检索结果-南通市图书馆

中国神经肿瘤杂志 2010年第2期8卷 81-81页

作者： Gururangan S Chi SN Young Poussaint T Onar-Thomas A gilbertson rj Vajapeyam S Friedman HS Packer rj Rood BN Boyett JM Kun LE Preston Robert Tisch Brain Tumor Center Duke University Medical Center Dana-Farber Cancer Institute Children's Hospital Boston St Jude Children's Research Hospital Operations and Biostatistics Center for the Pediatric Brain Tumor Consortium the Children's National Medical Center

PURPOSE:A phase Ⅱ study of bevacizumab(BVZ) plus irinotecan(CPT-11) was conducted in children with recurrent malignant glioma(MG) and intrinsic brainstem glioma(BSG).PATIENTS AND METHODS:Eligible patients received tw... 详细信息

关键词：肿瘤临床 BSG BVZ 治疗

ERBB1 Is Amplified and Overexpressed in High-grade Diffusely Infiltrative Pediatric Brain Stem Glioma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国神经肿瘤杂志 2003年第3期1卷 161-161页

作者： gilbertson rj Hill DA Hernan R Kocak M Geyer R Olson J Gajjar A Rush L Hamilton RL Finkelstein SD Pollack IF Brain Tumor Program and Department of Biostatistics St. Jude Children's Research Hospital Memphis Tennessee 38105

PURPOSE:This study was conducted to investigate the incidence of ERBB1 amplification and overexpression in samples of diffusely infiltrative (WHO grades Ⅱ-Ⅳ) pediatric brain stem glioma (BSG) and determine the relationship of these abnormalities to expression and mutation of TP53 and tumor grade. Experimental Design: After central pathology review, the incidence of ERBB1 amplification and overexpression was determined in 28 samples (18 surgical biopsy and 10 postmortem specimens) of BSG using quantitative PCR and immunohistochemistry,

关键词： in of BSG ERBB1 Is Amplified and Overexpressed in High-grade Diffusely Infiltrative Pediatric Brain Stem Glioma

A molecular fingerprint for medulloblastoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国神经肿瘤杂志 2003年第3期1卷 139-139页

作者： Lee Y Miller HL Jensen P Hernan R Connelly M Wetmore C Zindy F Roussel MF Curran T gilbertson rj McKinnon PJ Department of Genetics and Tumor Cell Biology Saint Jude Children's Research Hospital Memphis Tennessee 38105 USA

Medulloblastoma is the most common malignant pediatric brain tumor. In mice, Ptcl haploinsufficiency and disruption of DNA repair (DNA ligase IV inactivation) or cell cycle regulation (Kipl, Ink4d, or Inkd.c inactivation), in conjunction with p53 dysfunction, predispose to medulloblastoma. To identify genes important for this tumor, we evaluated gene expression profiles in medulloblastomas from these mice. Unexpectedly, medulloblastoma

关键词： for in A molecular fingerprint for medulloblastoma DNA

Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国神经肿瘤杂志 2006年第1期4卷 18-18页

作者： Thompson MC Fuller C Hogg TL Dalton J Finkelstein D Lau CC Chintagumpala M Adesina A Ashley DM KeUie SJ Taylor MD Curran T Gajjar A gilbertson rj St Jude Children＇s Research Hospital Memphis TN Texas Children＇ s Hospital Houston TX Royal Chil-dren＇s Hospital Melbourne The Children＇ s Hospital at Westmead and University of Sydney Sydney Australia and Hospital for Sick Children Toronto Ontario Canada.

PURPOSE: Traditional genetic approaches to identify gene mutations in cancer are expensive and laborious. Nonetheless, if we are to avoid rejecting effective molecular targeted therapies, we must test these drugs in patients whose tumors harbor mutations in the drug target. We hypothesized that gene expression profiling might be a more rapid and cost-effective method of identifying tumors that contain specific genetic abnormalities.

关键词：成神经管细胞瘤基因鉴定遗传