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OxInflammation in Alzheimer's disease

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Neural Regeneration Research 2023年第12期18卷 2709-2710页

作者： Carlo Cervellati Giovanni Zuliani giuseppe Valacchi Department of Translational Medicine and for Romagna University of FerraraFerraraItaly Department of Environmental Sciences and Prevention University of FerraraFerraraItaly Plants for Human Health Institute Animal Science DepartmentNC State UniversityKannapolisNCUSA Department of Food and Nutrition Kyung Hee UniversitySeoulSouth Korea

Oxlnflammation:definition and role in disease:Oxlnflammation has been introduced as a new term in the biomedical field to highlight the deep and mutual relationship between the dysregulation of redox and immune homeostasis(Valacchi et al.,2018).Regardless of which is the initial spark,inflammation cannot take place without a concomitant oxidative stress response and *** other words,they are sides of the same coin.

关键词： al. homeostasis inflammation

Effect of stepover and torch tilting angle on a repair process using WAAM

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Advances in Manufacturing 2022年第4期10卷 541-555页

作者： Francesco Baffa giuseppe Venturini Gianni Campatelli Emanuele Galvanetto Department of Industrial Engineering University of FlorenceFlorenceItaly

To sustain the transition to a greener economy and greener manufacturing,it is necessary to develop new approaches and technologies to repair metal components;this will result in a drastic reduction in energy and material *** this study,wire arc additive manufacturing(WAAM)was used to deposit a layer of new material on an existing surface,with the objective of finding the optimal configuration that maximized the layer quality and material *** parameters considered are the stepover among the deposited beads and the inclination of the torch with respect to the repaired *** inclination angle is crucial when repairing complex surfaces,like those of a mold,owing to accessibility issues,the torch cannot be maintained orthogonal to the surfaces along the entire *** configurations were tested in order to assess the quality of the materials in terms of the presence of material voids,depth of penetration,and the heat affected zone(HAZ)and to understand the effects of these variables on the material efficiency and thickness of the repairing *** should be noted that by adopting deposition parameters set to have a low heat input,the use of a tilting angle has beneficial effects on the quality of the deposited layer and the process *** and geometrical measurements were carried out to assess the effect of these two variables depositing a layer of plain carbon steel.

关键词： Wire arc additive manufacturing(WAAM) Repairing·Torch inclination Stepover Remanufacturing

Target Capturing in an Ellipsoidal Region for a Swarm of Double Integrator Agents

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IEEE/CAA Journal of Automatica Sinica 2022年第5期9卷 801-811页

作者： Antonio Bono Luigi D'Alfonso giuseppe Fedele Veysel Gazi IEEE Department of Informatics ModelingElectronics and Systems EngineeringUniversity of CalabriaRende 87036Italy Dept.Electrical and Electronics Eng. Faculty of EngineeringMarmara UniversityIstanbul 34722 Department of Control and Automation Engineering Faculty of Electrical and Electronics EngineeringYildiz Technical UniversityEsenler 34220Turkey

In this paper we focus on the target capturing problem for a swarm of agents modelled as double integrators in any finite space *** agent knows the relative position of the target and has only an estimation of its velocity and *** that the estimation errors are bounded by some known values,it is possible to design a control law that ensures that agents enter a user-defined ellipsoidal ring around the moving *** know the relative position of the other members whose distance is smaller than a common detection ***,in the case of no uncertainty about target data and homogeneous agents,we show how the swarm can reach a static configuration around the moving *** simulations are reported to show the effectiveness of the proposed strategy.

关键词： Agents-based systems cooperative control swarms target-capturing

Role of exercise in the brain:focus on oligodendrocytes and remyelination

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Neural Regeneration Research 2023年第12期18卷 2645-2646页

作者： Grazia Maugeri Velia D'Agata giuseppe Musumeci Section of Anatomy Histology and Movement SciencesDepartment of Biomedical and Biotechnological SciencesUniversity of CataniaCataniaItaly Research Center on Motor Activities(CRAM) University of CataniaCataniaItaly Department of Biology Sbarro Institute for Cancer Research and Molecular MedicineCollege of Science and TechnologyTemple UniversityPhiladelphiaPAUSA

The phrase“Mens sana in corpore sano”taken from Juvenal's Satires(127 a.C.)represents one of the best-known and most used sentences of all time,whose meaning in the modern age refers to the importance of physical activity for mental health and *** literature demonstrated the positive role of exercise in counteracting several diseases,such as diabetes,cardiovascular diseases,neurodegenerative diseases,cancers and age-related disorders including muscle atrophy,the reduction of aerobic capacity,bone and cartilage loss.

关键词： meaning such exercise

Intermediate-term oncological and functional outcomes in prostate cancer patients treated with perineal robot-assisted radical prostatectomy:A single center analysis

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Asian Journal of Urology 2023年第4期10卷 423-430页

作者： Umberto Carbonara giuseppe Lippolis Luciano Rella Paolo Minafra giuseppe Guglielmi Antonio Vitarelli giuseppe Lucarelli Pasquale Ditonno Department of Emergency and Organ Transplantation Urology UnitAldo Moro UniversityBariItaly

Objective:In the last 10 years,robotic platforms allowed to resume of some alternative surgical approaches,including perineal robot-assisted radical prostatectomy(p-RARP).Herein,we present in detail the oncological and functional outcomes of patients who underwent p-RARP with a median follow-up of 30 ***:Patients presenting low-or intermediate-risk prostate cancer and prostate volume up to 60 mL who underwent p-RARP between November 2018 and November 2022 were ***,intraoperative,pathological,and postoperative data were collected and then ***:Thirty-seven p-RARP cases were *** patients presented mean age of 62 years and a mean Charlson comorbidity index of *** mass index of≥25 kg/m^(2)was reported by 24(64.9%)patients,as well as 7(18.9%)patients reported a past surgical *** prostate volume and median prostate-specific antigen were 41 mL and 6.2 ng/mL,*** median operative time was 242 *** positive surgical margin rate was 45.9%.In terms of postoperative complications,10 patients reported complications with any grade;however,a single case(2.7%)of major(Clavien-Dindo grade≥3)complication was *** patient with biochemical recurrence or distant metastasis was reported at 2 years of *** of continence rates were 67.6%,75.7%,and 92.9%,at 6 months,12 months,and 24 months after surgery,respectively.

关键词： Prostate cancer Robotic Perineal Radical prostatectomy Continence Robot-assisted radical prostatectomy Nerve-sparing

Phenotyping Key Fruit Quality Traits in Olive Using RGB Images and Back Propagation Neural Networks

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Plant Phenomics 2023年第3期5卷 484-500页

作者： giuseppe Montanaro Angelo Petrozza Laura Rustioni Francesco Cellini Vitale Nuzzo Università degli Studi della Basilicata 85100 PotenzaItaly ALSIA Agenzia Lucana Sviluppo Innovazione in AgricolturaMetapontum Agrobios Research Center75010 MetapontoItaly Department of Biological and Environmental Sciences and Technologies University of SalentoLecceItaly

To predict oil and phenol concentrations in olive fruit,the combination of back propagation neural networks(BPNNs)and contact-less plant phenotyping techniques was employed to retrieve RGB image-based digital proxies of oil and phenol *** of cultivars(×3)differing in ripening time were sampled(~10-day interval,×2 years),pictured and analyzed for phenol and oil *** to this,fruit samples were pictured and images were segmented to extract the red(R),green(G),and blue(B)mean pixel values that were rearranged in 35 RGB-based colorimetric *** BPNNs were designed using as input variables(a)the original 35 RGB indexes,(b)the scores of principal components after a principal component analysis(PCA)pre-processing of those indexes,and(c)a reduced number(28)of the RGB indexes achieved after a sparse *** results show that the predictions reached the highest mean R^(2) values ranging from 0.87 to 0.95(oil)and from 0.81 to 0.90(phenols)across the *** addition to the R^(2),other performance metrics were calculated(root mean squared error and mean absolute error)and combined into a general performance indicator(GPI).The resulting rank of the GPI suggests that a BPNN with a specific topology might be designed for cultivars grouped according to their ripening *** present study documented that an RGB-based image phenotyping can effectively predict key quality traits in olive fruit supporting the developing olive sector within a digital agriculture domain.

关键词： Image image supporting

SARS-CoV-2 and the pancreas: What do we know about acute pancreatitis in COVID-19 positive patients?

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World Journal of Gastroenterology 2022年第36期28卷 5240-5249页

作者： giuseppe Brisinda Maria Michela Chiarello giuseppe Tropeano Gaia Altieri Caterina Puccioni Pietro Fransvea Valentina Bianchi Department of Medical and Surgical Sciences Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy Department of Medicine and Surgery UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Surgery Azienda Sanitaria Provinciale di CosenzaCosenza 87100Italy Emergency Surgery and Trauma Center Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)can cause pancreatic damage,both directly to the pancreas via angiotensin-converting enzyme 2 receptors(the transmembrane proteins required for SARS-CoV-2 entry,which are highly expressed by pancreatic cells)and indirectly through locoregional vasculitis and *** that,there is no clear evidence that SARS-CoV-2 is an etiological agent of acute *** pancreatitis in coronavirus disease 2019(COVID-19)positive patients often recognizes biliary or alcoholic *** prevalence of acute pancreatitis in COVID-19 positive patients is not exactly ***,COVID-19 positive patients with acute pancreatitis have a higher mortality and an increased risk of intensive care unit admission and necrosis compared to COVID-19 negative *** respiratory distress syndrome is the most frequent cause of death in COVID-19 positive patients and concomitant acute *** this article,we reported recent evidence on the correlation between COVID-19 infection and acute pancreatitis.

关键词： Acute pancreatitis SARS-CoV-2 Severe acute pancreatitis Multiparametric scores Infected necrosis Step-up approach

Role of PTX3 and complement modulation in the tumor microenvironment

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BIOCELL 2022年第10期46卷 2235-2239页

作者： giuseppe STEFANO NETTI FEDERICA SPADACCINO VALERIA CATALANO giuseppe CASTELLANO GIOVANNI STALLONE ELENA RANIERI Clinical Pathology Unit and Center for Molecular Medicine Department of Medical and Surgical SciencesUniversity of FoggiaFoggia71122Italy Nephrology Dialysis and Renal Transplant UnitDepartment of Clinical Sciences and Community HealthFondazione IRCCS Ca’Granda-OspedaleMaggiore Policlinico-University of MilanMilan20122Italy Nephrology Dialysis and Transplantation Unit Advanced Research Center on Kidney Aging(A.R.K.A.)Department of Medical and Surgical SciencesUniversity of FoggiaFoggia71122Italy

Pentraxin-3(PTX3),the prototype of long pentraxins,seems to influence complement system(CS)***3 and CS sustain carcinogenesis,enriching tumor microenvironment(TME)with pro-inflammatory molecules promoting angiogenesis in prostate cancer(PC)and renal cell carcinoma(RCC).Furthermore,cancer cells overexpress complement regulatory proteins,such as CD46,CD55 and CD59,which negatively affect complement pathways for support cancer cells *** viewpoint aims to elucidate the ambivalent role of PTX3 and the CS in the context of tumor microenvironment(TME).

关键词： Pentraxin-3 Complement system Tumor microenvironment Prostate cancer Renal cell carcinoma

Therapeutic strategies in Crohn’s disease in an emergency surgical setting

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World Journal of Gastroenterology 2022年第18期28卷 1902-1921页

作者： Maria Michela Chiarello Gilda Pepe Valeria Fico Valentina Bianchi giuseppe Tropeano Gaia Altieri giuseppe Brisinda Department of Surgery San Giovanni in Fiore HospitalAzienda Sanitaria Provinciale di CosenzaCosenza 87100Italy Emergency Surgery and Trauma Center Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy Department of Surgery Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy Medical and Surgical Science UniversitàCattolica del Sacro CuoreRome 00168Italy

Crohn’s disease(CD)remains a chronic,incurable disorder that presents unique challenges to the *** factors must be considered to allow development of an appropriate treatment *** therapy often precedes or complements the surgical *** indications for operative management of CD include acute and chronic disease complications and failed medical *** surgery comes into play when patients are refractory to medical treatment if they have an obstructive *** colitis,acute obstruction,perforation,acute abscess,or massive hemorrhage represent indications for emergency *** patients are generally in critical conditions and present with intra-abdominal sepsis and a preoperative status of immunosuppression and malnutrition that exposes them to a higher risk of complications and mortality.A multidisciplinary team including surgeons,gastroenterologists,radiologists,nutritional support services,and enterostomal therapists are required for optimal patient care and decision *** of each emergency should be individualized based on patient age,disease type and duration,and patient goals of ***,the recurrent nature of disease mandates that we continue searching for innovative medical therapies and operative techniques that reduce the need to repeat surgical *** this review,we aimed to discuss the acute complications of CD and their treatment.

关键词： Crohn’s disease Intestinal obstruction Free perforation Intra-abdominal sepsis Perineal sepsis Acute bleeding