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Novel role for gabapentin in neuroprotection of central nervous system in streptozotocine-induced diabetic rats

Acta Pharmacologica Sinica 2005年第4期26卷 417-422页

作者： giyasettin baydas Ertugrul SONKAYA Mehmet TUZCU Abdullah YASAR Emir DONDER Department of Physiology Department of Internal Medicine College of Medicine Firat University Department of Biology Faculty of Science Firat University Elazig 23119 Turkey Department of Physiology Department of Internal Medicine College of Medicine Firat University

Aim:To investigate the effect of gabapentin on neural [neuron-specific enolase（NSE）] and glial markers [glial fibrillary acidic protein （GFAP） and S 100B] in differ-ent brain regions of diabetic ***:Diabetes was induced by a singleintraperitoneal injection of streptozotocine （50 mg/kg body weight）.Rats in onediabetic group received gabapentin (50 ***-1.d-1) and rats in the other diabeticgroup received vehicle only for 6 *** levels of GFAP,S100B,and NSE weredetermined by immunoblotting in the hippocampus,cortex,and *** （LPO as malondialdehyde+ 4-hydroxyalkenals） and glutathione （GSH）levels were also determined in the same brain ***:Total and degradedGFAP content and S100B protein expression in different areas of brain tissuessignificantly increased in diabetic rats compared to control ***,NSElevels were also significantly elevated in hyperglycemic *** addition,therewas a significant increase in LPO levels in the diabetic rat brain compared tocontrol rat *** with gabapentin prevented the upregulation ofGFAP,S 100B,and NSE in all brain regions of diabetic *** level of LPO wasreduced,but not completely halted,by treatment with ***:These results suggest that diabetes causes glial and neuronal injury,possibly asa result of elevated oxidative stress,and that gabapentin protects neurons andglial ***,we predict that gabapentin treatment will attenuate the hippo-campal and cortical neurodegeneration observed during diabetes mellitus in rats.

关键词： gabapentin glial fibrillary acidic protein neurotrophic protein S100beta phosphopyruvate hydratase lipid peroxidation

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The association of various social capital indicators and physical activity participation among Turkish adolescents

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Journal of Sport and Health Science 2018年第1期7卷 27-33页

作者： Günay Y1ld1zer Emre Bilgin Ezel Nur Korur Dario Novak giyasettin Demirhan Department of Physical Education and Sports Teaching Anadolu University Eskisehir 26555 Turkey Department of Physical Education and Sports Teaching Haeettepe University Ankara 06800 Turkey Department of Physical Education and Sports Teaching Ordu University Ordu 52200 Turkey Department of General and Applied Kinesiology University of Zagreb Zagreb 10110 Croatia

Background: Physical activity participation(PAP) has been proven to improve health and promote optimal growth among adolescents. However,most adolescents do not meet the current physical activity(PA) recommendations in Turkey. The role of the social environment and social factors on PAP is being increasingly recognized. Although social capital(SC) indicators have been examined in high-income countries, there are few studies on developing countries. The aim of this study was to examine the relationship between SC indicators and PAP among Turkish ***: A survey was conducted among 19 high schools in 4 different cities in Turkey in 2016. A total of 506 female and 729 male high school students participated in this study. The dependent variable was overall PAP, which was measured using the short form of the International Physical Activity Questionnaire. The independent variables included self-perceived family, neighborhood, and school SC. Self-rated health and obesity status, measured by body mass index, were other study covariates in multiple binary logistic regression models. Chi-square tests were used to assess the differences between ***: PAP levels were significantly different between males and females. A higher percentage of males reported PAP(77.4%) compared to females(51.0%). Among males, teacher–student interpersonal trust and informal social control were inversely associated with PAP, while high students interpersonal trust was positively associated with increased odds of PAP. For females, students interpersonal trust was inversely associated with ***: Various SC indicators are associated with PAP for males and females. These associations are different from findings of studies conducted in developed countries. Therefore, health-promotion interventions and policies should consider gender and different social agents on the social and cultural background to improve PAP among Turkish adolescents.

关键词： Adolescents Family Neighborhood Physical activity Public health School Social capital

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