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World Journal of Gastroenterology 2012年第34期18卷 4677-4683页

作者： Guglielmo Borgia Maria Aurora Carleo giovanni battista gaeta Ivan Gentile Department of Public Medicine and Social Security Section of Infectious DiseasesUniversity of Naples "Federico Ⅱ"80131 NaplesItaly Department of Internal Medicine Section of Infectious DiseasesSecond University of Naples80131 NaplesItaly

Chronic hepatitis B virus (HBV) infection affects about 350 million individuals worldwide. Management of HBV infection in pregnancy is difficult because of several peculiar and somewhat controversial aspects. The aim of the present review is to provide a tool that may help physicians to correctly manage HBV infection in pregnancy. This review focuses on (1) the effect of pregnancy on HBV infection and of HBV infection on pregnancy; (2) the potential viral transmission from mother to newborn despite at-birth prophylaxis with immunoglobulin and vaccine; (3) possible prevention of mother-to-child transmission through antiviral drugs, the type of antiviral drug to use considering their efficacy and potential teratogenic effect, and the timing of their administration and discontinuation; and (4) the evidence for the use of elective caesarean section vs vaginal delivery and the possibility of breastfeeding.

关键词： Hepatitis B virus Pregnancy Therapy Te-nofovir Lamivudine Telbivudine Entecavir Breastfeed-ing Elective caesarean section

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Is spleen circulation impaired in systemic sclerosis and what is the role of liver fibrosis?

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World Journal of Gastroenterology 2011年第12期17卷 1606-1613页

作者： giovanni Tarantino Angelo Spanò Gabriella Loi Anna Parisi Marianna Tarantino Giuseppina Brancaccio giovanni battista gaeta Antonio Riccio Department of Clinical and Experimental Medicine Federico II University Medical School of Naples80131 NaplesItaly Department of Biomorphological and Functional Sciences Federico II University Medical School of Naples80131 NaplesItaly Department of Infectious Diseases Second University of Naples80131 NaplesItaly

AIM:To investigate the spleen vascular involvement and the presence of liver fibrosis in a population of subjects with established systemic sclerosis(SSc).METHODS:In a cross-sectional fashion,17 patients with SSc were compared with 18 patients suffering from hepatitis C virus(HCV) -related liver cirrhosis,grade A and B Child-Pugh *** non elderly subjects,apparently healthy,were used as the control *** artery resistivity index(SARI) at doppler ultraSound,transient elastography of liver and nailfold capillaroscopy were the main ***:Transient elastography values of SSc patients were similar to those of controls;5.2±1.1 vs 4.5 ±1,(P=0.07).Median Alanine amino transferase(ALT) concentrations of cirrhotic patients were greater than those of controls and SSc patients,i.e.66.5(36-89) U/L vs 29(22-34) U/L and 31(22-41) U/L,respectively,(P =0.005).SARI determinations in cirrhotic patients,although significantly higher than those found in controls and SSc patients,showed some degree of overlap with SSc patients,i.e.0.59 vs 0.52 and 0.57,respectively,(P =0.04).Mean systolic blood pressure was significantly higher in SSc patients than in cirrhotics and controls,i.e.142 mmHg vs 128.2 mmHg and 127 mmHg,respectively,(P=0.005).Mean diastolic blood pressure behaved in a similar fashion,i.e.84 mmHg vs 72.2 mmHg and 76.9 mmHg(P=0.005).Nailfold Capillaroscopy grades and diastolic blood pressure values correlated well with SARI ***:An enhanced resistivity of the splenic artery was found in patients suffering from SSc;they did not have evidence of splenomegaly as well as no liver fibrosis or any other form of liver damage.

关键词： Splenic artery resistivity index Doppler ultrasound Transient elastography Nailfold capillaroscopy Systemic sclerosis Liver fibrosis

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Viral blips during long-term treatment with standard or double dose lamivudine in HBe antigen negative chronic hepatitis B

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World Journal of Gastroenterology 2007年第42期13卷 5642-5647页

作者： Gianfranca Stornaiuolo Maria Stanzione Giuseppina Brancaccio Gianluca Cuomo Vincenza Precone Sebastiano Di Biase Francesca M Felaco Felice Piccinino giovanni B gaeta Viral Hepatitis Unit Department of Infectious Diseases Second University Naples Italy Infectious Disease Unit Department of Infectious Diseases Second University Naples Italy Merigen Laboratory of Molecular Biology Naples Italy

AIM:To evaluate safety and effect on hepatitis B virus(HBV)suppression of a long-term treatment with lamivudine(LAM)at standard(100 mg/d)or double(200 mg/d)dose in chronic hepatitis ***:This was a case study with matched controls(1:3)in patients with chronic hepatitis B with anti-HBe ***:Twelve patients received LAM 200 mg/d and 35 LAM 100 mg/d,for a median of 28 mo.A primary response(PR;*** HBV-DNA with Amplicor assay)was achieved in 100% of LAM-200 patients and 83% of LAM-100 patients.A virological breakthrough occurred in 16.7 and 24.7%,respectively,of the PR-patients,with the appearance of typical LAM resistance mutations in all but one *** blips(*** HBV-DNA below 80 IU/mL in patients who tested negative at Amplicor assay)were detected using a real time polymerase chain reaction(PCR)and occurred in seven out of nine patients with subsequent BT and in four out of 32 patients with end-of-study response(77.7% vs 12.5%;P = 0.001)at chi-square test).At the end of the study,51.4% of LAM-100 patients and 83.3% of LAM-200 patients had remained stably HBV-DNA ***-dose LAM was well ***:Long-term treatment of anti-HBe positive chronic hepatitis B with double dose lamivudine causes a more profound and stable viral suppression ascompared to conventional treatment.

关键词： Lamivudine Hepatitis B Chronic Hepatitis Polymerase chain reaction

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