Is spleen circulation impaired in systemic sclerosis and what is the role of liver fibrosis?

作     者：Giovanni Tarantino Angelo Spanò Gabriella Loi Anna Parisi Marianna Tarantino Giuseppina Brancaccio Giovanni Battista Gaeta Antonio Riccio 

作者机构：Department of Clinical and Experimental MedicineFederico II University Medical School of Naples80131 NaplesItaly Department of Biomorphological and Functional SciencesFederico II University Medical School of Naples80131 NaplesItaly Department of Infectious DiseasesSecond University of Naples80131 NaplesItaly 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2011年第17卷第12期

页      面：1606-1613页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by Funds of the Department of Clinical and Experimental Medicine of the Federico II University 

主　　题：脾的动脉抵抗力索引 Doppler 超声 短暂 elastography Nailfold capillaroscopy 全身的硬化 肝纤维变性 

摘      要：AIM:To investigate the spleen vascular involvement and the presence of liver fibrosis in a population of subjects with established systemic sclerosis(SSc).METHODS:In a cross-sectional fashion,17 patients with SSc were compared with 18 patients suffering from hepatitis C virus(HCV) -related liver cirrhosis,grade A and B Child-Pugh *** non elderly subjects,apparently healthy,were used as the control *** artery resistivity index(SARI) at doppler ultraSound,transient elastography of liver and nailfold capillaroscopy were the main ***:Transient elastography values of SSc patients were similar to those of controls;5.2±1.1 vs 4.5 ±1,(P=0.07).Median Alanine amino transferase(ALT) concentrations of cirrhotic patients were greater than those of controls and SSc patients,i.e.66.5(36-89) U/L vs 29(22-34) U/L and 31(22-41) U/L,respectively,(P =0.005).SARI determinations in cirrhotic patients,although significantly higher than those found in controls and SSc patients,showed some degree of overlap with SSc patients,i.e.0.59 vs 0.52 and 0.57,respectively,(P =0.04).Mean systolic blood pressure was significantly higher in SSc patients than in cirrhotics and controls,i.e.142 mmHg vs 128.2 mmHg and 127 mmHg,respectively,(P=0.005).Mean diastolic blood pressure behaved in a similar fashion,i.e.84 mmHg vs 72.2 mmHg and 76.9 mmHg(P=0.005).Nailfold Capillaroscopy grades and diastolic blood pressure values correlated well with SARI ***:An enhanced resistivity of the splenic artery was found in patients suffering from SSc;they did not have evidence of splenomegaly as well as no liver fibrosis or any other form of liver damage.