What is new in the pathogenesis and treatment of IgA glomerulonephritis
作者机构：Department of Renal TransplantationCareggi University HospitalFlorence 50139TuscanyItaly Division of NephrologySan Giovanni di Dio HospitalFlorence 50143ToscanaItaly
出 版 物：《World Journal of Nephrology》 (世界肾病学杂志（英文）)
年 卷 期：2024年第13卷第4期
页 面：13-27页
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
主 题：IgA nephropathy Anti IgA autoantibodies Genetic wide association studies Microbiota Anti B cell-activating factor agents Anti A proliferation-inducing ligand agents Anti complement agents
摘 要：Recently,new findings have been clarified concerning both pathogenesis and treatment of IgA *** four hits theory has been confirmed but several genetic wide association studies have allowed finding several genes connected with the pathogenesis of the *** these new genes apply to each of the four ***,new discoveries concerning the microbiota and its connection with immune system and IgA generation have allowed finding out the role of the mucosa in IgA nephropathy *** IgA treatment is also changed included the future *** treatment of the chronic kidney disease,associated with the nephropathy,is mandatory,since the beginning of the *** classical immunosuppressive agents have poor *** corticosteroids remain an important cornerstone in any phase of the *** effect is related to the treatment of B cells and plasma *** particular,in very recent studies have been documented the efficacy of anti B cell-activating factor and anti A proliferation-inducing ligand *** of these studies are to date in phase II/***,new agents targeting complement are *** agents also are still in randomized trials and act principally in hit 4 where the immunocomplexes in the mesangium activate the different pathways of the complement cascade.
维普期刊数据库