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Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery

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Nano Research 2019年第5期12卷 973-990页

作者： Abdullah A.Ghawanmeh gomaa a.m.ali H.Algarni Shaheen m.Sarkar Kwok Feng Chong Faculty of Industrial Sciences & Technology Universiti Malaysia PahangGambang26300 KuantanMalaysia Chemistry Department Faculty of ScienceAl-Azhar UniversityAssiut71524Egypt Department of Physics Faculty of SciencesKing Khalid UniversityAbha 61413P. O. Box 9004Saudi Arabia Research Center for Advanced materials Science (RCAmS) King Khalid UniversityAbha 61413P. O. Box 9004Saudi Arabia Bernal Institute Department of Chemical SciencesUniversity of LimerickCastletroyV94 LimerickIreland

Graphene oxide (GO) possesses excellent mechanical strength,biocompatibility,colloidal stability,large surface area and high adsorption *** has driven to cancer nanotechnology to defeat cancer therapy obstacles,via integration into three-dimensional (3D) hydrogel network with biocompatible polymers as nanocomposites carrier,and controllable release of anticancer ***,the surface of GO affords π-π stacking and hydrophilic interactions with anticancer ***,modification of GO with various polymers such as natural and synthetic polymers enhances its biodegradability,drug loading,and target *** this review,GO based hydrogels research accomplishments are reviewed on the aspects of crosslinking strategies,preparation methods,the model drug,polymer conjugation and modification with targeting ***,swelling kinetics,drug release profile and biological activity in vivo and in vitro are *** biocompatibility of GO based hydrogels is also discussed from the perspective of its nano-bio *** from that,the clinical potential of GO based hydrogels and its major challenges are addressed in ***,this review concludes with a summary and invigorating future perspectives of GO based hydrogels for anticancer drug *** is anticipated that this review can stimulate a new research gateway to facilitate the development of anticancer drug delivery by harnessing the unique properties of GO based hydrogels,such as large surface area,chemical purity,high loading capacity of drug,chemical stability,and the nature of lipophilic for cell membrane penetration.

关键词： graphe ne oxide cancer nan otechnology hydrogel nanocarrier drug delivery

Depositional environment， petrophysical evaluation and electrical properties of Zeit Formation， Northwestern shore of Gulf of Suez， Egypt

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Journal of Earth Science 2024年

作者： mohamed m.gomaa Emad A.Abd El Aziz Geophysical Sciences Department National Research Centre El-Behoos St. Dokki Cairo Egypt.

The Zeit sand reservoir is one of the most prolific formations at Northwestern side of the Gulf of Suez. In this research we will try to coordinate between electrical， petrophysical properties， depositional environment and facies discrimination in order to evaluate the hydrocarbon potentiality of studied Zeit formation. The statistical parameters for potassium (K)， thorium (Th) and Th/U ratio contents have a general increase towards northwestern parts， whereas uranium (U) content has a general increase towards southeastern parts. The sandstone facies is distinguished from the other facies by its thorium content >4 ppm. U has high carbonate content (U ≥1 ppm). Rocks’ electrical properties vary greatly depending on a number of factors. Electrical measurements were taken at frequencies range of (5×10-4Hz–100 kHz) for fully saturated samples (clayey sandstone) with NaCl (20 gm/Littre). As salinity， clay content， and frequency increase， consequently does the electrical properties. The continental condition are present in northwestern part (back-sea) which is distinguished by high K percent， high Th， high Th/U ratio， and low U contents. Low K， Th， and Th/U ratio contents， with high U contents， characterize the marine depositional environment that existed around the east and southeastern parts (fore-sea coincide with the dipping of strata). Furthermore， the studied Zeit Formation has good petrophysical properties that coincide with marine conditions. The middle and eastern parts (around ISS-94 and CSS-288) is a good reservoir (porosity 36%–39%， shale content <15%， hydrocarbon saturation 71%–92%， and net pay thickness 17–63 feet).

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Hydration Characteristics and Immobilization of Cr(Ⅵ) in Slag Cement-CKD Pastes under Hydrothermal Treatment

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Journal of Wuhan University of Technology(materials Science) 2015年第5期30卷 1013-1019页

作者： m R Shatat gomaa a.m.ali m A Tantawy Chemistry Department Faculty of Science Al-Azhar University Faculty of Industrial Science and Technology University Malaysia Pahang (UMP) Chemistry Department Faculty of Science Minia University

The effect of hydrothermal curing regimes on the hydration characteristics of slag cement containing different ratios of cement kiln dust has been studied. The samples for this study were combination of slag cement and cement kiln dust(5%-25%) without and with immobilization of 5% Cr(VI) by mass. Pastes were hydrothermally treated at 180 ℃ for different periods(2-24 h) in well closed stainless steel capsule. The hydration characteristics of these pastes were studied by measuring the compressive strength, bulk density, total porosity and combined water content. The findings were further supported by XRD and SEm analysis. The results indicated that the hydration characteristics of slag cement paste containing cement kiln dust 10% by mass were enhanced, especially at later ages(24 h) of hydration. That is due to the hydrothermal curing regimes of immobilized pastes accelerating hydration reactions and precipitation of Ca Cr O4, indicating that Cr(VI) can be solidified in the cement paste. This precipitation leads to pore formation in hydrated slag cement pastes.

关键词： hydrothermal immobilization slag cement CKD pastes

middle East respiratory syndrome coronavirus： a comprehensive review

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Frontiers of medicine 2016年第2期10卷 120-136页

作者： mahmoud m. Shehata mokhtar R. gomaa mohamed A. ali Ghazi Kayali Center of Scientific Excellence for Influenza Viruses National Research Centre Giza Egypt Department of Infectious Diseases St. Jude Children's Research Hospital Memphis TN 38105 USA

The middle East respiratory syndrome eoronavirus was first identified in 2012 and has since then remained uncontrolled. Cases have been mostly reported in the middle East, however travel-associated cases and outbreaks have also occurred. Nosocomial and zoonotic transmission of the virus appear to he the most important routes. The infection is severe and highly fatal thus necessitating rapid and efficacious interventions. Here, we performed a comprehensive review of published literature and summarized the epidemiology of the virus. In addition, we summarized the virological aspects of the infection and reviewed the animal models used as well as vaccination and antiviral tested against it.

关键词： mERS coronavirus review

Experimental Design Technique on Removal of Hydrogen Sulfide using CaO-eggshells Dispersed onto Palm Kernel Shell Activated Carbon：Experiment,Optimization,Equilibrium and Kinetic Studies

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Journal of Wuhan University of Technology(materials Science) 2017年第2期32卷 305-320页

作者： OmAR Abed Habecb RAmESH Kanthasamy gomaa A. m. ali ROSLI bin mohd Yunus Faculty of Chemical & Natural Resources Engineering Universiti Malaysia Pahang Gambang 26300 Kuantan Malaysia Faculty of Industrial Sciences and Technology Universiti Malaysia Pahang Gambang 26300 Kuantan Malaysia Chemistry Department Faculty of Science Al-Azhar University Assiut 71524 Egypt Al-Azhar Center of Nanoscience and Applications (ACNA) Al-Azhar University Assiut 71524 Egypt.

This study presents the use of chicken eggshells waste utilizing palm kernel shell based activated carbon（PKSAC） through the modification of their surface to enhance the adsorption capacity of H2S. Response surface methodology technique was used to optimize the process conditions and they were found to be： 500 mg/L for H2S initial concentration, 540 min for contact time and 1 g for adsorbent mass. The impacts of three arrangement factors（calcination temperature of impregnated activated carbon（IAC）, the calcium solution concentration and contact time of calcination） on the H2S removal efficiency and impregnated AC yield were investigated. Both responses IAC yield（IACY, %） and removal efficiency（RE, %） were maximized to optimize the IAC preparation conditions. The optimum preparation conditions for IACY and RE were found as follows： calcination temperature of IAC of 880 ℃, calcium solution concentration of 49.3% and calcination contact time of 57.6 min, which resulted in 35.8% of IACY and 98.2% RE. In addition, the equilibrium and kinetics of the process were investigated. The adsorbent was characterized using TGA, XRD, FTIR, SEm/EDX, and BET. The maximum monolayer adsorption capacity was found to be 543.47 mg/g. The results recommended that the composite of PKSAC and Ca O could be a useful material for H2S containing wastewater treatment.

关键词： water treatment hydrogen sulfide response surface methodology optimization activated carbon adsorption isotherm kinetics calcium oxide

Optimization of double chamber microbial fuel cell for domestic wastewater treatment and electricity production

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燃料化学学报 2015年第9期43卷 1092-1099页

作者： Amr El-Hag ali Ola m.gomaa Reham Fathey Hussein Abd El Kareem mohamed Abou Zaid Polymer Chemistry Department microbiology Department National Center for Radiation Research and Technology (NCRRT) Egyptian Atomic energy Authority ( EAEA ) Nasr City Cairo Egypt DAS Taibah University Medinah KSA

microbial fuel cells(m FCs)represent a new approach for treating w aste w ater along w ith electricity *** present study addressed electricity production from domestic w astew ater using a mediator-less double chamber m *** electricity production w as monitored under different operational conditions for both summer and w inter *** of the anodic and cathodic chambers resulted in a maximal current of 0.784 and 0.645 m A w ith the maximal pow er intensity of 209 and 117 m W/m2in pow er duration of 24 h for the summer and w inter samples,*** electron microscopy show ed that the bacterial biofilm formation on the anode w as denser for the summer sample than that w hen the w inter sample w as used,so w as the total bacterial ***,samples taken during summer w ere considered better in electricity production and w aste w ater treatment than those taken during w inter basically because of the high microbial load during the hot *** parallel,there w as a decrease in both biological oxygen demand(BOD5)and chemical oxygen demand(COD)values which reached 71.8%and 72.85%,respectively at the end of the operation process for the summer sample,w hile there w as no evident decrease for the w inter *** the operating conditions not only increased the potential of using domestic w aste w ater in microbial fuel cells to produce electricity,but also improved the quality of the domestic w aste w ater.

关键词：微生物引起的燃料房间国内废水处理操作条件电生产

A Paucity of Detection of the middle East Respiratory Syndrome Coronavirus (mERS-CoV) Nucleic Acids in the Vaginal Secretions and the Urine of Some Naturally Infected Dromedary Camels

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Open Journal of Veterinary medicine 2021年第12期11卷 327-335页

作者： maged gomaa Hemida ali m. ali Abdelmohsen Alnaeem Department of microbiology College of Veterinary Medicine King Faisal University Al-Hasa Saudi Arabia Department of Virology Faculty of Veterinary Medicine Kafrelsheikh University Kafrelsheikh Egypt Department of Biological Sciences College of Science King Faisal University Al-Hasa Saudi Arabia Department of Botany and microbiology Faculty of Science Minia University Minia Egypt Department of Clinical Sciences College of Veterinary Medicine King Faisal University Al-Hasa Saudi Arabia

The dromedary camels play some critical roles in the evolution and transmission cycle of the mERS-CoV. There are no current available vaccines or antiviral medications to do prevention or to treat humans against the virus, respectively. Few studies reported the course of the mERS-CoV infection in dromedary camels under both the experiment and natural infection approaches. The curve of the viral particle, as well as its nucleic acids in nasal secretions of the dromedary camels, was reported in more details. However, mERS-CoV shedding in some other secretions such as vaginal secretions still understudied. The main goal of the current study was to check the possibility of mERS-CoV shedding of the mERS-CoV through the vaginal mucous membranes of some female camels. To achieve these goals, we conducted molecular surveillance on one dromedary camel herd in eastern Saudi Arabia. We collected the following swabs per each animal (nasal, rectal, and vaginal) as well as urine samples during the period from Jan 2020-April 2020. Testing of mERS-CoV nucleic acid (NA) was conducted in these swabs by the real-time PCR kits. Our results are showing that (47%, 21%, 0%, and 0%) of the (nasal, rectal, and vaginal) swabs, as well as the urine, were positive, respectively. All the tested vaginal swabs were negative. This may suggest the absence of mERS-CoV shedding in the female genital tract and urine samples despite the detection of the viral NA in the nasal swabs. This study is showing for the first time the failure of detection of the mERS-CoV in the vaginal secretions of some naturally infected dromedary camels. This result is enriching our understanding of the mERS-CoV shedding in various body secretions and excretions.

关键词： mERS-CoV rt-RT-PCR Dromedary Camels Nasal Swabs Rectal Swabs Vaginal Swabs Urine

DNA Binding and Antitumor Activity of a New Fluores cent ProbeEu(Ⅲ)-Complex Containing 4-methyl-Coumarin moiety

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光谱学与光谱分析 2018年第11期38卷 3611-3621页

作者： Belal H m Hussein mostafa A Gouda Omer Sakin Abdulla Faluji mohamed gomaa Hassan A Azab Walid Fathalla Sherin Arabi Sa wsan mosa Chemistry Department Faculty of Science&ArtsAl UlaTaibah UniversityAl Madina Al MonawarahKSA Department of Chemistry Faculty of ScienceSuez Canal UniversityIsmailiaEgypt Chemistry Department Faculty of ScienceMansoura UniversityAl MansouEgypt Biotechnology Research Center Suez Canal Universitylsmailia 41522Egypt medicinal Chemistry Department Faculty of PharmacySuez Canal Universitylsmailia 41522Egypt Department of mathematical and Physical Sciences Faculty of EngineeringPort-Said UniversityPort-SaidEgypt Department of mathematical and Physical Sciences Faculty of EngineeringSuez Canal UniversitylsmailiaEgypt Department of Chemistry Faculty of Educationel Arish UniversityEgypt

A new europium(Ⅲ)complex containing(4-methyl-2-oxo-2 H-chromen-7-yloxy)-acetic acid moiety(CmmC)was synthesized,characterized,and confirmed as antitumor agent and fluorescent *** spectroscopic measurements of Eu(Ⅲ)in the presence of CmmC were obtained in different *** results show that the strongest Eu(Ⅲ)emission bands were monitored in iso-propyl alcohol while the weakest Eu(Ⅲ)emission band was observed in *** interaction of Eu(Ⅲ)-(CmmC)2 complex with DNA was monitored using absorption and emission *** fluorescence titration measurements,the binding constants of DNA with Eu(Ⅲ)-(CmmC)_2 complex were found to be 1.04×10~5 L·mol^(-1) in Tris-HCl and 1.17×10~7 L·mol^(-1) in DmSO-Tris-HCl buffer(9∶1 V/V).Hypochromism was observed from the absorption titration experiment which indicates the intercalation of Eu(Ⅲ)-complex between the base pair of *** result further confirmed by fluorescent Ethidium bromide displacement *** fluorescence calibration curve was used for the determination of DNA with LOD of 1.2 ng in DmSO-Tris-HCl buffer(9∶1 V/V)and 5 ng in Tris-HCl *** preliminary antitumor investigation shows promising cytotoxicity against mDA-mB-231,mCF-7(mammary cancer),and PC-3(prostate carcinoma)cell lines with IC50 values of 40.63,25.42 and 30.25μmol·L^(-1),respectively.

关键词： Europium (4-methyl-2-oxo-2H-chromen-7-yloxy)-acetic acid DNA sensing Spectroscopic properties Antitumor activ ity

Efficacy and Safety of Ombitasvir plus Paritaprevir,Ritonavir and Ribavirin in Non-cirrhotic Treatment-naive and Treatment-experienced Egyptians with Chronic HCV Genotype-4 Infection

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Current medical Science 2021年第3期41卷 581-586页

作者： manar Ahmed Azza E.mansey Engy A.Wahsh Ahmed A.gomaa Hoda m.Rabea Department of Clinical Pharmacy Faculty of PharmacyBeni Suef UniversityBeni Suef 62521Egypt Department of Clinical Pharmacy Faculty of PharmacyMenoufia UniversityAl Menoufia 32511Egypt Department of Clinical Pharmacy Faculty of PharmacyOctober 6 universityGiza 12573Egypt Department of Tropical medicine Faculty of MedicineFayoum UniversityFayoum 63511Egypt

Hepatitis C virus genotype 4(HCV-GT4)is a risk factor for cirrhosis,hepatocellular carcinoma and liver failure.A combination of three new direct-acting antivirals ombitasvir,paritaprevir,and ritonavir has been recommended for treatment of HCV-GT4 *** current study was aimed to assess the efficacy and safety of this combination plus ribavirin in non-cirrhotic,treatment-naive and-experienced Egyptians with HCV-GT4 infection in a real-world setting.A total of 255 Egyptians with HCV-GT4 infection were enrolled,including 82 treatment-experienced and 173 treatment-naive *** of them completed 12-week treatment protocol of ombitasvir,paritaprevir and ritonavir as an oral dose combination with *** response(VR)was measured,as well as the biochemical parameters related to treatment efficacy and adverse events at baseline and after treatment,at 4(VR4)and 12(VR12)weeks *** results showed that the VR4 rates were 98.8%in both groups,and VR12 rates were 97.7%and 96.3%in treatment-naive and-experienced patients,respectively,with no significant differences found between the groups concerning VR4(P=0.9)and VR 12(P=0.3).The most common adverse events were headache and fatigue,which were significantly more common(P=0.001 and 0.003,respectively)in treatment-experienced than in treatment-naive *** quadruple regimen was well-tolerated,and the reported adverse events were generally mild to *** real-world setting study confirms that the combination of ombitasvir,paritaprevir,ritonavir,and ribavirin is highly effective in the treatment of HCV-GT4 infection with a good safety and tolerability profile.

关键词： hepatitis C virus genotype-4 ombitasvir paritaprevir ribavirin