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Hypertransaminasemia in the course of infection with SARS-CoV-2:Incidence and pathogenetic hypothesis

World Journal of Clinical Cases 2020年第8期8卷 1385-1390页

作者： Maddalena Zippi Sirio Fiorino giuseppe occhigrossi Wandong Hong Unit of Gastroenterology and Digestive Endoscopy Sandro Pertini HospitalRome 00157Italy Unit of Internal Medicine Maggiore HospitalLocal Health Unit of BolognaBologna 40133Italy Department of Gastroenterology and Hepatology First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

In patients infected with severe acute respiratory syndrome coronavirus 2,the respiratory symptoms,such as fever,cough and dyspnea,are the most frequent clinical *** patients may also present with less well-defined symptoms like diarrhea,nausea,vomiting and/or abdominal discomfort both at the time of diagnosis and during the clinical *** a few cases,these symptoms may also present before the appearance of respiratory *** penetrate the body,Severe acute respiratory syndrome coronavirus 2 uses ACE2 receptors,which are present not only in respiratory epithelium but also in gastrointestinal mucosa and liver *** several cases,viral RNA is detectable in the stool of patients with coronavirus disease 2019(COVID-19).The liver damage seems to show a multifactorial *** 2%-11%of patients with COVID-19 have known underlying hepatic *** 14%-53%of COVID-19 cases,there is an alteration of the indices of liver cytolysis and is more frequently observed in severe forms of COVID-19,especially during hospitalization.

关键词： Coronavirus COVID-19 Hypertransaminasemia Liver Meta-analysis SARS-CoV-2

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Endoscopic papillary balloon dilation for diffi cult common bile duct stones:Our experience

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World Journal of Clinical Cases 2013年第1期1卷 19-24页

作者： Maddalena Zippi Isabella De Felici Roberta Pica Giampiero Traversa giuseppe occhigrossi Unit of Gastroenterology and Digestive Endoscopy Sandro Pertini Hospital 00157 Rome Italy

AIM: To evaluate the eff icacy and safety of endoscopic balloon dilation(EBD) performed for common bile duct(CBD) ***: From a computer database, we retrospectively analyzed the data relating to EBD performed in patients at the gastrointestinal unit of the Sandro Pertini Hospital of Rome(small center with low case volume) who underwent endoscopic retrograde cholangiopancreatography(ERCP) for CBD from January 1, 2010 to February 29, 2012. All patients had a proven diagnosis of CBD stones studied with echography, RMN cholangiography and, when necessary, with computed tomography of the abdomen(for example, in cases with pace-makers). Prophylactic therapies, with gabexate mesilate 24 h before the procedure and with an antibiotic(ceftriaxone 2 g) 1 h before, were administered in all patients. The duodenum was intubated with a side-viewing endoscope under deep sedation with intravenous midazolam and propofol. The patients were placed in the supine position in almost all cases. EBDof the ampulla was performed under endoscopic and f luoroscopic guidance with a balloon through the scope(Hercules, wireguided balloon, Cook Ireland Ltd. and CRE, Microvasive, Boston Scientific Co., Natick, MA, United States). RESULTS: A total of 14 patients(9 female, 5 male; mean age of 73 years; range 57-82 years) were enrolled in the study, in whom a total of 15 EBDs were performed. All patients underwent minor endoscopic sphincterotomy(ES) prior to the EBD. The size of balloon insuff lation depended on stone size and CBD dilation and this was performed until it reached 16 mm in diameter. EBD was performed under endoscopic and f luoroscopic guidance. The balloon was gradually f illed with diluted contrast agent and was maintained inf lated in position for 45 to 60 s before def lation and removal. The need for precutting the major papilla was 21.4%. In one patient(an 81-year-old), EBD was performed in a Billroth Ⅱ. Periampullary diverticula were found only in a 74-year-old female. T

关键词： Choledocholithiasis Endoscopic balloon dilation Endoscopic retrograde cholangiopancreatography Endoscopic sphincterotomy Mechanical lithotripsy

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Schwannoma of the rectum:A case report and literature review

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World Journal of Clinical Cases 2013年第1期1卷 49-51页

作者： Maddalena Zippi Roberta Pica Renzo Scialpi Claudio Cassieri Eleonora Veronica Avallone giuseppe occhigrossi Department of Gastroenterology and Digestive Endoscopy Sandro Pertini Hospital 00157 Rome Italy Department of Pathology Sandro Pertini Hospital 00157 Rome Italy

Schwannoma is a tumor originating from the Schwann cells. Gastrointestinal schwannomas are uncommon stromal tumors of the intestinal tract and, in particular, rectal schwannomas are extremely rare. In fact, it is well established that schwannomas appear more frequently in the stomach and in the small intestine, while location in the colon or in the rectum is uncommon. Reading the literature, only few cases of rectal schwannoma have been reported. Their diagnosis is confirmed by the immunohisto chemical panel(S-100 protein). When these tumors are located in the colon and in the rectum, radical excision with wide margins is mandatory, due to their tendency to recur locally or become malignant, if left untreated. In the present study, we describe a case of a rectal schwannoma occured in a 72-year-old man, presented as a small polypoid lesion, which was successfully removed in toto by hot-biopsy, during the same endoscopy, due to the dimensons. No recurrence of the lesion was observed after 6 mo of follow-up.

关键词： Rectum Schwannoma Immunohistochemistry S-100 protein Treatment

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