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GIS-based soil maps as tools to evaluate land capability and suitability in a coastal reclaimed area(Ravenna,northern Italy)

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International Soil and Water Conservation Research 2021年第2期9卷 167-179页

作者： Mauro De Feudis gloria Falsone Massimo Gherardi Maria Speranza Gilmo Vianello Livia Vittori Antisari Department of Agricultural and Food Sciences Alma Mater Studiorum-University of BolognaVia Fanin4040127BolognaItaly Boreal Mapping Via Casella23/a40030Grizzana MorandiItaly Centro Sperimentale per lo Studio e l’Analisi Del Suolo(CSSAS) Alma Mater Studiorum-University of BolognaBolognaItaly

Land capability and suitability maps are useful tools for soil resource *** study aimed to build land capability and suitability maps using a multi-thematic approach by GIS in a salt-affected coastal area of ***,morphological,geological,pedological delineations and land cover maps,remote sensing image and climate data were acquired and the main physical and chemical properties,including electrical conductivity(EC)and available water capacity,were analysed on the soil samples collected in the study *** acquired information were elaborated through QGIS software to obtain the land capability and suitability *** suitability map showed that most of the area(80%)is suitable for cultivation and,therefore,can be addressed for agricultural purposes without risk of *** fact,the land capability map showed that 42%of the investigated area belongs to class I and II indicating that they can be used for a wide range of *** 44%of the investigated area clustered in class III and *** these latter the cultivation should be allowed to a limited range of crops due to the high sand content,which does not allow a good water retention,and due to a strong intrusion of sea water with consequent increase of the soil *** our study area,where agricultural productivity and environmental impact are in conflict,to classify the lands on base the land capability and suitability could help to define the best agricultural practices to apply in order to preserve soil functions.

关键词： Agricultural lands Salt affected soils Geographic information system Land capability map Land suitability map

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Nature-derived compounds modulating Wnt/β-catenin pathway:a preventive and therapeutic opportunity in neoplastic diseases

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Acta Pharmaceutica Sinica B 2020年第10期10卷 1814-1834页

作者： Gianluca Sferrazza Marco Corti gloria Brusotti Pasquale Pierimarchi Caterina Temporini Annalucia Serafino Enrica Calleri Department of Drug Sciences University of PaviaPavia 27100Italy Institute of Translational Pharmacology National Research Council of ItalyRome 03018Italy

The Wnt/β-catenin signaling is a conserved pathway that has a crucial role in embryonic and adult *** of the Wnt/β-catenin pathway has been associated with diseases including cancer,and components of the sisnaling have been proposed as innovative therapeutic targets,mainly for cancer *** attention of the worldwide researchers paid to this issue is increasing,also in view of the therapeutic potential of these agents in diseases,such as Parkinson’s disease(PD),for which no cure is existing *** evidence indicates that abnormal Wnt/β-catenin signaling is involved in tumor immunology and the targeting of Wnt/β-catenin pathway has been also proposed as an attractive strategy to potentiate cancer *** the last decade,several products,including naturally occurring dietary agents as well as a wide variety of products from plant sources,including curcumin,quercetin,berberin,and ginsenosides,have been identified as potent modulators of the Wnt/β-catenin signaling and have gained interest as promising candidates for the development of chemopreventive or therapeutic drugs for *** this review we make an overview of the nature-derived compounds reported to have antitumor activity by modulating the Wnt/β-catenin signaling,also focusing on extraction methods,chemical features,and bio-activity assays used for the screening of these compounds.

关键词： Wnt/β-catenin pathway Nature-derived compounds Anticancer therapy Cancer prevention

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Three-dimensional organ modeling based on deformable surfaces applied to radio-oncology

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第6期11卷 407-417页

作者： gloria BUENO Oscar DéNIZ Jesús SALIDO Carmen CARRASCOSA José M. DELGADO Grupo de Visióny Sistemas Inteligentes Universidad de Castilla-La Mancha E.T.S. Ingenieros Industriales Avda. Camilo José Cela 3. 13071 Ciudad Real Spain Hospital General de Ciudad Real Tomelloso s/n. 13005 Ciudad Real Spain Instituto Oncológico (Grupo IMO) Modesto Lafuente 14 28010 Madrid Spain

This paper describes a method based on an energy minimizing deformable model applied to the 3D biomechanical modeling of a set of organs considered as regions of interest (ROI) for radiotherapy. The initial model consists of a quadratic surface that is deformed to the exact contour of the ROI by means of the physical properties of a mass-spring system. The exact contour of each ROI is first obtained using a geodesic active contour model. The ROI is then parameterized by the vibration modes resulting from the deformation process. Once each structure has been defined, the method provides a 3D global model including the whole set of ROIs. This model allows one to describe statistically the most significant variations among its structures. Statistical ROI variations among a set of patients or through time can be analyzed. Experimental results are presented using the pelvic zone to simulate anatomical variations among structures and its application in radiotherapy treatment planning.

关键词： 3D biomechanical organ modeling Energy minimizing deformable model Finite element model Geodesic active contour Radiotherapy treatment planning

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Endoscopic ultrasound-guided celiac plexus neurolysis using a reverse phase polymer

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World Journal of Gastroenterology 2010年第6期16卷 728-731页

作者： Keith L Obstein Fernanda P Martins gloria Fernández-Esparrach Christopher C Thompson Gastroenterology Division Brigham and Women's Hospital Federal University of So Paulo Department of Gastroenterology Endoscopy UnitHospital Clinic(Spain)

AIM:To assess the feasibility of endoscopic ultrasound(EUS)guided celiac plexus neurolysis(CPN) using a poloxamer. METHODS:In this prospective evaluation,six Yorkshire pigs underwent EUS-guided *** received an injection of 10 mL of 0.25%Lidocaine plus methylene blue(group 1) and three received an injection of 10 mL of 0.25%Lidocaine plus blue colored poloxamer(PS137-25)(group 2) .Necropsy was performed immediately after the animals were *** abdominal and pelvic cavities were examined for the presence of methylene blue and the blue colored ***:EUS-guided CPN was successfully performed in all 6 pigs without immediate *** blue was identified throughout the peritoneal and retroperitoneal cavity in group *** blue colored poloxamer was found in the retroperitoneal cavity immediately adjacent to the aorta,in the exact location of the celiac plexus in group ***:EUS-guided CPN using a reverse phase polymer in a non-survival porcine model was technically *** presence of a poloxamer gel at the site of the celiac plexus at necropsy indicates a precise delivery of the neurolytic agent.

关键词： Celiac plexus neurolysis Celiac plexus blockade Endoscopic ultrasound Polymer

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Increased risk of postsurgical macular edema in high stage idiopathic epiretinal membranes

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Eye and Vision 2021年第1期8卷 286-294页

作者： Lorenzo Iuliano gloria Cisa di Gresy Giovanni Fogliato Eleonora Corbelli Francesco Bandello Marco Codenotti Department of Ophthalmology Vita-Salute UniversitySan Raffaele Scientific InstituteVia Olgettina 6020132 MilanItaly

Purpose:To assess the rate of occurrence and the risk factors of postsurgical macular edema(PSME)in eyes with idiopathic epiretinal membrane(iERM)or full-thickness macular hole(FTMH).Methods:Retrospective longitudinal analysis of all subjects scheduled for vitrectomy with or without combined cataract surgery over a 6-month *** medical charts and imaging data were analyzed preoperatively and at 1,3 and 6 months after ***:From 101 patients diagnosed with iERM or FTMH,71 patients were eligible for the ***-nine eyes with iERM(69.0%)and 22 eyes with FTMH(31.0%)underwent vitrectomy either isolated(31.0%)or combined with cataract extraction(69.0%).The overall rate of PSME was 26.7%,without differences between the two groups(P=0.9479).Combined cataract extraction did not affect the overall occurrence of PSME rate in both groups(P=0.9255 in FTMH and P=0.8658 in iERM).If grouped by stage,eyes with stage 4 iERM though disclosed an increased rate of PSME(57.1%)compared to lower(1 to 3)stages(14.3%,P=0.0021),particularly when combined with cataract surgery(71.4%vs.15.4%in stages≤3,P=0.0021).The PSME odds ratio for a stage 4 iERM is 8(95%CI:1.933-33.1;P=0.0041)compared to stages 3 and ***:PSME remains a clinically relevant and frequent event after surgery for iERM and *** with stage 4 iERM have an 8-fold higher likelihood of developing PSME in a 6-month postsurgical period compared to iERM in 1-3 stages,especially when combined with cataract extraction.

关键词： Epiretinal membrane Macular edema Macular hole Vitrectomy Postsurgical macular edema

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Nutritional value of high fiber co-products from the copra,palm kernel,and rice industries in diets fed to pigs

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Journal of Animal Science and Biotechnology 2016年第2期7卷 125-133页

作者： Hans Henrik Stein gloria Amparo Casas Jerubella Jerusalem Abelilla Yanhong Liu Rommel Casilda Sulabo Department of Animal Science University of IllinoisUrbana 61801USA Departamento de Produccion Animal Facultad de Medicina Veterinariay deZootecniaUniversidad Nacional de ColombiaBogotaColombia. University of California Davis 95616USA. University of the Philippines Los BanosPhilippines.

High fiber co-products from the copra and palm kernel industries are by-products of the production of coconut oil and palm kernel oil. The co-products include copra meal, copra expellers, palm kernel meal, and palm kernel expellers. All 4 ingredients are very high in fiber and the energy value is relatively low when fed to pigs. The protein concentration is between 14 and 22 % and the protein has a low biological value and a very high Arg：Lys ratio. Digestibility of most amino acids is less than in soybean meal but close to that in corn. However, the digestibility of Lys is sometimes low due to Maillard reactions that are initiated due to overheating during *** and palm kernel ingredients contain 0.5 to 0.6 % P. Most of the P in palm kernel meal and palm kernel expellers is bound to phytate, but in copra products less than one third of the P is bound to phytate. The digestibility of P is, therefore, greater in copra meal and copra expellers than in palm kernel ingredients. Inclusion of copra meal should be less than 15 % in diets fed to weanling pigs and less than 25 % in diets for growing-finishing pigs. Palm kernel meal may be included by 15 % in diets for weanling pigs and 25 % in diets for growing and finishing *** bran contains the pericarp and aleurone layers of brown rice that is removed before polished rice is *** bran contains approximately 25 % neutral detergent fiber and 25 to 30 % starch. Rice bran has a greater concentration of P than most other plant ingredients, but 75 to 90 % of the P is bound in phytate. Inclusion of microbial phytase in the diets is, therefore, necessary if rice bran is used. Rice bran may contain 15 to 24 % fat, but it may also have been defatted in which case the fat concentration is less than 5 %. Concentrations of digestible energy（DE） and metabolizable energy（ME） are slightly less in full fat rice bran than in corn, but defatted rice bran contains less than 75 % of the DE and ME in corn. The concentrat

关键词： Copra expellers Copra meal Palm kernel expellers Palm kernel meal Rice bran

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Utilizing Statistical Semantic Similarity Techniques for Ontology Mapping——with Applications to AEC Standard Models

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Tsinghua Science and Technology 2008年第S1期13卷 217-222页

作者： Chin-Pang Jack Cheng gloria T. Lau Kincho H. Law Engineering Informatics Group Stanford University

The objective of this paper is to introduce three semi-automated approaches for ontology mapping using relatedness analysis techniques. In the architecture, engineering, and construction (AEC) industry, there exist a number of ontological standards to describe the semantics of building models. Although the standards share similar scopes of interest, the task of comparing and mapping concepts among standards is challenging due to their differences in terminologies and perspectives. Ontology mapping is therefore necessary to achieve information interoperability, which allows two or more information sources to exchange data and to re-use the data for further purposes. The attribute-based approach, corpus-based approach, and name-based approach presented in this paper adopt the statistical relatedness analysis techniques to discover related concepts from heterogeneous ontologies. A pilot study is conducted on IFC and CIS/2 ontologies to evaluate the approaches. Preliminary results show that the attribute-based approach outperforms the other two approaches in terms of precision and F-measure.

关键词： ontology mapping similarity analysis information interoperation statistical analysis techniques

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Botulinum toxin associated with fissurectomy and anoplasty for hypertonic chronic anal fissure: A case-control study

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World Journal of Clinical Cases 2021年第32期9卷 9722-9730页

作者： Beatrice D'Orazio Girolamo Geraci Fausto Famà gloria Terranova Gaetano Di Vita Department of Surgical Oncological and Stomatological SciencesUniversity of PalermoPalermo 90100SicilyItaly Department of Human Pathology in Adulthood and Childhood"G.Barresi" University Hospital of MessinaMessina 98121SicilyItaly Department of Surgical Oncological and Stomatological SciencesPostgraduate Medical School in General SurgeryUniversity of PalermoPalermo 90100SicilyItaly

BACKGROUND Lateral internal sphincterotomy is still the approach of choice for the treatment of chronic anal fissure(CAF)with internal anal sphincter(IAS)hypertonia,but it is burdened by high-risk postoperative faecal incontinence(FI).Sphincter saving procedures have recently been reconsidered as treatments to overcome this *** most employed procedure is fissurectomy with anoplasty,eventually associated with pharmacological *** To evaluate whether fissurectomy and anoplasty with botulinum toxin injection improves the results of fissurectomy and anoplasty *** We conducted a case-control study involving 30 male patients affected by CAF with hypertonic IAS who underwent fissurectomy and anoplasty with V-Y cutaneous flap *** patients were divided into two groups:Those in group I underwent surgery alone,and those in group II underwent surgery and a botulinum toxin injection directly into the *** were followed up for at least 2 *** goals were to achieve complete healing of the patient and to assess the FI and recurrence rate along with manometry *** The intensity and duration of post-defecatory pain decreased significantly in both groups of patients starting with the first defecation,and this reduction was higher in group *** days after surgery,we achieved complete wound healing in all the patients in group II but only in 80%of the patients in group I(P<0.032).We recorded 2 cases of recurrence,one in each group,and both healed with conservative *** recorded one temporary and low-grade postoperative case of“de novo”*** parameters reverted to the normal range earlier for group II *** The injection of botulinum toxin A in association with fissurectomy and anoplasty with a V-Y advancement flap improves the results of surgery alone in patients affected by CAF with IAS hypertonia.

关键词： Proctology Fissurectomy Anoplasty Anal fissure Botulinum toxin

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Overcoming endocrine resistance in metastatic breast cancer: Current evidence and future directions

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World Journal of Clinical Oncology 2014年第5期5卷 990-1001页

作者： Andrea Milani Elena Geuna gloria Mittica Giorgio Valabrega Institute for Cancer Research and Treatment at Candiolo University of Torino Medical School FPO(Fondazione del Piemonte per l'Oncologia) Department of Oncology University of Torino Medical School

About 75% of all breast cancers are estrogen receptor(ER)-positive. They generally have a more favorable clinical behavior, prognosis, and pattern of recurrence, and endocrine therapy forms the backbone of treatment. Anti-estrogens(such as tamoxifen and fulvestrant) and aromatase inhibitors(such as anastrozole, letrozole, and exemestane) can effectively control the disease and induce tumor responses in a large proportion of patients. However, the majority of patients progress during endocrine therapy(acquired resistance) and a proportion of patients may fail to respond to initial therapy(de novo resistance). Endocrine resistance is therefore of clinical concern and there is great interest in strategies that delay or circumvent it. A deeper knowledge of the molecular mechanisms that drive endocrine resistance has recently led to development of new strategies that have the promise to effectivelyovercome it. Many resistance mechanisms have been described, and the crosstalk between ER and growth factor receptor signaling pathways seems to represent one of the most relevant. Compounds that are able to inhibit key elements of these pathways and restore endocrine sensitivity have been studied and more are currently under development. The aim of this review is to summarize the molecular pathophysiology of endocrine resistance in breast cancer and its impact on current clinical management.

关键词： Everolimus Mammalian target of rapamycin PI3K inhibitors Estrogen receptor Endocrine resistance

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西南天山前陆盆地侏罗纪-白垩纪盆山格局——来自碎屑锆石年代学的证据

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大地构造与成矿学 2017年第3期41卷 533-550页

作者：杨威郭召杰姜振学 gloria Heilbronn 张晨王思维中国石油大学(北京)油气资源与探测国家重点实验室北京102249 中国石油大学(北京)非常规天然气研究院北京102249 北京大学地球与空间科学学院北京100871 Géosciences Rennes Université Rennes 1 中国石油大学(北京)地球科学学院北京102249

目前对天山地区,特别是天山南缘中生代盆山格局认识尚存分歧。本文着眼于侏罗纪-白垩纪这一盆山演化关键阶段,利用碎屑锆石LA-ICP-MS U-Pb定年法对西南天山前陆盆地康苏剖面中侏罗统杨叶组、下白垩统克孜勒苏群沉积开展物源分析。发现... 详细信息

目前对天山地区,特别是天山南缘中生代盆山格局认识尚存分歧。本文着眼于侏罗纪-白垩纪这一盆山演化关键阶段,利用碎屑锆石LA-ICP-MS U-Pb定年法对西南天山前陆盆地康苏剖面中侏罗统杨叶组、下白垩统克孜勒苏群沉积开展物源分析。发现中侏罗统杨叶组碎屑锆石U-Pb年龄分布于369~2687 Ma间,基本分布在369~404 Ma(约占4%)、418~501 Ma(约占19%)和544~2687 Ma(约占77%)3个范围;下白垩统克孜勒苏群碎屑锆石U-Pb年龄分布于243~2820 Ma间,集中于253~414 Ma(约占35%)、423~489 Ma(约占27%)和668~2820 Ma(约占37%)3个范围。中侏罗统碎屑锆石年龄分布范围广,各年龄组分均较突显,反映中侏罗世西南天山前缘流域体系宽广,天山内各主要源区均得到沟通,物源范围广阔。下白垩统克孜勒苏群锆石年龄分布明显集中,反映早白垩世西南天山前缘源区范围有所缩小。西南天山前缘与库车前陆盆地的物源构成在中侏罗世存在一定差异,而在早白垩世呈现相似特征。包括西南天山前陆盆地在内的天山南缘或于早白垩世经历一期小规模构造反转,导致山-盆构造分异与抬升-剥蚀增强。

关键词：西南天山碎屑锆石U-Pb年龄物源盆山格局构造反转

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