Flip the switch: BTG2–PRMT1 protein complexes antagonize pre-B-cell proliferation to promote B-cell development

作     者：Glendon S Wu Craig H Bassing 

作者机构：Immunology Graduate GroupChildren’s Hospital of PhiladelphiaPerelman School of Medicine at the University of PennsylvaniaPhiladelphiaPA 19104USA Divsion of Cancer PathobiologyDepartment of Pathology and Laboratory MedicineChildren’s Hospital of PhiladelphiaAbramson Family Cancer Research InstitutePerelman School of Medicine at the University of PennsylvaniaPhiladelphiaPA 19104USA 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2018年第15卷第9期

页      面：808-811页

核心收录：

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by the Immune System Development and Regulation T32-AI055428(to GSW) the National Institutes of Health R01 grants AI112621 and AI112621(to CHB) 

主　　题：lymphocytes lymphoid complexes 

摘      要：B lymphocytes are vital components of vertebrate adaptive immune ***,B-cell dysfunction can promote autoimmunity and immunodefi-ciency,and errors in development can cause B-lineage lymphoid malignancies.B-cell development requires RAG1/RAG2(RAG)endonuclease-mediated assembly of immunoglobulin(Ig)*** assembly of Ig heavy chain(IgH)genes in G1-phase pro-B cells produces IgH proteins that pair with VpreB/λ5 to form pre-B-cell receptor(pre-BCR)*** pro-B cells,pre-BCR signaling inhibits Rag1/Rag2 transcription,stabilizes Cyclin D3 to drive cellular proliferation and promotes differentiation of large pre-B cells.