosciences

Abundant perfectly-preserved phosphatic microspherules have been discovered across the Frasnian-Famennian （F-F） transition from the yangdi section in Guilin, Guangxi, South China. They are mostly spherical or elliptical in shape and about 150 gin in diameter with smooth exterior surfaces. Each microspherule consistently possesses a small dimple on the surface. The internal texture of microspherules consists of concentric light-colored apatite and dark-colored organic matter bands alternating around a central core. Conodonts have also been found preserved together with phosphatic microspherules in the same horizon, and the abundance of the former is obviously higher than that of the latter. Laser Raman spectral studies show close similarities in spectral patterns between the outer shells of phosphatic microspherules and the blade of the conodont genus Palmatolepis sp., as well as between the microspherule nucleus and the platform of the same conodont genus. Furthermore, the statistical results and geochemical data demonstrate that the elevated abundance of phosphatic microspherules roughly coincides with the blooms of bacteria and algae, but is later than the sharp increase of oceanic nutrients. The phosphatic microspherules are inter- preted here to be the ＇otoliths＇ secreted by conodont animals based on the compositional similarities between phosphatic mi- crospherules and conodonts and their interrelated abundances. In addition, an analogous study reveals morphological and tex- tural similarities between fish otoliths and phosphatic microspherules. The formation of phosphatic microspherules is probably related to seawater eutrophication. We speculate that the explosive growth of bacteria and algae is probably caused by the en- richment of nutrients that is most likely associated with the increase of terrestrial inputs, submarine hydrothermal activities or the upwelling anoxic bottom waters in the late Devonian, which would stimulate the conodont animals to secrete

关键词： microspherules conodont animal otoliths eutrophication Devonian F-F South China

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长周期变星的脉冲

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紫金山天文台台刊 1994年第2期13卷 168-173页

作者： gong,ZG Li,y

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CO2固定的合成生物学

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中国科学：生命科学 2015年第10期45卷 993-1002页

作者：巩伏雨蔡真李寅中国科学院微生物研究所中国科学院微生物生理与代谢工程重点实验室北京100101 中国科学院大学北京100049

将CO2转化为燃料或化学品,实现CO2的资源化利用,是缓解化石能源枯竭和温室效应这两大问题的有效途径之一.自养生物能够以光能/氢气/硫等为能量来源,在常温常压下将CO2转化为有机物,提供了一种CO2资源化利用的途径.利用经过代谢工程改造... 详细信息

将CO2转化为燃料或化学品,实现CO2的资源化利用,是缓解化石能源枯竭和温室效应这两大问题的有效途径之一.自养生物能够以光能/氢气/硫等为能量来源,在常温常压下将CO2转化为有机物,提供了一种CO2资源化利用的途径.利用经过代谢工程改造的自养生物(如蓝藻),已经可以实现从CO2生物合成十余种化学品,但整体固碳和转化效率尚低,不能满足工业应用的需求.本文首先介绍了目前已发现的6条天然生物固碳途径,重点从固碳途径及能量供给两方面总结了近年来生物固碳合成生物学研究取得的进展,并对生物固碳的前景和未来方向进行了展望.

关键词：碳固定合成生物学天然固碳途径能量供给

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一篇长恨有风情——论白居易《长恨歌》主题对影视剧的影响

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电影评介 2008年第24期 102-,106页

作者：龚玉兰南京审计学院

白居易《长恨歌》浓缩了野史、杂记等的"风情"韵味,不仅在文学领域具有不可估量的魅力,而且对相关影视题材作品的创作、观众的审美趣味等都产生了潜移默化的影响,足以印证"一篇长恨有风情"。

关键词：自居易长恨歌主题影视剧风情

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Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

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Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing Qiu Mengting yang Danfeng gong Haiying Liang Tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

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Transgenic rice expressing ictB and FBP/SBPase derived from Cyanobacteria exhibits enhanced photosynthesis and mesophyll conductance to CO2

Transgenic rice expressing ictB and FBP/SBPase derived from ...

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中国遗传学会第九次全国会员代表大会暨学术研讨会

作者： Han y.gong yang Li Sun Sa Dao H.Hu yang S.Li State Key Laboratory of Hybrid Rice College of Life SciencesWuhan University Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China College of Life SciencesSouth-Central University For Nationalities

In order to find a way to promote the rate of carbon flux and further improve photosynthetic rate in rice(Oryza sativa L.).Two CO-transporting and fixing relevant genes ictB and FBP/SBPase derived from cyanobacterium arranged with respective 35SMV promotor as a whole construct were introduced into Oryza sativa *** *** homologous transgenic lines in T generation were selected according to the molecular biological experimental assays,and the functional effect of these two genes acting on improving the rate of carbon flow and chloroplastic CO concentration,further enhancing photosynthetic rate in rice mesophyll cells were investigated by means of the physiological biochemical experiments and analysis of leaf anatomy Our results indicated that photosynthetic rate,chloroplastic CO concentration(C) and mesophyll conductance(gm) in transgenic lines were higher about 11.5-21.7%,24.2-37.6%and 21.6-27.7% but without any changes in leaf anatomy structure compared to wild types *** multi-gene transformation technology,functional synergistic interaction of the two genes for improving CO2-transporting and assimilation rate and potential utility value for improving yield in rice were discussed.

关键词： rice Cyanobacteria photosynthesis Mesophyll Conductance to CO2

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The Mechanism of Heating Rate on the Secondary Recrystallization Evolution in Grain Oriented Silicon Steel

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 275-282页

作者： GAO Qian LI Jun WANG Xianhui CAO Laifu gong Jian LI Bo Central Iron and Steel Research Institute Group Beijing 100081China Shougang Zhixin Electromagnetic Material R&D(Beijing)Co. Ltd.Beijing 101300China Beijing Shougang Co. Ltd.Qian’an 064404China

Grain-oriented silicon steels were prepared at different heating rates during high temperature annealing,in which the evolution of magnetic properties,grain orientations and precipitates were *** illustrate the Zener factor,the diameter and number density of precipitates of interrupted testing samples were statistically *** effect of precipitate ripening on the Goss texture and magnetic property was *** indicated that the trend of Zener factor was similar under different heating rates,first increasing and then decreasing,and that the precipitate maturing was greatly inhibited as the heating rate *** recrystallization was developed at the temperature of 1010℃when a heating rate of 5℃/h was used,resulting in Goss,Brass and{110}oriented grains growing abnormally and a magnetic induction intensity of ***,increasing the heating rate to 20℃/h would inhibit the development of undesirable oriented grains and obtain a sharp Goss ***,when the heating rate was extremely fast,such as 40℃/h,poor secondary recrystallization was developed with many island grains,corresponding to a decrease in magnetic induction intensity to 1.87 *** a suitable heating rate of 20℃/h,the sharpest Goss texture and the highest magnetic induction of 1.94 T with an onset secondary recrystallization temperature of 1020℃were found among the experimental variables in this *** heating rate affected the initial temperature of secondary recrystallization by controlling the maturation of precipitates,leading to the deviation and dispersion of Goss texture,thereby reducing the magnetic properties.

关键词： high temperature annealing heating rate secondary recrystallization grain oriented silicon steel

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胰腺导管腺癌组织中WT1,IGF-IR表达与细胞凋亡的关系

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世界华人消化杂志 2006年第28期14卷 2810-2814页

作者：龚勇赵秋杨芳王渝马松林华中科技大学同济医学院附属同济医院消化内科湖北省武汉市430030

目的:研究胰腺导管腺癌组织中WT1,IGF-IR的表达与细胞凋亡关系．方法:应用免疫组化技术检测WT1,IGF-IR在49例胰腺导管腺癌及15例正常胰腺组织中的表达,并应用TUNEL法检测细胞凋亡,计算凋亡指数(AI)．结果:WT1,IGF-IR在正常胰腺组织中的... 详细信息

目的:研究胰腺导管腺癌组织中WT1,IGF-IR的表达与细胞凋亡关系．方法:应用免疫组化技术检测WT1,IGF-IR在49例胰腺导管腺癌及15例正常胰腺组织中的表达,并应用TUNEL法检测细胞凋亡,计算凋亡指数(AI)．结果:WT1,IGF-IR在正常胰腺组织中的阳性表达率分别为26．67％(4／15)、40．00％(6／15);在胰腺导管腺癌组织中的阳性表达率分别为71．43％(35／49)、77．55％(38／49),两者在癌组织中的表达分别明显高于其在正常胰腺组织中的表达(P<0．05),且在癌组织中的表达呈正相关(r=0．385,P<0．05)．正常胰腺组织及癌组织中的AI分别为0．41±0．13、5．93±4．18,两者比较有显著性差异(P<0．05),癌组织中AI随组织分化程度的升高而升高．IGF-IR表达阳性组的AI显著低于阴性组(4．11±3．68 vs 12．21±5．67,P<0．01)．结论:胰腺导管腺癌组织中IGF-IR的高表达抑制细胞凋亡,WT1,IGF-IR的高表达以及细胞凋亡的减少可能在胰腺导管腺癌的发生发展中起重要作用．

关键词： Wilms肿瘤基因胰岛素样生长因子Ⅰ受体胰腺导管腺癌免疫组织化学细胞凋亡

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Engine Misfire Fault Detection Based on the Channel Attention Convolutional Model

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Computers, Materials & Continua 2025年第1期82卷 843-862页

作者： Feifei yu yongxian Huang Guoyan Chen Xiaoqing yang Canyi Du yongkang gong School of Mechatronic Engineering Guangdong Polytechnic Normal UniversityGuangzhou510665China School of Automotive and Transportation Engineering Guangdong Polytechnic Normal UniversityGuangzhou510665China

To accurately diagnosemisfire faults in automotive engines,we propose a Channel Attention Convolutional Model,specifically the Squeeze-and-Excitation Networks(SENET),for classifying engine vibration signals and precisely pinpointing misfire *** the experiment,we established a total of 11 distinct states,encompassing the engine’s normal state,single-cylinder misfire faults,and dual-cylinder misfire faults for different *** collection was facilitated by a highly sensitive acceleration signal collector with a high sampling rate of 20,*** collected data were methodically divided into training and testing sets based on different experimental groups to ensure generalization and prevent overlap between the two *** results revealed that,with a vibration acceleration sequence of 1000 time steps(approximately 50 ms)as input,the SENET model achieved a misfire fault detection accuracy of 99.8%.For comparison,we also trained and tested several commonly used models,including Long Short-Term Memory(LSTM),Transformer,and Multi-Scale Residual Networks(MSRESNET),yielding accuracy rates of 84%,79%,and 95%,*** underscores the superior accuracy of the SENET model in detecting engine misfire faults compared to other ***,the F1 scores for each type of recognition in the SENET model surpassed 0.98,outperforming the baseline *** analysis indicated that the misclassified samples in the LSTM and Transformer models’predictions were primarily due to intra-class misidentifications between single-cylinder and dual-cylinder misfire *** delve deeper,we conducted a visual analysis of the features extracted by the LSTM and SENET models using T-distributed Stochastic Neighbor Embedding(T-SNE)*** findings revealed that,in the LSTMmodel,data points of the same type tended to cluster together with significant ***,in the SENET model,data points of various types were more widely and evenly dispersed,demonstra

关键词： Channel attention SENET model engine misfire fault fault detection

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等温扩增快速准确检测鲍曼不动杆菌碳青霉烯耐药基因

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中华烧伤杂志 2021年第1期37卷 581-581页

作者： Liu S Huang G gong y 曾茁(译) 彭毅志(审校) Department of Plastic & Burns Surgery The Affiliated Hospital of Southwest Medical University Tai Ping Street Luzhou 646000 China. Institute of Burn Research Southwest Hospital The Army Medical University Gao Tan Yan Street Chongqing 400038 China. Department of Emergency The First Affiliated Hospital Zhejiang University School of Medicine Qingchun Road Hangzhou 310003 China. Sichuan Translational Medicine Center of Chinese Medicine Sichuan Academy of Chinese Medical Sciences Ren Min Nan Lu Road Chengdu 610041 China. School of Medicine Chengdu University Xindu Avenue Chengdu 610106 China. Department of Infectious Diseases The Affiliated Hospital of Southwest Medical University Tai Ping Street Luzhou 646000 China.

鲍曼不动杆菌是引起医源性感染的关键病原体之一。近年来,对碳青霉烯抗生素耐药的鲍曼不动杆菌正在增加,临床医护人员急需快速且准确地检测鲍曼不动杆菌中的碳青霉烯抗性基因。我国西南医科大学刘爽等学者近期在《Burns&Trauma》杂志发... 详细信息

鲍曼不动杆菌是引起医源性感染的关键病原体之一。近年来,对碳青霉烯抗生素耐药的鲍曼不动杆菌正在增加,临床医护人员急需快速且准确地检测鲍曼不动杆菌中的碳青霉烯抗性基因。我国西南医科大学刘爽等学者近期在《Burns&Trauma》杂志发文《Rapid and accurate detection of carbapenem-resistance gene by isothermal amplification in Acinetobacter baumannii》.

关键词：鲍曼不动杆菌临床医护人员等温扩增医源性感染碳青霉烯耐药抗性基因

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