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Layered double hydroxide(LDH)-based materials:A mini-review on strategies to improve the performance for photocatalytic water splitting

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Journal of Energy Chemistry 2022年第1期31卷 406-431,I0011页

作者： Hanane Boumeriame Eliana S.Da silva Alexey S.Cherevan Tarik Chafik Joaquim L.faria Dominik Eder Laboratory of Separation and Reaction Engineering-Laboratory of Catalysis and Materials(LSRE-LCM) Faculdade de EngenhariaUniversidade do PortoRua Dr Roberto Frias s/n4200-465 PortoPortugal Institute of Materials Chemistry Technische Universicat Wien(TU Wien)Getreidemarkt 9Vienna 1060Austria Laboratory of Chemical Engineering and Valorization of Resources(LGCVR-UAE/L01FST).Faculte des Sciences et Techniques Universite Abdelmalek EssaadiTangierMorocco

The high energy demand we currently face in society and the subsequent large consumption of fossil fuels cause its depletion and increase the pollution *** quest for the production of clean energy from renewable and sustainable sources remains *** conversion of solar energy into hydrogen via the water-splitting process,assisted by pho tores pons ive semiconductor catalysts,is one of the most promising *** progress has been made on water splitting in the past few years and a variety of photocatalysts active not only under ultra-violet(UV) light but especially with the visible part of the electromagnetic spectrum have been *** double hydroxides(LDH)-based materials have emerged as a promising class of nanomaterials for solar energy applications owing to their unique layered structure,compositional flexibility,tunable bandgaps,ease of synthesis and low manufacturing *** review covers the most recent research dedicated to LDH materials for photocatalytic water-splitting applications and encompasses a range of synthetic strategies and post-modifications used to enhance their ***,we provide a thorough discussion of the experimental conditions crucial to obtaining improved photoactivity and highlight the impact of some specific parameters,namely,catalysts loading,cocatalysts,sacrificial agents,and irradiation *** review provides the necessary tools to select the election technique for adequately enhancing the photoactivity of LDH and modified LDH-based materials and concludes with a critical summary that outlines further research directions.

关键词： Layered double hydroxides Water splitting Photocatalysis Hydrogen generation Oxygen evolution Nanomaterials

The spindle assembly checkpoint:perspectives in tumorigenesis and cancer therapy

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Frontiers in Biology 2011年第2期6卷 147-155页

作者： Joana BARBOSA Ana Vanessa NASCIMENTO Juliana faria Patrícia silva Hassan BOUSBAA Centro de Investigação em Ciências da Saúde(CICS) Instituto Superior de Ciências da Saúde-NorteCESPURua Central de Gandra13174585-116 Gandra PRDPortugal

Loss or gain of chromosomes,a condition known as aneuploidy,is a common feature of tumor cells and has therefore been proposed as the driving force for *** chromosomal instability can arise during mitosis as a result of mis-segregation of the duplicated sister chromatids to the two daughter *** normal cells,missegregation is usually prevented by the spindle assembly checkpoint(SAC),a sophisticated surveillance mechanism that inhibits mitotic exit until all chromosomes have successfully achieved bipolar attachment to spindle *** abrogation of SAC activity is lethal to normal as well as to tumor cells,as a consequence of massive chromosome ***,many human aneuploid tumor cells exhibit a weakened SAC activity that allows them to tolerate gains or losses of a small number of chromosomes;and interfering with this SAC residual activity may constitute a suitable strategy to kill cancer *** review focuses on the potential link between SAC and tumorigenesis,and the therapeutic strategy to target the SAC for cancer treatment.

关键词： spindle assembly checkpoint mitosis chromosome instability tumor cancer therapy

Acute diverticulitis in younger patients:Any rationale for a different approach?

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World Journal of Gastroenterology 2011年第2期17卷 207-212页

作者： Gil R faria Ana B Almeida Herculano Moreira Joo Pinto-de-Sousa Pedro Correia-da-silva Amadeu P Pimenta Department of General Surgery Hospital de So Joo Faculty of Medicine of the University of Porto Institute of Pathology and Molecular Immunology of the University of Porto-IPATIMUP-Rua Dr.Roberto Frias s/n 4200-465 PortoPortugalPortoPortugal Institute of Pathology and Molecular Immunology of the University of Porto-IPATIMUP-Rua Dr.Roberto Frias s/n 4200-465 PortoPortugal

AIM:To compare the natural history and course of acute diverticulitis in a younger age group with an older population and to evaluate whether younger patients should be managed differently. METHODS:This study was a retrospective review of 157 patients treated with acute diverticulitis between January 1,2004 and December 31,*** was stratified according to the Hinchey classification. Patients were divided into 2 populations:group A≤ 50 years(n=31) ;group B>50 years(n=126) .Mean patient follow-up was 15 mo. RESULTS:The median age was 60 years.A significantly higher proportion of patients in group B presented with complicated diverticulitis(36.5%vs 12.9%,P=0.01) .Recurrence was more frequent in group A(25.8%vs 11.1%,P=0.03) and the mean time-torecurrence was shorter(12 mo vs 28 mo,P=0.26) . The most severe recurrent episodes of acute diverticulitis were classified as Hinchey stageⅠand none of the patients required emergency *** multivariate analysis,only age(P=0.024) was identified as an independent prognostic factor for recurrence. CONCLUSION:Based on the results of this study,we recommend that diverticulitis management should be based on the severity of the disease and not on the age of the patient.

关键词： Acute diverticulitis Recurrence Age factors Severity Surgical treatment

Cubosome nanoparticles for enhanced delivery of mitochondria anticancer drug elesclomol and therapeutic monitoring via sub-cellular NAD(P) H multi-photon fluorescence lifetime imaging

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Nano Research 2019年第5期12卷 991-998页

作者： Ana R.faria Oscar F.Silvestre Christian Maibohm Ricardo M.R.Adao Bruno F.B.silva Jana B.Nieder Department of Nanophotonics Ultrafast Bio- and Nanophotonics GroupINL - International Iberian Nanotechnology LaboratoryAv.Mestre Jose Veiga s/n4715-330 BragaPortugal Department of Life Sciences INL-International Iberian Nanotechnology LaboratoryAv.Mestre Jose Veiga s/n4715-330 BragaPortugal

Elesclomol (ELC) is an anticancer drug inducing mitochondria cytotoxicity through reactive oxygen ***,for the first time,we encapsulate the poorly water soluble ELC in monoolein-based cubosomes stabilized with Pluronic *** uptake and nanocarrier accumulation close to the mitochondria with sub-micrometer distance is identified via three-dimensional (3D) confocal microscopy and edge-to-edge compartment *** monitor the therapeutic effect of the ELC nanocarrier,we apply for the first time,label-free time-lapse multi-photon fluorescence lifetime imaging microscopy (MP-FLIM) to track NAD(P)H cofactors with sub-cellular resolution on live cells exposed to an anticancer *** in vitro cytotoxicity is verified when loading the pre-complexed ELC with copper (ELC-Cu).Importantly,for equivalent copper concentration,cubosomes loaded with ELC-Cu show higher cytotoxicity compared to the free *** novel nanocarrier shows promising features for systemic ELC-Cu administration,and furthermore we establish the MP-FLIM technique for the assessment of anticancer drug delivery systems.

关键词： cubosomes mitoch on dria reactive oxyge n species elesclomol NAD(P)H fluoresce nee lifetime anticancer therapy

Directional derivative-based method for quasi-stationary voltage support analysis of single-infeed VSC-HVDC units

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High Voltage 2020年第5期5卷 511-522页

作者： Arcadio Perilla Jose Luis Rueda Torres Elyas Rakhshani Roni Irnawan Filipe faria da silva Mart van der Meijden Claus Leth Bak Alex Alefragkis Anna Lindefelt Electrical Sustainable Energy Department Delft University of TechnologyMekelweg 42628 CDDelftThe Netherlands 2Department of Energy TechnologyAalborg UniversityPontoppidanstraede 1119220AalborgDenmark 3TenneT TSO B.VArnhemThe Netherlands 4EnerginetFredericiaDenmark

This study presents an investigation of the impact of the quasi-stationary voltage support provided by a voltage source converter(VSC)connected to a single point of a power *** on the directional derivative concept,an analytical method is developed to quantify the sensitivities of the AC bus voltage with respect to the VSC reactive power control *** on a real case study,it is shown that the method applies to VSC units that are part of VSC-HVDC systems,which can operate in a point-to-point or multi-terminal ***-domain simulations are performed to verify the findings from the application of the analytical method on a reduced size power system.

关键词： stationary method system.

Non-invasive tests for the prediction of primary hepatocellular carcinoma

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World Journal of Gastroenterology 2020年第24期26卷 3326-3343页

作者： giovanni Marasco Antonio Colecchia giovanni silva Benedetta Rossini Leonardo Henry Eusebi Federico Ravaioli Elton Dajti Luigina Vanessa Alemanni Luigi Colecchia Matteo Renzulli Rita Golfieri Davide Festi Department of Medical and Surgical Sciences(DIMEC) University of BolognaBologna 40138Italy Unit of Gastroenterology Borgo Trento University Hospital of VeronaVerona 37126Italy Radiology Unit Sant’Orsola Malpighi HospitalUniversity of BolognaBologna 40138Italy

Hepatocellular carcinoma(HCC)is one of the most common malignancies in the world and it is one of the main complications of cirrhosis and portal *** in the presence of a well-established follow-up protocol for cirrhotic patients,to date poor data are available on predictive markers for primary HCC occurrence in the setting of compensated advanced chronic liver disease patients(cACLD).The gold standard method to evaluate the prognosis of patients with cACLD,beyond liver fibrosis assessed with histology,is the measurement of the hepatic venous pressure gradient(HVPG).An HVPG≥10 mmHg has been related to an increased risk of HCC in cACLD ***,these methods are burdened by additional costs and risks for patients and are mostly available only in referral *** the last decade increasing research has focused on the evaluation of several,simple,non-invasive tests(NITs)as predictors of HCC *** reviewed the currently available literature on biochemical and ultrasound-based scores developed for the noninvasive evaluation of liver fibrosis and portal hypertension in predicting primary *** found that the most reliable methods to assess HCC risk were the liver stiffness measurement,the aspartate aminotransferase to platelet ratio index score and the fibrosis-4 *** promising NITs need further investigations and validation for different liver disease aetiologies.

关键词： Non-invasive test Fibrosis-4 index Hepatocellular carcinoma Liver stiffness measurement Spleen stiffness measurement Albi

Interactive Multimodal Narrative as an Approach to Developing Emergent Literacy in Early Childhood Education

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Sino-US English Teaching 2013年第4期10卷 328-333页

作者： Adila Ferreira Lopes de faria Paulo Manuel Miranda faria Maria Altina silva Ramos University ofMinho Braga Portugal

At present, the Portuguese education system promotes the development of new literacies in all education levels in response to new requirements of the digital world which imply changes in children＇s education. In fact, reading and writing are no longer limited exclusively to books, rather they are associated with diversified digital media integrating text, sound, image, and video. In this context, we developed an exploratory study in a kindergarten with the children and their family members. Data were collected through participant observation, children conversational interviews, and digital narratives produced by children. Data analysis is based on content analysis with NVivo software support. The emergence of literacy is evident in verbal interactions in peer-group work, in contact with the written text, in ＂writing＂ in various media, and in sharing knowledge, discoveries, and digital narratives produced in an online community （http：//***）. This paper presents：（1） a systematic literature review in the field of digital narrative and emergent literacy; （2） the description of children＇s activities concerning interactive multimodal narrative; （3） the results of this work; and （4） the conclusion about contribution of multimodal narratives to the emergence of reading, writing, and digital skills

关键词： emergent literacy multimodal narrative systematic literature review NVivo

Proximal sensor-enhanced soil mapping in complex soil-landscape areas of Brazil

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Pedosphere 2021年第4期31卷 615-626页

作者： Sérgio H.G.silva David C.WEINDORF Wilson M.faria Leandro C.PINTO Michele D.MENEZES Luiz R.G.GUILHERME Nilton CURI Department of Soil Science Federal University of LavrasLavras 37200-000(Brazil) Department of Earth and Atmospheric Sciences Central Michigan UniversityMount Pleasant 48858(USA)

Portable X-ray fluorescence(pXRF) spectrometry and magnetic susceptibility(MS) via magnetometer have been increasingly used with terrain variables for digital soil mapping. However, this methodology is still emerging in many countries with tropical soils. The objective of this study was to use proximal soil sensor data associated with terrain variables at varying spatial resolutions to predict soil classes using the Random Forest(RF) algorithm. The study was conducted on a 316-ha area featuring highly variable soil classes and complex soil-landscape relationships in Minas Gerais State, Brazil. The overall accuracy and Kappa index were evaluated using soils that were classified at 118 sites, with 90 being used for modeling and 28 for validation. Digital elevation models(DEMs) were created at 5-, 10-, 20-, and 30-m resolutions using contour lines from two sources. The resulting DEMs were processed to generate 12 terrain variables. Total Fe, Ti, and SiO_(2) contents were obtained using pXRF, with MS determined via a magnetometer. Soil class prediction was performed using the RF algorithm. The quality of the soil maps improved when using only the five most important covariates and combining proximal sensor data with terrain variables at different spatial resolutions. The finest spatial resolution did not always provide the most accurate maps. The high soil complexity in the area prevented highly accurate predictions. The most important variables influencing the soil mapping were MS, Fe, and Ti. Proximal sensor data associated with terrain information were successfully used to map Brazilian soils at variable spatial resolutions.

关键词： magnetic susceptibility magnetometer portable X-ray fluorescence spectrometer soil class soil spatial analysis spatial resolution terrain variables

Different risk factors influence peptic ulcer disease development in a Brazilian population

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World Journal of Gastroenterology 2012年第38期18卷 5404-5411页

作者： Rodrigo Buzinaro Suzuki Rodrigo faria Cola Larissa Tranquilino Bardela Cola Camila Garcia Ferrari Fred Ellinger Altino Luiz Therezo Luis Carlos da silva André Eterovic Márcia Aparecida Sperana Department of Genotyping Hemocenter Marilia Medical School Marilia 17519-030 So Paulo Brazil Center for Natural and Human Sciences Universidade Federal do ABC Santo André 09210-170 So Paulo Brazil Department of Molecular Biology Marilia Medical School Marilia 17519-030 So Paulo Brazil Department of Pathology Marilia Medical School Marilia 17519-030 So Paulo Brazil

AIM: To investigate age, sex, histopathology and Helicobacter pylori (H. pylori) status, as risk factors for gastroduodenal disease outcome in Brazilian dyspeptic *** submitted to upper gastroscopy at Hospital das Clinicas of Marilia, antral biopsy specimens were obtained and subjected to histopathology and H. pylori diagnosis. All patients presenting chronic gastritis (CG) and peptic ulcer (PU) disease localized in the stomach, gastric ulcer (GU) and/or duodenal ulcer (DU) were included in the study. Gastric biopsies (n = 668) positive for H. pylori by rapid urease test were investigated for vacuolating cytotoxin A (vacA ) medium (m) region mosaicism by polymerase chain reaction. Logistic regression analysis was performed to verify the association of age, sex, histopathologic alterations, H. pylori diagnosis and vacA m region mosaicism with the incidence of DU, GU and CG in patients. RESULTS: Of 1466 patients submitted to endoscopy, 1060 (72.3%) presented CG [male/female = 506/554; mean age (year) ± SD = 51.2 ± 17.81], 88 (6.0%) presented DU [male/female = 54/34; mean age (year) ± SD = 51.4 ± 17.14], and 75 (5.1%) presented GU [male/female = 54/21; mean age (year) ± SD = 51.3 ± 17.12] and were included in the comparative analysis. Sex and age showed no detectable effect on CG incidence (overall c 2 = 2.1, P = 0.3423). Sex [Odds ratios (OR) = 1.8631, P = 0.0058] but not age (OR = 0.9929, P = 0.2699) was associated with DU and both parameters had a highly significant effect on GU (overall c 2 = 30.5, P < 0.0001). The histopathological results showed a significant contribution of ageing for both atrophy (OR = 1.0297, P < 0.0001) and intestinal metaplasia (OR = 1.0520, P < 0.0001). Presence of H. pylori was significantly associated with decreasing age (OR = 0.9827, P < 0.0001) and with the incidence of DU (OR = 3.6077, P < 0.0001). The prevalence of m1 in DU was statistically significant (OR = 2.3563, P = 0.0018) but not in CG (OR = 2.678, P = 0.0863) and G

关键词： Helicobacter pylori Gastric ulcer disease Duodenal ulcer disease Gastric atrophy Helicobacter pylori vacuolating cytotoxin A medium region mosaicism