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World Journal of Gastroenterology 2008年第45期14卷 6948-6953页

作者： Emiliano Giangreco Cinzia D'agate Carmelo Barbera Lidia Puzzo giuseppe Aprile Pietro Naso Giacomo Bonanno Alessandra Nicoletti Salvatore Incarbone giuseppe Trama antonio Russo Francesco Paolo Russo Department of Surgery Gastroenterology and Endoscopy Unit University of Catania Department of Surgical and Gastro-enterological Sciences Gastroenterology Section University of Padova

AIM: To investigate the prevalence of celiac disease (CD) in adult patients referred to an open access gas-troenterology clinic in the south of Italy and submitted to esophago-gastro-duodenoscopy (EGD) for evaluation of refractory functional ***: Seven hundred and twenty six consecutive dyspeptic patients (282 male, 444 female; mean age 39.6 years, range 18-75 years) with unexplained prolonged dyspepsia were prospectively enrolled. Duo-denal biopsies were taken and processed by standard staining. Histological evaluation was carried out according to the Marsh-Oberhuber ***: The endoscopic findings were: normal in 61.2%, peptic lesions in 20.5%, malignancies in 0.5%, miscellaneous in 16.7%. CD was endoscopically diagnosed in 8 patients (1.1%), histologically in 15 patients (2%). The endoscopic features alone showed a sensitivity of 34.8% and specificity of 100%, with a positive predictive value (PPV) of 100% and a negative predictive value (NPP) of 97.9%.CONCLUSION: This prospective study showed that CD has a high prevalence (1:48) in adult dyspeptic patients and suggests the routine use of duodenal biopsy in this type of patient undergoing EGD.

关键词： Celiac disease Endoscopy Biopsy Functional Dyspepsia

Laparoscopic calibrated total vs partial fundoplication following Heller myotomy for oesophageal achalasia

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World Journal of Gastroenterology 2011年第29期17卷 3431-3440页

作者： Natale Di Martino antonio Brillantino Luigi Monaco Luigi Marano Michele Schettino Raffaele Porfidia giuseppe Izzo Angelo Cosenza VIII Department of General and Gastrointestinal Surgery School of MedicineSecond University of NaplesPiazza Miraglia 280138 NaplesItaly

AIM:To compare the mid-term outcomes of laparoscopic calibrated Nissen-Rossetti fundoplication with Dor fundoplication performed after Heller myotomy for oesophageal ***:Fifty-six patients(26 men,30 women;mean age 42.8±14.7 years)presenting for minimally invasive surgery for oesophageal achalasia,were *** patients underwent laparoscopic Heller myotomy followed by a 180°anterior partial fundoplication in 30 cases(group 1)and calibrated NissenRossetti fundoplication in 26(group 2).Intraoperative endoscopy and manometry were used to calibrate the myotomy and fundoplication.A 6-mo follow-up period with symptomatic evaluation and barium swallow was *** and two years after surgery,the patients underwent symptom questionnaires,endoscopy,oesophageal manometry and 24 h oesophago-gastric pH ***:At the 2-year follow-up,no significant difference in the median symptom score was observed between the 2 groups(P=0.66;Mann-WhitneyU-test).The median percentage time with oesophageal pH< 4 was significantly higher in the Dor group compared to the Nissen-Rossetti group(2;range 0.8-10 vs 0.35;range 0-2)(P<0.0001;Mann-WhitneyU-test).CONCLUSION:Laparoscopic Dor and calibrated Nissen-Rossetti fundoplication achieved similar results in the resolution of ***-Rossetti fundoplication seems to be more effective in suppressing oesophageal acid exposure.

关键词： Achalasia Dor fundoplication Dysphagia Gastroesophageal reflux Laparoscopy Nissen-Rossetti fundoplication

Diverticular disease of the colon:New perspectives in symptom development and treatment

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World Journal of Gastroenterology 2003年第7期9卷 1385-1389页

作者： antonio Colecchia Lorenza Sandri Simona Caoodicasa Amanda Vestito giuseppe Mazzella Tommaso Staniscia Enrico Roda Davide Festi Department of Internal Medicine and Gastroenterology University of BolognaItaly Department of Medicine and Aging University G.d'AnnunzioChietiItaly

Diverticular disease of the colon is a common disease *** the disease is asymptomatic in about 70-80 % of patients,it represents,at least in Western countries,one of the most important gastrointestinal diseases in terms of direct and indirect health *** of the disease is still ***,it is the result of complex interactions between colonic structure,intestinal motility,diet and genetic *** efficacious preventive strategies remain to be identified,fibre supplementation in the diet is *** symptoms develop is still *** of recent experimental studies on irritable bowel syndrome speculated that low grade inflammation of colonic mucosa,induced by changes in bacterial microflora, could affect the enteric nervous system,which is crucial for normal gut function,thus favouring symptom development. This hypothesis could be extrapolated also for diverticular disease,since bacterial overgrowth is present,at least in a subgroup of *** perspectives on symptom development are reviewed and new therapeutic approaches are hypothesized.

关键词： Diverticulitis, Colonic Gastroenterology Humans

A New Volumetric Parameter for a Comparative Finite-Element Analysis of a Six- or Four-Implant Mandibular Total-Arch Rehabilitation

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Open Journal of Stomatology 2016年第1期6卷 12-21页

作者： Alfredo Natali Enrico Bertocchi Andrea Baldini giuseppe antonio Mulas Matteo Martinolli Bortolini Sergio DDS Teacher at the PhD “Enzo Ferrari” in Industrial and Environmental Engineering University of Modena and Reggio Emilia Modena Italy Department of Engineering “Enzo Ferrari” University of Modena and Reggio Emilia Modena Italy Tecnopolo di Mirandola Science and Technology Park for Medicine Mirandola Italy School of High Mechanics and Automotive Design & Technology Department of Mechanical and Civil Engineering University of Modena and Reggio Emilia Modena Italy Department of Surgery Medicine Dentistry and Morphologic Science with Interests in Transplant Oncologic and Regenerative Medicine University of Modena and Reggio Emilia Modena Italy

In a full-arch implant rehabilitation ad modum Branemark, the distribution of stress and strain in mandibular bone is influenced by the type, number and position of implants used. In particular, the biomechanical behaviour of the bone structure after complete osseointegration depends on the load transferred to the bone by each fixture. In this study, a finite-element analysis of two models was performed. Models of an all-on-four configuration and a six-implant configuration were compared in a worst-case scenario. A new V parameter is presented to aid the quantitative and comparative analysis of the all-on-four and six-implant configurations. The influence of orthotropy was also investigated, and a geometric change in the all-on-four configuration is presented.

关键词： Finite-Element Analysis Oral Implants All-on-Four Configuration Six-Implant Configuration Bone Mechanics Comparative Analysis

Self-worth and psychological adjustment of obese children:An analysis through the Draw-A-Person

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World Journal of Psychiatry 2016年第3期6卷 329-338页

作者： giuseppe Scimeca Amelia Alborghetti antonio Bruno Giulia Maria Troili Gianluca Pandolfo Maria Rosaria Anna Muscatello Rocco antonio Zoccali Psychiatric Unit Department of BiomedicalDental Sciences and Morpho-functional ImagingUniversity of Messina "Don Carlo Gnocchi" Foundation

AIM To investigate psychopathological correlates of child obesity via the Draw-A-Person test(DAP).METHODS The participants were 50 children with a mean age of 9.74 *** mass index(BMI) was used as a measure of body *** were divided into normal(n = 17),overweight(n = 14) and obese(n = 19).Two qualitative methods of scoring the DAP based on an integrative approach were used to assess self-concept(ESW) and overall level of children's adjustment(EAC).A procedure for judging interpretative skills of clinicians was implemented before they evaluated children's *** As predicted by our hypothesis,BMI was negatively correlated with ESW,r(50) =-0.29,P < 0.05,but not with EAC,r(50) =-0.08,P = *** evaluate the effect of gender,Pearson correlations were re-computedregrouping the sample accordingly:BMI and EAC reached a significant negative correlation in female subjects,r(24) =-0.36,P < 0.05,and a positive correlation in male subjects,r(26) = 0.37,P = < 0.05;negative correlation between BMI and ESW became stronger in females,r(24) =-0.51,P < 0.01 but not in males,whose correlation disappeared resulting not-significant,r(26) =-0.06,P = *** effect of age was *** indicate that obesity has a negative correlation exclusively on overall adjustment and self-concept in female *** It was concluded that there is a negative bias toward females that reveals how the stigma of obesity is widespread in Western society.

关键词： Obesity Draw a person Draw-A-Person test Projective techniques Psychopathology

Proficiency score as a predictor of early trifecta achievement during the learning curve of robot-assisted radical prostatectomy for high-risk prostate cancer:Results of a multicentric series

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Current Urology 2024年第2期18卷 110-114页

作者： Umberto Anceschi Rocco Simone Flammia antonio Tufano Michele Morelli antonio Galfano Lorenzo giuseppe Luciani Leonardo Misuraca Paolo Dell’Oglio Gabriele Tuderti Aldo Brassetti Maria Consiglia Ferriero Alfredo Maria Bove Riccardo Mastroianni Francesco Prata Isabella Sperduti Giovanni Petralia SilviaSecco Ettore Di Trapani DanieleMattevi Tommaso Cai Aldo Massimo Bocciardi giuseppe Simone Department of Urology IRCCS“Regina Elena”National Cancer InstituteRomeItaly Urologic Clinic Department of Maternal-Child and Urologic SciencesSapienza University of RomeItaly Ospedale Niguarda Ca’Granda Department of UrologyMilanItaly Department of Urology APSS Santa Chiara Regional HospitalTrentoItaly Department of Biostatistical Unit IRCCS Regina Elena National Cancer InstituteRomeItaly

Background:Recently,an innovative tool called“proficiency score”was introduced to assess the learning curve for robot-assisted radical prostatectomy(RARP).However,the initial study only focused on patients with low-risk prostate cancer forwhompelvic lymph node dissection(PLND)was not *** address this issue,we aimed to validate proficiency scores of a contemporarymulticenter cohort of patients with high-risk prostate cancer treated with RARP plus extended PLND by trainee *** andmethods:Between 2010 and 2020,4 Italian institutional prostate-cancer datasets weremerged and queried for“RARP”and“high-risk prostate cancer.”High-risk prostate cancer was defined according to the most recent European Association of Urology guidelines as follows:prostate-specific antigen>20 ng/mL,International Society ofUrological Pathology≥4,and/or clinical stage(cT)≥2c on preoperative *** selected cohort(n=144)included clinical cases performed by trainee surgeons(n=4)after completing their RARP learning curve(50 procedures for low-risk prostate cancer).The outcome of interest,the proficiency score,was defined as the coexistence of all the following criteria:a comparable operation time to the interquartile range of the mentor surgeon at each center,absence of any significant perioperative complications Clavien-Dindo Grade 3–5,no perioperative blood transfusions,and negative surgical margins.A logistic binary regression model was built to identify the predictors of 1-year trifecta achievement in the trainee *** all statistical analyses,a 2-sided p<0.05 was considered ***:A proficiency score was achieved in 42.3%*** univariable level,proficiency score was associated with 1-year trifecta achievement(odds ratio,8.77;95%confidence interval,2.42–31.7;p=0.001).After multivariable adjustments for age,nerve-sparing,and surgical technique,the proficiency score independently predicted 1-year trifecta achievement(odds ratio,9.58;95%confidence i

关键词： Trifecta Learning curve Robot-assisted radical prostatectomy High-risk prostate cancer

Unilateral post-chemotherapy robot-assisted retroperitoneal lymph node dissection in Stage II non-seminomatous germ cell tumor:A tertiary care experience

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Asian Journal of Urology 2023年第4期10卷 440-445页

作者： Dario Franzese antonio Tufano Alessandro Izzo Raffaele Muscariello Giovanni Grimaldi giuseppe Quarto Luigi Castaldo Sabrina Rossetti Savio Domenico Pandolfo Sonia Desicato Paola Del Prete Matteo Ferro Sandro Pignata Sisto Perdonà Department of Urology National Cancer InstitutePascale FoundationNaplesItaly Urology Unit Department of Maternal-Child and Urological Sciences“Sapienza”UniversityRomeItaly Department of Neurosciences Science of Reproduction and OdontostomatologyUniversity of Naples Federico IINaplesItaly Scientific Directorate Istituto Nazionale Tumori di NapoliIRCCS“G.Pascale”NaplesItaly Division of Urology European Institute of Oncology(IEO)IRCCSMilanItaly Division of Medical Oncology Department of Uro-Gynaecological OncologyIstituto Nazionale per lo Studio e la Cura dei Tumori“Fondazione G.Pascale”IRCCSNaplesItaly

Objective Post-chemotherapy retroperitoneal lymph node dissection(PC-RPLND)represents an integral component of the management of patients with non-seminomatous germ cell tumor(NSGCT).Modified templates have been proposed to minimize the surgical morbidity of the ***,the implementation of robotic surgery in this setting has been *** report our experience with unilateral post-chemotherapy robot-assisted retroperitoneal lymph node dissection(PC-rRPLND)for clinical Stages IIA and IIB *** A retrospective single institution review was performed including 33 patients undergoing PC-rRPLND for Stages IIA and IIB NSGCTs between January 2015 and February *** orchiectomy,patients were scheduled for chemotherapy with three cycles of *** with a residual tumor of<5 cm and an ipsilateral metastatic disease on pre-and post-chemotherapy CT scans were eligible for a unilateral template in absence of rising tumor *** statistics were provided for demographics,clinical characteristics,intraoperative and postoperative ***,oncological,and functional outcomes were *** Overall,7(21.2%)patients exhibited necrosis or fibrosis;14(42.4%)had mature teratoma;and 12(36.4%)had viable tumor at final *** median lymph node size at surgery was 25(interquartile range[IQR]21-36)*** operative time was 180(IQR 165-215)min and no major postoperative complications were *** ejaculation was preserved in 75.8%of *** follow-up was 26(IQR 19-30)months and a total of three recurrences were *** PC-rRPLND is a reliable and technically reproducible procedure with safe oncological outcomes and acceptable postoperative ejaculatory function in well selected patients with NSGCTs.

关键词： Testis tumor Robot-assisted retroperitoneal lymph node dissection Retroperitoneal lymph node dissection Non-seminomatous germ cell tumor Unilateral dissection Modified template Post-chemotherapy

Substrate Type Affects Growth, Yield and Mineral Composition of Cucumber and Zucchini Squash

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Journal of Life Sciences 2012年第7期6卷 766-770页

作者： Mariateresa Cardarelli Youssef Rouphae Salem Darwich Elvira Rea antonio Fiorillo giuseppe Colla Department of Agriculture Forestry Nature and Energy University of Tuscia via S. C. De Lellis snc Viterbo 01100 Italy Faculty of Agricultural and Veterinary Sciences Lebanese University Dekwaneh-El Maten Beirut Lebanon CRA-Research Centre for Soil~Plant System via della Navicella 2-4 Roma 00184 Italy

The expansion of hydroponics in many countries of the world in the last few decades may be ascribed to the ability of soilless growing systems to avoid various problems arising from the use of the soil. Cucumber （Cucurnis sativus L.） and zucchini （Cucurbita pepo L.） plants were grown in closed-soilless culture under unheated-greenhouse conditions at the experimental farm of University of Tuscia, Central Italy to evaluate the effects of four substrates （rockwool, pumice, perlite, and cocofiber） on growth, yield and plant mineral composition. For both cultures, plants grown in cocofiber, perlite and pumice yielded more than those grown in rockwool. The better temperature regime in cocofiber, perlite and pumice was due to the greater thermal inertia compared to rockwool slabs. Thc concentration of N in zucchini and cucumber leaves was significantly higher in cocofiber, perlite and pumice in comparison to the rockwool treatment. The concentration of K was significantly affected by the substrate only for the zucchini squash with the highest value recorded on the organic substrate （cocofiber）, whereas the Ca concentration was significantly influenced by the growing media only for cucumber with the highest value observed on pumice. Finally, the lowest Mg concentration in leaf tissue was observed on plants grown with the rockwool substrate for both zucchini squash and cucumber. We can conclude that cocofiber, perlite and pumice are suitable for zucchini and cucumber production in closed soilless system, whereas the use of rockwool is more suitable for crops grown under heated greenhouse conditions.

关键词： Substrate type yield mineral composition cucumber zucchini squash.

Activity and safety of pegylated liposomal doxorubicin,5-fluorouracil and folinic acid in inoperable hepatocellular carcinoma:A phase Ⅱ study

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World Journal of Gastroenterology 2007年第48期13卷 6553-6557页

作者： giuseppe Di Lorenzo antonio Rea Chiara Carlomagno Stefano Pepe Giovannella Palmieri Roberto Labianca antonio Chirianni Alfonso De Stefano Vincenzo Esposito Sabino De Placido Vincenzo Montesarchio Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica Università degli Studi Federico Ⅱ Naples Italy Divisione di Oncologia Azienda Ospedaliera Cotugno Naples Italy Oncology Section Ospedali Riuniti Bergamo Italy

AIM: To improve the results of New therapeutic strategies in hepatocellular carcinoma (HCC). We have conducted a phase Ⅱ study with pegylated liposomal doxorubicin (PLD), 5-fluorouracil (5FU) and folinic acid (FA). METHODS: Thirty-one patients with hystologically- confirmed, inoperable HCC, received combination chemotherapy with PLD 25 mg/mq on d 1, 5FU 1200 mg/mq in 48 h continuous infusion, and oral FA 30 mg on d 1 and 2 every 3 wk until disease progression or intolerable toxicity. RESULTS: The median age was 65 years (range 41-82) and 28 patients were hepatitis C virus seropositive (90%). The majority of patients were Child-Pugh Class B (55%). Two patients showed a partial response (PR), and 16 had stable disease (SD). With a median follow-up of 14 mo, the median time to progression of all evaluable patients was 4 mo (95% CI 1.7-7). Median overall survival was 9 mo (95% CI 3-24 mo). After 1 year, 9 of 18 PR/SD patients were alive. Chemotherapy was well tolerated. CONCLUSION: PLD/FU/FA combination seems capable of achieving durable stabilization of HCC. The manageable toxicity supports a role for combination with other anticancer agents.

关键词： Pegylated liposomal doxorubicin 5-fluorouracil Folinic acid Hepatocellular carcinoma

Autism genetics: Methodological issues and experimental design

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Science China(Life Sciences) 2015年第10期58卷 946-957页

作者： Roberto SACCO Carla LINTAS antonio M.PERSICO Department of Child Neuropsychiatry and Laboratory of Molecular Psychiatry and Neurogenetics University "Campus Bio-Medico" Department of Experimental Neurosciences I.R.C.C.S."Fondazione Santa Lucia"

Autism is a complex neuropsychiatric disorder of developmental origin, where multiple genetic and environmental factors likely interact resulting in a clinical continuum between "affected" and "unaffected" individuals in the general population. During the last two decades, relevant progress has been made in identifying chromosomal regions and genes in linkage or association with autism, but no single gene has emerged as a major cause of disease in a large number of patients. The purpose of this paper is to discuss specific methodological issues and experimental strategies in autism genetic research, based on fourteen years of experience in patient recruitment and association studies of autism spectrum disorder in Italy.

关键词： autistic disorder endophenotype genetic association genetics pervasive developmental disorders