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World Journal of Stem Cells 2024年第2期16卷 89-101页

作者： Pier Luigi Surico Anna Scarabosio giovanni Miotti Martina Grando Carlo Salati Pier Camillo parodi Leopoldo Spadea Marco Zeppieri Schepens Eye Research Institute of Mass Eye and Ear Harvard Medical SchoolBostonMA 02114United States Department of Ophthalmology Campus Bio-Medico UniversityRome 00128Italy Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Internal Medicine Azienda Sanitaria Friuli OccidentaleSan Vito al Tagliamento 33078Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I“Sapienza”University of RomeRome 00142Italy

This review comprehensively explores the versatile potential of mesenchymal stem cells(MSCs)with a specific focus on adipose-derived *** and oculoplastic surgery,encompassing diverse procedures for ocular and periocular enhancement,demands advanced solutions for tissue restoration,functional and aesthetic refinement,and *** immunomodulatory,regenerative,and healing capacities of MSCs,this review underscores the potential use of adipose-derived MSCs as a cost-effective alternative from bench to bedside,addressing common unmet needs in the field of reconstructive and regenerative surgery.

关键词： Stem cells Adipose stem cell Ocular therapy Oculoplastics Regenerative

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RES:定制材料成形

世界建筑导报 2015年第4期30卷 38-40页

作者： Andre Felipe Escudero Dimitrije Miletic giovanni parodi Dimitar Pouchnikovl Robert Stuart-Smith

该研究策略性地执行了场外和现场施工流程,从而创造出一种能够将浪费最小化的设计和施工方法,无需在现场使用大量脚手架,并能带来成形生产工艺所固有的新的设计潜力。该项目设计了一座采用轻型纤维复合材料的宜居桥梁。桥梁预制件切自... 详细信息

该研究策略性地执行了场外和现场施工流程,从而创造出一种能够将浪费最小化的设计和施工方法,无需在现场使用大量脚手架,并能带来成形生产工艺所固有的新的设计潜力。该项目设计了一座采用轻型纤维复合材料的宜居桥梁。桥梁预制件切自工厂的平面纤维材料,然后将其裁剪组合成三维构件,这种方式类似于对大块布料的操作方式。

关键词：纤维复合材料 RES 纤维材料在现场施工方法 factory 生产工艺 costly 结构分析 fibre

Fat management in upper blepharoplasty:Addition or subtraction blepharoplasties,how and when

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World Journal of Clinical Cases 2024年第16期12卷 2796-2802页

作者： giovanni Miotti Jacopo Di Filippo Martina Grando Carlo Salati Pier Camillo parodi Leopoldo Spadea Caterina Gagliano Mutali Musa Marco Zeppieri Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Internal Medicine Azienda Sanitaria Friuli OccidentaleSan Vito al Tagliamento 33078Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I"Sapienza"University of RomeRome 00142Italy Department of Medicine and Surgery University of Enna"Kore"Enna 94100Italy Eye Clinic Catania University San Marco HospitalCatania 95121Italy Department of Optometry University of BeninBenin 3000283Nigeria Department of Ophthalmology Centre for Sight AfricaNkporOnitsha 434112Niger

BACKGROUND As one of the most common aesthetic surgical procedures carried out today,blepharoplasty should be in the repertoire of every plastic *** term blepharoplasty encompasses a wide range of techniques and options that must be tailored to the specific defect and patient one has to treat.A sound knowledge of the upper and lower eyelids’anatomy is essential for proper surgical *** have shifted towards more conservative methods(especially of the fat compartment)and sometimes in combination with augmentation techniques,helping to reach a rejuvenated *** To present an overview of the surgical techniques considered for upper lid blepharoplasty and fat pad management,in addition to information on how a surgeon may approach the best treatment for his patient based on current publications in *** We searched the literature published between 2013,to 2023 using Medline and Reference Citation *** database was searched using the keywords“upper blepharoplasty”AND“fat”.Papers without full text/abstracts and reviews were *** search strategy followed the *** American Society of Plastic Surgeons guidelines for Therapeutic Studies checklist was used to assess all *** authors individually reviewed each article and rated them for importance and relevance to the topic.A consensus was sought and the most relevant *** After the application of the selection criteria used in our review,13 publications were found to address upper lid blepharoplasty *** of these studies were reviews and three were retrospective *** publications were comparative studies and a further two were clinical *** The tendency of modern surgery is to be conservative,by removing adipose tissue only if strictly necessary and restoring the volume of the upper eyelid in a concept of beauty that espouses a"full"*** is no gold standard technique to achieve younger and enhanced eyelids

关键词： Blepharoplasty Fat pads Eye lid surgery Cosmetic aesthetic surgery Rejuvenation Plastic surgery

Fat or fillers:The dilemma in eyelid surgery

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World Journal of Clinical Cases 2024年第17期12卷 2951-2965页

作者： giovanni Miotti Luca De Marco Davide Quaglia Martina Grando Carlo Salati Leopoldo Spadea Caterina Gagliano Mutali Musa Pier Luigi Surico Pier Camillo parodi Marco Zeppieri Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Internal Medicine Azienda Sanitaria Friuli OccidentaleSan Vito al Tagliamento 33078Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I“Sapienza”University of RomeRome 00142Italy Department of Medicine and Surgery University of Enna“Kore”Enna 94100Italy Eye Clinic Catania University San Marco Hospital Viale Carlo Azeglio CiampiCatania 95121Italy Department of Optometry University of BeninBenin 300283Nigeria Department of Ophthalmology Africa Eye Laser CentreKm 7Benin 300105Nigeria Schepens Eye Research Institute of Mass Eye and Ear Harvard Medical SchoolBostonMA 02114United States

The aging of the periocular region has always aroused great interest.A fresh,young,and attractive sight determined an ever-greater attention to surgical and non-surgical techniques to obtain this *** particular,the change in the concept of a young look,considered then“full”,led to the increasing use of surgical(fat grafting)or medical(hyaluronic acid)filling *** rejuvenation became increasingly popular in the field of cosmetic treatments,with a focus on achieving a youthful and refreshed *** the various techniques available,the choice between using fat grafting or fillers presented a clinical *** particular,what surgery considered of fundamental importance was a long-lasting result over *** the other hand,aesthetic medicine considered it fundamental not to have to resort to invasive *** what was the reality?Was there one path better than the other,and above all,was there a better path for patients?The minireview aims to explore the physiopathology,diagnosis,treatment options,prognosis,and future studies regarding this *** analyzed the literature produced in the last 20 years comparing the two *** literature reveals advancements in biomaterials,stem cell research and tissue engineering held promise for further enhancing the field of eyelid *** choice between fat grafting and fillers in eyelid cosmetic treatments presented a clinical *** physiopathology,accurately diagnosing eyelid aging,exploring treatment options,assessing prognosis,and conducting future studies were essential for providing optimal care to patients seeking eyelid rejuvenation.

关键词： Stem cells Adipose stem cell Ocular therapy Oculoplastics Regenerative

Stem cell therapy in ocular pathologies in the past 20 years

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World Journal of Stem Cells 2021年第5期13卷 366-385页

作者： giovanni Miotti Pier Camillo parodi Marco Zeppieri Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy

Stem cell therapies are successfully used in various fields of *** new approach of research is also expanding in *** investments,resources and important clinical trials have been performed in stem cell research and in potential *** recent years,great strides have been made in genetic research,which permitted and enhanced the differentiation of stem ***,the possibility of exploiting stem cells from other districts(such as adipose,dental pulp,bone marrow stem cells,etc.)for the treatment of ophthalmic diseases,renders this topic ***,great strides have been made in biomedical engineering,which have proposed new materials and threedimensional structures useful for cell therapy of the *** encouraging results obtained on clinical trials conducted on animals have given a significant boost in the creation of study protocols also in *** are limited to date,but clinical trials continue to *** attention is centered on the literature reported over the past 20 years,considering animal(the most represented in literature)and human clinical trials,which are *** aim of our review is to present a brief overview of the main types of treatments based on stem cells in the field of ophthalmic pathologies.

关键词： Stem cells Multipotent mesenchymal cells Adipose stem cells Novel therapies Eye pathology Cornea Cell therapies New materials

Modern blepharoplasty:From bench to bedside

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World Journal of Clinical Cases 2023年第8期11卷 1719-1729页

作者： giovanni Miotti Marco Zeppieri Giacomo Pederzani Carlo Salati Pier Camillo parodi Department of Medical Surgical and Health SciencesPlastic and Reconstructive Surgery UnitUniversity of TriesteTrieste 34123Italy Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy

The demand for procedures aiming to rejuvenate the upper third part of the face and the periocular region has increased in the past several *** is one of the most frequently performed procedures worldwide to *** is currently the first choice in order to achieve permanent and effective results;however,it is burdened by potential surgical complications feared by *** is an increasing trend in individuals to request less invasive,non-surgical,effective,and safe procedures for eyelid *** aim of this minireview is to present a brief overview of non-surgical blepharoplasty techniques that have been reported in the literature in the past 10 *** modern techniques that provide a rejuvenation of the entire area have been *** less invasive methods have been proposed in the current literature and in modern-day routine clinical *** fillers are a commonly chosen option for providing enhanced aesthetic results,especially considering that volume loss can be one of the main underlying causes of facial and periorbital *** acid use may be considered when the problem is represented by periorbital excess fat *** simultaneous excess and loss of elasticity of the skin can be assessed with techniques such as lasers and plasma ***,techniques such as platelet-rich plasma injections and the insertion of twisted polydioxanone threads are emerging as viable methods to rejuvenate the periorbital region.

关键词： Non-surgical blepharoplasty Laser treatment Dermatochalasis Aesthetic Non-invasive procedures Hyaluronic acid Plasma exeresis Eyelids

How and when of eyelid reconstruction using autologous transplantation

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World Journal of Transplantation 2022年第7期12卷 175-183页

作者： giovanni Miotti Marco Zeppieri Agostino Rodda Carlo Salati Pier Camillo parodi Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Medical Surgical and Health SciencesPlastic and Reconstructive Surgery UnitUniversity of TriesteTrieste 34123Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy

Reconstructive surgery of the eyelid after tumor excision,trauma or other causes can be challenging,especially due to the complexities of the anatomic structures and to the necessity of both functional and aesthetic successful *** aim of this minireview was to investigate the use of tissue transplantation in eyelid *** procedures are various,based on the use of both flaps,pedicled or free,and grafts,in order to guarantee adequate tissue reconstruction and blood supply,which are necessary for correct *** techniques normally include the use of local tissues,combining non-vascularized grafts with a vascularized flap for the two lamellae repair,to attempt a reconstruction similar to the original *** defects are too wide,vast,deep,and complex or when no adjacent healthy tissues are available,distant area tissues need to be recruited as free flaps or grafts and paired with mucosal layer *** regards to the anterior lamella,full thickness skin grafts are commonly *** regards to the reconstruction of posterior lamella,there are different graft options,which include conjunctival or tarsoconjunctival,mucosal or palatal or cartilaginous grafts usually combined with local *** flap transplantation,normally reserved for rare select cases,include the use of the radial forearm and anterolateral flaps combined with mucosal grafts,which are surgical options currently reported in the literature.

关键词： Eyelid reconstruction Graft transplantation Flap transplantation Eyelid lamella grafts Cartilage grafts Dermis grafts Mucosa grafts