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Neglected tropical diseases:exploring long term practical approaches to achieve sustainable disease elimination and beyond

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Infectious Diseases of Poverty 2017年第1期6卷 1301-1312页

作者： giuseppina Ortu Oliver Williams Malaria Consortium Development House56-54 Leonard streetLondon EC244LTUK

Background:Remarkable progress has been made in the fight against neglected tropical diseases,but new challenges have *** diagnostics,better drugs and new insecticides are often identified as the priority;however,access to these new tools may not be sufficient to achieve and sustain disease elimination,if certain challenges and priorities are not *** body:The authors summarise key operational challenges,and based on these,identify two major priorities:strengthening the capacity of the primary health care health system in correctly diagnosing and managing neglected tropical diseases;and establishing an effective disease surveillance *** steps are proposed as concrete actions to build an effective primary health care service for neglected tropical diseases,and a health management information system capable of accurately reporting these *** engagement and formalization of community health workers role are proposed as essential components of these *** of financial support from disease oriented programmes to disease integrated interventions,improved access to international guidelines for primary health care staff,and availability of donated drugs in health care structures are also suggested as key elements of the proposed ***:The authors conclude that failure to address these priorities now may lead to further challenges on the long path towards neglected tropical disease elimination and beyond.

关键词： NTDs Primary health care Integration Surveillance Community engagement

A long story for a short peptide:therapeutic efficacy of a cleavagespecific tau antibody

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Neural Regeneration Research 2021年第12期16卷 2417-2419页

作者： giuseppina Amadoro Valentina Latina Pietro Calissano Institute of Translational Pharmacology(IFT)-National Research Council(CNR) Via Fosso del Cavaliere 10000133-RomeItaly(Amadoro G)European Brain Research Institute(EBRI)Viale Regina Elena 29500161-RomeItaly

Tau is the prime participant in the Alzheimer’s disease(AD) neurodegeneration:AD,the main cause of dementia in elderly people,is a multifactorial neurodegenerative disorder characterized by a long prodromal phase(starting more than two decades before clinical symptoms appear)with brain accumulation/misfolding of amyloidβ(Aβ)in insoluble amyloid plaques and of tau protein in neurofibrillary tangles.

关键词： tau Aβ Alzheimer

Assessing the operational design domain of lane support system for automated vehicles in different weather and road conditions

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第4期9卷 631-644页

作者： giuseppina Pappalardo Riccardo Caponetto Rosario Varrica Salvatore Cafiso Department of Civil Engineering and Architecture University of CataniaCatania 95125Italy Department of Electrical Electronic and Computer EngineeringUniversity of CataniaCatania 95125Italy

With the growing rate of automated vehicles(AVs)at the lower level of automation,the experimental tests are also in progress with vehicles at higher *** the absence of extended digital infrastructures and deployment of level 5 full automated vehicles,the physical infrastructure is required to maintain a fundamental role to enable their introduction in public *** paper focuses on lane support system(LSS)whose operational design domain(ODD)is strongly connected to the road characteristics and *** experimental test was carried out with a state of the art,and LSS and advanced technologies were used for road monitoring on different roads under various environmental conditions including dry,wet pavements and *** applied the generalized estimation equation for logistic regression to account within-cluster homogeneity which is induced by repeated measures on the same road *** models allow the identification of variables that are significant for the LSS fault probability among various effects of road features including marking,pavement distress,weather conditions,horizontal curvature,and cross *** pointed out the relevance of the wet retro-reflection of marking(RLw)and the horizontal curvature in the definition of ODD for *** values have been proposed for the tested *** pavement doesn’t affect the LSS performance when compared to the dry *** was shown to be critical even with very good road characteristics.

关键词： Lane support system Physical infrastructure Operational design domain Weather condition

Update on the reciprocal interference between immunosuppressive therapy and gut microbiota after kidney transplantation

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World Journal of Transplantation 2024年第1期14卷 72-83页

作者： Maurizio Salvadori giuseppina Rosso Department of Renal Transplantation Careggi University HospitalFlorence 50139TuscanyItaly Division of Nephrology San Giovanni di Dio HospitalFlorence 50143ToscanaItaly

Gut microbiota is often modified after kidney *** principally happens in the first period after *** and,most of all,immunosuppressive drugs are the main *** relationship between immunosuppressive drugs and the gut microbiota is *** one side immunosuppressive drugs modify the gut microbiota,often generating dysbiosis;from the other side microbiota may interfere with the immunosuppressant pharmacokinetics,producing products more or less active with respect to the original *** phenomena have influence over the graft outcomes and clinical consequences as rejections,infections,diarrhea may be caused by the dysbiotic ***,calcineurin inhibitors such as tacrolimus and cyclosporine,mycophenolate mofetil and mTOR inhibitors are the immunosuppressive drugs whose effect on the gut microbiota is better *** contrast is well known how the gut microbiota may interfere with glucocorticoids,which may be transformed into *** may be transformed by microbiota into a product called M1 that is 15-fold less active with respect to *** pro-drug mycophenolate mofetil is normally transformed in mycophenolic acid that according the presence or not of microbes producing the enzyme glucuronidase,may be transformed into the inactive product.

关键词： Immunosuppressive therapy Kidney transplantation Gut microbiota Dysbiosis Pathobionts Graft outcomes

Biobanking in the digital pathology era

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Oncology Research 2021年第4期29卷 229-233页

作者： giuseppina BONIZZI LORENZO ZATTONI NICOLA FUSCO Biobank for Translational and Digital Medicine Unit Division of PathologyIEOEuropean Institute of Oncology IRCCSUniversity of MilanMilan20141Italy

Digital Pathology is becoming more and more important to achieve the goal of precision *** in whole-slide imaging,software integration,and the accessibility of storage solutions have changed the pathologists’clinical practice,not only in terms of laboratory workﬂow but also for diagnosis and biomarkers *** parallel with the pathology setting advancement,translational medicine is approaching the unprecedented opportunities unrevealed by artiﬁcial intelligence(AI).Indeed,the increased usage of biobanks’datasets in research provided new challenges for AI applications,such as advanced algorithms,and computer-aided *** this scenario,machine learning-based approaches are being propose in order to improve biobanks from biospecimens collection repositories to computational *** date,evidence on how to implement digital biobanks in translational medicine is still *** viewpoint article summarizes the currently available literature that supports the biobanks’role in the digital pathology era,and to provide possible practical applications of digital biobanks.

关键词： Biobank Pathology Digital pathology Biomarkers Translational research

What is new in the pathogenesis and treatment of IgA glomerulonephritis

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World Journal of Nephrology 2024年第4期13卷 13-27页

Recently,new findings have been clarified concerning both pathogenesis and treatment of IgA *** four hits theory has been confirmed but several genetic wide association studies have allowed finding several genes connected with the pathogenesis of the *** these new genes apply to each of the four ***,new discoveries concerning the microbiota and its connection with immune system and IgA generation have allowed finding out the role of the mucosa in IgA nephropathy *** IgA treatment is also changed included the future *** treatment of the chronic kidney disease,associated with the nephropathy,is mandatory,since the beginning of the *** classical immunosuppressive agents have poor *** corticosteroids remain an important cornerstone in any phase of the *** effect is related to the treatment of B cells and plasma *** particular,in very recent studies have been documented the efficacy of anti B cell-activating factor and anti A proliferation-inducing ligand *** of these studies are to date in phase II/***,new agents targeting complement are *** agents also are still in randomized trials and act principally in hit 4 where the immunocomplexes in the mesangium activate the different pathways of the complement cascade.

关键词： IgA nephropathy Anti IgA autoantibodies Genetic wide association studies Microbiota Anti B cell-activating factor agents Anti A proliferation-inducing ligand agents Anti complement agents

Vibro-acoustic characteristics of multifunctional carbon fiber reinforced panel

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Defence Technology（防务技术） 2023年第6期24卷 129-139页

作者： Liberata Guadagno Marialuigia Raimondo Luigi Vertuccio giuseppina Barra Maurizio Arena Massimo Viscardi Department of Industrial Engineering University of SalernoVia Giovanni Paolo II13284084FiscianoSAItaly Department of Engineering University of Campania“Luigi Vanvitelli”Via Roma 29I-81031AversaItaly Department of Industrial Engineering Aerospace SectionUniversity of Naples“Federico Ⅱ”Via Claudio 2180125NaplesItaly

This paper deals with the assessment of vibro-acoustic properties of a multifunctional carbon fiber reinfo rced panel manu factured by bulk infu sion,a modified resin film infusion *** components of the epoxy resin were chosen to contrast the electrical insulating property and poor flame resistance of the epoxy resins impregnating carbon woven *** confer electrical conductivity to the resin a percentage of 0.5 wt%of Multi-Wall Carbon Nanotubes(MWCNTs)was dispersed in the resin,whereas to increase flame resistance a percentage of 5 wt%of Glycidil Polyhedral Oligomeric Silsesquioxanes(GPOSS)was solubilized in the epoxy ***,as hardener agents,a mixture of 4,4’-DiaminoDiphenyl Sulfone(DDS)(53.4 wt%)and Bis(3-Aminophenyl)Methyl Phosphine Oxide(BAMPO)(46.7 wt%)was *** values of the electrical conductivity were found satisfactory enough,being4.02×10^(-2)S/m for the multifunctional resin and 1.39×10^(4)S/m for the in-plane conductivity of the panel,whereas the Limiting Oxygen Index(LOI)value of the multifunctional resin was found to increase from 27%to 36%.Considering these promising results,an experimental assessment of the vibro-acoustic properties of the manufactured multifunctional panel was also *** panel was tested mainly to evaluate its low-frequency vibration damping and sound insulation *** manufactured panel demonstrated an improved efficiency if compared to a baseline configuration,presenting almost the double modal damping and a gain of 10 dB on the global noise reduction.

关键词： Composite materials Electrical properties Damping Tunneling atomic force microscopy(TUNA) Vibro-acoustic properties

Artificial intelligence in detection of small bowel lesions and their bleeding risk:A new step forward

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World Journal of Gastroenterology 2024年第18期30卷 2482-2484页

作者： Silvia Cocca giuseppina Pontillo Giuseppe Grande Rita Conigliaro Gastroenterology and Endoscopy Unit Azienda Ospedaliero Universitaria Policlinico di ModenaModena 41121Italy Gastroenterology and Endoscopy Unit Presidio Ospedaliero San Giuseppe Moscati(AversaCE)-ASL CasertaCaserta 81100Italy Department of Gastroenterology and Digestive Endoscopy Azienda Ospedaliero Universitaria di ModenaModena 41121Italy

The present letter to the editor is related to the study with the title“Automatic detection of small bowel(SB)lesions with different bleeding risk based on deep learning models”.Capsule endoscopy(CE)is the main tool to assess SB diseases but it is a time-consuming procedure with a significant error *** development of artificial intelligence(AI)in CE could simplify physicians’*** novel deep learning model by Zhang et al seems to be able to identify various SB lesions and their bleeding risk,and it could pave the way to next perspective studies to better enhance the diagnostic support of AI in the detection of different types of SB lesions in clinical practice.

关键词： Capsule endoscopy Small bowel Artificial intelligence Bleeding risk Vascular lesions

ER exit pathways and the control of proteostasis:Crucial role of the UPR,COPII,and ER-phagy in the secretory pathway

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BIOCELL 2022年第5期46卷 1131-1137页

作者： giuseppina AMODIO VALENTINA PAGLIARA PAOLO REMONDELLI ORNELLA MOLTEDO Dipartimento di Medicina Chirurgia e Odontoiatria“Scuola Medica Salernitana”Universitàdegli Studi di SalernoBaronissi84034Italy2 Dipartimento di FarmaciaUniversitàdegli Studi di SalernoFisciano84084Italy

The endoplasmic reticulum(ER)is the site of entry of all proteins that function in the secretory pathway including the extracellular *** it controls the folding of newly synthesized secretory proteins,the ER is indispensable for the maintenance of proteostasis in the secretory *** the ER and,in part,in post-ER compartments,the quality control of protein folding is under the regulation of the unfolded protein response(UPR)*** UPR strategy is to enhance protein folding,increase the ER degradation pathway of misfolded proteins,and allow the exit from the ER of only correctly folded *** latter is controlled by the multimeric complex COPII,which also provides some of the components for ER-phagy the only route for the disposal of protein *** this overview,we wish to contribute to the introduction of new perspectives in the study of the mechanisms underlying the control of proteostasis within the secretory pathway.

关键词： Proteostasis ER stress Unfolded protein response COPII ER-phagy