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The EsCRT protein CHMP5 escorts αβ T cells through positive selection

Cellular & Molecular Immunology 2018年第7期15卷 654-656页

作者： glendon s wu Craig H Bassing Immunology Graduate Group Perelman School of Medicine at the University of PennsylvaniaPhiladelphiaPA 19104USA Divsion of Cancer Pathobiology Department of Pathology and Laboratory MedicineChildren’s Hospital of PhiladelphiaAbramson Family Cancer Research InstitutePerelman School of Medicine at the University of PennsylvaniaPhiladelphiaPA 19104USA

αβ T lymphocytes are critical for host protection against pathogens and are notable for their recent use as immunotherapeutic agents for the treatment of human ***,their dysfunction is associated with a variety of disease states,including autoimmune and immunodeficient syndromes that frequently result from improper αβT cell development in the *** thymic egress,mature αβ T cells are activated when their surface T-cell receptor(TCR)engages peptide antigens displayed by major histocompatibility complex(MHC)proteins expressed on antigenpresenting *** the thymus,each developing αβ T cell(thymocyte)recombines its TCRβ and TCRαgenes in an attempt to assemble and express a unique functional αβ TCR。

关键词： lymphocytes autoimmune combine

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Flip the switch: BTG2–PRMT1 protein complexes antagonize pre-B-cell proliferation to promote B-cell development

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Cellular & Molecular Immunology 2018年第9期15卷 808-811页

作者： glendon s wu Craig H Bassing Immunology Graduate Group Children’s Hospital of PhiladelphiaPerelman School of Medicine at the University of PennsylvaniaPhiladelphiaPA 19104USA Divsion of Cancer Pathobiology Department of Pathology and Laboratory MedicineChildren’s Hospital of PhiladelphiaAbramson Family Cancer Research InstitutePerelman School of Medicine at the University of PennsylvaniaPhiladelphiaPA 19104USA

B lymphocytes are vital components of vertebrate adaptive immune ***,B-cell dysfunction can promote autoimmunity and immunodefi-ciency,and errors in development can cause B-lineage lymphoid malignancies.B-cell development requires RAG1/RAG2(RAG)endonuclease-mediated assembly of immunoglobulin(Ig)*** assembly of Ig heavy chain(IgH)genes in G1-phase pro-B cells produces IgH proteins that pair with VpreB/λ5 to form pre-B-cell receptor(pre-BCR)*** pro-B cells,pre-BCR signaling inhibits Rag1/Rag2 transcription,stabilizes Cyclin D3 to drive cellular proliferation and promotes differentiation of large pre-B cells.

关键词： lymphocytes lymphoid complexes

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