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Energy Geoscience 2024年第1期5卷 1-11页

作者： David O.Ubuara Yinka A.Olayinka godwin O.Emujakporue Geoffrey C.Soronnadi-Ononiwu Department of Geology University of Port HarcourtNigeria Mease Energy Nigeria Limited Port HarcourtNigeria Department of Geology University of IbadanNigeria Department of Physics University of Port HarcourtNigeria

Wellbore instability and sand production are all common challenges in the Niger Delta oil province,resulting in high drilling and production cost as well as damage to oil *** vulnerability of lithologic formations to wellbore instability and resultant sand production is investigated in the four delineated reservoirs of the“Areo”field,western part of Niger Delta *** foundation for establishing the geomechanical properties in this study was a 1-dimensional mechanical earth model,using gamma ray(GR),density(RHOB),compressional slowness(DTC),and shear slowness(DTS)*** the Areo oil field,two wells(well 001 and well 002)were *** evaluated formations are still primarily composed of compacted shale and unconsolidated sandstone,with reservoir sand units exhibiting lower elastic and rock strength properties than shale *** compressibility and porosity make sand more brittle,while low compressibility and porosity make shale stiffer due to high *** maximum force that can be applied to a shale unit without causing it to fail is 17.23 MPa,which is the maximum average rock strength of the *** means that shale requires more vertical stress or pressure than sand does in order to deform it(15.06 MPa).The three sand prediction approaches used in the analysis of sand production predictions have cut-off values that are higher than the average values of the *** Schlumberger sand production index method(S/I)indicates that the reservoir has potential for sand influx in the two wells,with the average of the four reservoirs studied in wells 001 and 002 being 1.551012 psi and 1.141012 psi ***,when a formation's sand production index is less than 1.241012 psi,as it is in this study,the formation is likely to produce *** findings support the notion that the defined sandstone units are highly unconsolidated and have a high potential for producing sands;therefore,sand control techniques must be factored in

关键词： Wireline log Stress Geo-mechanicanical characterization Sand prediction Niger delta

Toxicity and phyto-bioactive constituent of Ficus aurea L. leaf extract: A trado-medicinal herb used in southeastern Nigeria

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Clinical Traditional Medicine and Pharmacology 2024年第4期5卷 54-64页

作者： Sonachi Nnedimma Okeke Chinyere godwin Chinyere Okezie Emmanuel Department of Biochemistry Abia State UniversityUturuPMB 2000Uturu Abia StateNigeria Department of Animal Sciences College of FoodAgricultural and Environmental Sciencesthe Ohio State UniversityWoosterOH 44691US

Background:The intrinsic adroitness of medicinal plants as a therapy for several maladies is well-documented in African Herbal *** of Ficus aurea L.(Moraceae)are commonly used in folkloric medicine in southeastern Nigeria and other areas of the world to treat malaria,dermatitis,circulatory and intestinal parasitic health ***:The aim of the study was to explore the phytochemical composition and potential toxicity of the ethanolic leaf extract of *** L.(herein afterwards referred to as ELEFA)in albino rats of both ***:Gas chromatography mass spectrometry(GC–MS)was performed to analyze the chemical constituents of *** the acute toxicity study,a single oral dose of up to 5000 mg/kg ELEFA was *** the sub-acute toxicity study,rats were randomly assigned to individual cages to eschew *** groups(A2-A4)and female groups(B2-B4)were administered varying doses of ELEFA(250,500,750 mg/kg)for 28 days,while control groups A1 and B1 received 1 mL/kg of distilled *** analytical procedures were utilized to evaluate the biochemical and haematological profiles,as well as liver and kidney ***:The GC–MS analysis identified 13 phyto-compounds,six of which possess known bioactive and pharmacological *** bioactive compounds include gamma-dodecalactone,n-hexadecanoic acid,methyl stearate,9,12-octadecadienoic acid,oleic acid,octadecanoic *** the acute toxicity,no death was recorded within 24 h following oral administration of ***,haematological and renal biomarkers remained unaltered post-ELEFA ***,elevated levels of serum aspartate and alanine transaminases were detected in ELEFA-treated groups,indicating potential hepatotoxicity.A reduction in atherogenic lipid markers and a dose-dependent elevation in antioxidant concentrations were observed,suggesting a nuanced impact on oxidative ***:The study emphasized caution reg

关键词： Antioxidant Ficus aurea Phytochemical Toxicity Trado-medicine

Role of adsorption behavior on metal build-up in urban road dust

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Journal of Environmental Sciences 2019年第9期31卷 85-95页

作者： Ayomi Jayarathne Buddhi Wijesiri Prasanna Egodawatta godwin A. ayoko Ashantha Goonetilleke Science and Engineering Faculty Queensland University of Technology (QUT) GPO Box 2434 Brisbane 4001 Queensland Australia College of Chemistry and Environmental Engineering Shenzhen University Shenzhen 518060 China

Metal pollution of stormwater runoff can cause potential toxic impacts on the receiving water environment and human health. Effective pollution mitigation requires accurate stormwater quality modeling. Even though a significant knowledge base exists on the factors influencing metal build-up on urban roads, very limited studies have investigated how metal–particulate interaction influences metal build-up. This study quantitatively assessed the influence of particulate characteristics, together with vehicular traffic and land use, on the build-up of Zn, Cu, Pb, Cr, Ni and Cd on urban roads. The study outcomes revealed that the variability in metal build-up is highly influenced by the variability associated with metal adsorption to particulates. The percentage contribution from particulate properties influencing metal adsorption in the case of 150 μm size road dust particles. Among different particulate properties influencing metal adsorption, effective cation exchange capacity showed a strong positive relationship with the build-up of Cd compared to other metals,highlighting the potential role of Cd in stormwater quality as a readily available metal. The build-up of metals such as Cr and Ni are highly influenced by metal oxides of Al, Fe and Mn and clay forming minerals, indicating that Cr and Ni are relatively stable in nature.

关键词： Metal adsorption Metal build-up Process variability Stormwater quality Stormwater pollutant processes

Diversity of Macro Invertebrates of the River Rwizi in Western Uganda: A Citizen Science-BioBlitz Approach

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Open Journal of Ecology 2024年第4期14卷 343-365页

作者： John Bosco Nkurunungi godwin Muhairwe Upton Nuwagira Nickson Araka Nestor Mugabe Osbert Natwijuka Jeninah Atwebembeire Mbarara University of Science and Technology Mbarara Uganda Department of Directorate of Research and Graduate Training Makerere University Kampala Uganda

This study elucidates the pivotal role of citizen science-BioBlitz methodologies for rapid assessment of the macro-invertebrate taxa within the threatened River Rwizi of South-western Uganda. Utilizing a comprehensive mixed-methods approach, the investigation focused on six distinct river segments to demonstrate the efficacy of participatory citizen science-BioBlitz approaches conducted by experts, students and community volunteers. BioBlitz events included rigorous macro-invertebrate sampling at each of the selected sites along River Rwizi on nine occasions, incorporating collaborative taxonomic identification procedures involving experts, students, and the local community. Analyzing pollution concerns, diversity metrics, and community narratives yielded insights into river health and socio-ecological dynamics. A total of 43 macro-invertebrate families across 17 orders were documented with class Insecta dominating. Participants in BioBlitz events expressed predominantly positive sentiments, emphasizing satisfaction, education, and heightened awareness, besides negative sentiments rooted in historical mistrust. Intriguingly, the study unveiled an unforeseen trend in macro-invertebrate taxa richness, rising from upstream to urban sprawl and diminishing at peri-urban downstream sites. The study underscores the potential of citizen science-BioBlitz methodologies in advancing community science education and unraveling the intricate dynamics of threatened river ecosystems. The insights offered are invaluable for policymakers and conservationists seeking effective strategies to address challenges in the River Rwizi and comparable ecosystems. .

关键词： Diversity Macroinvertebrates Rwizi Citizen-Science-BioBlitz 6

Outcrops as windows to petroleum systems:Insights from the southern Bida Basin,Nigeria

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Energy Geoscience 2024年第3期5卷 284-304页

作者： godwin Okumagbe Aigbadon Felix Iwebunor Chinyem Tope Shade Alege Brume Overare Obinna Chigoziem Akakuru Ikenna Arisi Obasi Ernest Orji Akudo Azuka Ocheli Jeremiah Ayok Onimisi Abdullateef Jimoh Elesius Okey Akpunonu Mu'awiya Baba Aminu Bashir Ozovehe Aminu Department of Geology Faculty of SciencesFederal University LokojaKogi StateNigeria Department of Geology Faculty of ScienceDelta State UniversityAbrakaDelta StateNigeria Department of Earth Sciences Memorial University of NewfoundlandCanada Department of Earth Sciences Federal University of Petroleum ResourcesEffurunDelta StateNigeria Department of Geology School of Physical SciencesFederal University of TechnologyOwerriImo StateNigeria Department of Geology Nnamdi Azikiwe UniversityAwkaAnambra StateNigeria Department of Geology University of IlorinKwara StateNigeria

The study assessed petroleum systems in the southern Bida Basin,Nigeria,focusing on the Cretaceous *** comprise Lokoja and Patti Formation sandstones,while shales,claystone,and siltstone serve as source rocks and stratigraphic traps/*** studies delineating the key elements of the petroleum systems in the basin have not been conducted due to a lack of subsurface *** goal of the current study was to use field observations,Scanning Electron Microscopy(SEM),X-ray diffraction(XRD),and geochemical and geomechanical data to evaluate key components of petroleum systems in the southern Bida *** results presented in this investigation are intended to attain specific objectives,especially those lacking in the basin's study *** analysis revealed that the Lokoja Sandstone has porosity of 37%-39.5%and moderate permeability of 23.22-42.29 *** Patti Formation sandstone reservoirs exhibited high porosity(38%-42%)and moderate to good permeability(31.54-66.48 mD),suggesting good potential *** results revealed intragranular pores and micro-fractures in the Patti Shale,whereas the sandstone reservoirs in the Lokoja and Patti formations displayed fractures,facilitating hydrocarbon *** was the dominant mineral in the sandstone units of both *** analysis revealed that brittle and clay minerals influenced the microstructure of Patti *** analysis indicated promising petroleum potential in the Patti Shale,with a total organic carbon(TOC)content of 1.87 wt%,free hydrocarbon from kerogen(S1)of 0.41 mg/g,hydrogen index(HI)of 0.75 mg HC/g TOC,and production index(PI)of *** Patti and Lokoja formations'shale,claystone,and siltstone exhibited sealing potential,with a plasticity index of 24-35 and coefficient permeability of 2.8×10^(-4)-3.6×10^(-4)cm/*** studies,XRD,geochemical data,and geomechanical index values have confirmed the key components of the petroleum system,which in turn

关键词： Geochemical analysis Plasticity index Source rock Reservoir rock Stratigraphic trap Bida Basin

C19MC miRNA-520G induces SP100 antiviral gene transcription and inhibits melanin production in skin cutaneous melanoma

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Genes & Diseases 2024年第1期11卷 60-63页

作者： Goodwin G.Jinesh Marian T.Smallin Nino Mtchedlidze Isha godwin Marco Napoli Nicole Hackel Manali S.Phadke Avani A.Deshpande Xiaobo Li John H.Lockhart Jaden R.Baldwin Suehelay Acevedo-Acevedo Yifeng Gao Michelle A.Reiser Keiran S.M.Smalley Elsa R.Flores Andrew S.Brohl Department of Molecular Oncology H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Molecular Medicine Program H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Saveetha Medical College ChennaiTamil Nadu 602105India Tumor Biology Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Sarcoma Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA

SP100 is an antiviral protein that restricts the productive stage of human papillomavirus(HPV)and multiple other viruses,and viruses in turn block sUMO-1-mediated stabilization of SP100 and promotes its degradation(Table S1).Interferon(IFN)signaling could still produce more SP100 through transcription to counteract viruses.1 Viruses also disable the transcriptional up-regulation of SP100 to achieve persistent infection in hosts.

关键词： SP100 melanoma stabilization

Ginkgo biloba supplement modulates mTOR/ERK1/2 activities to mediate cardio-protection in cyclosporin-A-induced cardiotoxicity in Wistar rats

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Clinical Traditional Medicine and Pharmacology 2024年第2期5卷 32-42页

作者： Jerome Ndudi Asiwe Benneth Ben-Azu godwin D.Yovwin Vincent-Junior Onoriode Igben Benjamin Oritsemuelebi Israel Ofejiro Efejene Olusegun Gafar Adebayo Nicholas Asiwe Anthony Emeka Ojieh Department of Physiology Faculty of Basic Medical SciencesDelta State UniversityAbraka 330105Delta StateNigeria Department of Physiology Faculty of Basic Medical SciencesUniversity of IbadanIbadan 200223Oyo StateNigeria Department of Pharmacology Faculty of Basic Medical SciencesDelta State UniversityAbraka 330105Delta StateNigeria Department of Family Medicine Faculty of Clinical MedicineDelta State University330105Delta StateNigeria Department of Physiology Faculty of Basic Medical SciencesNovena UniversityOgume 322103Delta StateNigeria Department of Physiology PAMO University of Medical SciencesPort-HarcourtPort-Harcourt 500262Rivers StateNigeria Department of Anatomy University of Port-HarcourtPort-Harcourt 500262Rivers StateNigeria

Background:Cyclosporine-A(Cs-A),an immunosuppressant drug indicated for organ transplant patients has been associated with toxicities arising from activation of pathological *** Ginkgo biloba supplement(GBS)is an antioxidant-enhancing herbal product widely used for treating neurological and vascular ***:This study investigated the ameliorative effect of GBS on cyclosporine-A induced cardiotoxicity in Wistar ***:The study included 20 Wistar rats(n=5)and they were treated as follows:group 1 received distilled water(10 mL/kg),group 2 received Cs-A(25 mg/kg),group 3 received GBS(50 mg/kg)and group 4 received Cs-A(25 mg/kg)and GBS(50 mg/kg).All treatment were done intraperitoneal for 14 days and thereafter,animals were euthanised and heart tissues were harvested for biochemical assays as well as immunohistochemical *** was also collected for serum biochemical ***:Our results revealed that GBS reduces Cs-A induced increase of AST,ALT,ALP,LDH,and GGT levels in serum relative to Cs-A ***,increased oxido-nitrergic markers like MDA,NO,together with elevated concentrations of cholesterol,triglycerides,LDL,creatine kinase-MB,troponin-I,as well as pro-inflammatory cytokines(IL-6,and TNF-α)and heart weight index were reduced by *** Cs-A induced suppression of low-density lipoprotein,antioxidant(GSH,SOD,CAT),Na-K ATPase activities and antiapoptotic element,Bcl-2 were increased by ***,signalling pathways including ERK1/2,and mTOR as well as ventricular thickness were significantly alleviated by GBS ***:The findings suggest that GBS ameliorated Cs-A-induced cardiotoxicity by activating mTOR/ERK1/2 signalling pathways.

关键词： Apoptosis Antioxidant Cyclosporine-A Ginkgo biloba supplement Inflammation

DNA Barcoding of Insects and Its Direct Application for Plant Protection

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Open Journal of Applied Sciences 2024年第3期14卷 676-686页

作者： Peter Quandahor Iddrisu Yahaya Francis Kusi Issah Sugri Julius Yirzagla Abdul Karim Alhassan Jerry A. Nboyine George Y. Mahama godwin Opoku Mohammed Mujitaba Dawuda Asieku Yahaya Theophilus Kwabla Tengey Rofela Combey John Abraham CSIR-Savanna Agricultural Research Institute Tamale Ghana Faculty of Agriculture Food and Consumer Science University for Development Studies Tamale Ghan Department of Conservational Biology and Entomology School of Biological Sciences University of Cape Coast Ghana

The introduction of invasive insect pests across national borders has become a major concern in crop production. Accordingly, national plant protection organizations are challenge to reinforce their monitoring strategies, which are hampered by the weight and size of inspection equipment, as well as the taxonomic extensiveness of interrupted species. Moreover, some insect pests that impede farmer productivity and profitability are difficult for researchers to address on time due to a lack of appropriate plant protection measures. Farmers’ reliance on synthetic pesticides and biocontrol agents has resulted in major economic and environmental ramifications. DNA barcoding is a novel technology that has the potential to improve Integrated Pest Management decision-making, which is dependent on the ability to correctly identify pest and beneficial organisms. This is due to some natural traits such as phenology or pesticide susceptibility browbeaten by IPM strategies to avert pest establishment. Specifically, Deoxyribonucleic acid (DNA) sequence information was applied effectively for the identification of some micro-organisms. This technology, DNA barcoding, allows for the identification of insect species by using short, standardized gene sequences. DNA barcoding is basically based on repeatable and accessible technique that allows for the mechanisation or automation of species discrimination. This technique bridges the taxonomic bio-security gap and meets the International Plant Protection Convention diagnostic standards for insect identification. This review therefore discusses DNA barcoding as a technique for insect pests’ identification and its potential application for crop protection.

关键词： DNA Barcoding Integrated Pest Management Taxonomy Biosecurity Crop Protection

A novel three-step implicit iteration process for threeΦ-hemicontractive mapping in the intermediate sense

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Applied Mathematics(A Journal of Chinese Universities) 2023年第2期38卷 248-263页

作者： godwin Amechi Okeke Austine Efut Ofem Functional Analysis and Optimization Research Group Laboratory(FANORG) Department of Math-ematicsSchool of Physical SciencesFederal University of Technology OwerriP.M.B.1526 OwerriImo StateNigeria School of Mathematics Statistics and Computer ScienceUniversity of KwaZulu-NatalDurbanSouth Africa Department of Mathematics University of UyoUyoNigeria

In this paper,we introduce a three-step composite implicit iteration process for approximating the common fixed point of three uniformly continuous and asymptotically generalizedΦ-hemicontractive mappings in the intermediate *** prove that our proposed iteration process converges to the common fixed point of three finite family of asymptotically generalizedΦ-hemicontractive mappings in the intermediate *** results extends,improves and complements several known results in literature.

关键词： xed point asymptotically genralizedΦ-hemicontractive mapping in the intermediate sense uniformly continuos implicit iteration process strong convergence Banach spaces