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Flow Behavior of Clay-Silt to Sand-Silt Water-Rich Suspensions at Low to High Shear Rates: Implications for Slurries, Transitional Flows, and Submarine Debris-Flows

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Acta Geologica Sinica(English Edition) 2018年第6期92卷 2395-2404页

作者： Pierdomenico DEL GAUDIO guido VENTURA Istituto Nazionale di Geofisica e Vulcanologia Via di Vigna Murata 60500143 RomeItaly Istituto per l'Ambiente Marino Costiero Consiglio Nazionale delle RicercheNaplesItaly

Water-rich clay to sand suspensions show a shear rate dependent flow behavior and knowledge of the appropriate rheological model is relevant for sedimentological, industrial and hydraulic studies. We present experimental rheological measurements of water-rich(40 to 60 wt%) clay to silt(population A) and silt to sand(population B) suspensions mixed in different proportions. The data evidence a shear rate dependent shear thinning-shear thickening transition. At lower shear rates, the suspensions organize in chains of particles, whereas at higher shear rates, these chains disrupt so increasing the viscosity. The viscosity, consistency and yield stress decrease as the A+B fraction decreases as the content of B particles increases. This behavior reflects the competing effects of the lubrication and frictional processes as a function of particle size and water content. Transitional flows form by the incorporation of small amounts of the finer fraction while ‘oceanic floods’ form at the estuary of rivers and the submarine debris-flows increase their velocity by incorporating water. The critical Reynolds number of the studied suspensions is ～2000±100 suggesting that the grainsize plays a major role in the laminar to turbulent transition. Our results have implications for the modeling of sediment flows and the hazard related to floods.

关键词： rheology water-sediment suspensions slurry sludge transitional flows and mud flows volcanogenic sediment-water flows oceanic floods

Impact of climate change on hydropower generation in Rio Jubones Basin, Ecuador

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Water Science and Engineering 2018年第2期11卷 157-166页

作者： Mohammad Mehedi Hasan guido Wyseure Hydraulic Research Directorate River Research Institute Department of Earth and Environmental Sciences KU Leuven

This study attempted to use the soil and water assessment tool(SWAT), integrated with geographic information systems(GIS), for assessment of climate change impacts on hydropower generation. This methodology of climate change impact modeling was developed and demonstrated through application to a hydropower plant in the Rio Jubones Basin in Ecuador. ArcSWAT 2012 was used to develop a model for simulating the river flow. The model parameters were calibrated and validated on a monthly scale with respect to the hydro-meteorological inputs observed from 1985 to 1991 and from 1992 to 1998, respectively. Statistical analyses produced Nash-Sutcliffe efficiencies(NSEs) of 0.66 and 0.61 for model calibration and validation, respectively, which were considered acceptable. Numerical simulation with the model indicated that climate change could alter the seasonal flow regime of the basin, and the hydropower potential could change due to the changing climate in the *** analysis indicates that, though the hydropower generation will increase in the wet season, the plant will face a significant power shortage during the dry season, up to 13.14% from the reference scenario, as a consequence of a 17% reduction of streamflow under an assumption of a 2.9℃ increase in temperature and a 15% decrease in rainfall. Overall, this study showed that hydrological processes are realistically modeled with SWAT and the model can be a useful tool for predicting the impact of climate change.

关键词： SWAT Hydropower generation Climate change Sensitivity analysis Nash-Sutcliffe efficiency(NSE)

Novel findings about management of gastric cancer: A summary from 10^(th) IGCC

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World Journal of Gastroenterology 2014年第27期20卷 8986-8992页

作者： Danila Penon Letizia Cito Antonio giordano Department of Biochemistry and Medical Biotechnology University of Naples Federico Ⅱ 80131 Naples Italy Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale" IRCCS 80131 Naples Italy Sbarro Institute for Cancer Research and Molecular Medicine Philadelphia PA 19122 United States Center of Biotechnology College of Science and Technology Temple University Philadelphia PA 19122 United States Department of Medicine Surgery and Neuroscience University of Siena 53100 Siena Italy

The Tenth International Gastric Cancer Congress(IGCC) was held in Verona, Italy, from June 19 to 22, 2013. The meeting enclosed various aspects of stomach tumor management, including both tightly clinical approaches, and topics more related to basic research. Moreover, an overview on gastrointestinal stromal tumors was provided too, although here not discussed. Here we will discuss some topics related to molecular biology of gastric cancer(GC), inherent to prognostic, diagnostic and therapeutic tools shown at the conference. Results about well known subjects, such as E-cadherin loss of expression/function, were presented. They revealed that other mutations of the gene were identified, showing a continuous research to improve diagnosis and prognosis of stomach tumor. Simultaneously, new possible molecular markers with an established role for other neoplasms, were discussed, such as mesothelin, stomatin-like protein 2 and Notch-1. Hence, a wide overview including both old and new diagnostic/prognostic tools was offered. Great attention was also dedicated to possible drugs to be used against GC. They included monoclonal antibodies, such as MS57-2.1, drugs used in other pathologies, such as maraviroc, and natural extracts from plants such as biflorin. We would like to contribute to summarize the most impressive studies presented at the IGCC, concerning novel findings about molecular biology of gastric cancer. Although further investigations will be necessary, it can be inferred that more and more tools were developed, so as to better face stomach neoplasms.

关键词： Gastric cancer Prognostic tools Markers Therapy

Online Adaptive Approximate Optimal Tracking Control with Simplified Dual Approximation Structure for Continuous-time Unknown Nonlinear Systems

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IEEE/CAA Journal of Automatica Sinica 2014年第4期1卷 412-422页

作者： Jing Na guido Herrmann the Faculty of Mechanical and Electrical Engineering Kunming University of Science and Technology the Department of Mechanical Engineering University of Bristol

This paper proposes an online adaptive approximate solution for the infinite-horizon optimal tracking control problem of continuous-time nonlinear systems with unknown *** requirement of the complete knowledge of system dynamics is avoided by employing an adaptive identifier in conjunction with a novel adaptive law, such that the estimated identifier weights converge to a small neighborhood of their ideal *** adaptive steady-state controller is developed to maintain the desired tracking performance at the steady-state, and an adaptive optimal controller is designed to stabilize the tracking error dynamics in an optimal manner. For this purpose, a critic neural network(NN) is utilized to approximate the optimal value function of the Hamilton-Jacobi-Bellman(HJB) equation,which is used in the construction of the optimal controller. The learning of two NNs, i.e., the identifier NN and the critic NN, is continuous and simultaneous by means of a novel adaptive law design methodology based on the parameter estimation *** of the whole system consisting of the identifier NN,the critic NN and the optimal tracking control is guaranteed using Lyapunov theory; convergence to a near-optimal control law is proved. Simulation results exemplify the effectiveness of the proposed method.

关键词： Adaptive control optimal control approximate dynamic programming system identification

The formation and growth mechanisms of young back-arc spreading ridges from high-resolution bathymetry:The Marsili Seamount(Tyrrhenian Sea,Italy)

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Geoscience Frontiers 2024年第1期15卷 325-338页

作者： Eugenio Nicotra Salvatore Passaro guido Ventura Dipartimento di Biologia Ecologia e Scienze della Terra Universitàdella Calabria87036 Arcavacata di RendeCosenzaItaly Istituto di Scienze Marine CNR 80133 NapoliItaly Istituto Nazionale di Geofisica e Vulcanologia 00143 RomaItaly Istituto per lo Studio degli impatti Antropici e Sostenibilitáin ambiente marino CNR 91026 Capo GranitolaTrapaniItaly

The formation and growth mechanisms of Mid-Ocean Ridges(MOR)are relatively well known,whereas those of back-arc spreading ridges are comparatively less known because geophysical,geochemical,and morphological data are scarce and of low *** we present a high-resolution bathymetry of the Marsili Seamount(MS;1 Ma-3 ka),which represents the inflated spreading ridge of the 2 Ma old Marsili back-arc basin associated to the subduction of the Ionian Sea below the Calabrian Arc and Tyrrhenian *** is 70 km long,30 km wide,and its height reaches about 3000 m from surrounding *** new digital bathymetric model has a 5 m grid cell size resolution and covers the MS bathymetry from-1670 mbsl to the top at-491 *** conduct morphometric and morphological analyses of the bathymetry and recognize landforms due to volcanic,tectonic,hydrothermal and gravity *** consists of volcanoes related to fissural and central-type activity,this latter located at the northern and southern tips of the main dike *** swarms represent the surface expression of different ridge segments whose strikes are controlled by the larger scale back-arc spreading processes and by the local occurrence of an active hydrothermal *** latter develops in a flat area between two partly overlapping ridge segments where historical volcanism and extensional processes *** ridges represent the embryonic stage of the formation of transform-like *** volcanoes,the northern of which is characterized by a caldera,form at the tips of MS because the decrease in width of the major volcanic fissures promotes vent localization associated with the formation of sill-like reservoirs from which central-type vents may *** processes affecting the MS flanks are due to shallow seafloor *** collapses affecting the northernmost central-type polygenic volcano must be included in the evaluation of the hazard related to potential *** dipping faul

关键词： Back-arc spreading ridge Morphology Tectonics Volcanism Marsili seamount

On-Site Manufacturing in Tip-Growing Cells through RALF1-FERONIA-Mediated Local mRNA Translation

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Molecular Plant 2020年第5期13卷 682-684页

作者： Marjorie Guichard guido Grossmann Centre for Organismal Studies(COS) Heidelberg UniversityIm Neuenheimer Feld 23069120 HeidelbergGermany

Construction sites,particularly in the public sector,are notoriously *** matter how well thought out the construction plan,no matter how rigorously calculated the time schedule,the rate of construction or the time point when the building will ultimately welcome its residents remains largely,*** availability of resources,interactions between contractors,and environmental conditions,as well as control mechanisms and restrictions,form a complex"regulatory network"that governs the construction progress largely independent of the architecfs schedule and accounts for a certain"plasticity"along the way.

关键词： schedule rigorous Site

Lattice Boltzmann Simulation of Free-Surface Temperature Dispersion in Shallow Water Flows

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Advances in Applied Mathematics and Mechanics 2009年第3期1卷 415-437页

作者： Mohammed Seaid guido Thommes School of Engineering University of DurhamSouth RoadDurham DH13LEUK Fraunhofer-Institut fur Techno-und Wirtschaftsmathematik 67663 KaiserslauternGermany

We develop a lattice Boltzmann method for modeling free-surface temperature dispersion in the shallow water *** governing equations are derived from the incompressible Navier-Stokes equations with assumptions of shallow water flows including bed frictions,eddy viscosity,wind shear stresses and Coriolis *** thermal effects are incorporated in the momentum equation by using a Boussinesq *** dispersion of free-surface temperature is modelled by an advection-diffusion *** distribution functions are used in the lattice Boltzmann method to recover the flow and temperature variables using the same lattice *** upwind discretization procedures nor Riemann problem solvers are needed in discretizing the shallow water *** addition,the source terms are straightforwardly included in the model without relying on well-balanced techniques to treat flux gradients and source *** validate the model for a class of problems with known analytical solutions and we also present numerical results for sea-surface temperature distribution in the Strait of Gibraltar.

关键词： Shallow water flows free-surface temperature lattice Boltzmann method advection-diffusion equation strait of Gibraltar

Peroxisome:the new player in ferroptosis

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Signal Transduction and Targeted Therapy 2020年第1期5卷 221-222页

作者： Daolin Tang guido Kroemer Department of Surgery University of Texas Southwestern Medical CenterDallasTexas 75390USA Center for DAMP Biology University of Texas Southwestern Medical CenterDallasTexas 75390USA Equipe labellisée par la Ligue contre le cancer Universitéde ParisSorbonne UniversitéINSERM U1138Centre de Recherche des CordeliersParisFrance Metabolomics and Cell Biology Platforms Gustave Roussy Cancer Campus94800 VillejuifFrance Pôle de Biologie Hôpital Européen Georges PompidouAP-HP75015 ParisFrance

A recent paper published in Nature by Zou et *** that peroxisomes,membrane-bound oxidative organelles,contribute to ferroptosis through the biosynthesis of plasmalogens for lipid peroxidation(Fig.1).1 These observatio... 详细信息

关键词： peroxidation al death

Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development

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World Journal of Gastroenterology 2019年第15期25卷 1797-1816页

作者： Enrique Rozengurt guido Eibl Department of Medicine David Geffen School of Medicine University of California at Los Angeles CURE: Digestive Diseases Research Center Department of Surgery David Geffen School of Medicine University of California at Los Angeles

Pancreatic ductal adenocarcinoma(PDAC) remains a deadly disease with no efficacious treatment options. PDAC incidence is projected to increase, which may be caused at least partially by the obesity epidemic. Significantly enhanced efforts to prevent or intercept this cancer are clearly warranted. Oncogenic KRAS mutations are recognized initiating events in PDAC development, however, they are not entirely sufficient for the development of fully invasive *** genetic alterations and/or environmental, nutritional, and metabolic signals, as present in obesity, type-2 diabetes mellitus, and inflammation, are required for full PDAC formation. We hypothesize that oncogenic KRAS increases the intensity and duration of the growth-promoting signaling *** exciting studies from different laboratories indicate that the activity of the transcriptional co-activators Yes-associated protein(YAP) and WW-domaincontaining transcriptional co-activator with PDZ-binding motif(TAZ) play a critical role in the promotion and maintenance of PDAC operating as key downstream target of KRAS signaling. While initially thought to be primarily an effector of the tumor-suppressive Hippo pathway, more recent studies revealed that YAP/TAZ subcellular localization and co-transcriptional activity is regulated by multiple upstream signals. Overall, YAP has emerged as a central node of transcriptional convergence in growth-promoting signaling in PDAC cells. Indeed, YAP expression is an independent unfavorable prognostic marker for overall survival of PDAC. In what follows, we will review studies implicating YAP/TAZ in pancreatic cancer development and consider different approaches to target these transcriptional regulators.

关键词： Pancreatic cancer Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif Oncogenic Kras Obesity Signaling network and loops