A molecular fingerprint for medulloblastoma

作     者：Lee Y Miller HL Jensen P Hernan R Connelly M Wetmore C Zindy F Roussel MF Curran T Gilbertson RJ McKinnon PJ 

作者机构：Department of Genetics and Tumor Cell Biology Saint Jude Children's Research Hospital Memphis Tennessee 38105 USA 

出 版 物：《中国神经肿瘤杂志》 (Chinese Journal of Neuro-Oncology)

年 卷 期：2003年第1卷第3期

页      面：139-139页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：for in A molecular fingerprint for medulloblastoma DNA 

摘      要：Medulloblastoma is the most common malignant pediatric brain tumor. In mice, Ptcl haploinsufficiency and disruption of DNA repair (DNA ligase IV inactivation) or cell cycle regulation (Kipl, Ink4d, or Inkd.c inactivation), in conjunction with p53 dysfunction, predispose to medulloblastoma. To identify genes important for this tumor, we evaluated gene expression profiles in medulloblastomas from these mice. Unexpectedly, medulloblastoma