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Management of antiplatelet or anticoagulant therapy in endoscopy: A review of literature

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World Journal of Gastrointestinal Endoscopy 2020年第6期12卷 172-192页

作者： Marcello Maida Sandro Sferrazza Carlo Maida Gaetano Cristian Morreale Alessandro Vitello giovanni longo Vincenzo Garofalo Emanuele Sinagra Gastroenterology and Endoscopy Unit S.Elia-Raimondi HospitalCaltanissetta 93100Italy Gastroenterology and Endoscopy Unit Santa Chiara HospitalTrento 38123Italy U.O.C di Medicina Interna con Stroke Care Dipartimento di Promozione della SaluteMaterno-Infantiledi Medicina Interna e Specialistica di Eccellenza“G.D’Alessandro”University of PalermoPalermo 93100Italy Cardiology Unit S.Elia-Raimondi HospitalCaltanissetta 93100Italy Gastroenterology and Endoscopy Unit Istituto San Raffaele GiglioCefalu 90015Italy

Endoscopic procedures hold a basal risk of bleeding that depends on the type of procedure and patients’***,they are often performed in patients taking antiplatelet and anticoagulants agents,increasing the potential risk of intraprocedural and delayed *** if the interruption of antithrombotic therapies is undoubtful effective in reducing the risk of bleeding,the thromboembolic risk that follows their suspension should not be ***,it is fundamental for each endoscopist to be aware of the bleeding risk for every procedure,in order to measure the risk-benefit ratio for each ***,knowledge of the proper management of antithrombotic agents before endoscopy,as well as the adequate timing for their resumption is *** review aims to analyze current evidence from literature assessing,for each procedure,the basal risk of bleeding and the risk of bleeding in patients taking antithrombotic therapy,as well as to review the recommendation of American society for gastrointestinal endoscopy,European society of gastrointestinal endoscopy,British society of gastroenterology,Asian pacific association of gastroenterology and Asian pacific society for digestive endoscopy guidelines for the management of antithrombotic agents in urgent and elective endoscopic procedures.

关键词： Antiplatelet Anticoagulant Endoscopy Management Bleeding Risk

Phosphodiesterase 9 localization in cytoplasm and nucleus:the gateway to selective targeting in neuroprotection?

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Neural Regeneration Research 2025年第6期20卷 1701-1702页

作者： giovanni Ribaudo Matteo Giannangeli Margrate Anyanwu Alessandra Gianoncelli Department of Molecular and Translational Medicine University of BresciaBresciaItaly

The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous *** diseases affect more than 50million people *** disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully *** of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon *** kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.

关键词： gateway homeostasis preserve

The Rise and Fall of the Secular Trend in Body Height in Sardinia:An Age-Period-Cohort Analysis

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Biomedical and Environmental Sciences 2020年第3期33卷 183-190页

作者： giovanni Mario PES Roberta SALIS Alessandra ERRIGO Marco SATURNO Stefano BIBBO’ Bianca Maria QUARTA COLOSSO Nunzio Pio longo Maria Pina DORE Department of Medical Surgical and Experimental SciencesUniversity of SassariI-07100 SassariItaly

Objective Over the last century, a progressive rise in stature, known as the ‘secular trend’, was documented worldwide, and especially in Sardinia, it has reached a peak in Europe. However, this situation recently ceased in several populations. In this study, we tested the hypothesis that the stature secular trend has significantly leveled off in the Sardinian younger *** Height measurements were retrieved from a database of patients undergoing digestive endoscopy, spanning generations between 1920 and 1990. Sex-specific principal component regression models were fitted to decompose stature variation into the contribution of age, period, and birth *** A steady increase in stature was observed in generations born after 1920, with an upward surge in those born after 1950. However, a significant leveling off was observed among cohorts born after 1970 among both sexes, as mean heights stabilized at 171.1 cm with a standard error(SE) of 0.9 cm among men and a mean of 160.1 cm(SE = 0.9 cm) among *** Our findings support a significant slowdown in the secular trend of stature among the latest Sardinian generations. Several factors, including the consumption of low-quality food, lack of physical activity, and late motherhood, among others, may explain the decline in the secular trend.

关键词： Body height Secular trend Socioeconomic status Sardinia

Potential therapeutic applications of mesenchymal stem cells for the treatment of eye diseases

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World Journal of Stem Cells 2021年第6期13卷 632-644页

作者： Giuliana Mannino Cristina Russo Anna longo Carmelina Daniela Anfuso Gabriella Lupo Debora Lo Furno Rosario Giuffrida giovanni Giurdanella Department of Biomedical and Biotechnological Sciences School of MedicineUniversity of CataniaCatania 95123Italy

Stem cell-based treatments have been extensively explored in the last few decades to develop therapeutic strategies aimed at providing effective alternatives for those human pathologies in which surgical or pharmacological therapies produce limited *** stem cells of different sources,mesenchymal stem cells(MSCs)offer several advantages,such as the absence of ethical concerns,easy harvesting,low immunogenicity and reduced tumorigenesis *** than a multipotent differentiation ability,MSCs can release extracellular vesicles conveying proteins,mRNA and *** to these properties,new therapeutic approaches have been designed for the treatment of various pathologies,including ocular *** this review,the use of different MSCs and different administration strategies are described for the treatment of diabetic retinopathy,glaucoma,and retinitis *** a large number of investigations,positive results have been obtained by in vitro experiments and by MSC administration in animal *** authors agree that beneficial effects are likely related to MSC paracrine *** on these considerations,many clinical trials have already been carried ***,although some adverse effects have been described,promising outcomes are *** can be assumed that in the near future,safer and more effective protocols will be developed for more numerous clinical applications to improve the quality of life of patients affected by eye diseases.

关键词： Mesenchymal stem cells Eye diseases Diabetic retinopathy Glaucoma Retinitis pigmentosa Regenerative medicine

Locking plates for distal fibula fractures in young and elderly patients:A retrospective study

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World Journal of Orthopedics 2023年第7期14卷 540-546页

作者： Francesco Roberto Evola giovanni Francesco Di Fede Giuseppe Evola Martina Barchitta Antonella Agodi Gianfranco longo Department of Surgery Division of Orthopedics and Trauma Surgery“Cannizzaro”HospitalCatania 95100Italy Department of Radiodiagnostics Division of Radiology“S.Marta and S.Venera”HospitalAcireale 95024Italy Department of Surgery Division of Surgery“Garibaldi”HospitalCatania 95100Italy Department of Medical and Surgical Sciences and Advanced Technologies“GF Ingrassia” University of CataniaCatania 95100Italy

BACKGROUND Ankle fractures are common injuries in the young and elderly *** prevent post-traumatic arthritis,an anatomic reconstruction of the ankle structure is *** reduction and internal fixation is the treatment of choice among *** plates allow stability of the fracture if bone quality is *** plates might offer an advantage for the treatment of lateral malleolar fracture in patients with comminution,severe instability,distal fractures,or osteoporotic *** hospital introduced a new locking plate for fracture of the distal *** To evaluate locking plates in terms of outcomes and complications in young and elderly *** We retrospectively reviewed a total of 67 patients treated for displaced distal fibula *** data,number of comorbidities,use of inter fragmentary screw,complication,time of fracture healing,partial or full weight bearing,and reoperation were recorded for all *** outcome was assessed by the American Orthopedic Foot and Ankle Society clinical scoring *** were obtained at 4,8,12,16,20,and 24 wk until radiographic union was *** All patients displayed complete bony union on radiographic assessment,and no patients developed any serious *** observed two superficial infections,one delayed wound healing,and two plate *** differences were observed between the two age groups in terms of radiographic healing(11.9 wk in younger patients vs 13.7 wk in older patients;P=0.011)and in the American Orthopedic Foot and Ankle Society score at 6 mo after surgery(88.2 in younger patients vs 86.0 in older patients;P=0.001)and at 12 mo after surgery(92.6 in younger patients vs 90.0 in older patients;P=0.000).CONCLUSION Locking plates provide a stable and rigid fixation in multifragmentary and comminuted fractures or in the presence of poor bone quality.

关键词： Ankle fracture Locking plate Distal fibula fracture Outcome Complications Osteoporosis

High voltage direct current transmission cables to help decarbonisation in Europe:Recent achievements and issues

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High Voltage 2022年第4期7卷 633-644页

作者： giovanni Mazzanti Department of Electrical Electronic and Information EngineeringUniversity of BolognaBolognaItaly

High Voltage Direct Current(HVDC)underground and submarine cables constitute an essential technology for the long-distance transmission of renewable electrical power with low losses,thereby fostering *** the past 2 decades,all this yielded a quasi-exponential rise of HVDC cable systems installed worldwide,but has also made the working conditions of HVDC cables *** this paper,the contribution of HVDC cables to decarbonisation is tackled,with particular reference to the situation in Europe,and a few simple calculations showing in general terms the quantitative contribution provided by HVDC cable systems to decarbonisation are ***,the major issues towards long-lasting and reliable HVDC cable systems are summarised briefly,focussing-for the sake of brevity-on the influence of the main HVDC cable technologies,of cable laying environment and of duty *** hints are also provided at the chances given by multiterminal HVDC systems.

关键词： cable submarine thereby

Deep learning to develop zero-equation based turbulence model for CFD simulations of the built environment

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Building Simulation 2024年第3期17卷 399-414页

作者： giovanni Calzolari Wei Liu Division of Sustainable Buildings Department of Civil and Architectural EngineeringKTH Royal Institute of TechnologyBrinnelvägen 23Stockholm11428Sweden

This study aims to improve the accuracy and speed of predictions for thermal comfort and air quality in built environments by creating a coupled framework between computational fluid dynamics(CFD)simulations and deep learning *** coupling approach is showcased by the development of a data-driven turbulence *** new turbulence model is built using a deep learning neural network,whose mapping structure is based on a zero-equation turbulence model for built environment simulations,and is coupled with the CFD software OpenFOAM to create a hybrid *** neural network is a standard shallow multi-layer *** number of hidden layers and nodes per layer was optimized using Bayesan optimization *** framework is trained on an indoor environment case study,as well as tested on an indoor office simulation and an outdoor building array *** show that the deep learning based turbulence model is more robust and faster than traditional two-equation Reynolds average Navier-Stokes(RANS)turbulence models,while maintaining a similar level of *** model also outperforms the standard algebraic zero-equation model due to its superior ability to generalize to various flow *** some challenges,namely the mapping constraint,the limited training dataset size and the source of generation of training data,the hybrid framework demonstrates the viability of the coupling technique and serves as a starting point for future development of more reliable and advanced models.

关键词： neural networks computational fluid dynamics(CFD) turbulence model OpenFOAM

Numerical modeling of deep-seated landslides interacting with man-made structures

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第6期10卷 1020-1036页

作者： giovanni Barla Politecnico di Torino TorinoItaly

This paper describes the interaction between deep-seated landslides and man-made structures such as dams, penstocks, viaducts, and tunnels. Selected case studies are reported first with the intent to gain insights into the complexities associated with the interaction of these structures with deep-seated landslides(generally referred to as deep-seated gravity slope deformations, DSGSDs). The main features, which characterize these landslides, are mentioned together with the interaction problems encountered in each case. Given the main objective of this paper, the numerical modeling methods adopted are outlined as means for increase in the understanding of the interaction problems being investigated. With the above in mind, the attention moves to an important and unique case history dealing with the interaction of a large-size twin-tunnel excavated with an earth pressure balance(EPB)tunnel boring machine(TBM) and a deep-seated landslide, which was reactivated due to the stress changes induced by tunnel excavation in landslide shear zone. The geological and geotechnical conditions are described together with the available monitoring data on the landslide movements, based on the advanced and conventional monitoring tools used. Numerical modeling is illustrated as an aid to back-analyze the monitored surface and subsurface deformations and to assist in finding the appropriate engineering solution for putting the tunnel into service and as a follow-up means for future understanding and control of the interaction problems. The simulation is based on a novel time-dependent model representing the landslide behavior.

关键词： Deep-seated landslides Man-made structures Landslide-structure interaction Monitoring of landslide movement Numerical modeling

When Edge Computing Meets IoT Systems: Analysis of Case Studies

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China Communications 2020年第10期17卷 50-63页

作者： Fabio Arena giovanni Pau Faculty of Engineering and Architecture Kore University of EnnaCittadella UniversitariaEnna 94100Italy

On a macroscopic level,an edge computing architecture looks like a distributed and decentralized IT(Information Technology)*** in detail,it could be defined as a mesh network of micro data centers capable of processing and storing critical data locally,and to transmit all data received and/or processed to a central data center or a cloud storage *** network topology,also taking advantage of the availability on the market of cost-effective small form factor(SFF)electronic components and systems decreasing,brings the essential components of processing,storage,and networking closer to the sources that generate the *** typical use case is that of Internet of Things(IoT)devices and implementations,which often face latency problems,lack of bandwidth,reliability,which cannot be addressed through the conventional cloud *** this context,the edge computing architecture can reduce the size of data to be sent to the cloud,processing critical data,sensitive to latency,at the point of origin,via a smart device,or sending it to an intermediate server,located *** aim of this paper is to report some of the main aspects and significant features of edge computing and analyzing several popular case studies.

关键词： edge computing fog computing cloud computing analysis internet of things