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Estimation of mutagenic properties of polycyclic aromatic hydrocarbons

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Estimation of mutagenic properties of polycyclic aromatic hy...

Thermal effects and evolution of the defect concentration based on shear modulus relaxation data in a Zr-based metallic glass

中国的遗传学研究——遗传学进步推动中国西部经济与社会发展——2011年中国遗传学会大会

作者： Mukasheva T.D. goncharova a.v Karpenyuk T.A. Berzganova R.Zg. Sydykbekova R.K. Ignatova L.v. Al-Farabi Kazakh National University

Mutagenic and carcinogenic properties of polycyclic aromatic hydrocarbons have been the subject of intensive study for a long ***,the majority of nitroderivatives of fluorene and fluorenone,formed as a result of incomplete combustion of various kinds of fuel in internal combustion engines,are mutagens of direct action in bacterial cells,in animal cells,they can cause chromosomal aberrations,sister chromatin exchanges and gene *** is known that heterocyclic analogues of pyrene have mutagenic activity,which depends on their *** greatest activity possess nitrocompounds,mutagenicity of which depends on restoration of the nitro group and is defined N-hydroxylated *** presence of the carbonyl group in the structure of these substances plays an important role in their bi-functionality and their ability to produce loss of two adjacent pairs in the test strain Salmonella typhimurium.

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Chinese Physics B 2020年第8期29卷 133-136页

作者： Qi Hao Ji-Chao Qiao E v goncharova G v Afonin Min-Na Liu Yi-Ting Cheng v A Khonik School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072China Department of General Physics Voronezh State Pedagogical UniversityLenin Street 86Voronezh 394043Russia

A relationship between thermal effects and relaxation of the high-frequency shear modulus upon heat treatment of bulk Zr48(Cu5/6Ag1/6)44Al8 metallic glass is *** relationship is attributed to the relaxation of a interstitial-type defect system frozen-in from the melt upon glass *** data show that thermal effects occurring on heating include heat release below the glass transition temperature,heat absorption above it and heat release caused by *** equation derived within the Interstitialcy theory can be used to calculate the shear modulus relaxation using the calorimetric *** obtained results are used to trace the defect concentration as functions of temperature and thermal prehistory.

关键词： shear modulus metallic glass structural relaxation interstitialcy theory

Combined effects of oncolytic vaccinia.virus and dendritic cells on the progression of melanoma B16-F10 in mice

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 67-80页

作者： Elena P.goncharova Tatiana A.Gamburg Oleg v.Markov Marina A.Zenkova Laboratory of Biochemistry of Nucleic Acid Institute of Chemical Biology and Fundamental Medicine SB RASNovosibirsk 630090Russia Faculty of natural science Novosibirsk State UniversityNovosibirsk 630090Russia

Aim:We aimed to test the hypothesis that loading of dendritic cells(DCs)with both viral and tumor-specific antigens would enhance the efficacy antitumor DC-based therapy applied simultaneously with oncolytic ***:vaccinia.virus LIvP/GFP and melanoma B16-F10 were used in this *** were pulsed with various combinations of viral and tumor-associated *** maturation status of DCs was verified by expression of the markers CD80,CD86,and CCR7 and assessment of IL-6,TNF-α,and IL-12 *** most efficient combination of antigens for DC loading was selected based on the analysis of the cytotoxic activity of T *** therapy using vaccinia.virus LIvP/GFP and DCs pulsed with viral and tumor-specific antigens was administered to the B16-F10 melanoma/mouse C57Bl tumor ***:We found that loading of DCs with viral antigens,or with a combination of viral and tumor antigens,resulted in similar levels of expression of DC maturation *** maximal in vitro cytotoxicity against virus-infected and non-infected B16 melanoma cells exhibited T lymphocytes activated by DCs loaded with the heat inactivated lysate of vaccinia.virus LIvP/GFP infected tumor *** results show that the combination of vaccinia.virus LIvP/GFP and DCs loaded with both tumor and viral antigens inhibit tumor growth of B16-F10 murine melanoma by more than ***:Combination therapy with oncolytic vaccinia.virus LIvP/GFP and tumor/virus antigen-loaded DCs limited the growth of established melanoma B16-F10,but no synergistic antitumor effects were *** propose that optimization of the therapy regimen could enhance the efficiency of combination therapy.

关键词： Oncolytic virus vaccinia.virus melanoma B16 dendritic cells cytotoxic T lymphocytes cancer immunotherapy

Study of moisture migration in clay soils considering rate of freezing

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Research in Cold and Arid Regions 2014年第5期6卷 474-478页

作者： S.A.Kudriavtcev a.v.Kazharskii E.D.goncharova I.B.Berestianyi Far Eastern State Transport University (FESTU) Research Construction and Engineering Company (Dv-GEOSYNTHETICS)

The paper presents some methods of numerical modeling and a study of moisture changing in frozen clay soils considering rates of freezing in the base of *** impact assessment of moisture changes in clay soils affectin... 详细信息

关键词： numerical modeling permafrost soil freezing thawing

Study of moisture migration in clay soils considering rate of freezing

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Journal of Groundwater Science and Engineering 2014年第4期2卷 35-40页

作者： Kudryavtsev S A Kazharskii a.v goncharova E D Berestianyi I B Far Eastern State Transport University (FESTU) Research Construction and Engineering Company “Dv-GEOSYNTHETICS”

The paper presents some methods of numerical modelling and a study of moisture changing in frozen clay soils considering rates of freezing in the foundation. An impact assessment of moisture changes in clay soils affe... 详细信息

关键词： Moisture Clay soil Freezing Numerical modelling

Predictive modeling of the permafrost thermal regime in Russian railroad subgrade support systems

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Research in Cold and Arid Regions 2013年第4期5卷 404-407页

作者： Sergei Kudriavtcev Tatiana.valtseva Alexei Kazharskyi Elena goncharova Iurii Berestianyi Far Eastern State Transport University (FESTU) Research Construction and Engineering Company "Dv-GEOSYNTHETICS "

The goal of a predictive thermotechnical calculation is to model the behavior of the top permafrost boundary under current operational conditions as well as increasing average annual air temperatures that results in degradation of the permafrost layer. Numerical modeling was used to assess the efficient application of construction measures to create sustainable operation of the railroad. The numerical modeling was carried out in the programming complex FEM-models developed by geotechnical engineers of St. Petersburg, Russia under Prof. v. M. Ulitsky＇s guidance. The Termoground Program as a part of the FEM-models enables the research of freezing, heaving and thawing in different design solutions. Research was carried out in space resolution for a year cycle. The performed model has shown that the designing measures accepted for permafrost protection from retreat in the subrade support were generally effective.

关键词： reinforcement modeling deformations permafrost soil embankment

Individual Differences in Stress Responsiveness of the Hypothalamic-Pituitary-Adrenal Axis and Its vasopressinergic Regulation in Old Monkeys

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Journal of Behavioral and Brain Science 2015年第7期5卷 280-294页

作者： Nadezhda D. goncharova victor Yu. Marenin Tamara E. Oganyan Laboratory of Endocrinology Federal State Budgetary Scientific Institution “Research Institute of Medical Primatology” Sochi Russia

Stress adaptation is fundamental for health, and the hypothalamic-pituitary-adrenal axis (HPA) is one of its main mechanisms. Considerable data indicate that arginine vasopressin (AvP) related disturbances of stress adaptation can occur with aging. However, most studies of such kind have been performed on rodents, give contradictory results and fail to consider individual characteristics of the animals. The purpose of this study was to investigate individual HPA responsiveness to acute stress and its vasopressinergic regulation in old female rhesus monkeys that differ in their behavioral responses to stress. Animals with depression-like or anxiety-like behavior (DAB) responded with higher plasma levels of ACTH and AvP, lower levels of corticosteroids and higher cortisol/DHEAS molar ratios to restraint stress and to insulin-induced hypoglycemia compared with animals with healthy adaptive behavior. AvP and ACTH dynamics were closely correlated in most animals. AvP treatment produced differences in HPA responses similar to those produced by the stressors. The ACTH response to hypoglycemic stress in the DAB animal with highest HPA responsiveness was dramatically reduced by prior administration of a.v1b receptor antagonist. These results suggest that the dysfunctions of HPA observed in old animals with DAB are caused by increased tone of the vasopressinergic system in regulation of HPA stress reactivity.

关键词： Hypothalamic-Pituitary-Adrenal Axis Stress Responsiveness vasopressinergic Regulation Different Types of Adaptive Behavior Aging