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modelling policy combinations of vaccination and transmission suppression of SARS-CoV-2 in Rio de Janeiro,Brazil

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Infectious Disease modelling 2022年第1期7卷 231-242页

作者： Naiara C.m.Valiati Daniel A.m.villela Universidade Federal Rural do Rio de Janeiro SeropedicaRJBrazil Programa de Computaçao Científica Fundaçao Oswaldo CruzRio de JaneiroRJBrazil

COVID-19 vaccination in Brazil required a phased program,with priorities for age groups,health workers,and vulnerable *** distancing and isolation interventions have been essential to mitigate the advance of the pandemic in several *** developed a mathematical model capable of capturing the dynamics of the SARS-CoV-2 dissemination aligned with social distancing,isolation measures,and *** data from the city of Rio de Janeiro provided a case study to analyze possible scenarios,including non-pharmaceutical interventions and vaccination in the epidemic *** results demonstrate that the combination of vaccination and policies of transmission suppression potentially lowered the number of hospitalized cases by 380þand 66þthousand cases,respectively,compared to an absence of such *** top of transmission suppressiononly policies,vaccination impacted more than 230þthousand averted hospitalized cases and 43þthousand averted ***,health surveillance activities should be maintained along with vaccination planning in scheduled groups until a large vaccinated coverage is ***,this analytical framework enables evaluation of such scenarios.

关键词： SARS-CoV-2 Vaccination COVID-19

Performance evaluation of a water erosion tracer using plot-scale experiments and process-based modeling

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International Soil and Water Conservation Research 2023年第4期11卷 622-632页

作者： João m.villela Jamil A.A.Anache Alex m.Watanabe Dennis C.Flanagan Edson C.Wendland Silvio Crestana EmBRAPA-Brazilian Agricultural Research Corporation LNNA-National Laboratory of Nanotechnology for AgrobusinessSt.XV de NovembroSão CarlosSP13560-970Brazil University of São Paulo(USP) São Carlos School of Engineering.Graduate Program in Environmental Engineering Sciences(PPG-SEA)Av.Trabalhador São-CarlenseCxP.359São CarlosSP13566590Brazil Department of Hydraulics and Sanitation São Carlos School of Engineering(EESC)University of São Paulo(USP)CxP.359São CarlosSP13566-590Brazil Federal University of mato Grosso Do Sul CxP.549Campo Grande.MS.79070-900Brazil USDA-Agricultural Research Service National Soil Erosion Research Laboratory275 S.Russell StWest LafayetteIN47907USA

Socioeconomic and environmental losses caused by water erosion have highlighted the importance of quantifying and understanding the dynamics of soil redistribution in the landscape to develop effective soil management *** methods are applied to estimate erosion/deposition rates and identify sources of sediments,among them,the one that uses rare earth elements(REE)as a tracer stands ***,an alternative not yet explored that can benefit the accuracy of the estimates provided by the method is using a tracer containing a chemical signature composed of more than one *** present study aimed to evaluate the performance of a new water erosion tracer based on montmoril-lonite labeled with rare earth elements(La40-mmT).The innovative aspects of this La40-mmT tracer include its highly stable multi-chemical signature(Nd^(3+),La^(3+),and Pr^(3+)),which enhances tracer detection in the environment,and its low production cost due to the use of an industrial residue in the synthesis *** tracer was evaluated for a typical soil of the Cerrado biome,using a natural rainfall field-scale plot-NRFP(5 m × 20 m)and a physical predictive erosion model(WEPP).The results showed that the La40-mmT tracer could be used to estimate erosion/deposition rates,with agreement between the values observed with the tracer and the WEPP ***,this study confirmed the great potential of La40-mmT as a tool to identify patterns of soil redistribution at the field scale and aid in the validation of erosion models.

关键词： Soil erosion Tracer Rare earth elements Deposition Sediment source WEPP model

Performance of Geometric multigrid method for Two-Dimensional Burgers’Equations with Non-Orthogonal,Structured Curvilinear Grids

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Computer modeling in Engineering & Sciences 2020年第12期125卷 1061-1081页

作者： Daiane Cristina Zanatta Luciano Kiyoshi Araki marcio Augusto villela Pinto Diego Fernando moro State University of Centro-Oeste IratiBrazil Federal University of Parana Department of Mechanical EngineeringCuritibaBrazil Positivo University CuritibaBrazil

This paper seeks to develop an efficient multigrid algorithm for solving the Burgers problem with the use of non-orthogonal structured curvilinear grids in L-shaped *** this,the differential equations were discretized by Finite Volume method(FVm)with second-order approximation scheme and deferred ***,the algebraic method and the differential method were used to generate the non-orthogonal structured curvilinear ***,the influence of some parameters of geometric multigrid method,as well as lexicographical Gauss–Seidel(Lex-GS),η-line Gauss–Seidel(η-line-GS),modified Strongly Implicit(mSI)and modified incomplete LU decomposition(mILU)solvers on the Central Processing Unit(CPU)time was ***,several parameters of multigrid method and solvers were tested for the problem,with the use of nonorthogonal structured curvilinear grids and multigrid method,resulting in an algorithm with the combination that achieved the best results and CPU *** geometric multigrid method with Full Approximation Scheme(FAS),V-cycle and standard coarsening ratio for this problem were *** article shows how to calculate the coordinates transformation metrics in the coarser *** show that the mSI and mILU solvers are the most ***,themSI solver is faster thanmILU for both grids generators;and the solutions are more accurate for the Burgers problem with grids generated using elliptic equations.

关键词： Computational fluid dynamics finite volume method Burgers’equation geometric multigrid non-orthogonal curvilinear grids

Hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis

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World Journal of Gastroenterology 2023年第2期29卷 343-356页

作者： Cristiane Valle Tovo Angelo Zambam de mattos Gabriela Perdomo Coral Giovana D P Sartori Livia villela Nogueira Gustavo Tovo Both Cristiane A villela-Nogueira Angelo A de mattos Department of Internal medicine Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050170RSBrazil Department of Internal medicine Fundação Técnico Educacional Souza MarquesRJ 21491-630RJBrazil Department of Internal medicine Universidade Luterana do BrasilCanoas 92425-350RSBrazil Department of Internal medicine Universidade Federal do Rio de JaneiroRio de Janeiro 21491-630RJBrazil

Cirrhosis is an emerging major cause of the development of hepatocellular carcinoma(HCC),but in non-alcoholic fatty liver disease(NAFLD),up to 50%of patients with HCC had no clinical or histological evidence of *** is currently challenging to propose general recommendations for screening patients with NAFLD without cirrhosis,and each patient should be evaluated on a caseby-case basis based on the profile of specific risk factors *** HCC screening in NAFLD,a valid precision-based screening is ***,when evaluating this population of patients,the use of non-invasive methods can guide the selection of those who should undergo a screening and surveillance ***,the objective of the present study is to review the epidemiology,the pathophysiology,the histopathological aspects,the current recommendations,and novel perspectives in the surveillance of non-cirrhotic NAFLD-related HCC.

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Hepatocellular carcinoma Genetic variants microbiota Obesity

Non-alcoholic fatty liver disease and the impact of genetic,epigenetic and environmental factors in the offspring

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World Journal of Gastroenterology 2022年第25期28卷 2890-2899页

作者： Natalia Balassiano Wajsbrot Nathalie Carvalho Leite Gil F Salles Cristiane A villela-Nogueira Division of Hepatology Clementino Fraga Filho University HospitalFederal University of Rio de JaneiroRio de Janeiro 20941-913Brazil Department of Internal medicine Medical SchoolFederal University of Rio de JaneiroRio de Janeiro 22750-240Brazil

Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide and is strongly associated with metabolic *** recently,a significant impact of parental NAFLD in the offspring was demonstrated and has been widely ***,pathogenetic pathways implicated in the inheritance by the offspring and relatives are still under ***,multiple mechanisms are involved as well as in NAFLD pathogenesis *** the multifactorial involved mechanisms,genetic,epigenetic and environmental backgrounds are strongly related to NAFLD development in the ***,based on recent evidence from the available literature concerning genetic,epigenetic and environmental disease modifiers,this review aimed to discuss the relationship between parental NAFLD and its impact on the offspring.

关键词： Steatosis Genetic Epigenetic Environmental Offspring Non-alcoholic fatty liver disease

High Order of Accuracy for Poisson Equation Obtained by Grouping of Repeated Richardson Extrapolation with Fourth Order Schemes

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Computer modeling in Engineering & Sciences 2021年第8期128卷 699-715页

作者： Luciano Pereira da Silva Bruno Benato Rutyna Aline Roberta Santos Righi marcio Augusto villela Pinto Graduate Program in Numerical methods in Engineering Federal University of ParanaCuritiba81531-980Brazil Graduate Program in Space Sciences and Technologies Aeronautics Institute of TechnologySao Jose dos Campos12228-900Brazil Department of mechanical Engineering Federal University of ParanaCuritiba81531-980Brazil

In this article,we improve the order of precision of the two-dimensional Poisson equation by combining extrapolation techniques with high order *** high order solutions obtained traditionally generate non-sparse matrices and the calculation time is very *** can obtain sparse matrices by applying compact *** this article,we compare compact and exponential finite difference schemes of fourth *** numerical solutions are calculated in quadruple precision(Real*16 or extended precision)in FORTRAN language,and iteratively obtained until reaching the round-off error magnitude around 1.0E−*** procedure is performed to ensure that there is no iteration *** Repeated Richardson Extrapolation(RRE)method combines numerical solutions in different grids,determining higher orders of *** main contribution of this work is based on a process that initializes with fourth order solutions combining with RRE in order to find solutions of sixth,eighth,and tenth order of *** multigrid Full Approximation Scheme(FAS)is also applied to accelerate the convergence and obtain the numerical solutions on the fine grids.

关键词： Tenth order accuracy RRE compact scheme exponential scheme multigrid finite difference

Non-alcoholic fatty liver disease and diabetes: From physiopathological interplay to diagnosis and treatment

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World Journal of Gastroenterology 2014年第26期20卷 8377-8392页

作者： Nathalie C Leite Cristiane A villela-Nogueira Claudia R L Cardoso Gil F Salles Internal medicine Department University Hospital Clementino Fraga FilhoSchool of MedicineUniversidade Federal do Rio de Janeiro

Non-alcoholic fatty liver disease(NAFLD)is highly prevalent in patients with diabetes mellitus and increasing evidence suggests that patients with type 2diabetes are at a particularly high risk for developing the progressive forms of NAFLD,non-alcoholic steatohepatitis and associated advanced liver ***,diabetes is an independent risk factor for NAFLD progression,and for hepatocellular carcinoma development and liver-related mortality in prospective ***,patients with NAFLD have an elevated prevalence of *** studies have shown that NAFLD presence predicts the development of type2 *** and NAFLD have mutual pathogenetic mechanisms and it is possible that genetic and environmental factors interact with metabolic derangements to accelerate NAFLD progression in diabetic *** diagnosis of the more advanced stages of NAFLD in diabetic patients shares the same challenges as in non-diabetic patients and it includes imaging and serological methods,although histopathological evaluation is still considered the gold standard diagnostic *** effective established treatment is not yet available for patients with steatohepatitis and fibrosis and randomized clinical trials including only diabetic patients are *** sought to outline the published data including epidemiology,pathogenesis,diagnosis and treatment of NAFLD in diabetic patients,in order to better understand the interplay between these two prevalent diseases and identify the gaps that still need to be fulfilled in the management of NAFLD in patients with diabetes mellitus.

关键词： Non-alcoholic fatty liver disease Diabetes mellitus Pathogenesis Diagnosis Treatment

On the Robustness of the xy-Zebra-Gauss-Seidel Smoother on an Anisotropic Diffusion Problem

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Computer modeling in Engineering & Sciences 2018年第11期117卷 251-270页

作者： michely Laís de Oliveira marcio Augusto villela Pinto Simone de Fátima Tomazzoni Goncalves Grazielli Vassoler Rutz Graduate Program in Numerical methods in Engineering Federal University of Paraná81531-980Curitiba-PRBrazil Department of mechanical Engineering Federal University of Paraná81531-980Curitiba-PRBrazil Federal Institute of Education Science and Technology of Santa Catarina89813-000Chapecó-SCBrazil.

Studies of problems involving physical anisotropy are applied in sciences and engineering,for instance,when the thermal conductivity depends on the *** this study,the multigrid method was used in order to accelerate the convergence of the iterative methods used to solve this type of *** asymptotic convergence factor of the multigrid was determined empirically(computer aided)and also by employing local Fourier analysis(LFA).The mathematical model studied was the 2D anisotropic diffusion equation,in whichε>0 was the coefficient of a *** equation was discretized by the Finite Difference method(FDm)and Central Differencing Scheme(CDS).Correction Scheme(CS),pointwise Gauss-Seidel smoothers(Lexicographic and Red-Black ordering),and line Gauss-Seidel smoothers(Lexicographic and Zebra ordering)in x and y directions were used for building the *** best asymptotic convergence factor was obtained by the Gauss-Seidel method in the direction x for 0>*** this sense,an xy-zebra-GS smoother was proposed,which proved to be efficient and robust for the different anisotropy ***,the convergence factors calculated empirically and by LFA are in agreement.

关键词： Physical anisotropy diffusion problem finite difference method multigrid,local Fourier analysis Gauss-Seidel zebra

New Technique to Create a Suspension Containing Bacteriophages and How It Can Be Used to Control Cabbage Leaf Spot Caused by <i>Xanthomonas campestris</i>PV. <i>campestris</i>

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Agricultural Sciences 2014年第4期5卷 286-297页

作者： Igor villela marroni José Carlos Germani Department of Basic Health Sciences Rua Sarmento Leite Universidade Federal do Rio Grande do Sul Porto Alegre Brazil

The purpose of the present study was to develop a new method for producing and identifying a bacteriophage suspension and research its potential against plant bacteria. The suspension obtained with the new technique was effective in controlling Xanthomonas campestris PV. campestris both in vitro and in vivo. A difference was observed between the suspension with pathogen (PLP) and crude suspension with lesioned plant without the pathogen originated from it (PLN). Clear zones were observed at 48 h/28°C in both (PLS) suspension added saccharose and (PLP). Although PLP and PLS treatments showed no statistical difference in CFU values (5 × 105 and 1 × 105, respectively), they differed from the crude suspension (PLN) and the control. Then, in vivo assessment of suspensions with clear zones in the dishes was performed. In vivo (PLPS) and (PLPP) treatments consisting of inoculum were added to the crude suspensions (PLS and PLP) to increase bacteriophages. A decrease in the disease severity index compared to the control was observed, showing that treatment with the phage suspension protects the plant. The lowest disease indexes were reported with (PLP) and (PLS), with values of 1.46 and 1.40, respectively. The highest averages in dry matter (5.1 inboth treatments) were obtained with (PLP) and (PLS) treatments.

关键词： Biocontrol Virus Bacteria Disease Index