检索结果-南通市图书馆

Assessing the impact of TB/HIV services integration on TB treatment outcomes and their relevance in TB/HIV monitoring in Ghana

引用

Infectious Diseases of Poverty 2012年第1期1卷 110-117页

作者： gloria akosua ansa John D Walley Kamran Siddiqi Xiaolin Wei University Hospital LegonUniversity of GhanaP.O.Box LG 79LegonAccraGhana Nuffield Centre for International Health and Development University of Leeds101 Clarendon RoadLeeds LS29LJUnited Kingdom Department of Health Sciences The University of YorkSeebohm Rowntree BuildingHeslingtonYork YO105DDUnited Kingdom School of Public Health and Primary Care Chinese University of Hong KongHong KongChina

Background:The impact of the human immunodeficiency virus(HIV)on tuberculosis(TB),and the implications for TB and HIV control,is a public health challenge in Ghana-almost a quarter(23%)of all TB cases were HIV positive in *** integration of TB/HIV services has therefore emerged as an essential component of the national response to TB and *** aim is to reduce fragmentation,improve access,enhance efficiency and improve quality of ***’s TB/HIV policy comprises three linked sets of activities:effective implementation of the Stop TB Strategy for TB control,improved HIV prevention and care,and the implementation of additional TB/HIV *** models of service delivery with increasing integration of TB/HIV activities are expected to provide greater access to more comprehensive *** objective of this paper is to assess the impact of TB/HIV integration on TB treatment outcomes and to explore the usefulness of TB treatment outcomes as TB/HIV ***:A before-and-after study to observe the introduction of TB/HIV activities into TB programmes in three hospitals with different levels of integration was *** patient data was collated from TB registers from each facility,and analysed to determine if TB treatment outcomes changed significantly after ***:TB treatment success was 50%(95%CI 49-52)prior to,and 69%(95%CI 65-73)after,integration(Χ243.96,p<0.00).Treatment success increased from 43%to 53%at the one-stop shop(OSS),from 69%to 78%at the partially integrated site(PIS)and substantially from 46%to 78%at the referral site(RS)(Χ264.54;p<0.01).Defaults and cases transferred out reduced from 14.3%and 15.3%prior to integration,to 1.4%and 9.0%after integration,respectively,accounting for a significant increase in treatment *** rates remained high at 18%in all cases studied and 25%in HIV-associated cases after ***:TB/HIV integration may improve TB treatment success,but its exact impa

关键词： Tuberculosis HIV Integration Indicator Treatment outcome Referral Partial integration One-stop shop

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Escherichia coil Removal in Tropical Oligotrophic and Eutrophic Lakes

引用

Journal of Environmental Science and Engineering(A) 2013年第12期2卷 719-724页

作者： Ebenezer David Okwaning ansa Anthonia Helga Andoh gloria akosua ansa Jackson Adiyiah MikeAgbesi Acheampong Water Research Institute Council for Scientific & Industrial Research Accra Ghana Department of Public Health University Hospital Accra Ghana Department of Field Operations Environmental Protection Agency Sunyani Ghana Department of Chemical Engineering Kumasi Polytechnic Kumasi Ghana

The mechanisms by which oligotrophic and eutrophic lakes rid itself of Escherichia coli or faecal coliforms are still not clearly understood. This study sought to review the various means by which E. coli or faecal coliforms are inactivated or removed in lakes. The review cited temperature, solar radiation, predation, starvation, attachment and sedimentation as key factors that aid the removal of E. coli in lakes. In eutrophic lakes additional factors such as the role of algal biomass may play a role due to increased pH and dissolved oxygen levels attributed to algal presence. Algal toxins or exudates may also play a role although this is still under debate. The interactive effect of two or more of these factors on E. coli inactivation and the relative importance of these mechanisms on E. coli removal are still not known. Areas for further research include the role of algae in sedimenting E. coli or faecal coliforms and the possible role of algal exudates on E. coli inactivation.

关键词： Predation sedimentation solar radiation starvation temperature.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

King's College criteria and the Clichy-Villejuif criteria require adjustments for assessing acute liver failure due to yellow fever

引用

World Journal of Transplantation 2025年第1期15卷 124-134页

作者： Bruno da Silva Athanasio Antonio Marcio de Faria Andrade Vivian Vasconcelos Costa Juliano Felix Castro Silverio Leonardo Macedo Garcia Mauro Martins Teixeira Daniele da gloria Souza Paula Vieira Teixeira Vidigal Cristiano Xavier Lima Department of Surgery Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Liver Transplantation Unit Felicio Rocho HospitalBelo Horizonte 30110-934Minas GeraisBrazil Department of Morphology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Biochemistry and Immunology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Pathology Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Acute liver failure(ALF)is a severe condition characterized by rapid deterioration of liver function in individuals without preexisting liver *** transplantation(LT)is the most impactful *** fever(YF)is an infectious disease that primarily affects the liver and has a high mortality ***,LT can be a viable option for treating rare cases with extensive liver ***,the criteria for assessing the severity of ALF and determining the indications for transplantation have not been specifically validated for cases caused by *** To present necessary adjustments to established scoring systems for ALF secondary to *** This was an observational,retrospective,single-center *** consecutive patients with confirmed ALF due to YF were monitored in the intensive care unit by a specialized liver transplant team during a three-month epidemic outbreak in *** hospitalization,general supportive therapeutic measures were implemented,and the patients were regularly assessed using the King's College criteria and the Clichy-Villejuif criteria to determine the severity of liver *** is considered a viable measure for patients with signs of end-stage liver *** Eight of 14(57%)patients developed severe neurological alterations within the first 96 hours after hospital *** patients underwent emergency LT,and despite a moderate viral infection of the graft after transplantation,the 5-year survival rate was 50%.Although the King's College criteria and the Clichy-Villejuif criteria are the main scoring systems for ALF,they are insufficient for predicting the risk of mortality in this context,primarily because of low serum bilirubin levels in the final stage of the disease and significant disparities between coagulation abnormalities and patient *** To ensure good applicability in cases of YF-induced ALF,the authors suggest adaptations to the King's College and Clichy-Vill

关键词： Yellow fever Acute liver failure Liver transplantation King's College criteria Clichy-Villejuif criteria

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enterolithiasis

引用

World Journal of Gastroenterology 2014年第47期20卷 17819-17829页

作者： Grigoriy E Gurvits gloria Lan Division of Gastroenterology New York University School of Medicine/Langone Medical CenterNew YorkNY 10016United States Department of Medicine New York University School of MedicineNew YorkNY 10016United States

Enterolithiasis or formation of gastrointestinal concretions is an uncommon medical condition that develops in the setting of intestinal stasis in the presence of the intestinal diverticula, surgical enteroanastomoses, blind pouches, afferent loops, incarcerated hernias, small intestinal tumors, intestinal kinking from intra-abdominal adhesions, and stenosing or stricturing Crohn’s disease and intestinal tuberculosis. Enterolithiasis is classified into primary and secondary types. Its prevalence ranges from 0.3% to 10% in selected populations. Proximal primary enteroliths are composed of choleic acid salts and distal enteroliths are calcified. Clinical presentation includes abdominal pains, distention, nausea, and vomiting of occasionally sudden but often fluctuating subacute nature which occurs as a result of the enterolith tumbling through the bowel lumen. Thorough history and physical exam coupled with radiologic imaging helps establish a diagnosis in a patient at risk. Complications include bowel obstruction, direct pressure injury to the intestinal mucosa, intestinal gangrene, intussusceptions, afferent loop syndrome, diverticulitis, iron deficiency anemia, gastrointestinal hemorrhage, and perforation. Mortality of primary enterolithiasis may reach 3% and secondary enterolithiasis 8%. Risk factors include poorly conditioned patients with significant obstruction and delay in diagnosis. Treatment relies on timely recognition of the disease and endoscopic or surgical intervention. With advents in new technology, improved outcome is expected for patients with enterolithiasis.

关键词： Enterolithiasis Gallstone ileus Intestinal obstruction Crohn’ s disease Meckel’ s diverticulum Diverticulosis Intestinal tuberculosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Structural and functional insights into the TEAD-YAP complex in the Hippo signaling pathway

引用

Protein & Cell 2010年第12期1卷 1073-1083页

作者： Liming Chen Portia gloria Loh Haiwei Song Cancer and Developmental Cell Biology Division Institute of Molecular and Cell BiologyA*STAR(Agency for ScienceTechnology and Research)61 Biopolis DriveSingapore 138673Republic of Singapore Department of Biological Sciences National University of Singapore14 Science Drive 4Singapore 117543Republic of Singapore School of Biological Sciences Nanyang Technological University50 Nanyang AvenueSingapore 639798Republic of Singapore

The control of organ size growth is one of the most fundamental aspects of *** the past two decades,a highly conserved Hippo signaling pathway has been identified as a key molecular mechanism for governing organ size *** the middle of this pathway is a kinase cascade that negatively regulates the downstream component Yes-associated protein(YAP)/transcriptional coactivator with PDZ-binding motif(TAZ)/Yorkie through *** of YAP/TAZ/Yorkie promotes its cytoplasmic localization,leads to cell apoptosis and restricts organ size *** the Hippo pathway is inactivated,YAP/TAZ/Yorkie translocates into the nucleus to bind to the transcription enhancer factor(TEAD/TEF)family of transcriptional factors to promote cell growth and *** this review,we will focus on the structural and functional studies on the downstream transcription factor TEAD and its coactivator YAP.

关键词： Hippo Yes-associated protein(YAP) transcription enhancer factor(TEAD) Yki phosphorylation crystal structure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asymmetric dimethylarginine as a mediator of vascular dysfunction in cirrhosis

引用

World Journal of Gastroenterology 2015年第32期21卷 9466-9475页

作者： Paloma Lluch gloria Segarra Pascual Medina Department of Gastroenterology and Hepatology and Institute of Health Research INCLIVA Hospital Clínico Universitario Valencia Department of Physiology University of Valencia and Institute of Health Research INCLIVA Hospital Clínico Universitario Valencia

Cirrhosis is associated with marked abnormalities in the circulatory function that involve a reduction in systemic vascular resistance. An important cause of this vasodilatation is the increased production or activity of nitric oxide(NO) in the splanchnic circulation. During portal hypertension and cirrhosis an increased endothelial NO synthase(e NOS) activity is demonstrated in splanchnic vessels. In contrast, the activity of e NOS in the cirrhotic liver is decreased, which suggests a different regulation of e NOS in the liver and in the splanchnic vessels. Asymmetric dimethylarginine(ADMA) is an endogenous NO inhibitor and higher plasma levels of ADMA are related to increased cardiovascular risk in both the general population and among patients with cirrhosis. It has been demonstrated that the liver is a key player in the metabolism of ADMA. This observation was further supported by investigations in human patients, showing a close correlation between ADMA plasma levels and the degree of hepatic dysfunction. ADMA is degraded to citrulline and dimethylamine by dimethylarginine dimethylaminohydrolases(DDAHs). DDAHs are expressed as type 1 and 2 isoforms and are widely distributed in various organs and tissues, including the liver. In this review, we discuss experimental and clinical data that document the effects of dimethylarginines on vascular function in cirrhosis. Our increasing understanding of the routes of synthesis and metabolism of methylarginines is beginning to provide insights into novel mechanisms of liver disease and allowing us to identify potential therapeutic opportunities.

关键词： Dimethylarginine dimethylaminohydrolase Nitric oxi

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Refining Linked Data with Games with a Purpose

引用

Data Intelligence 2020年第3期2卷 417-442页

作者： Irene Celino gloria Re Calegari Andrea Fiano Cefriel Milano 20126Italy

With the rise of linked data and knowledge graphs,the need becomes compelling to find suitable solutions to increase the coverage and correctness of data sets,to add missing knowledge and to identify and remove *** approaches-mostly relying on machine learning and natural language processing techniques-have been proposed to address this refinement goal;they usually need a partial gold standard,i.e.,some“ground truth”to train automatic *** standards are manually constructed,either by involving domain experts or by adopting crowdsourcing and human computation *** this paper,we present an open source software framework to build Games with a Purpose for linked data refinement,i.e.,Web applications to crowdsource partial ground truth,by motivating user participation through fun *** detail the impact of this new resource by explaining the specific data linking“purposes”supported by the framework(creation,ranking and validation of links)and by defining the respective crowdsourcing tasks to achieve those *** also introduce our approach for incremental truth inference over the contributions provided by players of Games with a Purpose(also abbreviated as GWAP):we motivate the need for such a method with the specificity of GWAP *** crowdsourcing;we explain and formalize the proposed process,explain its positive consequences and illustrate the results of an experimental comparison with state-of-the-art *** show this resource’s versatility,we describe a set of diverse applications that we built on top of it;to demonstrate its reusability and extensibility potential,we provide references to detailed documentation,including an entire tutorial which in a few hours guides new adopters to customize and adapt the framework to a new use case.

关键词： Human computation Games with a purpose Linked data Knowledge graph Data refinement Data linking Truth inference

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SIRENE: A Spatial Data Infrastructure to Enhance Communities' Resilience to Disaster-Related Emergency

引用

International Journal of Disaster Risk Science 2018年第1期9卷 129-142页

作者： Simone Sterlacchini gloria Bordogna Giacomo Cappellini Debora Voltolina Institute for the Dynamics of Environmental Processes –National Research Council of Italy (CNR-IDPA) Institute for Electromagnetic Sensing of the Environment –National Research Council of Italy (CNR-IREA)

Planning in advance to prepare for and respond to a natural hazard-induced disaster-related emergency is a key action that allows decision makers to mitigate unexpected impacts and potential damage. To further this aim, a collaborative, modular, and information and communications technology-based Spatial Data Infrastructure(SDI)called SIRENE—Sistema Informativo per la Preparazione e la Risposta alle Emergenze(Information System for Emergency Preparedness and Response) is designed and implemented to access and share, over the Internet, relevant multisource and distributed geospatial data to support decision makers in reducing disaster risks. SIRENE flexibly searches and retrieves strategic information from local and/or remote repositories to cope with different emergency phases. The system collects, queries, and analyzes geographic information provided voluntarily by observers directly in the field(volunteered geographic information(VGI) reports) to identify potentially critical environmental conditions. SIRENE can visualize and cross-validate institutional and research-based data against VGI reports,as well as provide disaster managers with a decision support system able to suggest the mode and timing of intervention, before and in the aftermath of different types of emergencies, on the basis of the available information and in agreement with the laws in force at the national andregional levels. Testing installations of SIRENE have been deployed in 18 hilly or mountain municipalities(12 located in the Italian Central Alps of northern Italy, and six in the Umbria region of central Italy), which have been affected by natural hazard-induced disasters over the past years(landslides, debris flows, floods, and wildfire) and experienced significant social and economic losses.

关键词： Data retrieval Decision support system Disaster management Italy Spatial data infrastructure Susceptibility/hazard and risk maps Volunteered geographic information

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of elevated atmospheric CO2 and nitrogen fertilization on nitrogen cycling in experimental riparian wetlands

引用

Water Science and Engineering 2018年第1期11卷 39-45页

作者： Jun Liu gloria Appiah-Sefah Theresa Oteng Apreku College of Materials Science and Technology Nanjing Forestry UniversityNanjing 210037China Nanjing Technical Vocational College Nanjing 210019China Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes of Ministry of Education Hohai UniversityNanjing 210098China

Studies on the relationship between plant nitrogen content and soil nitrogen reduction under elevated CO2 conditions and with different nitrogen additions in wetland ecosystems are lacking. This study was meant to assess the effects of elevated CO2 concentrations and inorganic nitrogen additions on soil and plant nitrogen cycling. A cultured riparian wetland, alligator weeds, and two duplicated open top chambers （OTCs） with ambient （380μmol/mol） and elevated （700 μmol/mol） CO2 concentrations at low （4 mg/L） and high （6 mg/L） nitrogen fertilization levels were used. The total plant biomass increased by 30.77% and 31.37% at low and high nitrogen fertilization levels, respectively, under elevated CO2 conditions. Plant nitrogen content decreased by 6.54% and 8.86% at low and high nitrogen fertilization levels, respectively. The coefficient of determination （R2） of soil nitrogen contents ranged from 0.81 to 0.96. Under elevated CO2 conditions, plants utilized the assimilated inorganic nitrogen （from the soil） for growth and other internal physiological transformations, which might explain the reduction in plant nitrogen content. A reduction in soil dissolved inorganic nitrogen （DIN） under elevated CO2 conditions might have also caused the reduction in plant nitrogen content. Reduced plant and soil nitrogen contents are to be expected due to the potential exhaustive use of inorganic nitrogen by soil microorganisms even before it can be made available to the soil and plants. The results from this study provide important information to help policy makers make informed decisions on sustainable management of wetlands. Larger-scale field work is recommended in future research.

关键词： Elevated CO2 concentration Invasive species Plant growth Climate change Inorganic nitrogen Nitrogen cycling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Assessing the impact of heat mitigation measures on thermal performance and energy demand at the community level:A pathway toward designing net-zero energy communities

引用

Building Simulation 2024年第8期17卷 1379-1400页

作者： Khan Rahmat Ullah Veljko Prodanovic gloria Pignatta Ana Deletic Mattheos Santamouris School of Built Environment Faculty of ArtsDesign&ArchitectureUniversity of New South WalesSydney2052 NSWAustralia School of Civil and Environmental Engineering University of New South WalesSydney2052 NSWAustralia Institute for Artificial Intelligence Research and Development of Serbia 21000 Novi SadSerbia Institute for Multidisciplinary Research University of BelgradeKneza Višeslava 111000 BelgradeSerbia School of Civil and Environmental Engineering Engineering FacultyQueensland University of TechnologyQLD 4001Australia

In the context of escalating global energy demands,urban areas,specifically the building sector,contribute to the largest energy consumption,with urban overheating exacerbating this *** urban modelling for heat-mitigation and reduction of energy demand is crucial steps towards a sustainable built-environment,complementing onsite energy generation in the design and development of Net-zero Energy(NZE)Settlement,especially in the context of Australian weather *** a significant gap in existing literature,this study offers empirical analysis on the climate and energy efficacy of integrated heat mitigation strategies applied in 14 neighbourhood typologies located in Sydney,*** the application of cool materials on roads,pavements,and rooftops,alongside urban vegetation enhancement,the analysis demonstrates scenario effectiveness on heat mitigation that leads to reduce ambient temperature and energy demands along with CO_(2)emissions within the *** building arrangement,built-area ratio,building height,and locations,ENVI-met and CitySim are utilized to assess the heat-mitigation and the energy demand of neighbourhoods,*** indicate that mitigation measures can lead up to a 2.71℃reduction in ambient temperature and over 25%reduction in Cooling Degree Hours,with a 34.34%reduction in cooling energy demand and overall energy savings of up to 12.49%.In addition,the annual energy-saving yields a CO_(2)reduction of approximately 141.12 tonnes,where additional vegetation further amplifies these reductions by enhancing CO_(2)*** study showcases the pathway towards achieving NZE goals in climates similar to that of Australia,highlighting significant benefits in heat-mitigation,environmental impact,and energy-savings.

关键词： urban overheating cool materials vegetation,heat mitigation energy savings CO_(2)reduction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：