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Fine tuning of the default depth and rate of ablation of the epithelium in customized trans-epithelial one-step superficial refractive excimer laser ablation

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Eye and Vision 2019年第1期6卷 331-337页

作者： Michael Goggin Peter Stewart Vikija Andersons giuseppe Criscenti South Australian Institute of Ophthalmology University of AdelaideAdelaideAustralia Brisbane Laser Sight Clinic BrisbaneAustralia Ashford Advanced Eye Care AdelaideAustralia iVis Technologies TarantoItaly

Purpose:To fine tune the default depth and rate of ablation of the epithelium in cTen^(TM) customized trans-epithelial one-step superficial refractive surgery by the comparison between the attempted post-operative ideal corneal shape and the achieved corneal ***:88 consecutive eyes in 64 patients undergoing trans-epithelial superficial excimer ablation using the iVis laser Suite for either myopic/astigmatic or hyperopic/astigmatic refractive *** patient had at least 3 months of post-operative *** examination of all eyes was carried out pre-operatively and at least 3 months post-operatively using the Precisio^(TM) surgical *** comparison of these two measurements yielded values for depth,volumes and rates of ablated corneal *** determining the different ablation rates of stroma and epithelium,a refinement of the depth of epithelium to be removed and a refinement of the stromal ablation were *** mathematical model was applied on each one of the 88 clinical cases and the parameters for the fine tuning of the default depth and rate of ablation of the epithelium were determined using the least squares ***:The calculated pure stromal ablation rate was less than the average epithelium/stroma ablation rate used in planning the treatments by a factor of *** epithelial thickness predefined ablation assumption used to plan removal of the epithelium was adjusted considering the measured ablation and a radial adjustment function established for the fine tuning of the laser radial efficiency and allowing for the normal thickening of the epithelium in the peripheral *** a clinical point of view,this methodology produces an improvement of the efficacy and a reduction of the variance of the clinical ***:Comparison of accurately measured pre and postoperative topographies yields accurately established ablation rates of stroma and epithelium in trans-epithelial one step superficial a

关键词： Transepithelial photorefractive keratectomy Epithelial ablation Epithelial thickness refinement Stromal ablation rate refinement

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Stepwise approach and surgery for gallbladder adenomyomatosis: a mini-review

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Hepatobiliary & Pancreatic Diseases International 2013年第2期12卷 136-142页

作者： Gianluca Pellino Guido Sciaudone giuseppe Candilio giuseppe Perna Antonio Santoriello Silvestro Canonico Francesco SelvaggiAuthor Unit of General and Geriatric Surgery School of Medicine Second University of Naples

BACKGROUND: Gallbladder adenomyomatosis (GBA) is a hyperplastic disease affecting the wall of the gallbladder, with some typical features. It has historically been considered a benign condition, nevertheless recent reports highlighted a potential role of GBA in predisposing to malignancies of the gallbladder. DATA SOURCES: We reviewed the literature concerning GBA from its identification until July 2012. Owing to the relative rarity of the disease, studies often are case reports or case series. Thus we herein report a summary of the key-points concerning diagnosis and treatment of GBA, easily applicable in everyday practice, rather than a systematic review. Also, results are integrated with our recent experience. RESULTS: In our experience, we observed a trend toward an increase of GBA during the last years, probably due to enhanced ultrasonographic technical advancements and physician’s expertise. GBA has distinctive imaging features. Several recent reports highlight the potential risk of cancer associated with GBA; however the disease is still classified as a benign condition. Although its correlation with malignancy has not been demonstrated, it is prudent to recommend cholecystectomy in some cases. However, in selected asymptomatic patients, a wait-and-see policy is a viable alternative. We propose an algorithm, based on GBA pathological pattern (diffuse, segmental, localized or fundal), suitable for ***: In symptomatic patients and if the diagnosis is doubtful, cholecystectomy is mandatory. Postponing surgery is an option to be offered to asymptomatic patients with low-risk GBA pattern who adhere to scheduled follow-ups.

关键词： gallbladder adenomyomatosis gallbladder carcinoma cholecystectomy ultrasonography

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Cardiologic side effects of psychotropic drugs

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Journal of Geriatric Cardiology 2011年第4期8卷 243-253页

作者： giuseppe Marano Gianandrea Traversi Enrico Romagnoli Valeria Catalano Marzia Lotrionte Antonio Abbate giuseppe Biondi-Zoccai Marianna Mazza Department of Neurosciences Institute of PsychiatryUniversitàCattolica del Sacro CuoreRome 00168Italy Division of Cardiology Policlinico CasilinoRome 00168Italy Institute of Cardiology UniversitàCattolica del Sacro CuoreRome 00168Italy VCU Pauley Heart Center Medical College of VirginiaRichmond23298 VirginiaUSA Division of Cardiology University of Modena and Reggio EmiliaModena 41121Italy

Psychotropic drugs can produce cardiovascular side effects associated with a degree of *** coexistence of a heart disease complicates the management of mental illness,can contribute to a reduced quality of life and a worse illness *** co-occurrence of psychiatric disorders in cardiac patients might affect the clinical outcome and ***,the complex underlying mechanism that links these two conditions remains *** paper discusses the known cardiovascular complications of psychotropic drugs and analyzes the important implications of antidepressive treatment in patients with previous cardiac history.

关键词： antidepressants antipsychotics arrhythmia cardiotoxicity cardiovascular system psychiatric disorders

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DEMONSTRATING THE SYNERGY BETWEEN CAC AND SCHEDULING IN WIRELESS NETWORKS

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International Journal of Modeling, Simulation, and Scientific Computing 2013年第1期4卷 96-118页

作者： PAOLO PILEGGI giuseppe IAZEOLLA PIETER KRITZINGER Networking Group University of Rome‘Tor Vergata’ Italy Software Engineering and System Performance Modelling Group University of Rome‘Tor Vergata’ Italy Communications Research Group Department of Electrical Engineering University of Cape Town South Africa

Wireless technology is now an integral part of communication network *** their first beginnings,such as connection-oriented General System Mobile networks for voice traffic only and connectionless wireless local area networks for data traffic,new generation wireless networks are connection-oriented and provide differentiated services to the *** the arrival of more sophisticated services and mobility,have arisen the need for Connection Admission Control and traffic scheduling in the network to enhance the quality of experience(QoE)of the user and optimizing the revenue in dynamic workload environments.A great deal of research effort has gone into the study of the performance of one such network standard,namely the IEEE 802.16 *** optimization studies focus on scheduling(a very mature subject in computing)and ignore connection admission(a very mature subject in telephone engineering)or vice *** this paper we claim that one should not study the two in isolation and provide empirical evidence to prove our claim.

关键词： Scheduling connection admission control simulation IEEE 802.16 differentiated services.

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Phenotyping Key Fruit Quality Traits in Olive Using RGB Images and Back Propagation Neural Networks

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Plant Phenomics 2023年第3期5卷 484-500页

作者： giuseppe Montanaro Angelo Petrozza Laura Rustioni Francesco Cellini Vitale Nuzzo Università degli Studi della Basilicata 85100 PotenzaItaly ALSIA Agenzia Lucana Sviluppo Innovazione in AgricolturaMetapontum Agrobios Research Center75010 MetapontoItaly Department of Biological and Environmental Sciences and Technologies University of SalentoLecceItaly

To predict oil and phenol concentrations in olive fruit,the combination of back propagation neural networks(BPNNs)and contact-less plant phenotyping techniques was employed to retrieve RGB image-based digital proxies of oil and phenol *** of cultivars(×3)differing in ripening time were sampled(~10-day interval,×2 years),pictured and analyzed for phenol and oil *** to this,fruit samples were pictured and images were segmented to extract the red(R),green(G),and blue(B)mean pixel values that were rearranged in 35 RGB-based colorimetric *** BPNNs were designed using as input variables(a)the original 35 RGB indexes,(b)the scores of principal components after a principal component analysis(PCA)pre-processing of those indexes,and(c)a reduced number(28)of the RGB indexes achieved after a sparse *** results show that the predictions reached the highest mean R^(2) values ranging from 0.87 to 0.95(oil)and from 0.81 to 0.90(phenols)across the *** addition to the R^(2),other performance metrics were calculated(root mean squared error and mean absolute error)and combined into a general performance indicator(GPI).The resulting rank of the GPI suggests that a BPNN with a specific topology might be designed for cultivars grouped according to their ripening *** present study documented that an RGB-based image phenotyping can effectively predict key quality traits in olive fruit supporting the developing olive sector within a digital agriculture domain.

关键词： Image image supporting

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Planning of DC Electric Spring with Particle Swarm Optimization and Elitist Non-dominated Sorting Genetic Algorithm

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 574-583页

作者： Qingsong Wang Siwei Li Hao Ding Ming Cheng giuseppe Buja School of Electrical Engineering and Jiangsu Provincial Key Laboratory of Smart Grid Technology and Equipment Southeast UniversityNanjing 210096China School of Software Engineering Southeast universitySuzhou 215123China

This paper addresses the planning problem of parallel DC electric springs (DCESs). DCES, a demand-side management method, realizes automatic matching of power consumption and power generation by adjusting non-critical load (NCL) and internal storage. It can offer higher power quality to critical load (CL), reduce power imbalance and relieve pressure on energy storage systems (RESs). In this paper, a planning method for parallel DCESs is proposed to maximize stability gain, economic benefits, and penetration of RESs. The planning model is a master optimization with sub-optimization to highlight the priority of objectives. Master optimization is used to improve stability of the network, and sub-optimization aims to improve economic benefit and allowable penetration of RESs. This issue is a multivariable nonlinear mixed integer problem, requiring huge calculations by using common solvers. Therefore, particle Swarm optimization (PSO) and Elitist non-dominated sorting genetic algorithm (NSGA-II) were used to solve this model. Considering uncertainty of RESs, this paper verifies effectiveness of the proposed planning method on IEEE 33-bus system based on deterministic scenarios obtained by scenario analysis.

关键词： DC distribution network DC electric spring non-dominated sorting genetic algorithm particle swarm optimization renewable energy source

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Dimethyl ether as circular hydrogen carrier:Catalytic aspects of hydrogenation/dehydrogenation steps

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Journal of Energy Chemistry 2021年第7期30卷 55-77页

作者： Enrico Catizzone Cesare Freda Giacobbe Braccio Francesco Frusteri giuseppe Bonura ENEA–Italian Agency for New Technologies Department of Energetic TechnologiesLaboratory of Thermochemical Processes for Waste and Biomass ValorisationRotondellaItaly CNR-ITAE–Consiglio Nazionale delle Ricerche Istituto di Tecnologie Avanzate per l’Energia‘‘Nicola Giordano”Via S.Lucia Sopra Contesse 5I-98126 MessinaItaly

The intermittent nature of renewable resources requires for most applications the development of efficient and cost-effective technologies for steady supply of electrical *** storage of energy in the form of hydrogen chemically bound within organic molecules(rather than physically as compressed gas or cooled liquid)represents an alternative approach that is attracting great research *** to other liquid organic hydrogen carriers(LOHCs),dimethyl ether(DME)appears to have the largest potential impact on society,especially if inserted in technological chains of CO_(2) sequestration and utilization,so to determine an effective mitigation of environmental issues,without any net effect on the carbon ***,the steps of H2 storage and H2 release can take place in two coupled chemical processes,constituted by the exothermic synthesis of DME via CO_(2) hydrogenation and the endothermic steam reforming of DME,***,the latest advances in the development of heterogeneous bifunctional and hybrid catalysts for the direct hydrogenation of CO_(2) to DME are thoroughly reviewed,with special emphasis on thermodynamics,catalyst design and process *** many aspects behind the mechanism of DME synthesis from H2-CO_(2) streams are still to be uncovered,the recent progress in the research on H2 release by DME steam reforming is increasing the interest for effectively closing this binary H2 loop,in view of future green deals and sustainable research developments.

关键词： DME CO_(2)hydrogenation Steam Reforming Hybrid catalysts Hydrogen carrier

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Oil-in-water nanoemulsions loaded with lycopene extracts encapsulated by spray drying:Formulation,characterization and optimization

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Chinese Journal of Chemical Engineering 2024年第6期70卷 73-81页

作者： Junyang Li Roberta Campardelli giuseppe Firpo Jingtao Zhang Patrizia Perego Department of Civil Chemical and Environmental Engineering(DICCA)University of GenoaVia Opera Pia 15Genova 16145Italy Department of Physics University of GenoaVia Dodecaneso 32Genova 16146Italy School of Food and Bioengineering Zhengzhou University of Light IndustryZhengzhou 450002China

Lycopene is very susceptible to degradation once released from the protective chromoplast *** this study,oil-in-water(O/W)nanoemulsions coupled with spray drying technology were applied for the encapsulation and stabilization of lycopene extracted from tomato *** extract was obtained by ultrasound-assisted *** were prepared by a high-speed rotor stator using isopropyl myristate as the oil phase and Pluronic F-127 as the emulsifier for the aqueous external *** effect of emulsification process parameters was *** drying of the produced emulsions was attempted to obtain a stabilized dry powder after the addition of a coating *** effect of different coating agents(maltodextrin,inulin,gum arabic,pectin,whey and polyvinylpyrrolidone),drying temperature(120-170℃),and feed flow rate(3-9 ml·min^(-1))on the obtained particles was *** revealed that the emulsion formulation of 20/80(O/W)with 1.5%(mass fraction)of Pluronic F-127 as stabilizer in the aqueous phase resulted in a stable nanoemulsion with droplet sizes in the range of 259-276 nm with a unimodal and sharp size *** extract in the nanoemulsion was well protected at room temperature with a degradation rate of lycopene of about 50%during a month of storage *** most stable emulsions were then processed by spray drying to obtain a dry *** drying was particularly successful when using maltodextrin as a coating agent,obtaining dried spherical particles with mean diameters of(4.87±0.17)μm with a smooth *** possibility of dissolving the spray dried powder in order to *** original emulsion was also successfully verified.

关键词： Emulsions Powders Stability Isopropyl myristate Lycopene Spray-drying

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Microsurgical tunica albuginea transplantation in an animal model

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Asian Journal of Andrology 2017年第6期19卷 694-699页

作者： Salvatore Sansalone Carla Loreto Rosario Leonardi giuseppe Vespasiani giuseppe Musumeci Claudia Lombardo Sergio Castorina Venera Cardile Rosario Caltabiano Department of Experimental Medicine and Surgery Tor Vergata University Rome Italy Department of Biomedical and Technological Sciences Section of Human Anatomy and Histology University of Catania Catania Italy Musumeci CLinic GECS Catania Italy Department of Bio-Medical Sciences Section of Physiology University of Catania Catania Italy Department of Medical and Surgical Sciences and Advanced Technology "G.E Ingrassia" Section of Anatomic Pathology University of Catania Catania Italy.

Several andrological diseases require surgical repair or reconstruction of tunica albuginea, which envelops the corpora cavernosa penis. Despite intense research efforts involving a variety of biological materials, such as skin, muscle aponeurosis, human dura mater, tunica vaginalis, and pericardium, engineered tunica albuginea suitable for graft use is yet to be obtained. The study investigates microsurgical tunica albuginea allotransplantation in an animal model with the purpose of creation of an organ-specific tissue bank to store penile tissue, from cadaveric donors and male-to-female trans-sexual surgery, for allogeneic transplantation. Materials were tunica albuginea tissue explanted from 15 donor rats, cryopreserved at -80~C, gamma-irradiated, and implanted in 15 recipient rats, of which three rats were used as controls. Penile grafts were explanted at different time intervals; after macroscopic evaluation of the organ, the grafts were processed to morphological, histochemical, and immunohistochemical examinations by light microscopy. Detection of pro-inflammatory cytokines was also performed. Examination of the tunica albuginea allografts collected 1, 3, or 6 months after surgery and of control tunica albuginea fragments showed that tunica albuginea implants achieved biointegration with adjacent tissue at all-time points. The integration of cryopreserved rat tunica albuginea allografts, documented by our study, encourages the exploration of tunica albuginea allotransplantation in humans. In conclusion, the effectiveness and reliability of the tunica albuginea conditioning protocol described here suggest the feasibility of setting up a tunica albuginea bank as a further tissue bank.

关键词： penile tunica albuginea rat model transplant

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Polymorphisms in the IFNL3/IL28B gene and hepatitis C: From adults to children

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World Journal of Gastroenterology 2014年第28期20卷 9245-9252页

作者： giuseppe Indolfi Chiara Azzari Massimo Resti Paediatric and Liver Unit Meyer Children’s University Hospital of Florence Immunology Unit and Laboratory at Meyer Children’s University Hospital of Florence Department of Health Sciences University of Florence

The purpose of the present review is to summarise the current knowledge on the association between single nucleotide polymorphisms (SNPs) in the interferon L3 (IFNL3) gene and hepatitis C virus (HCV) infection in children. Many studies in adults have demonstrated that genetic variation in IFNL3 is a strong predictor of the virological response in treatment-naive patients with HCV genotype 1 who were treated with Pegylated-IFN-α and ribavirin. Genetic variation in IFNL3 is also associated with the spontaneous clearance of HCV. Thus far, few paediatric studies have explored the association between variations in the IFNL3 gene and either spontaneous or treatment-induced clearance of HCV. The CC genotype of the rs12979860 SNP is associated with the spontaneous clearance of HCV in children independently of HCV genotype. Four paediatric studies have shown that both the CC genotype of the rs12979860 SNP and the TT genotype of the rs8099917 SNP are associated with the treatment-induced (IFN monotherapy and Pegylated-IFN-α and ribavirin association) clearance of HCV, while the rs12980275 SNP did not affect the virological response. The possible role of IFNL3 gene variation as a pre-treatment and on-treatment predictor of virological response in children is highly attractive but still undetermined. Further paediatric studies are needed to evaluate if testing for SNPs in IFNL3, either alone or together with other predictors of response to treatment, could be used to direct treatment strategies, including an avoidance of unnecessary protease inhibitor therapy and the duration of treatment.

关键词： Hepatitis C virus Children Interferon L3 IL28B Interferon-λ Treatment Virological response

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