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Circulating extracellular vesicles:friends and foes in neurodegeneration

Neural Regeneration Research 2022年第3期17卷 534-542页

作者： Anna Picca Flora guerra Riccardo Calvani Hélio JoséCoelho-junior Cecilia Bucci Emanuele Marzetti Fondazione Policlinico Universitario“Agostino Gemelli”IRCCS RomeItaly Aging Research Center Department of NeurobiologyCare Sciences and SocietyKarolinska Institutet and Stockholm UniversityStockholmSweden Department of Biological and Environmental Sciences and Technologies Universitàdel SalentoLecceItaly UniversitàCattolica del Sacro Cuore Institute of Internal Medicine and GeriatricsRomeItaly

Extracellular vesicles have been identified as pivotal mediators of intercellular communication with critical roles in physiological and pathological *** this route,several molecules(e.g.,nucleic acids,proteins,metabolites) can be transferred to proximal and distant targets to convey specific *** vesicle-associated cargo molecules have been proposed as markers of several disease conditions for their potential of tracking down the generating ***,circulating extracellular vesicles may represent biomarkers of dysfunctional cellular quality control systems especially in conditions characterized by the accrual of intracellular misfolded ***,the identification of extracellular vesicles as tools for the delivery of nucleic acids or other cargo molecules to diseased tissues makes these circulating shuttles possible targets for therapeutic *** increasing interest in the study of extracellular vesicles as biomarkers resides mainly in the fact that the identification of peripheral levels of extracellular vesicle-associated proteins might reflect molecular events occurring in hardly accessible tissues,such as the brain,thereby serving as a "brain liquid biopsy".The exploitation of extracellular vesicles for diagnostic and therapeutic purposed might offer unprecedented opportunities to develop personalized ***,we discuss the bright and dark sides of extracellular vesicles in the setting of two main neurodegenerative diseases(i.e.,Parkinson's and Alzheimer's diseases).A special focus will be placed on the possibility of using extracellular vesicles as biomarkers for the two conditions to enable disease tracking and treatment monitoring.

关键词： Alzheimer's disease amyloid protein exosomes misfolded proteins mitochondrial-derived vesicles neuroinflammation Parkinson's disease quality control Tau protein α-synuclein

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Excitotoxicity-induced endocytosis as a potential target for stroke neuroprotection

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Neural Regeneration Research 2021年第2期16卷 300-301页

作者： Margarita Díaz-guerra Instituto de Investigaciones Biomédicas“Alberto Sols” Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

Decreased neuronal survival-signaling and brain damage:Stroke is a leading cause of death worldwide,the major cause of adult disability and second of *** spite of the social and economic importance of this disorder,an... 详细信息

关键词： drugs death damage

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Challenges and improvement strategies in the hospitalization of chronic multimorbid patients

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World Journal of Clinical Cases 2025年第3期13卷 35-41页

作者： Andres Fontalba-Navas Francisco Pozo Muñoz Rogelio Garcia Cisneros Maria Jose Garcia Larrosa Maria del Mar Callejon gil Ignacio Garcia Delgado Maria Belen Jimenez Martinez Antequera Hospital Northern Málaga Integrated Healthcare AreaAntequera 29200AndalusiaSpain Department of Public Health and Psychiatry University of MálagaMálaga 29010Spain Antequera Hospital Northern Málaga Antequera Integrated Healthcare AreaAntequera 29200MálagaSpain

BACKGROUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot *** diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient *** proven effective,this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid *** To evaluate the effectiveness of the high complexity unit(HCU)in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital *** The study employed a descriptive longitudinal approach,analyzing data from the Basic Minimum Data Set(BMDS)to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** The study employed a descriptive longitudinal approach,analyzing data from the BMDS to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** This study demonstrates the effectiveness of the HCU in managing patients with complex chronic diseases through a multidisciplinary *** coordinated care provided by the HCU results in improved patient outcomes,reduced unnecessary hospitalizations,and better management of patient *** superiority of the HCU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction,reinforcing its value as a model of ca

关键词： High complexity unit Chronic multimorbidity Patient-centered care Integrated care Healthcare management

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PERTURBATIONS OF ZEROS OF SOLUTIONS TO SECOND ORDER DIFFERENTIAL EQUATIONS WITH POLYNOMIAL COEFFICIENTS

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Acta Mathematica Scientia 2012年第3期32卷 1083-1092页

作者： Michael gil' Department of Mathematics Ben Gurion University of the NegevP.O.Box 653Beer-Sheva 84105Israel

Let P（z） and P（z） be polynomials of the same degree. We consider the equations u＂ = P（z）u and u＂ = P（z）u （z ∈ C） whose solutions are u（z） and u（z）, respectively. Let Zk（U） and zk（u）, k = 1, 2,..., be the zeros of u（z） and u（z）, respectively. We derive bounds for the quantity sup j inf k｜1/zk（u）-1/zj（u）｜

关键词： Complex differential equation zeros of solutions perturbation of zeros

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Inequalities for Sums and Products of Complex Zeros of Solutions to ODE with Polynomial Right Parts

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Communications on Applied Mathematics and Computation 2023年第4期5卷 1524-1533页

作者： Michael gil’ The Department of Mathematics Ben-Gurion University of the NegevBeer-Sheva84105Israel

The paper is devoted to non-homogeneous second-order differential equations with polynomial right parts and polynomial *** derive estimates for the partial sums and products of the zeros of solutions to the considered *** estimates give us bounds for the function counting the zeros of solutions and information about the zero-free domains.

关键词： Ordinary differential equations Linear equations Zeros of solutions

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Effect of anaerobic digestion on the high rate of nitritation,treating piggery wastewater

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Journal of Environmental Sciences 2011年第11期23卷 1787-1793页

作者： Jiyeol Im Kyungik gil Department of Civil Engineering Seoul National University of Science and TechnologySeoulSouth Korea School of Civil Engineering Seoul National University of Science and TechnologySeoulSouth Korea

The amount of piggery wastewater as domestic livestock is *** volume of piggery wastewater produced is less than the volume of other wastewaters,but piggery wastewater has a heavy impact on wastewater streams due to an extremely high concentration of nitrogen and *** this study,laboratory reactors were operated using piggery wastewater and the effluent of anaerobic digester from piggery wastewater *** purpose of this study was to induce the nitritation process,which is an economically advantageous nitrogen removal method that converts ammonium nitrogen into *** results showed that the effluent of anaerobic digester from piggery wastewater was more efficient than raw piggery wastewater in terms of inducing *** can be deduced that nitritation is largely affected by an organic fraction of piggery *** can also be concluded that a small amount of biodegradable organic matter in piggery wastewater is efficient in inducing nitritation.

关键词： piggery wastewater anaerobic digestion nitritation nitrogen

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Influence of wire spacing and plate spacing on electrostatic precipitation of nanoparticles: An approach involving electrostatic shielding and diffusion charging

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Particuology 2023年第9期80卷 127-139页

作者： Felipe de Aquino Lima Vádila Giovana guerra Department of Chemical Engineering Federal University of São CarlosRodovia Washington LuísKm 235C.P.676CEP 13560-970São CarlosSPBrazil

Electrostatic precipitation is a process widely used as gas cleaning device,to removal particles from gas ***,in a conventional and well-sized precipitator,the collection efficiency decreases for ultrafine particles,making it difficult to employ this equipment for controlling nanoparticle *** paper investigates the influence of plate spacing(4 and 6.5 cm)and wire spacing(4,6,and 12 cm)on the electric current and nanoparticle collection efficiency,considering the effect of diffusion charging and electrostatic *** laboratory-scale dry wire-plate electrostatic precipitators with different plate spacings were tested for the collection of nanoparticles(6.15–241.4 nm)at three air velocities(1.9,2.9,and 3.9 cm/s).The results demonstrated the effectiveness of the equipment in removing nanoparticles(99.9%)under the highest electric *** values of the wire spacing led to increases in the current and the collection *** was associated with reduced electrostatic shielding,which is more evident in smaller ducts with a higher density of field *** is expected that the findings should improve knowledge on electrostatic precipitation of nanoparticles,enabling optimization of collection efficiency by considering the effects of geometric parameters.

关键词： Electrostatic precipitation Nanoparticles Collection efficiency Plate spacing Wire spacing

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LENTICULAR NONCOMMUTATIVE TORI

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Acta Mathematica Scientia 2003年第1期23卷 83-94页

作者： Chun-gil Park Department of Mathematics Chungnam National University Daejeon 305-764 Korea

All C*-algebras of sections of locally trivial C* -algebra bundles over ∏i=1sLki(ni) with fibres Aw Mc(C) are constructed, under the assumption that every completely irrational noncommutative torus Aw is realized as an inductive limit of circle algebras, where Lki (ni) are lens spaces. Let Lcd be a cd-homogeneous C*-algebra over whose cd-homogeneous C*-subalgebra restricted to the subspace Tr × T2 is realized as C(Tr) A1/d Mc(C), and of which no non-trivial matrix algebra can be factored *** lenticular noncommutative torus Lpcd is defined by twisting in by a totally skew multiplier p on Tr+2 × Zm-2. It is shown that is isomorphic to if and only if the set of prime factors of cd is a subset of the set of prime factors of p, and that Lpcd is not stablyisomorphic to if the cd-homogeneous C*-subalgebra of Lpcd restricted to some subspace LkiLki (ni) is realized as the crossed product by the obvious non-trivial action of Zki on a cd/ki-homogeneous C*-algebra over S2ni+1 for ki an integer greater than 1.

关键词： Lens space homogeneous C*-algebra C*-algebra bundle twisted group C*-algebra noncommutative torus K-theory UHF-algebra Cuntz algebra

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Novel translational strategies in colorectal cancer research

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World Journal of Gastroenterology 2007年第44期13卷 5902-5910页

作者： Ignacio gil-Bazo Cancer Biology & Genetics Program Memorial Sloan-Kettering Cancer Center New York NY 10021 United States

Defining translational research is still a complex task. In oncology, translational research implies using our basic knowledge learnt from in vitro and in vivo experiments to directly improve diagnostic tools and therapeutic approaches in cancer patients. Moreover, the better understanding of human cancer and its use to design more reliable tumor models and more accurate experimental systems also has to be considered a good example of translational research. The identification and characterization of new molecular markers and the discovery of novel targeted therapies are two main goals in colorectal cancer translational research. However, the straightforward translation of basic research findings, specifically into colorectal cancer treatment and vice versa is still underway. In the present paper, a summarized view of some of the new available approaches on colorectal cancer translational research is provided. Pros and cons are discussed for every approach exposed.

关键词： Translational research Colorectal cancer Genomics Proteomics Targeted therapies

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Modeling novel methodologies for unmanned aerial systems–Applications to the UAS-S4 Ehecatl and the UAS-S45 Bálaam

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Chinese Journal of Aeronautics 2019年第1期32卷 58-77页

作者： Maxime Alex junior KUITCHE Ruxandra Mihaela BOTEZ ETS Laboratory of Active ControlsAvionics and AeroServoElasticity LARCASE

The rising demand for Unmanned Aerial Systems(UASs) to perform tasks in hostile environments has emphasized the need for their simulation models for the preliminary evaluations of their missions. The efficiency of the UAS model is directly related to its capacity to estimate its flight dynamics with minimum computational resources. The literature describes several techniques to estimate accurate aircraft flight dynamics. Most of them are based on system identification. This paper presents an alternative methodology to obtain complete model of the S4 and S45 unmanned aerial systems. The UAS-S4 and the UAS-S45 models were divided into four sub-models, each corresponding to a specific discipline: aerodynamics, propulsion, mass and inertia, and actuator. The‘‘aerodynamic" sub-model was built using the Fderivatives in-house code, which is an improvement of the classical DATCOM procedure. The ‘‘propulsion" sub-model was obtained by coupling a two-stroke engine model based on the ideal Otto cycle and a Blade Element Theory(BET) analysis of the propeller. The ‘‘mass and the inertia" sub-model was designed utilizing the Raymer and DATCOM methodologies. A sub-model of an actuator using servomotor characteristics was employed to complete the model. The total model was then checked by validation of each submodel with numerical and experimental data. The results indicate that the obtained model was accurate and could be used to design a flight simulator.

关键词： Aerodynamics Aerospace propulsion Flight dynamics Unmanned aerial vehicles modeling

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