Estimation of mutagenic properties of polycyclic aromatic hydrocarbons
作者单位：Al-Farabi Kazakh National University
会议名称：《中国的遗传学研究——遗传学进步推动中国西部经济与社会发展——2011年中国遗传学会大会》
会议日期：2011年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
摘 要：Mutagenic and carcinogenic properties of polycyclic aromatic hydrocarbons have been the subject of intensive study for a long ***,the majority of nitroderivatives of fluorene and fluorenone,formed as a result of incomplete combustion of various kinds of fuel in internal combustion engines,are mutagens of direct action in bacterial cells,in animal cells,they can cause chromosomal aberrations,sister chromatin exchanges and gene *** is known that heterocyclic analogues of pyrene have mutagenic activity,which depends on their *** greatest activity possess nitrocompounds,mutagenicity of which depends on restoration of the nitro group and is defined N-hydroxylated *** presence of the carbonyl group in the structure of these substances plays an important role in their bi-functionality and their ability to produce loss of two adjacent pairs in the test strain Salmonella typhimurium.